First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies by Peter Ellmark, Jeffrey Yachnin, Ana Carneiro, Lena Schultz, Amanda Hahn, Sumeet Ambarkhane, Karin Enell Smith, Gustav J. Ullenhag

“…Escalating doses were given until disease progression, unacceptable toxicity, or withdrawal of consent. …”
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Wnt/ β-catenin and CTNNB1 gene mutation in hepatocellular carcinoma, a case study in Egyptian patients by Ramy A. Abdelsalam, Ibrahim M. El-Shawaf, Azza Abdel-Aziz, Tarek A. Bismar, Shaimaa M. Yussif

“…It has been involved in progression, growth, epithelial mesenchymal transition and metastasis of hepatocellular carcinoma (HCC). …”
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The Validation of a Novel, Sex-Specific LDL-Cholesterol Equation and the Friedewald, Sampson-NIH, and Extended-Martin–Hopkins Equations Against Direct Measurement in Korean Adults... by Hyun Suk Yang, Soo-Nyung Kim, Seungho Lee, Mina Hur

“…In the TG ≥ 400 mg/dL group, the MAPE increased progressively: SSLE (10.2%), ext-Martin–Hopkins (12.0%), Sampson-NIH (12.7%), and Friedewald (27.4%). …”
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Impact of Amarogentin on Gastric Carcinoma Cell Multiplication, Apoptosis and Migration via circKIF4A/miR-152-3p by Zhi Tan, Weining Wang, Jin Peng, Zhen Zhou, Jia Pan, Aiming Peng, Hui Cao, Wenling Fan

“…The active ingredients extracted from natural plants have anti-GC actions and can slow down gastric carcinoma (GC) progression. To investigate the impact of Amarogentin (AG) on GC cell multiplication, apoptosis and migration and the possible mechanisms. …”
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Strategi Komunikasi Hadapi Penolakan Pemanfaatan Energi Nuklir sebagai Pembangkit Listrik di Indonesia by Syahdino Pratama, Satriani Aga Pasma, Mokhamad Hendayun, Isroil Samihardjo

“…In addition, the interpretation of the phrase “considering nuclear as the last resort” in the legislation is also one of the obstacles to the progress of the implementation of nuclear power plant construction. …”
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Time to Reconsider the Straddle-Arm Technique: Providing Care for the Conscious Infant who is Choking

“…This article serves as a report on work-in-progress.Il est temps de reconsidérer la technique du « chevauchement » sur le brasLa pratique consistant à asseoir un nourrisson à califourchon sur le bras d’un sauveteur pour porter le nourrisson pour lui administrer des tapes dans le dos et des poussées thoraciques dans le but de dégager ses voies respiratoires en cas d’obstruction des voies aériennes par un corps étranger, reste l’une des méthodes enseignées lorsque le nourrisson est conscient. …”
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Radiotherapy Combined with Immunotherapy and Chemotherapy Improves Prognosis and Demonstrates Synergistic Effects in Extensive-stage Small Cell Lung Cancer by Huaijun JI, Meiling SUN, Jingyi LI, Ge YU, Yongbing CHEN

“…Results The median overall survival (mOS) and median progression-free survival (mPFS) for the entire cohort were 15.7 and 6.9 mon, respectively. …”
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Prognostic Value of Novel CARWL Score in Stage IIIC Non-Small-Cell Lung Cancer Patients Undergoing Concurrent Chemoradiotherapy by Erkan Topkan, Ahmet Kucuk, Duriye Ozturk, Emine Elif Ozkan, Ali Ayberk Besen, Berrin Pehlivan, Ugur Selek

“…The availability of an ideal CAR cutoff that may categorize patients into two distinct progression-free (PFS) and overall survival (OS) outcomes was explored by employing receiver operating characteristic (ROC) curve analysis. …”
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How can competencies in minor surgery in general practice be increased? Assessing the effect of a compact intervention in postgraduate training: a mixed-methodsstudy by Joachim Szecsenyi, Jonas D Senft, Katja Krug, Simon Schwill, Aaron Poppleton, Dorothee Reith, Sandra Stengel

“…Such measures appear crucial to support individual progress of GP trainees to provide comprehensive primary care.…”
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Artrosis: ¿cambios degenerativos o cambios adaptativos? Consejos educativos breves en la consulta de atención primaria by Gema Izquierdo Enríquez, María Victoria García Espinosa, Isabel Prieto Checa, María Fernández de Paúl, Patricia Moreno Carrero, Silvia Fernanda García Vila

