Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy by Marco Delle Monache, Alessio Petrelli, Alessandra Rossi, Roberto Cecere, Concetta Mirisola, Gianfranco Costanzo, Chiara Francia, Federica Cerini, Andrea Cavani, Lorenzo Nosotti

“…To investigate the risk of progression of the liver disease, liver stiffness (LS) and HBV-DNA were monitored over time. …”
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Harnessing Human-Centered Design for Evidence-Based Psychosocial Interventions and Implementation Strategies in Community Settings: Protocol for Redesign to Improve Usability, Enga... by Aaron R Lyon, Sean A Munson, Michael D Pullmann, Brittany Mosser, Tricia Aung, John Fortney, Alex Dopp, Katie P Osterhage, Helen G Haile, Kathryn E Bruzios, Brittany E Blanchard, Ryan Allred, Macey R Fuller, Patrick J Raue, Ian Bennett, Jill Locke, Karen Bearss, Denise Walker, Elizabeth Connors, Eric Bruns, Jenna Van Draanen, Doyanne Darnell, Patricia A Areán

“… BackgroundAlthough substantial progress has been made in establishing evidence-based psychosocial clinical interventions and implementation strategies for mental health, translating research into practice—particularly in more accessible, community settings—has been slow. …”
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Exploring Mortality and Prognostic Factors of Heart Failure with In-Hospital and Emergency Patients by Electronic Medical Records: A Machine Learning Approach by Yu CS, Wu JL, Shih CM, Chiu KL, Chen YD, Chang TH

“…., Taipei, 11049, Taiwan; 5Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235603, Taiwan; 6Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; 7Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan; 8Taipei Heart Institute, Taipei Medical University, Taipei, 11031, Taiwan; 9Department of Family Medicine, Taipei Medical University Hospital, Taipei, 11031, Taiwan; 10School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; 11Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan*These authors contributed equally to this workCorrespondence: Tzu-Hao Chang; Yu-Da Chen, Email kevinchang@tmu.edu.tw; 153072@h.tmu.edu.twPurpose: As HF progresses into advanced HF, patients experience a poor quality of life, distressing symptoms, intensive care use, social distress, and eventual hospital death. …”
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Critical depth prediction based on in-situ stress and gas content model of deep coalbed methane in Liupanshui Coalfield in China by Fang Lv, Ruidong Yang, Wei Gao, Lingyun Zhao, Yaohui Liu, Zhihua Yan, Fulun Shi, Binxin Zhang, Jingui Tang, Tongsheng Yi

“…The study area is situated within the middle-high stress zone, exhibiting discernible evolution patterns from reverse fault mechanism to strike-slip fault mechanism to normal fault mechanism, progressing from shallow to deep. In the deeper stratigraphy, a strike-slip-normal fault mechanism emerges. …”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…Ling Wang,1,2,* Xuemei Deng,1,* Jiaxi Tang,3 Yi Gong,2 Shaojin Bu,4 Zuli Li,1 Bin Liao,2 Yao Ding,2 Tingting Dai,1,5 Yong Liao,1 Yongsheng Li2,6 1Department of Infectious Diseases, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Phase I Clinical Trial Ward, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China; 3Department of Anesthesiology, Chongqing University Cancer Hospital, Chongqing, China; 4Department of Anesthesiology, Fengdu People’s Hospital, Chongqing, People’s Republic of China; 5Department of Medical Oncology, Chongqing University Fuling Hospital, Chongqing, China; 6Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Liao, Department of Infectious Diseases, Second Affiliated Hospital, Chongqing Medical University, NO. 288 Chayuan Astronomy Avenue, Nanan District, Chongqing, 401336, People’s Republic of China, Email yongliao@cqmu.edu.cn Yongsheng Li, Department of Medical Oncology, Chongqing University Cancer Hospital, No. 181 hanyu Road, Shapingba District, Chongqing, 400030, People’s Republic of China, Email yongshengli2005@163.comPurpose: Colorectal cancer (CRC) is a prevalent malignancy, and lactate metabolism significantly influences tumorigenesis and progression. This study identifies key genes associated with lactic acid metabolism and explore their impact on CRC.Patients and Methods: This study utilized data from The Cancer Genome Atlas, Gene Expression Omnibus, other public databases, and our institutional resources. …”
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Protective effects and possible mechanisms of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles against kidney fibrosis in animal models: a systematic... by Yuanchen Lv, Zibo Hua, Xiaomei Lu

“…Although this study still suffers from three shortcomings: sample size, methodological consistency and translational challenges, the hUCB MSC and MSC-Exos have been demonstrated to reduce tubular apoptosis and inhibit fibrotic progression. The hUCB MSC and MSC-Exos offer a promising alternative due to their lower price and accessibility. …”
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Genome-Wide Profiling of Human Papillomavirus DNA Integration into Human Genome and Its Influence on PD-L1 Expression in Chinese Uygur Cervical Cancer Women by Feng Yang-chun, Wang Sen-yu, Zhang Yuan, Huang Yan-chun

