Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes by Mengyue Liu, Juan Tang, Nan Sun, Chuang Xi, Chentian Shen, Song Hongjun, Quanyong Luo, Xianzhao Deng, Zhongling Qiu

“…At the end of follow-up, eight patients (29.63%) had disease progression (PD), four (14.81%) had a partial response, and the remainder had stable disease; no patient achieved complete response. …”
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Intra-Articular Injection of Human Bone Marrow–Derived Mesenchymal Stem Cells in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial by Bong-Woo Lee, Jennifer Jooha Lee, Joon-Yong Jung, Ji Hyeon Ju

“…Quantitative T2 MRI mapping of the cartilage showed that IA BM-MSCs could have a preventive effect on OA progression for 12 months. Our findings suggest the potential of allogeneic BM-MSCs IA injection as a pain-relieving and disease-modifying treatment for patients with knee OA in the outpatient setting.…”
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Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis by Ailing Yu, Ailing Yu, Ailing Yu, Ailing Yu, Ailing Yu, Zian Bai, Zian Bai, Zian Bai, Zian Bai, Yijie Wang, Yijie Wang, Yijie Wang, Yijie Wang, Zhen Luo, Zhen Luo, Zhen Luo, Zhen Luo, Xiaochen Du, Mengxin Chen, Shuang Wen, Honglong Wang, Xiaoying Yuan, Chunyu Yang, Shanshan Bai, Bo Fan, Bo Fan, Bo Fan, Bo Fan

“…Furthermore, no notable disparities were observed in OS, CSS, or RFS between the finasteride group and the control group.ConclusionFinasteride plays a protective role against the progression of BCa, nevertheless, its effects on prognostic outcomes, including OS, CSS, and RFS, remain inconclusive. …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…Results Pristine, 200 nm SiNPs induced minimal changes to energy metabolism and proteomic profiles in vitro while treatment with SAD SiNPs resulted in mitochondrial membrane hyperpolarization, inhibited mitochondrial respiration, increased reactive oxygen species generation, and redox proteomic trends suggesting activation of aryl hydrocarbon receptor (AHR) and other signaling pathways with known roles in mitochondrial inhibition and CKD progression. Conclusion Results suggest that PCT cell exposure to SAD SiNPs could promote glycolytic and fibrotic shifts consistent with CKDu pathology via oxidative stress-mediated disruption of redox signaling pathways.…”
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Bibliometric analysis for sustainable food waste using multicriteria decision by . Syafrudin, I.B. Priyambada, M.A. Budihardjo, S. Al Qadar, A.S. Puspita

“…The combination of bibliometric analysis and multicriteria decision-making offered a formidable instrument to reduce food waste, enhance resource efficiency, and spur progress in global sustainability initiatives in a world where sustainable behavior is crucial. …”
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CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite by Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fábio Magalhães-Gama, Jacqueline Almeida Gonçalves Sachett, Iran Mendonça Silva, Kerolaine Fonseca Coelho, Eliane Campos Alves, Andréa Monteiro Tarragô, Luiz Carlos de Lima Ferreira, Adriana Malheiro, Wuelton Marcelo Monteiro, Allyson Guimarães Costa

“…In the AKI(+) group, levels of CXCL-8 and CCL-2 molecules were elevated on admission and progressively decreased during the clinical evolution of patients after antivenom administration. …”
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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…Severe bloodborne infections, exemplified in sepsis and the progression to septic shock, can not only disrupt the circadian rhythmicity of inflammatory processes but can be exacerbated by circadian misalignment. …”
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Clinical Benefits of Metronomic Chemotherapy in Platinum-Refractory, Recurrent, and Metastatic Head and Neck Squamous Cell Carcinoma by Amira Elwan, Adel Bakry, Mohamed Eesa, Hoda Ismail, Mohamed Alnemr

“…The multidisciplinary team evaluated treatment toxicity, response, progression-free survival (PFS), and overall survival (OS). …”
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Urinary I-FABP, L-FABP, TFF-3, and SAA Can Diagnose and Predict the Disease Course in Necrotizing Enterocolitis at the Early Stage of Disease by Stepan Coufal, Alena Kokesova, Helena Tlaskalova-Hogenova, Barbora Frybova, Jiri Snajdauf, Michal Rygl, Miloslav Kverka

“…It is characterized by unexpected onset and rapid progression with specific diagnostic signs as pneumatosis intestinalis or gas in the portal vein appearing later in the course of the disease. …”
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Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma by Zhong Zheng, Jian-Biao Wang, Rui Sun, Nan Wang, Xiang-Qin Weng, Tian-Yuan Xu, Di Fu, Yan Feng, Peng-Peng Xu, Shu Cheng, Li Wang, Yan Zhao, Bin Qu, Chuan-Xin Huang, Wei-Li Zhao

“…We found that inferior progression-free survival of the patients was significantly associated with elevated serum β2m and lymph node >6 cm, linking to decreased lymphoma cell autophagy and dendritic cell infiltration within the tumor microenvironment. …”
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Application of quality control circle activities to improve the correct rate of postoperative respiratory muscle training in patients undergoing surgery for lung cancer (提高肺癌患者术后呼吸... by GAO Caili (高彩丽), PENG Ya (彭娅), WU Qiaomei (吴巧梅), ZHU Lifang (朱莉芳)

