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16241
Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023)
Published 2025-02-01“…Recent research emphasizes the role of the tumor microenvironment (TME) and immune modulation in glioma progression and resistance. Despite these advances, a comprehensive bibliometric analysis of research trends in glioma chemoradiotherapy resistance over the past two decades is lacking. …”
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16242
BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function
Published 2025-01-01“…The findings reveal that exposure to BPZ leads to a reduction in early embryo quality and hinders developmental progression. RNA sequencing analysis has identified 593 differentially expressed genes as a result of BPZ exposure, highlighting considerable changes in early embryonic gene expression. …”
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16243
Real world experience with [99mTc]Tc-HYNIC-iPSMA SPECT prostate cancer detection: interim results from the global NOBLE registry
Published 2024-12-01“…Patients were followed until disease progression, death, serious or intolerable adverse events, registry termination by the sponsor, patient withdrawal, or lost to follow-up. …”
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16244
Normative and limit values of speed, endurance and power tests results of young football players
Published 2025-01-01“…The developed percentile charts and tables offer a valuable tool for coaches and sports scientists to monitor progress, optimize training loads, and minimize the risk of injury, providing a frame of reference for assessing the physical development of young soccer players. …”
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16245
Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer
Published 2025-02-01“…We identified them as proximal or distal to the tumor margin and demonstrated that patients with distal TLSs (dTLSs) had significantly prolonged overall survival and progression-free survival (PFS) across multiple cohorts [hazard ratio (HR), 0.56; 95% confidence interval (CI), 0.36–0.88; p = 0.01 for overall survival; HR, 0.58; 95% CI, 0.40–0.84; p = 0.004 for PFS]. …”
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16246
Recurrent Pneumothorax in a Critically Ill Ventilated COVID-19 Patient
Published 2020-01-01“…Despite the insertion of ICDs, the hydropneumothorax persisted over months and initially progressed in size on serial scans needing multiple ICDs. …”
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16247
Three-dimensional ultrasound fusion imaging in precise needle placement for thermal ablation of hepatocellular carcinoma
Published 2024-12-01“…The rate of adequate ablative margin, complete response (CR), local tumor progression (LTP), disease-free survival (DFS), and overall survival (OS) was evaluated.Results According to postoperative contrast-enhanced CT or MR imaging, the complete response rate was 100% (60/60), and 83% of tumors (30/36) achieved adequate ablative margin (>5 mm) three-dimensionally. …”
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16248
Evaluating an implementation programme for medication review with follow-up in community pharmacy using a hybrid effectiveness study design: translating evidence into practice
Published 2020-09-01“…A series of interventions were defined (1) to engage pharmacy owners with the implementation model and (2) to provide training to pharmacists consisting of clinical case studies, process of MRF, communication skills and data collection methods and (3) practice change facilitators.Primary and secondary outcome measures The primary outcomes for the implementation programme were progress, reach, fidelity and integration. The secondary outcomes were number of medications, non-controlled health problems, emergency visits, hospitalisations and health-related quality of life, which were compared with a previous 6-month cluster RCT.Results 55% of pharmacies reached the implementation phase and 35.6% remained in the testing phase at 12 months. …”
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16249
Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study
Published 2025-03-01“…Growing evidence suggest that alterations in the microbiota-gut-brain (MGB) axis contribute to the development and progression of aMCI. However, little is known about whether and how acupuncture change the MGB axis of aMCI individuals. …”
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16250
Exploring the metabolic dynamics, storage stability, and functional potential of Lacticaseibacillus rhamnosus Probio-M9-fermented milk
Published 2025-02-01“…We used Probio-M9 as the sole inoculant for milk fermentation, collecting samples at 1.5- to 3-h intervals to monitor fermentation progression. Moreover, the metabolomics changes of the fermented milk were investigated after a 28-d storage period to evaluate post-storage stability. …”
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16251
Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease
Published 2025-02-01“…ObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative (PPMI) database were included in this study, and depression, cognitive function, and ADL were measured using the Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment Scale (MoCA), and Unified Parkinson’s Disease Rating Scale, Part II (UPDRS II) respectively. …”
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16252
Production of subtilisin proteases in bacteria and yeast
Published 2021-03-01“…In this review, we discuss the progress in the study and modif ication of subtilisin proteases. …”
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16253
Developing and validating a drug recommendation system based on tumor microenvironment and drug fingerprint
Published 2025-01-01“…Application to TCGA data successfully predicted clinical outcomes, including a significant association with 6-month progression-free survival (PFS, P = 0.007, AUC = 0.793).DiscussionThe model demonstrates strong performance across preclinical datasets, showing its potential for real-world application in personalized cancer therapy. …”
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16254
Predictors of COVID-19 vaccine hesitancy among biomedical students of Rivers State University
Published 2024-11-01“… Despite vaccination progress and a return to normalcy, new SARS-CoV-2 variants highlight the ongoing threat and potential for future pandemics. …”
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16255
Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review
Published 2025-02-01“…Surgical resections and additional pathological examinations support the diagnosis of CCAU (palliative resection for case 1 and transurethral resection for case 2). Case 1 undergone progression 6 months after initial treatment with transurethral resection and chemotherapy with a 15-month overall survival. …”
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16256
Using a digital health intervention “INTERCEPT” to improve secondary prevention in coronary heart disease (CHD) patients: protocol for a mixed methods non-randomised feasibility st...
Published 2025-01-01“…Using pre-defined feasibility criteria, including recruitment, retention and engagement rates, together with data on intervention acceptability, will determine the appropriateness of progressing to a definitive trial. Discussion This study will provide important insights to help inform the feasibility of conducting a definitive trial of “INTERCEPT” among coronary heart disease patients in a critical health care setting.…”
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16257
Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis
Published 2025-01-01“…BackgroundTrimethylamine N-oxide (TMAO), a metabolite dependent on intestinal microbiota, is closely related to the emergence, progression, and prognosis of cardiovascular disease (CVD), and has received increasing attention in recent years.ObjectiveThe current research hotspots and future development trends in TMAO and CVD field are found through bibliometrics analysis, which provides reference for further study.MethodsThe bibliometrics tools VOSviewer and CiteSpace were used to analyze the publications from the Web of Science Core Collection (WOSCC) database. …”
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16258
Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study
Published 2025-01-01“…It focuses on evaluating the role of exosomal MALAT1 in the progression of dysplasia to OSCC by influencing the PI3K/AKT pathway. …”
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16259
Study on Discrete Null-Field Equation Methods for Bounded Simply Connected Domains: Better Locations of Source Nodes
Published 2024-12-01“…The development of algorithms based on the NFE lags far behind that of the traditional boundary element method (BEM). Some progress has been made by following the MFS, and reported in this paper. …”
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16260
The Relationship between Perirenal Fat Thickness and Reduced Glomerular Filtration Rate in Patients with Type 2 Diabetes
Published 2020-01-01“…Obesity has been considered as an important factor in the development and progression of chronic kidney diseases (CKD). Perirenal fat, which is surrounding the kidneys, has been reported to be unique in anatomy and biological functions. …”
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