Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity by Shin Koike, Hideo Kimura, Yuki Ogasawara

“…Prolonged UPR activation is associated with the development and progression of various diseases, making it essential to understanding the redox regulation of PERK. …”
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受轴压、双向弯曲和扭矩作用的两端简支工形截面压弯构件的稳定设计 by 陈骥

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Establishing a GRU-GCN coordination-based prediction model for miRNA-disease associations by Kai-Cheng Chuang, Ping-Sung Cheng, Yu-Hung Tsai, Meng-Hsiun Tsai

“…Abstract Background miRNAs (microRNAs) are endogenous RNAs with lengths of 18 to 24 nucleotides and play critical roles in gene regulation and disease progression. Although traditional wet-lab experiments provide direct evidence for miRNA-disease associations, they are often time-consuming and complicated to analyze by current bioinformatics tools. …”
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Efficacy and safety of antifibrotic drugs for interstitial lung diseases other than IPF: A systematic review, meta-analysis and trial sequential analysis. by Mei Yang, Yuying Tan, Ting Yang, Dan Xu, Mei Chen, Lei Chen

“…<h4>Conclusion</h4>Our study suggests that antifibrotic drugs are beneficial for patients with non-IPF ILDs in slowing disease progression, whereas may not correlate to all-cause mortality and SAEs. …”
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Protocol for a feasibility study evaluating a supported self-management intervention for stroke survivors with aphasia (StarStep study) by Faye Wray, Madeline Cruice, Ian Kellar, Anne Forster

“…Feasibility data will inform decision-making regarding progression to a future definitive cluster randomised controlled trial to evaluate the effectiveness of the intervention. …”
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波形腹板部分包覆组合柱弱轴方向偏心受压试验研究 by 王威, 包海洋, 白淙尤, 刘磊, 陈乐乐

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Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives by Dong Luo, Yunmei Liu, Zhengmao Lu, Lei Huang

“…Targeted therapies against key targets in GC, including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR), have shown remarkable therapeutic efficacies by inhibiting tumor progression and/or blood supply. In particular, markable breakthroughs have been made in HER2-targeting drugs for HER2-positive GC patients. …”
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Enhanced Bayesian model for multienvironmental selection of winter hybrids maize: assessing grain yield using ‘ProbBreed’ by Bikas Basnet, Chitra Bahadur Kunwar, Umisha Upreti

“…Over and above, integrating genomic information into Bayesian models expected to enhance prediction accuracy and expedite breeding progress.…”
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Impact of early versus late artificial rupture of membranes during oxytocin induction of labour on the incidence of chorioamnionitis: a randomised controlled trial (ARM trial) by Meghan G. Hill, Michelle R. Wise, Emmanuelle Pauleau, Beatrice Treadwell, Lynn Sadler

“…Some institutions favour performing artificial rupture of membranes prior to commencement of oxytocin infusion, with the belief that the labour will progress more efficiently. In other institutions, the approach recommended is for oxytocin infusion with intact amniotic membranes until the person has reached the active phase of labour, citing risk of infection with early amniotomy. …”
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Cost Effectiveness of Insulin Glargine versus Neutral Protamin Hagedorn Insulin in the Treatment of Type 2 Diabetes Patients in Turkey by Ilhan Satman, Hayley Bennett, Candeger Yilmaz, Sazi Imamoglu, Goksun Ayvaz, Abdurrahman Comlekci, Demet Ozkaya, Toros Sahin

“…**Methods:** A previously published discrete event simulation model of T2DM progression was utilised to characterise the cost-effectiveness of insulin glargine in a Turkish population given the benefits observed in clinical practice. …”
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Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study by L. Guiducci, C. Vassalle, P. Parchi, S. Maffei

“…All BMs, except for total calcium and BALP, progressively decreased over time (P≤0.05). No fractures and significant adverse events were reported. …”
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Impact of trachoma elimination efforts in afar regional state, Ethiopia: survey findings from 26 evaluation units by Getachew Gebreselassie, Kasahun Negash, Dawit Woga, Misrak Makonnen, Baye Deneke, Muluken Desalegn, Seada Ali, Colin L. Beckwith, Fentahun Tadesse, Fikre Seife, Genet Kiflu, Fikreab Kebede