“…Results The correct rate of postoperative respiratory muscle training increased from 53. 33% to 79. 17%, with a target achievement ratio of 104. 87% and progress ratio of 48. 6%. Nurses' comprehensive ability were enhanced after implementation of QCC activities. …”
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Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis by Kaiwen Sheng, Jun Chen, Ruitang Xu, Haoqiang Sun, Ran Liu, Yongjie Wang, Wenwen Xu, Jiao Guo, Miao Zhang, Shuai Liu, Juan Lei, Yawen Sun, Yang Jia, Dianhao Guo

“…Conclusions In summary, utilizing multiomics analyses, we have revealed chromatin accessibility maps and illuminated the intricate molecular mechanisms that underlie cellular heterogeneity during ESCC metastasis, offering valuable insights to further advance research on tumor progression and deterioration.…”
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Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions by Kyle D. Gromer, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Colin Shearn, Swati Antala, Swati Antala, Joshua B. Wechsler, Carla M. Cuda, Cara L. Mack, Ronald J. Sokol, William J. Janssen, Richard M. Green, Harris Perlman, Deborah R. Winter, Sarah A. Taylor, Sarah A. Taylor

“…IntroductionMacrophages play an important role in disease progression of pediatric cholestatic liver disease, particularly biliary atresia (BA); however, the restorative versus pathogenic role for precise macrophage subsets remains poorly defined. …”
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Sequential Docetaxel in ≥7 Cycles Followed by Cabazitaxel Improves Oncological Outcomes in Patients with Metastatic Castration-Resistant Prostate Cancer by Seiichi Kato, Manabu Takai, Koji Iinuma, Shota Fujimoto, Masahiro Nakano, Takashi Ishida, Masahiro Uno, Masayoshi Tamaki, Mitsuhiro Taniguchi, Hisao Komeda, Yoshito Takahashi, Takuya Koie

“…The primary endpoints were overall (OS) and progression-free survival (PFS). The secondary endpoints were the rates of ≥30% and ≥50% reduction in prostate-specific antigen (PSA) levels at chemotherapy initiation. …”
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ASSOCIATION BETWEEN LEUKEMIC EVOLUTION AND UNCOMMON CHROMOSOMAL ALTERATIONS IN PEDIATRIC MYELODYSPLASTIC SYNDROME by Viviane Lamim Lovatel, Beatriz Ferreira da Silva, Eliane Ferreira Rodrigues, Maria Luiza Rocha da Rosa Borges, Rita de Cássia Barbosa Tavares, Ana Paula Silva Bueno, Elaine Sobral da Costa, Terezinha de Jesus Marques, Teresa de Souza Fernandez

“… Background and objective: Pediatric myelodysplastic syndrome (pMDS) is a group of rare clonal neoplasms with a difficult diagnosis and risk of progression to acute myeloid leukemia (AML). The early stratification in risk groups is essential to choosing the treatment and indication for allogeneic hematopoietic stem cell transplantation (HSCT). …”
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Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients with chronic coronary artery disease (CAD) - current state of knowledge and perspective... by Hubert Bochenek, Anna Bielicka, Michał Bzoma, Julia Gugulska, Irmina Czerepak, Marcin Kapij, Karolina Niewczas, Adrianna Brzozowska

“…Although significant progress has been made, optimal DAPT regimens for specific patient groups remain uncertain, particularly in cases of shortened or intensified therapy. …”
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The Endocannabinoid, Anandamide, Acts as a Novel Inhibitor of LPS-Induced Inflammasome Activation in Human Gastric Cancer AGS Cell Line: Involvement of CB1 and TRPV1 Receptors by Sahar Sadat Sedeighzadeh, Hamid Galehdari, Mohammad Reza Tabandeh, Mehdi Shamsara, Ali Roohbakhsh

“…Inflammasome activation is a pivotal step for the maturation of IL-1β, which is involved in the development and progression of gastric cancer (GC). Endocannabinoids, such as anandamide (AEA), are emerging as new anticancer therapeutic agents; however, their effects on inflammasome components and underlying mechanisms have not been well elucidated. …”
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The prognostic role of mitosis index, stage and grade of endometrial cancer in Dr. Soetomo General Academic Hospital Surabaya, Indonesia, in 2018-2020 by Farida Umi Choviva, Willy Sandhika, Pungky Mulawardhana

“…An increase in the mitotic index, reflecting a higher proliferation rate of cancer cells, was associated with a more advanced cancer stage, suggesting that the mitotic index could potentially serve as a prognostic marker for assessing tumor progression in endometrial cancer. However, our analysis revealed no significant correlation between the mitotic index and the histological grade of endometrial cancer, implying that the grade, which typically reflects the differentiation status and morphological characteristics of the tumor cells, is independent of the proliferation rate as measured by the mitotic index. …”
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Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types by Jeanne Shen, Sergio Pereira, Chan-Young Ock, Yung-Jue Bang, Seulki Kim, Sehhoon Park, Se-Hoon Lee, George A Fisher, Young Kwang Chae, Yoon-La Choi, Jin-Haeng Chung, Tony S K Mok, Leeseul Kim, Jun-Eul Hwang, