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2281
Studying and enhancing the methods for distance teaching of computer science in Kazakh secondary school students during the pandemic
Published 2023-02-01“…The participants were divided into seven groups according to the educational level (5th–11th forms) in order to make it more convenient to trace qualitative changes in the academic progress depending on the selected method for distance teaching of computer science. …”
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2282
Experimental Search on the QCD Critical Point
Published 2025-01-01“…In these proceedings, we present recent experimental progress in the search for the QCD critical point. …”
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2283
Addition of Sildenafil in Patients with Pulmonary Arterial Hypertension with Inadequate Response to Bosentan Monotherapy
Published 2008-01-01“…BACKGROUND: Pulmonary arterial hypertension (PAH) remains a progressive disease despite improvement when using one of three medication classes: prostanoids, endothelin receptor antagonists or phosphodiesterase-5 inhibitors. …”
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2284
Real-world outcomes of Defocus Incorporated Multiple Segments lenses on retarding axial elongation in myopic children and adolescents
Published 2025-01-01“…Patients with a history of myopia control had greater myopia progression after wearing DIMS lenses. There was a significant negative correlation between age at baseline and annual change in AL (correlation coefficient, r = −0.61, p < 0.001), suggesting that myopia progression was faster in children with a younger age of onset. …”
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2285
Combining a WT1 Vaccine (Galinpepimut-S) With Checkpoint Inhibition (Nivolumab) in Patients With WT1–Expressing Diffuse Pleural Mesothelioma: A Phase 1 Study
Published 2025-01-01“…We enrolled patients with progressive or recurrent DPM treated with at least one course of pemetrexed-based chemotherapy. …”
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2286
Real-World Outcomes of Pralsetinib in RET Fusion-Positive NSCLC
Published 2025-01-01“…We also observe the aggressive nature of disease progression, frequent utilization of chemotherapy and antiangiogenic agents as initial subsequent therapies, and limited insight into resistance mechanisms due to infrequent rebiopsy and genomic profiling at progression.…”
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2287
The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network
Published 2025-01-01“…IntroductionMixed Lineage Kinase Domain-Like Protein (MLKL), as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke. Studies identified MLKL is a promoting factor in this process, suggesting its potential as a therapeutic target to mitigate posthemorrhagic stroke damage. …”
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2288
Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development
Published 2021-01-01“…To date, limited studies have explored the role of circ_0044516 in lung cancer progression. Recently, we observed that circ_0044516 expression levels were obviously elevated in lung cancer tissues and cells. …”
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2289
Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma
Published 2025-01-01“…Future research should further validate the role of MARCKSL1 in MVI progression and explore its potential clinical applications.…”
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2290
Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era
Published 2025-01-01“…BE is the consequence of chronic reflux disease and has a potential progression burden to esophageal adenocarcinoma (EAC). …”
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2291
Rebiopsy Enhances Survival with Afatinib vs. Osimertinib in EGFR Exon 19 Deletion Non-Small Cell Lung Cancer: A Multicenter Study in Taiwan
Published 2025-01-01“…Osimertinib demonstrated advantages, with fewer brain metastases upon progression and fewer adverse effects. In the Afatinib group, 64% of patients with disease progression underwent rebiopsy, with 39% testing positive for T790M mutation and subsequently receiving Osimertinib. …”
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2292
Lung adenocarcinoma metastasis within a pituitary neuroendocrine tumor: a case report with review of literature
Published 2024-03-01“…Considering the relatively rapid progression of neurological symptoms, semi-emergency endoscopic endonasal transsphenoidal surgery was performed. …”
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2293
Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting
Published 2025-02-01“…Altered genes and pathways were correlated with overall survival (OS) and evaluated regarding their association with real-world progression-free survival (rwPFS) in patients treated with different chemotherapy agents. …”
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2294
Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development
Published 2025-01-01“…Aberrant expression of SIRT5 has been closely linked to tumorigenesis and disease progression; however, its role remains controversial. …”
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2295
A Survey on Optical Coherence Tomography—Technology and Application
Published 2025-01-01“…This paper reviews the main research on Optical Coherence Tomography (OCT), focusing on the progress and advancements made by researchers over the past three decades in its methods and medical imaging applications. …”
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2296
Fractional Coins and Fractional Derivatives
Published 2013-01-01“…Based on the new conceptual perspective, some experiments are performed shading new light into possible future progress.…”
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2297
METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma
Published 2025-01-01“…Conclusion: These results suggest that METTL3/miR-192-5p/SCD1 axis regulates lipid metabolism and affects T cell differentiation, thus affecting asthma progression. This study may provide novel insights into the pathogenesis of asthma and a new treatment strategy.…”
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2298
Carbon Material Hybrid Construction on an Aptasensor for Monitoring Surgical Tumors
Published 2022-01-01“…This CEA quantification by the aptasensor can help diagnose various surgical tumors and monitor their progression.…”
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2299
Research on the Urban Village Renewal Mechanism Based on Rent Gap Theory: A Case Study in Xi’an, China
Published 2025-01-01“…It explores the internal mechanisms of urban village renewal and the key factors influencing the progress of renewal projects. The findings reveal that the size of the rent gap directly determines the attractiveness and timing of urban village renewal. …”
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2300
Viruses and neurodegeneration: a growing concern
Published 2025-01-01“…Abstract Neurodegenerative diseases (NDDs) cause a progressive loss of neurons. Since NDDs are multifactorial, the precise etiology varies on the basis of the type of disease and patient history. …”
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