“…Addressing these WASH (Water, Sanitation, and Hygiene) challenges remains critical for sustaining progress in trachoma control and achieving long-term public health improvements in the Afar region. …”
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装配式钢结构H形钢梁-钢管柱连接节点的力学性能研究 by 王燕, 马强强, 杨怡亭, 刘秀丽

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Molecular subtype of ovarian clear cell carcinoma: an analysis of 80 Chinese patients using the TCGA molecular classification of endometrial cancer by Wei Chen, Lu Yan, Qin Li, Shuling Zhou, Ting Hou, Huijuan Yang, Shuang Ye

“…No significant differences were observed between the molecular subtypes and clinicopathological features. The progression-free survival and overall survival of the entire cohort were closely associated with FIGO stage (p < 0.01), the presence of residual tumour (p < 0.01), and the platinum response (p < 0.01). …”
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Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review by Nidhi Garg, Ananya Sree Kunamneni, Pankaj Garg, Sandeep Sharma, Divakar Sharma, Adinarayana Kunamneni

“…The current recommendation for mild-moderate, nonhospitalized patients who are at a high risk of disease progression is to use Paxlovid as the first-line option. …”
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Neutrophil Extracellular Trap Production in Patients with Colorectal Cancer In Vitro by J. J. R. Richardson, C. Hendrickse, F. Gao-Smith, D. R. Thickett

“…Neutrophil Extracellular Traps (NETs) are extracellular neutrophil derived DNA webs which have been implicated in cancer progression and in the development of metastases. NETs production in patients with colorectal cancer was investigated to elucidate their role and prognostic significance. …”
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Gender and antimicrobial resistance: a conceptual framework for researchers working in livestock systems by Fiona Emdin, Alessandra Galiè, Arshnee Moodley, Arshnee Moodley, Susan Rogers Van Katwyk

“…Integrated questions offer a deeper understanding of gender dynamics and norms in livestock systems with the aim of improving them, while strategic questions focus on gender-related issues in livestock as entry points, highlighting some of the mechanisms behind these gender issues to progress towards gender equality.ConclusionAs gender-analysis in livestock research gains prominence, there is an increasing expectation for AMR researchers to integrate gender considerations into their work. …”
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Second-line systemic treatment for metastatic colorectal cancer: A systematic review and Bayesian network meta-analysis based on RCT. by Chengyu Sun, Enguo Fan, Luqiao Huang, Zhengguo Zhang

“…Markov Chain Monte Carlo (MCMC) technique was used in this network meta-analysis (NMA) to generate the direct and indirect comparison results among multiple treatments in progression-free survival (PFS), overall response rate (ORR), overall survival (OS), complete response (CR), partial response (PR), grade 3 and above adverse events (Grade ≥ 3AE), and any adverse events (Any AE). …”
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ERBB3-related gene PBX1 is associated with prognosis in patients with HER2-positive breast cancer by Shufen Mo, Haiming Zhong, Weiping Dai, Yuanyuan Li, Bin Qi, Taidong Li, Yongguang Cai

“…Conclusion PBX1, IGHM and CXCL13 are associated with the expression level of the ERBB3 and are prognostic markers for HER2-positive in BC, which may play an important role in the development and progression of BC.…”
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Circ-ADAM9 Promotes High Glucose-Induced Retinal Pigment Epithelial Cell Injury in DR via Regulating miR-338-3p/CARM1 Axis by Zeyu Liang, Chengzhe Lu, Tingting Feng, Xiang Gao, Yongfang Tu, Wenchao Yang, Yipeng Wang

“…More research is needed to confirm the role and mechanism of circ-ADAM9 in DR progression. Methods. High glucose (HG)-induced RPE cells (ARPE-19) were used to mimic the hyperglycemia condition. …”
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