AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…Abstract Background Most patients with prostate cancer inevitably progress to castration-resistant prostate cancer (CRPC), at which stage chemotherapeutics like docetaxel become the first-line treatment. …”
Get full text

Development of an artificial intelligence-based application for the diagnosis of sarcopenia: a retrospective cohort study using the health examination dataset by Chang-Won Jeong, Dong-Wook Lim, Si-Hyeong Noh, Sung Hyun Lee, Chul Park

“…The values for men gradually decreased after their 20s, and that for women gradually decreased after their 40s, which progressed to a more dramatic decline in the 70s for both sexes. …”
Get full text

Engagement With an Internet-Administered, Guided, Low-Intensity Cognitive Behavioral Therapy Intervention for Parents of Children Treated for Cancer: Analysis of Log-Data From the... by Christina Reuther, Louise von Essen, Mudassir Imran Mustafa, Markus Saarijärvi, Joanne Woodford

“…However, intervention adherence rates were marginally under progression criteria. ObjectiveThis study aimed to (1) describe user engagement with the EJDeR intervention and examine whether (2) sociodemographic characteristics differed between adherers and nonadherers, (3) depression and anxiety scores differed between adherers and nonadherers at baseline, (4) user engagement differed between adherers and nonadherers, and (5) user engagement differed between fathers and mothers. …”
Get full text

Deep learning-based CT radiomics predicts prognosis of unresectable hepatocellular carcinoma treated with TACE-HAIC combined with PD-1 inhibitors and tyrosine kinase inhibitors by Linan Yin, Ruibao Liu, Wei Li, Shijie Li, Xunbo Hou

“…Abstract Objective To develop and validate a computed tomography (CT)-based deep learning radiomics model to predict treatment response and progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHCC) treated with transarterial chemoembolization (TACE)-hepatic arterial infusion chemotherapy (HAIC) combined with PD-1 inhibitors and tyrosine kinase inhibitors (TKIs). …”
Get full text

Association between smoking status and health-related quality of life: a study on differences among age groups by Guanping Zhong, Yang Shu, Hongwei Li, Yuelin Zhou, Qiaoying Wei, Biao Yang, Lian Yang

“…In addition, effective smoking cessation support policies should be developed to encourage residents to quit or reduce smoking frequency, avoid the progression of moderate smoking to heavy smoking and thus lead to serious health threats.…”
Get full text

95-95-95 HIV indicators among children younger than 15 years in South Africa: results from the 2017 national HIV prevalence, incidence, behaviour, and communication survey by Rindidzani E. Magobo, Musawenkosi Mabaso, Sean Jooste, Lesiba Molopa, Inbarani Naidoo, Leickness Simbayi, Khangelani Zuma, Nompumelelo Zungu, Olive Shisana, Sizulu Moyo

“…This study examines the progress made towards achieving the 95-95-95 HIV indicators and associated factors among CLHIV < 15 years in South Africa. …”
Get full text

Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…Comparing low TMB (&lt;10 muts/Mb), high TMB (10–19 muts/Mb), and very high TMB (≥20 muts/Mb) receiving ICPI alone, we observed a stepwise increase in median rwPFS (real world-progression free survival) (6.5, 7.5, 17.2 months) and rwOS (real world-overall survival) (10.1, 11.8, 26.9 months) as TMB increased. …”
Get full text

Investigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis by Ning Qi, Zhuochen Lyu, Lu Huang, Yun Zhao, Wan Zhang, Xinfeng Zhou, Yang Zhang, Jiasen Cui

“…Immune responses and shifts in immune cell profiles are closely linked to the development and progression of VTE, yet current studies are limited by confounding factors and reverse causation. …”
Get full text

Therapeutic Effect of Core Stability Training Combined with Extracorporeal Shock Wave on Lumbar Disc Herniation by Shuo LI, Lishuang LIU, Jinna ZHOU, Qiaoyun XIANG, Tingting LUAN, Wenwen WANG

“…Following the principle of gradual progression, the training time and frequency were slowly increased, from easy to difficult, from simple to complex, including supine position, lateral position and prone position training, 40 minutes each time, 5 times a week, continuous treatment for 3 months. …”
Get full text

Estimating the Cost-Effectiveness of Tumor Treating Fields (TTFields) Therapy with an Immune Checkpoint Inhibitor or Docetaxel in Metastatic Non-Small Cell Lung Cancer by Furnback W, Wu E, Koh CYC, Nino de Rivera Guzman JF, Kruhl C, Kotecha R, Wang BC

