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16901
Navigating the Challenges of Sustainable Dental Practices: Opportunities for Green Innovation in Dentistry
Published 2025-01-01“… As environmental concerns progress, it is becoming increasingly crucial to consider the transition to sustainable periodontal care. …”
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16902
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16903
GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia
Published 2025-01-01“…Conclusions The study demonstrated that knockdown of GATA1 modulates M2 polarization of macrophage through the TrkB/cGMP–PKG signaling pathway, influencing the progression of PE. In addition, significant associations between GATA1 and the TrkB/cGMP–PKG signaling pathway were identified in the transcriptomic data from PE patient placentas.…”
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16904
UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer
Published 2025-01-01“…Abstract Background Immune cells within tumor tissues play important roles in remodeling the tumor microenvironment, thus affecting tumor progression and the therapeutic response. The current study was designed to identify key markers of plasma cells and explore their role in high-grade serous ovarian cancer (HGSOC). …”
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16905
Effects of dribbling restrictions in small-sided games on aerobic and anaerobic fitness in youth basketball players
Published 2025-01-01“…Both experimental groups followed identical SSG formats, court dimensions, and training regimens, with the only difference being that one group participated in free play while the other group was prohibited from dribbling during progression. Aerobic capacity was assessed using the Yo-Yo Intermittent Recovery Test Level 1 (YYIRT), while the 30-second Wingate Test measured peak power output (PPO) and average power output (APO) at baseline and post-intervention. …”
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16906
Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy
Published 2025-01-01“…Increasing evidence suggests that autophagy plays a crucial role in the initiation and progression of epilepsy. However, the precise mechanisms by which autophagy deficiencies involved in epileptogenesis are still not fully understood.MethodsTwo datasets of epilepsy (GSE143272 and GSE256068) were downloaded from the Gene Expression Omnibus (GEO) database. …”
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16907
c-FLIP and microRNA 708-5p gene expression in newly diagnosed and chemotherapy in acute myeloid leukemia of Iraqi patient
Published 2024-12-01“…Furthermore, miRNA 708-5p can act as a prognostic indicator in AML, with its expression levels offering valuable insights into disease progression and patient response to treatment. Further research into miRNA 708-5p can lead to a better understanding of its role in AML pathogenesis and its potential applications in clinical practice.…”
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16908
Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies
Published 2025-01-01“…Furthermore, these patients were more likely to have coronary artery calcification (OR: 2.28, 95% CI 1.74–3.00, P < 0.00001), multivessel CAD (OR: 2.04, 95% CI 1.50–2.77, P < 0.00001), and an increased risk of plaque progression (OR: 1.49, 95% CI 1.17–1.91, P = 0.001). …”
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16909
SUCCESSFUL REGISTRATION OF DOMESTIC BIOANALOGUE OF BEVACIZUMAB – NEW OPPORTUNITIES FOR EFFECTIVE TREA TMENT OF PATIENTS WITH NON-SQUAMOUS CELL NON-SMALL CELL LUNG CANCER
Published 2016-01-01“…The treatment lasted for six cycles of three weeks or until progression or until the development of intolerable toxic effects. …”
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16910
Immediate Results of Colonic Flat Epithelial Neoplasms Removal Using Diathermic Snare Endoscopic Mucosal Resection and Mucosectomy Combined with Dissection in the Submucosal Layer:...
Published 2023-11-01“…Only patients with benign epithelial neoplasms were included in the study since patients with suspected malignancy in laterally spreading tumors are indicated for ESD intervention to avoid fragmentary excision and risk of colorectal cancer progression due to possible positive resection margins. …”
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16911
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16912
The impact of successive Montessori programmes on cognitive achievement
Published 2024-12-01“…The results underscore the importance of successive Montessori Programmes Attended (MPA) in fostering cognitive development. Students who progressed through the complete Montessori spectrum exhibited superior cognitive outcomes and higher success rates in college admissions. …”
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16913
Beclin-1 as a potential prognostic marker in correlation with E-cadherin in oral lichen planus and oral squamous cell carcinoma: an immunohistochemical analysis
Published 2024-12-01“…The function of Beclin-1, as per a marker for autophagy, still needs to be verified in oral premalignant lesions and their progression to OSCC. E-cadherin is an integral intercellular epithelial component responsible for intercellular adhesion, in which its down-expression denotes diminished cellular adhesion and propensity for invasion. …”
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16914
Efficacy analysis of drug-eluting beads transcatheter arterial chemoembolization combining systemic chemotherapy and immune checkpoint inhibitors in unresectable intrahepatic chola...
Published 2025-01-01“…The objective response rate (ORR, 76.06%) and disease control rate (DCR, 97.18%) in the observed group were significantly higher than that in the control group (52.11%, 85.92%), Progression-free survival (PFS, 10 months) and overall survival (OS, 17 months) were higher than the control group (8 months, 11 months). …”
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16915
Evaluations of Morphometric Traits and Body Conformation Indices of Horse Ecotypes Reared in the Highlands of Bale Eco‐Region, Ethiopia
Published 2024-11-01“…Further, molecular studies will be essential to determine whether the predominated phenotypic multiplicity is genetic or environmentally progressed.…”
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16916
Prognostic impact of depth of response and early tumour shrinkage in patients with -mutated metastatic colorectal cancer treated with targeted therapy
Published 2025-01-01“…Relationships of DpR and ETS, both as binary, according to conventional (30% for DpR and 20% for ETS) and median cut-off values, and continuous variables, with progression-free (PFS), overall survival (OS) and duration of response (DoR) were assessed in non-primary resistant patients. …”
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16917
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16918
Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma
Published 2025-01-01“…Despite the growing recognition of histone modifications in tumor progression, their role in LGG remains poorly understood. …”
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16919
Conversion from clinically isolated syndrome to multiple sclerosis: what paraclinical tests findings are the most characteristic?
Published 2021-12-01“…The results indicate that pathological CSF findings (positive OCBs, elevated IgG levels) and prolonged BAEP latency are characteristic in patients with CIS who later progress to MS. Unspecified brain MRI lesions are also distinctive for MS patients; however, this result should be interpreted with consideration due to methodological reasons …”
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16920
Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Han...
Published 2025-01-01“…The bioinformatics analysis revealed that these compounds could regulate tumor-related pathways synergistically, inhibiting tumor cell growth, inducing cell apoptosis, and blocking cell cycle progression. Furthermore, the concentration ratio and total content of compounds in F973 and T271 were closely associated with their anti-breast cancer effects in extracts from various geographical origins. …”
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