MicroRNA-150-3p enhances the antitumour effects of CGP57380 and is associated with a favourable prognosis in non-small cell lung cancer by Hongmei Zheng, Songqing Fan, Jiadi Luo, Qiuyuan Wen, Hongjing Zang

“…Abstract MicroRNA (miRNA) dysregulation has been identified in several carcinomas, including non-small cell lung cancer (NSCLC), and is known to play a role in the development and progression of this disease. We initially conducted a miRNA microarray analysis, which revealed that the MNK inhibitor CGP57380 increased the expression of miR-150-3p. …”
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Efficacy and safety of neoadjuvant bevacizumab plus chemotherapy in locally advanced gastric cancer patients: a retrospective, comparative study by Bin Yin, Wei Luo

“…Results Objective response rate (52.2% vs. 35.4%), disease control rate (91.3% vs. 81.3%), surgical resection rate (95.7% vs. 85.4%), R0 resection rate (87.0% vs. 75.0%), and the proportion of patients with tumor regression grade 0–1 (31.8% vs. 17.1%) tended to increase in bevacizumab plus chemo group versus chemo group, although there was no statistical significance. The 48-month progression-free survival (PFS) rates were 58.3% and 33.4% in bevacizumab plus chemo group and chemo group. …”
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Persistence with Early-Line Abatacept versus Tumor Necrosis Factor-Inhibitors for Rheumatoid Arthritis Complicated by Poor Prognostic Factors by Xue Han, Francis Lobo, Michael S. Broder, Eunice Chang, Sarah N. Gibbs, David J. Ridley, Irina Yermilov

“…In adjusted analyses, abatacept patients had a lower risk of discontinuing index treatment due to disease progression (0.3 \[95% confidence interval (CI): 0.1-0.6\], *P*=0.001). …”
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Clinical value of serum biomarkers, squamous cell carcinoma antigen and apolipoprotein C-II in follow-up of patients with locally advanced cervical squamous cell carcinoma treated... by Yoko Harima, Takuro Ariga, Yuko Kaneyasu, Hitoshi Ikushima, Sunao Tokumaru, Shigetoshi Shimamoto, Takeo Takahashi, Noriko Ii, Kayoko Tsujino, Anneyuko I Saito, Hiroki Ushijima, Takafumi Toita, Tatsuya Ohno

“…In this multicenter prospective cohort study, the usefulness of pre- and posttreatment serum protein levels of potential biomarkers, including squamous cell carcinoma antigen (SCC-Ag), apolipoprotein C-II (ApoC-II), matrix metalloproteinase (MMP)1, and MMP2, were evaluated together with clinical factors in 145 cervical cancer patients in order to determine their suitability to predict survival. Progression-free survival (PFS) was the primary endpoint, and overall survival (OS), pelvic PFS (PPFS), and distant metastasis-free survival (DMFS) were the secondary endpoints. …”
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带低屈服点钢耗能梁段高强钢框筒结构的结构影响系数和位移放大系数研究 by 周玉浩, 连鸣, 韩瑞祥

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Effects of Resistant Starch on Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis by Xinyi Du, Jing Wu, Chenlin Gao, Qinqin Tan, Yong Xu

“…Recent studies shown that the progression of CKD may be related to the change of intestinal flora. …”
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Sustainable Distance E-Learning for Enhanced Students Retention and Support: Faculty of Law National Open University of Nigeria in Focus by Erimma Gloria Orie

“…Despite the monumental progress made by NOUN, there are challenges related to students’ retention and support militating against realization of the objectives of establishing the university. …”
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基于裂纹扩展分析的正交异性钢桥面板疲劳响应研究 by 叶华文, 叶杨帆, 周亚栋, 王翔, 李云友

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Tumor mutation burden for predicting immune checkpoint blockade response: the more, the better by Ming Zheng

“…ICB treatment outcomes were analyzed by overall survival, progression-free survival and objective response rate.Results No universally valid TMB cut-off was available for all cancer types. …”
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High Expression of Ten Eleven Translocation 1 Is Associated with Poor Prognosis in Hepatocellular Carcinoma by Haopeng Wen, Tengfei Ji, Liteng Lin, Nan Cheng, Kangshun Zhu, Liangqi Cao

“…Our study suggested TET1 as a potential indicator in HCC progression. TET1 was closely involved in immune infiltration and activation of oncogenic pathways. …”
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轴向荷载作用下小规格拉铆钉和普通螺栓疲劳性能对比研究 by 杨俊芬, 焦瑞婕, 钟炜辉, 李立和, 苗广威, 贾云龙

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Implementation of the School as a Learning Organisation Approach in Vocational Education: The Case of Latvia by Gunta Siliņa-Jasjukeviča, Ilze Briška, Inese Lūsēna-Ezera, Agnese Lastovska, Inga Linde

“…All 7 dimensions of the SLO can be found in the education policy documents of the EU and OECD countries and Latvia, as well as in the focus group interviews, which shows that there is a gradual progress towards the transformation of vocational education institutions into learning organisations.Conclusions. …”
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Occurrence Characteristics and Threshold Pore Throat Radius of Movable Fluids for Dolomite Intercrystalline Pores of Lacustrine Carbonate Rocks by Shiming Zhang, Xiaojun Zhang, Tingjing Zhang, Yongxian Zheng, Jun Cui, Juerong Fu, Chao Wang, Xiaofeng Yu

“…The reservoir evaluation and classification are restrained by the progress of research on the pore structure and fluid occurrence in dolomite intercrystalline pores of the Paleogene lacustrine carbonate rock in the western Qaidam Basin. …”
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螺栓连接和拉铆连接在剪切循环荷载作用下的松动行为研究 by 杨俊芬, 郝凯丽, 钟炜辉, 王维新, 苗广威, 张钦

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北京大兴国际机场航站楼大跨度钢结构C5区地震响应分析 by 张爱林, 方浩, 刘学春, 牟俊霖, 束伟农, 朱忠义

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Artificial Intelligence in Pediatric Epilepsy Detection: Balancing Effectiveness With Ethical Considerations for Welfare by Marina Ramzy Mourid, Hamza Irfan, Malik Olatunde Oduoye

“…It profoundly impacts both developmental progress and quality of life in affected children. …”
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Reperfusion injury or cytokine storm? Utilizing plasmapheresis in severe trauma-induced multiorgan failure: a case report by Gun Woo Kim, Suyeong Hwang, Kyoung Hoon Lim, Sung Hoon Cho

“…However, plasmapheresis may represent an effective treatment option in cases of severe progression.…”
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Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…These findings suggest a novel mechanism of plasma-AM interaction in sepsis-induced ALI, offering a plausible strategy for assessing septic progression and treating lung injury.…”
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预铸五螺箍矩形SRC柱之轴压与反复载重抗震试验 by 翁正强, 尹衍梁, 王瑞祯, 梁景裕

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开合屋盖结构闭合全过程模拟及参数分析 by 衡会, 汪凯超, 徐光明, 冯龙, 查晓雄

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