Antioxidants in Kidney Diseases: The Impact of Bardoxolone Methyl by Jorge Rojas-Rivera, Alberto Ortiz, Jesus Egido

“…Drugs targeting the renin-angiotensin-aldosterone system (RAAS) are the mainstay of therapy to retard the progression of proteinuric chronic kidney disease (CKD) such as diabetic nephropathy. …”
Get full text

Management of Acute Wilsonian Hepatitis with Severe Hemolysis: A Successful Combination of Chelation and MARS Dialysis by Jeremy Hassoun, Nathalie Hammer, Giulia Magini, Belen Ponte, Marie Ongaro, Anne-Laure Rougemont, Nicolas Goossens, Jean-Louis Frossard, Laurent Spahr

“…Wilson’s disease is a rare hereditary disorder of copper metabolism leading to progressive accumulation of copper in several organs including the brain and the liver. …”
Get full text

Pericardial Tamponade: An Uncommon Clinical Presentation in cANCA Related Vasculitis and Glomerulonephritis in Association with Very High Titres of ANA by Amaresh Vanga, Amna Z. Rana, Jolanta Kowalewska, Harlan Rust

“…He was found to have acute renal failure which progressively got better with cyclophosphamide.…”
Get full text

Thigmotropism of Malignant Melanoma Cells by Pascale Quatresooz, Claudine Piérard-Franchimont, Fanchon Noël, Gérald E. Piérard

“…During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. …”
Get full text

Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs by Curzio Raegg, Olivier Dormond

“…Importantly, NSAIDs suppress colon polyp formation and progression in patients diagnosed with familial adenomatous polyposis coli (APC)[2]. …”
Get full text

Genetic Rat Models of Parkinson's Disease by Ryan M. Welchko, Xavier T. Lévêque, Gary L. Dunbar

“…In this paper we focused on the various transgenic rat models of PD in terms of their ability to mimic key symptoms of PD in a progressive manner. In general, we found that most of these models provided useful tools for the early stages of PD, but the development of new transgenic rats that present significant neuropathologic and motoric deficits in a progressive manner that more accurately mimics PD is needed.…”
Get full text

Allografting for Bosutinib, Imatinib, Nilotinib, Dasatinib, and Interferon Resistant Chronic Myeloid Leukemia without ABL Kinase Mutation by B. Uz, O. Bektas, E. Eliacik, H. Goker, Y. Erbilgin, M. Sayitoglu, N. Sayinalp, S. Aksu, Y. Buyukasik, O. Ozcebe, I. C. Haznedaroglu

“…Meanwhile, challenging cases will always be present despite the hope and progress in CML in the TKI era.…”
Get full text

The Utility of Circulating Tumor DNA (ctDNA) Monitoring in Cancer Patients Who Are Pregnant or Planning to Become Pregnant by Stacey A. Cohen, Anup Kasi, Nicole Hook, Michael Krainock, Griffin Budde, Allyson Koyen Malashevich, Jeffrey Meltzer, Russ Jelsema, Perry Olshan, Paul R. Billings, Alexey Aleshin, Andrew S. Poklepovic

“…Conversely, insufficient monitoring and treatment can lead to cancer progression, compromising the health of the patient. …”
Get full text

A Brief Review on the Pathological Role of Decreased Blood Flow Affected in Retinitis Pigmentosa by Yi Jing Yang, Jun Peng, Deng Ying, Qing Hua Peng

“…Retinitis pigmentosa (RP) represents a clinically and genetically heterogeneous disease characterized by progressive photoreceptor loss. In recent years, research has been rarely made in blood flow affected in RP. …”
Get full text

Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation by Ricardo Londono, Vijay S. Gorantla, Stephen F. Badylak

“…Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. …”
Get full text

Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban by Azhar Farooqui, Tin Lwin, Daniel Costa, Simon Hetherington, Raj Mattu

“…Although successful thrombus resolution has been reported with direct oral anticoagulants’ (DOACs’) recurrence/progression while resuming Apixaban therapy is yet to be reported. …”
Get full text

On the regularity problems of Einstein equations by Wang, Qian

“…In this survey, we provide a review of recent progresses in the local well-posedness problem of Einstein equations in (3+1)-D with low regularity and its applications.…”
Get full text

Research on the Integration Method of Character Costume Culture in Dunhuang Murals Based on Deep Learning Algorithm by Ying Zhai, Ningjing Xuan, Hualong Shi, Qiao Liu

“…In this paper, the evolution and progress of character costumes are analyzed and the development process of Chinese costumes is studied. …”
Get full text

Maximizing Recovery in the Postpartum Period: A Timeline for Rehabilitation from Pregnancy through Return to Sport by Rachel Selman, Kate Early, Brianna Battles, Misty Seidenburg, Elizabeth Wendel, Susan Westerlund

“…This commentary presents a timeline and suggested progression for exercise participation to improve awareness of the musculoskeletal changes that occur after labor and delivery. …”
Get full text

‘TAM’ in English constructions vs. Polish renditions – Selected transference pitfalls by Dorota Chłopek

“…The pitfalls addressed in this paper concern absence of equivalent Polish constructions to English expressions in the perfect aspect, the progressive aspect and to English constructions which ‘lexicalize’, i.e. convey with words, a compilation of the perfect and the progressive aspects. …”
Get full text

Understanding glioblastoma at the single-cell level: Recent advances and future challenges. by Yahaya A Yabo, Dieter Henrik Heiland

“…Intrinsic heterogeneity and cellular plasticity contribute to its rapid progression under therapy; therefore, there is a need to fully understand these tumors at a single-cell level. …”
Get full text

Four Generations of ECMWF Reanalyses: An Overview of the Successes in Modeling Precipitation and Remaining Challenges for Freshwater Budget of Ocean Models by Raphael Dussin

“…Abstract This study reviews the progress made in modeling precipitations in four generations of reanalyses from the European Center for Medium‐Range Weather Forecasts, using traditional metrics and a new set of regional metrics. …”
Get full text

Molecular landscape of salivary gland malignancies. What is already known? by Julia Pikul, Anna Rzepakowska

“…Although uncommon, these tumours exhibit considerable aggressiveness, unpredictable progression, and significant mortality. The fifth edition of the World Health Organisation classification of head and neck tumours distinguishes between 24 salivary gland malignancies. …”
Get full text

Drug-induced liver injuries (Part 1) by S. F. Galimova

“…To present modern concepts on mechanisms of drug-induced liver injury (DILI), to give their classification, to present approaches to disease diagnostics.Original positions. DILI can progress under the mask of all known acute and chronic liver diseases. …”
Get full text

Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases by Tummidi Santosh, Tanya Sharma, Deepti Joshi, Dinesh Prasad Asati, Sanjeev Vijay Choudhary, Neelkamal Kapoor

“…EV is associated with beta-human papillomavirus infection and later the progression to malignancy. Early detection and preventive measures can help in the progression of the disease to Bowen’s disease or invasive SCC.…”
Get full text