“…Most high-frequency sites of HPV integration in Chinese Uygur cervical cancer are related to cancer progression, and the gene integration hotspots may be potential HPV carcinogenic targets. …”
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Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“…MIA offers 7 features: personalized tips, PA literacy, guided peer workouts, a community calendar, a personal activity diary, a progression monitor, and a chatbot. MethodsOur study used a mixed methods approach to evaluate the MIA app’s acceptability, feasibility, and usability. …”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Nonetheless, myrrh’s precise rudimentary mechanisms of action in regulating genes involved in breast cancer evolution and progression remain elusive. Purpose: Herein, we use a network pharmacology platform to identify the potential genes targeted by myrrh-active molecules in breast cancer. …”
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Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…The diagnostic model constructed based on these Hub PCD-DEGs demonstrated diagnostic efficiency in distinguishing OA tissues as well as progression of OA. Additionally, a correlation was observed between the expression levels of Hub PCD-DEGs, immune cell infiltration, and inflammatory cytokine levels. …”
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…EVs transport transforming growth factor-β (TGF-β), which is commonly activated under late stages of cancer progression. Nevertheless, whether TGF-β signaling coordinates EV biogenesis is a relevant topic that remains minimally explored. …”
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Lenvatinib Therapy in Patients with Unresectable Hepatocellular Carcinoma in Real Clinical Practice by V. V. Petkau, A. V. Sultanbaev, K. V. Menshikov, A. S. Antipin, M. V. Volkonsky, V. M. Filippova, Yu. V. Vasilyeva, A. A. Tarkhanov, M. R. Mukhitova, M. Zh. Murzalina, A. R. Safarova

“…The objective response rate (ORR), disease control rate (DCR), median overall survival (OS) and median progression-free survival (PFS) rates were assessed. …”
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Building resilient cattle through better management of buffalo health by Alfredo Sánchez, Merilio Montero

“…In particular, the immune system’s effectiveness in recognizing the progression and pathogenic action of some agents, from which the buffalo is not exempt from becoming infected, but which do not thrive or induce clinical manifestations or functionality variations. …”
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Feasibility and Acceptability of Antenatal Hepatitis C Screening: A Pilot Study by Joseph Valamparampil, Jaswant Sira, Maxine Brown, Saket Singhal, Deirdre Kelly

“…Antenatal screening would identify HCV-positive mothers and allow follow-up of their infants so that any infected mothers and infants could be offered effective curative therapy and prevent the progression of liver disease. The inclusion of HCV antenatal screening would complete the blood-borne virus profile and enhance the WHO target to eliminate HCV in the UK.…”
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Simultaneous Liver Venous Deprivation Following Hepatic Arterial Chemoembolization Before Major Hepatectomy for Hepatocellular Carcinoma: A New Methods to Achieve Hypertrophy Liver... by Zhang S, Song R, Hou C, Yao H, Xu J, Zhou H, Li S, Cai W, Fei Y, Meng F, Yin D, Wang J, Zhang S, Liu Y, Wang J, Liu L

“…The modified response evaluation criteria for solid tumor assessment revealed a disease control rate of 95.7%, with only 1 patient (Barcelona Clinic Liver Cancer stage C) developing intrahepatic disease progression.Conclusion: TACE-LVD seems to be a feasible, safe, and effective strategy for rapid FLR hypertrophy. …”
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Pengembangan Business Intelligence Dashboard untuk Monitoring Aktivitas Pariwisata (Studi Kasus: Dinas Pariwisata Provinsi Bali) by Evan Himawan Saragih, I Putu Agung Bayupati, Gusti Agung Ayu Putri

“…Based on this, local governments need strategies and decisions in the development of facilities and infrastructure that can support the development and progress of tourism in Bali. The use of business intelligence technology in analyzing large amounts of data will help. …”
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α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

“…These findings underscore the role of SLC6A14 in regulating intestinal immune cell infiltration during CD progression.Discussion: Our findings suggest that SLC6A14 could serve as a potential diagnostic biomarker and therapeutic target for CD. …”
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Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…In silico studies have shown that sarcosine is able to bind to unique plasmodia proteins (P. falciparum ATCase), whereas aniline can be a ligand to target protein (enoyl acyl carrier protein reductase), hence suppressing the progression of the disease. The main objective of this study was to synthesize and determine the efficacy and safety of antiplasmodial hybrid drug comprising the sarcosine and aniline derivative for management of plasmodial infections. …”
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Early Detection and Intervention of Preschool-Aged Children Using Android-Based Monitoring during the COVID-19 Pandemic in Central Java by Triwiji Lestari, Elisa

“…The study’s results underscore a significant influence between the initial developmental status of children and their subsequent progress following developmental intervention, with a remarkable p-value of 0.001. …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Loss of H3K27me3 signal peaks may up-regulate the expression of SLC7A11 in diffuse gastric cancer cells， and thereby promote tumor progression. …”
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