Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect by Chunying Cui, Yuji Wang, Yaonan Wang, Ming Zhao, Shiqi Peng

“…Alsterpaullone, a small molecule cyclin-dependent kinase (CDK) inhibitor, regulates the cell cycle progression. Beyond death-inducing properties, we identified the effect of alsterpaullone on cycle procedure and apoptosis of HeLa cell. …”
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Gelatin-based biomaterials as a delivery strategy for osteosarcoma treatment by Qifan Yang, Xingpeng Chen, Jing Liu, Yeteng He

“…Although surgery and chemoradiotherapy have made some progress in the treatment of osteosarcoma. However, the high recurrence and metastasis rate of osteosarcoma and bone defects caused by surgery are still the main problems faced by osteosarcoma. …”
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Evaluation of the a-amylase enzyme, Carbohydrate Antigen CA-15.3 ( C.A 15.3),and some biochemical variables in the blood serum of breast cancer patients by Nagham abd, Ebtehal Sabri Mohammed, Amer Fadel Dawood

“…The results of this study also indicate that AST, ALT, and ALP rise, with disease progression. Keywords: Amylase Enzyme ,Carbohydrate Antigen CA-15.3 , Breast cancer. …”
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A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer by Bohao Zhang, Haozhe Zhang, Yanru Qin

“…This article reviews current research progress on the role of TP53 mutations in regulating the TME and in the mechanism of EC tumorigenesis, as well as progress on drugs that target TP53 mutations.…”
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Maternal Preeclampsia and Neonatal Outcomes by Carl H. Backes, Kara Markham, Pamela Moorehead, Leandro Cordero, Craig A. Nankervis, Peter J. Giannone

“…Because preeclampsia is a progressive disorder, in some circumstances, delivery is needed to halt the progression to the benefit of the mother and fetus. …”
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Idiopathic subglottic stenosis in a 32-year-old pregnant woman by Bo Toennesen, Thomas Kjærgaard, Johannes Martin Schmid

“…Several cases have reported symptom progression and increased stenosis, during or in between pregnancies in younger women. …”
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MRI findings in organophosphate-induced delayed neuropathy: A case report by Salma Moussaoui, Salma El Ouadih, Anas Orgi, Aicha Merzem, Hasna Belgadir, Omar Amriss, Nadia Moussali, Naima El Benna

“…It also emphasizes the need for timely imaging to guide treatment and monitor disease progression.…”
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A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab by Azusa Okude, Etsuko Tagaya, Mitsuko Kondo, Manabu Nonaka, Jun Tamaoki

“…It is suggested that early initiation of omalizumab therapy may inhibit the progression of progressive EOM.…”
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Mucopolysaccharidosis: A rare case from ophthalmology perspective by Santosh Singh Patel, Rajesh Kumar Sahu, Reshu Malhotra, Anju Bhaskar, A. K. Chandrakar

“…MPS type-I is a rare autosomal recessive disorder that is clinically progressive caused by deficiency of the lysosomal enzyme, α-L-iduronidase, which is required to break down heparan and dermatan sulfates resulting in progressive accumulation of glycosaminoglycans within the lysosomes, subsequently leading to multiorgan dysfunction and damage. …”
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The Pattern of Social Changes in the Samin Community and Its Influencing Factors by Muhamad Arif, Abdul Ghofur, Dhanang Respati Puguh

“…In general, social changes occurred progressively, but it is not happened in the Samin community. …”
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Intricating connections: the role of ferroptosis in systemic lupus erythematosus by Guowang Zhao, Xinghai Li, Ying Zhang, Ying Zhang, Xingzi Wang, Li Deng, Juan Xu, Shumei Jin, Zan Zuo, Zan Zuo, Linting Xun, Linting Xun, Mei Luo, Mei Luo, Fan Yang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Ping Fu

“…Multiple types of programmed cell death (PCD) implicated in SLE progression have recently been identified. Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected. …”
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Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies by Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wen Zhang, Feifeng Song, Ping Huang, Tong Xu

“…This paper primarily explores how HDAC inhibitors can regulate cancer progression via the tumor microenvironment and suppress tumor growth through multiple pathways, in addition to examining the synergistic effects of combined drug therapies involving HDAC inhibitors.…”
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Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities by Ping Na Zhang, Meng Qi Zhou, Jing Guo, Hui Juan Zheng, Jingyi Tang, Chao Zhang, Yu Ning Liu, Wei Jing Liu, Yao Xian Wang

“…Diabetic nephropathy (DN) is a progressive microvascular diabetic complication. Growing evidence shows that persistent mitochondrial dysfunction contributes to the progression of renal diseases, including DN, as it alters mitochondrial homeostasis and, in turn, affects normal kidney function. …”
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MicroRNAs in Human Pituitary Adenomas by Xu-Hui Li, Elaine Lu Wang, Hai-Meng Zhou, Katsuhiko Yoshimoto, Zhi Rong Qian

“…Deregulated miRNAs and their targets contribute to pituitary adenomas progression and are associated with cell cycle control, apoptosis, invasion, and pharmacological treatment of pituitary adenomas. …”
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Impact of R-loops on oncogene-induced replication stress in cancer cells by Heuzé, Jonathan, Lin, Yea-Lih, Lengronne, Armelle, Poli, Jérôme, Pasero, Philippe

“…Replication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. …”
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Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis by Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu

“…Inflammation is a critical factor at all stages of atherosclerosis progression. Proinflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. …”
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The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer by Nina Nayara Ferreira Martins, Kelly Cristina da Silva Oliveira, Amanda Braga Bona, Marília de Arruda Cardoso Smith, Geraldo Ishak, Paulo Pimentel Assumpção, Rommel Rodríguez Burbano, Danielle Queiroz Calcagno

“…This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. …”
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Primary Bilateral Non-Hodgkin’s Lymphoma of the Adrenal Gland Presenting as Incidental Adrenal Masses by Christopher Rizzo, David James Camilleri, Alexandra Betts, Andre’ Gatt, Stephen Fava

“…The patient was started on systemic chemotherapy, but her disease progressed with neurological involvement which responded to second-line therapy. …”
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The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape by Yasuto Araki, Toshihide Mimura

“…In this paper, we review the roles of epigenetic mechanisms relevant for the progression of RA.…”
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Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome by Maria Giovanna Danieli, Lucia Pettinari, Ramona Morariu, Fernando Monteforte, Francesco Logullo

“…We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. …”
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