“…TTFields therapy extended mean lifetime survival, offering a clinically meaningful and economically justifiable option for patients progressing after platinum-based chemotherapy.Plain language summary: Recent clinical data from the LUNAR study has shown that Tumor Treating Fields (TTFields) therapy concomitant with immune checkpoint inhibitors (ICIs) or docetaxel improves survival in patients with metastatic non-small cell lung cancer (NSCLC) on or after platinum-based therapy. …”
Get full text

miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-κB Signaling Pathway by Jie Bian, Weizhong Ge, Zhengmei Jiang

“…Conclusion. miR-26a-5p inhibits oxidative stress and inflammation in DR progression by targeting USP14 and inactivating the NF-κB signaling pathway.…”
Get full text

Integrating bulk and single-cell RNA sequencing data: unveiling RNA methylation and autophagy-related signatures in chronic obstructive pulmonary disease patients by Shi-Xia Liao, Lan-Ying Zhang, Ling-Mei Shi, Huai-Yu Hu, Yan-Hui Gu, Ting-Hua Wang, Yao Ouyang, Peng-Peng Sun

“…Emerging evidence also suggests that autophagy plays a crucial role in immune cell infiltration and is implicated in COPD progression. This study aimed to investigate key RNA methylation regulators and explore the roles of RNA methylation and autophagy in COPD pathogenesis. …”
Get full text

Prevalence and Determinants of Diarrheal Diseases among Under-Five Children in Horo Guduru Wollega Zone, Oromia Region, Western Ethiopia: A Community-Based Cross-Sectional Study by Kefalew Alemayehu, Lemessa Oljira, Melake Demena, Abdi Birhanu, Dasselegn Workineh

“…Although efforts have been made to reduce the morbidity and mortality resulting from diarrheal diseases, there is scarce information on the progress of the interventions against the burdens. …”
Get full text

Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer by Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti

“…Background: Promoter hypermethylation is one of the events that downregulate microRNAs (miRNA), resulting in the differential expression of genes implicated in the progression of cancer. We previously reported that microRNAs (miRNA)-299-3p and −30e target androgen receptor (AR) and are downregulated in advanced prostate cancer (PCa). …”
Get full text

Development and Validation of the Systemic Inflammatory Response Index-Based Nomogram for Predicting Short-Term Adverse Events in Patients With Acute Uncomplicated Type B Aortic In... by Wang Y, Wu X, Wang Y, Zhang Z, Liu X, Sun D, Liu X, Zhou T, Wang X

“…ARAEs were defined as death related to aortic disease, and the progression of IMH to aortic dissection or penetrating aortic ulcer. …”
Get full text

Buffalo genetic improvement program in Vene- zuela by José A. Aranguren-Méndez, Rafael M. Román-Bravo, Ricardo A. Briceño-Rojas, Mauricio G. Briceño-Rojas, Luis A. Pacheco-Díaz

“…In conclusion, genetic improvement programs based on the selection index and the massive use of reproductive biotechnologies are potent tools that must simultaneously accelerate buffalo herds’ genetic progress. …”
Get full text

Çocuklarda Dental Anksiyete: Başarılı Dental Tedavinin Önündeki Engel by Aysun Avşar, Büşra Mutlu

“…In children with dental anxiety, increased heart rate, changes in breathing, sweating, abdominal pain, tremor, nausea, dry mouth, crying, restlessness, and distraction are frequently observed during dental treatment. In order to progress and complete the steps of dental treatment, anxiety can be managed non-pharmacologically with pharmacological methods such as sedation and general anesthesia, aromatherapy, music therapy, visual and auditory distraction and hypnosis by watching videos during treatment. …”
Get full text

Advanced approach to primary microsurgical debridement of extensive scleral lacerations involving simultaneous vitrectomy and chorioretinal wound closure by S.S. Shamkin, S.N. Subbotina, A.B. Stepanyants, D.V. Salov

“…During the follow-up, no phthisis bulbi was reported. The progression of proliferative vitreoretinopathy (formation of intraretinal adhesions or subretinal bands involving healthy retina) was reported in 3 patients (21.4%). …”
Get full text

Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…BC cell proliferation was detected with the Cell Counting Kit-8 and by the colony formation assay. Cell cycle progression was analyzed by flow cytometry, and the expression of cell cycle-related proteins (E2F1, cyclin D3, and cyclin-dependent kinase 2) was determined by western blots in SAE1 small interfering RNA (siRNA) transfected cells. …”
Get full text

Analysis of the correlation between the dose exposure intensity and apatinib in advanced gastric cancer: a retrospective cohort study by Xiao Ma, Xiao Ma, Lan Gao, Siying Che, Chaofeng Tao

“…The primary endpoint was progression-free survival (PFS), and the secondary endpoints were overall survival (OS) and safety. …”
Get full text