CD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation by Hussain Z, Abdulrahim Abdul Moti L, Jagal J, Thu HE, Khan S, Kazi M

“…Moreover, the lowest cell viability depicted in MCF-7 (~25%), SK-BR-3 (~20%), and RAW 264.7 cells (~20%), induction of apoptosis, cell cycle arrest, enhanced cell internalization, and alleviation of MCF-7 and SK-BR-3 migration proved the superior anticancer potential of HA-PTX-TMX-CS-NPs compared to unfunctionalized NPs and other control medicines.Conclusion: HA-functionalization of NPs is a promising multiprong strategy for CD44-receptors-mediated targeting of BC cells and TAMs to mitigate the progression, metastasis, and relapse in the BC. Keywords: paclitaxel, tamoxifen, hyaluronic acid, polymeric nanoparticles, CD44-receptors, breast cancer, cell uptake, anticancer efficacy…”
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ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism by Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä, Johanna Schleutker

“…A major challenge in managing PrCa is the early identification of aggressive cases for targeted treatment, while avoiding unnecessary interventions in slow-progressing cases. Therefore, there is a critical need for genetic biomarkers that can distinguish between aggressive and non-aggressive PrCa cases. …”
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Size distribution of extracellular vesicles in pretreatment ascites and plasma is correlated with primary treatment outcome in advanced high-grade serous carcinoma by Maruša Herzog, Ivan Verdenik, Borut Kobal, Katarina Černe

“…The correlations of the EV concentration and size distribution in ascites and plasma with treatment outcome, progression-free survival (PFS) and overall survival (OS) were analysed. …”
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Identification and Analysis of Key Immune- and Inflammation-Related Genes in Idiopathic Pulmonary Fibrosis by Tan Y, Qian B, Ma Q, Xiang K, Wang S

“…It is submitted to the journal not only because of its high international recognition, but also because of its emphasis on a progress in this field. The research scope covers a wide range of content from basic theory to practical cases, which has a guiding effect on clinical research.This manuscript is closely related to the core purpose and readership of Journal of Inflammation Research, a journal known for its in-depth and comprehensive coverage of the immune system and encouragement of original research. …”
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Sustainable Energy Sector Using Waste Woody Biomass and Miscanthus in the Energy Transition by Nihad Hodžić, Kenan Kadić, Anes Kazagić

“…None of the treated types of biomass, up to the level of applicable content in the mixture with lignite and brown coal, does not worsen the progress of the process from the aspect of possible slagging/fouling heating surfaces in the boiler.…”
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The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages by Duaa Abuarqoub, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, Dima A. Sabbah

“…We can conclude that our nanocomplex is a potent effector that prevents tumoral progression by activating three main immunological strategies: switching the surface expression profile of the activated macrophages into a proinflammatory M1-like phenotype, downregulating the expression of proinflammatory cytokines, and upregulating the expression level of anti-inflammatory cytokines.…”
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Transgressive hybrids as hopeful holobionts by Benjamin Thomas Camper, Andrew Stephen Kanes, Zachary Tyler Laughlin, Riley Tate Manuel, Sharon Anne Bewick

“…By contrast, there has been substantially less progress made towards understanding the positive eco-evolutionary consequences of hybridization on holobionts. …”
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L’échelon manquant ? Les archives municipales en Algérie : histoire de fonds et possibilités historiographiques by Thierry Guillopé

“…The results of this survey show that the situations vary significantly: there are differences in the volumes conserved, in the chronological ranges covered, in the physical condition of the archives and repositories, and in the degree of progress made in filing.The third part of this study concludes with a presentation of the archive’s holdings. …”
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Conditional diffusion-generated super-resolution for myocardial perfusion MRI by Changyu Sun, Changyu Sun, Neha Goyal, Yu Wang, Darla L. Tharp, Senthil Kumar, Talissa A. Altes

“…The forward diffusion process introduces Gaussian noise incrementally, while the reverse process employs a U-Net architecture to progressively denoise the images, conditioned on the low-resolution input image.ResultsWe trained and validated the model on a retrospective dataset of dynamic contrast-enhanced (DCE) perfusion MRI, consisting of both stress and rest images from 47 patients with heart disease. …”
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Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study by Bo-Ning Cao, Cai-Yan Zhang, Zhen Wang, Yao-Xian Wang, Yao-Xian Wang

“…The bacterial microbiota involved in fatty acid oxidation is associated with diabetic kidney disease (DKD) progression, positively correlated with glycocholenate sulfate levels, and negatively correlated with the phosphate linoleyl-tetraenyl-glycerol (18:2 to 20:4) ratio. …”
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Evaluating the impact of faculty development programs at the workplace by using reflective critique writing technique by Sarah Amin, Shabana Ali Muhammad, Rahila Yasmeen

“…REFLECT rubric grading showed that in 3rd Reflective Critique writing almost 80% of the participants became critical reflectors, improving from an initial 60% progress in first writing, showing the effectiveness of the training program & increased effectiveness of teaching skills, learning transfer & behavior change at workplace. …”
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Comparison of radiation esophagitis associated with daytime versus evening radiotherapy in patients with esophageal carcinoma by Yun Xing, Yutian Yin, Liang Yu, Cong Zhang, Guangjin Chai, Bo Lyu, Bin Wang, Lina Zhao, Geng Xiang

“…There was no difference in the overall survival (OS), locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and progression-free survival (PFS) (all p > 0.05) between the daytime treatment group and evening treatment group. …”
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Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis by Leonie Ruths, Jana Hengge, Graciosa Q. Teixeira, Melanie Haffner-Luntzer, Anita Ignatius, Jana Riegger

“…Overall, targeting TCC formation could be a future approach to attenuate OA progression.…”
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Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Rand... by Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

“…This suggests that nonguided ICBT may be effective in preventing SI and SD from progressing to the full threshold. However, appropriate definitions of subthreshold symptoms are necessary. …”
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Tradition and Development of Lithuanian Terminology by Antanas Smetona

“…The first stage is characterised by elemental terminology development, marked by unsystematic progress before the Industrial Revolution. Due to Lithuania’s socio-cultural circumstances—such as the prevalence of science in international languages, the absence of a standardised public Lithuanian language, occupation, and its peripheral status within the empire—terminology primarily relied on the spoken folk language, lacking a structured scientific foundation. …”
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The burden of chronic kidney disease attributable to high sodium intake: a longitudinal study in 1990–2019 in China by Yongyao Shen, Liying Jiang, Liying Jiang, Jin Yu, Bo Chen, Aidong Liu, Yongjin Guo, Yongjin Guo

“…Targeting to reduce sodium intake remains a priority, and progress requires systematic monitoring and evaluation, particularly in middle SDI regions that are experiencing rising trends and low-middle SDI regions being susceptible to approaches.…”
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Virtual Reality Interventions for Older Adults With Mild Cognitive Impairment: Systematic Review and Meta-Analysis of Randomized Controlled Trials by Qin Yang, Liuxin Zhang, Fangyuan Chang, Hongyi Yang, Bin Chen, Zhao Liu

“… BackgroundAlzheimer disease is incurable, but it is possible to intervene and slow down the progression of dementia during periods of mild cognitive impairment (MCI) through virtual reality (VR) technology. …”
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Optic nerve sheath diameter in chronic myeloproliferative disorders by E.M. Yunusova, T.R. Mukhamadeev, B.A. Bakirov

“…For patients with chronic MPD, it is recommended to have more detailed follow-up to prevent vision loss and life-threatening complications in the central nervous system due to disease progression, in particular, those with an increase in ONSD. …”
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台湾第一部钢骨钢筋混凝土构造(SRC)设计规范之设计理念与重点内容 by 翁正强

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Exploring practical experience with different treatments in NSCLC patients with MET-deregulated: a retrospective analysis from the real world by Mengmeng Li, Jiuyan Huang, Ruyue Xing, Xinyang Du, Chunhua Wei, Huijuan Wang

“…Results Among METex14 skipping mutations patients (n = 57), median progression free survival (PFS) was: Chemotherapy 7.64 m, Crizotinib 8.5 m, Savolitinib 9.3 m, and Immunotherapy 3.87 m. …”
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