“…Moreover, there are no disease-modifying drugs or curative treatment at present; the basic or first-line treatment is non-pharmacological, based on education and physical exercise.The presence of degenerative changes in imaging tests is present in a high percentage of the general asymptomatic population, i.e. in those who have no pain or functional limitation, and this percentage increases progressively with age. In short, osteoarthritis is part of the normal aging process of the population.As with low back pain, it is proposed to apply a salutogenic model of health, paying special attention to the terms used when informing and advising patients.It is proposed a review of the main causes, effectiveness and prognosis of osteoarthritis treatment, in order to provide brief educational advice to patients.…”
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高强钢组合K形偏心支撑结构的结构影响系数和位移放大系数研究 by 李慎, 王泽宇, 田建勃, 李晓蕾

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Resistance of spring bread wheat cultivars and lines to Septoria leaf blotch, tan spot, and spot blotch pathogens by Yu. V. Zeleneva, V. P. Sudnikovа, N. M. Kovalenkо, I. V. Gusev

“…Leaf and stem diseases of cereal crops are among the most harmful in the agrocenoses of Tambov Province, significantly reducing grain yield and rapidly progressing in many regions of Russia. The aim of the study was to identify spring bread wheat lines and cultivars developed at the Middle-Russian Branch of the I.V. …”
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Factors affecting attitudes towards caring for terminally ill patients among nursing students in Switzerland: a cross-sectional study by Jérôme Pasquier, Pauline Laporte, Typhaine Juvet, Jean-François Desbiens, Diane Tapp, Marc-Antoine Bornet

“…In the multivariate analysis, professionally encountering terminally ill patients remained significant (β=3.00; 95% CI 1.43 to 4.57; p<0.001).Conclusions Nursing students’ attitudes towards caring for terminally ill patients were positive and improved as their year of study progressed. Professional exposure to terminally ill patients was the strongest factor, followed by private encounters, self-perceived palliative care nursing skills, year of study and age.…”
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Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights by Lingxia Wu, Chenxiaoxiao Liu, Weicai Hu

“…Subsequent validation across multiple cohorts confirmed significant (p-value < 0.05) elevated MMP expression levels in SKCM tissues, particularly in advanced disease stages, further emphasizing their role in tumor progression. Furthermore, we elucidated potential regulatory pathways involving miR-22-3p, which targets MMP7, MMP11, and MMP14 genes in SKCM. …”
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Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome by Gao Y, Chen C, Huang X, Liu Y, Zhou Z, Pan Y

“…In a one-year follow-up, serum omentin-1 levels showed potential to reflect the disease progression. Additionally, lower omentin-1 levels were found to be accompanied with higher levels of serum pro-inflammatory cytokine concentrations in patients with IBS-D. …”
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Arab representation in Israeli healthcare professions: achievements, challenges and opportunities by Bruce Rosen, Sami Miaari

“…To build on achievements to date, and to promote continued progress, policymakers should expand access to health professional education within Israel, upgrade the skills of graduates of non-Israeli universities, promote diversity in leadership positions and key specialties, and expand specialty care services in Arab localities.…”
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Identification of Five m6A-Related lncRNA Genes as Prognostic Markers for Endometrial Cancer Based on TCGA Database by Li Shan, Ye Lu, Cheng-Cheng Xiang, Xiaoli Zhu, Er-Dong Zuo, Xu Cheng

“…Conclusions. m6A-related lncRNAs play an important role in UCEC progression. The risk-based model constructed from the five key m6A-related lncRNAs was implicated in immune cell infiltration and can potentially be an accurate prognosticator for UCEC.…”
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Socioeconomic disparities in child malnutrition: trends, determinants, and policy implications from the Kenya demographic and health survey (2014 - 2022) by Amos O. Okutse, Henry Athiany

“…Socioeconomic factors include household income, parental education, and access to healthcare, which influence a child’s nutritional status. Despite overall progress in reducing under-five child malnutrition in Kenya, disparities persist. …”
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Herbicide resistance in Leptochloa chinensis (L.) Nees populations from different regions of Jiangsu Province, China: sensitivity differences and underlying mechanisms by Peng Xu, Ke Wang, Yawen Ju, Yousheng Fu, Axiu Zhu, Kaige Cao, Hongchun Wang

“…The proportion of populations resistant to acetyl-CoA carboxylase (ACCase)-inhibiting herbicides increased progressively from the south to the north of Jiangsu. …”
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Combined oven/freeze drying as a cost and energy-efficient drying method for preserving quality attributes and volatile compounds of carrot slices by Zobabalo Progress Mina, Tafadzwa Kaseke, Tafadzwa Kaseke, Tobi Fadiji, Yardjouma Silue, Olaniyi Amos Fawole, Olaniyi Amos Fawole

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