The natural immune molecules urinary Tamm–Horsfall protein and pentraxin 3 as predictors for recurrent urinary tract infection severity: a single-center self-control study by Zongping Li, Yingru Xu, Qian Wang, Gang Yuan, Jing Shu, Shiwei Liu, Xuezhong Gong

“…These biomarkers may serve as valuable predictors for assessing symptom severity, recurrence risk, and therapeutic efficacy in patients with RUTI at risk of disease progression.…”
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Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcino... by Lei Yu, Lan Zhang, Xin Xu, Zheng Wang, Jian Zhou, Jia Fan, Wentao Wang, Zhenggang Ren, Lixing Li, Peiran Huang

“…The study’s primary objectives were to assess progression-free survival (PFS) and safety. Secondary objectives included measuring the objective response rate (ORR) and disease control rate (DCR) as per both Response Evaluation Criteria in Solid Tumors (RECIST) V.1.1 and modified RECIST (mRECIST) criteria, as well as overall survival (OS). …”
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Genome-wide association mapping of biochemical traits and its correlation with MYMIV resistance in mungbean (Vigna radiata L. Wilczek) by Manju Kohli, Hina Bansal, Muraleedhar Aski, Gyan P. Mishra, B. R. Shashidhar, Anirban Roy, Soma Gupta, Subodh K. Sinha, Brijesh Kumar Mishra, Nikki Kumari, Atul Kumar, Ranjeet Ranjan Kumar, Ramakrishnan M. Nair, Harsh Kumar Dikshit

“…A wide range was recorded for the Area Under Disease Progress Curve (AUDPC; 1.75-1266.98) and coefficient of infection (CI; 0.33–45.53). …”
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Immunological and autonomic profile of ischemic stroke in lowlands by Nargiza T. Chekeeva, Svetalana G. Shleifer, Bolot B. Kulov, Begimai B. Kadyrova, Asel T. Jusupova, Elena V. Andrianova

“…The study provides new insights into the interplay between immune and autonomic systems in IS, enriching knowledge of disease pathogenesis and progression. The results of this study can enhance the treatment of IS patients by incorporating HRV and immunological assessments into clinical practice. …”
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Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the Che... by Enriqueta Felip, David P. Carbone, Martin Reck, Luis Paz-Ares, Yong Yuan, Nan Hu, Niels Reinmuth, Xiaoqing Zhang, Thomas John, Ying Cheng, Shun Lu, Manuel Cobo, Michael Schenker, Tudor-Eliade Ciuleanu, Stéphanie Bordenave, Oscar Juan-Vidal, Juliana Menezes, Eduardo Richardet, Hideaki Mizutani, Bogdan Zurawski, Aurelia Alexandru, Javed Mahmood, Tuli De, Irene Santi, John R. Penrod, Adam Lee

“…Assessments included OS, progression-free survival, and objective response rate. …”
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Efficacy, safety and cost-effectiveness of obinutuzumab in patients with follicular lymphoma: a rapid review by Chao Wang, Yunzhuo Dong, Peng Men, Ruixia Zhang, Ying Xiao, Yishan Bu, Yinpeng Qin, Xinran Zhang, Qianqian Dou, Yiheng Yang, Huier Gao, Yi Zhang

“…Simultaneously, the quality of the literature was thoroughly assessed.ResultsObinutuzumab based chemotherapy (the chemotherapy regimen-cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP); cyclophosphamide, vincristine, and prednisone (CVP); or bendamustine) significantly prolonged progression free survival (PFS) compared to other chemotherapy regimen at primary and updated analyses. …”
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The association between metabolomic profiles of lifestyle and the latent phase of incident chronic kidney disease in the UK Population by Tingting Jin, Yunqi Wu, Siyi Zhang, Ya Peng, Yao Lin, Saijun Zhou, Hongyan Liu, Pei Yu

“…In contrast, higher levels of albumin and eGFR slowed the onset of CKD, reducing the speed of progression by 3.0% and 3.9% per unit increase, respectively. …”
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THE АNAPA AMPELOGRAPHIC COLLECTION IS THE LARGEST CENTER OF VINE GENE POOL ACCUMULATION AND RESEARCH IN RUSSIA by M. I. Pankin, V. S. Petrov, A. A. Lukianova, E. T. Ilnitskaya, G. E. Nikulushkina, A. G. Kovalenko, V. А. Bolshakov

“…The collection has given birth to twenty seven varieties and elite forms, of which twelve varieties have been sent to the State Committee for the Testing of New Varieties of Agricultural Plants (Pluto, Muzhestvenniy (Courageous), Gordiy (Proud), Maran, Varvarovsky, Harmony, Progress, Gorniy (Mountaneous), Saturn, Dimitry, Vladimir, Kurchansky). …”
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A study of bacterial community structure of shrimp farms along the Ratnagiri coast, Maharashtra by Bhavesh Choudhary, Anil S. Pawase, Gajanan S. Ghode, Raju M. Tibile, Varsha R. Bhatkar, Divyashree Choudhary, Utkarsh Choudhary

“…The bacterial load was observed to increase with the progression of the culture period on both farms. The usage of probiotics, chemicals, and water exchange was observed to promote a decrease in the bacterial community.…”
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Green Tea Extract (<i>Theaceae</i>; <i>Camellia sinensis</i> L.): A Promising Antimicrobial, Anti-Quorum Sensing and Antibiofilm Candidate Against Multidrug-Resistant <i>Campylobac... by Mona S. Emara, Ahmed M. Ammar, Ashraf M.O. Abdelwahab, Attia A. Elgdawy, Adel Abdelkhalek, Elena Pet, Gabi Dumitrescu, Mirela Ahmadi, Norhan K. Abd El-Aziz

“…Background: Thermophilic <i>Campylobacter</i> species are among the main culprits behind bacterial gastroenteritis globally and have grown progressively resistant to clinically important antimicrobials. …”
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A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation by Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng

“…Thus, KSHV lytic infection controls the expression of a subset of genes for signaling, cell cycle progression, and proliferation to potentially contribute to viral oncogenesis.…”
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Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer by Jingmin Che, Bo Chen, Xusheng Wang, Baoe Liu, Cuixiang Xu, Huxia Wang, Jingying Sun, Qing Feng, Xiangrong Zhao, Zhangjun Song

“…Prior research has indicated that the expression level of the cell polarity protein discs large homolog 5 (DLG5) correlates with the malignant progression and prognosis of breast cancer; nevertheless, its influence on PD-L1 expression and its function in immunotherapy for TNBC require further investigation. …”
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Early Prediction of Abdominal Aortic Aneurysm Rupture Risk Using Numerical Biomechanical Analysis by Kristina Grassl, Thomas C. Gasser, Florian K. Enzmann, Alexandra Gratl, Josef Klocker, David Wippel, David C. Walcher, Elke R. Gizewski, Sabine H. Wipper

“…<b>Results</b>: Both groups had the same median aortic diameter of 5.5 cm in the first imaging but had significantly different aneurysm progressions with 6.9 cm (5.5–9.4 cm) in the second rAAA vs. 6.0 cm (5.1–7.3 cm) in the second control group (<i>p</i> = 0.006). …”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…PD-L1 is a checkpoint protein that plays important roles in immune regulation and has been implicated in the initiation and progression of multiple autoimmune diseases.MethodIn a previous study, we demonstrated that intra-articular injection with adeno-associated virus (AAV) vectors encoding wild type PD-L1 improved local inflammation in the joint in the collagen-induced arthritis (CIA) mouse model of RA. …”
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Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer’s disease: a systematic review and network meta-analysis of... by Wenting Cai, Wenting Cai, Hui Zhang, Hui Zhang, Yan Wu, Yan Wu, Yao Yao, Jinping Zhang

“…By investigating the effects of monoclonal antibodies on cognitive function, disease progression, and overall quality of life in patients with AD, which can provide valuable insights into their potential as a therapeutic option for this devastating neurodegenerative disorder.MethodsThe randomized controlled trials (RCTs) investigating the efficacy of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in Alzheimer’s disease (AD) were systematically searched across PubMed, Embase, Web of Science and Cochrane Library, up to May 2024. …”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…Immunohistochemical analysis identified neointima‐specific markers, while NIH progression was assessed in SD rats with four and a half LIM domains protein 1 (Fhl1) knockout and in human saphenous veins (HSV) with adenovirus‐mediated Fhl1 overexpression. …”
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EyeLiner by Yoga Advaith Veturi, MSc, Steve McNamara, OD, Scott Kinder, MS, Christopher William Clark, MS, Upasana Thakuria, MS, Benjamin Bearce, MS, Niranjan Manoharan, MD, Naresh Mandava, MD, Malik Y. Kahook, MD, Praveer Singh, PhD, Jayashree Kalpathy-Cramer, PhD

“…Objective: Detecting and measuring changes in longitudinal fundus imaging is key to monitoring disease progression in chronic ophthalmic diseases, such as glaucoma and macular degeneration. …”
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Efficacy of PD-1 blockade plus chemotherapy in patients with oncogenic-driven non-small-cell lung cancer by Haowei Wang, Lei Cheng, Jian Chen, Peixin Chen, Zhuoran Tang, Qianyi Wang, Ying Ma, Chao Zhao, Xuefei Li, Tao Jiang, Fei Zhou, Xiaoxia Chen, Caicun Zhou

“…Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were compared to evaluate the therapeutic outcomes differences among patients with different oncogenic drivers. …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…IntroductionStudies have demonstrated that injectable GnRH receptor agonists further suppress cancer progression when paired with radiotherapy (RT) in patients with intermediate- to high-risk prostate adenocarcinoma. …”
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Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer by Jing Wang, Zhe Li, Wei Wang, Md Tauhidul Islam, Xiaoyan Wang, Zhen Han, Zihan Li, Guoxin Li, Yuming Jiang, Taojun Zhang, Wenjun Xiong, Zepang Sun, Lequan Yu, Zhicheng Zhang, Xianqi Yang, Shengtian Sang, Alyssa A Guo

“…The univariate Cox regression analysis revealed that the prediction signature of pathomics-driven ensemble model was a prognostic factor for progression-free survival in patients with gastric cancer who underwent immunotherapy (p&lt;0.001, HR 0.35 (95% CI 0.24 to 0.50)), and remained an independent predictor after multivariable Cox regression adjusted for clinicopathological variables, (including sex, age, carcinoembryonic antigen, carbohydrate antigen 19-9, therapy regime, line of therapy, differentiation, location and programmed death ligand 1 (PD-L1) expression in all patients (p&lt;0.001, HR 0.34 (95% CI 0.24 to 0.50)). …”
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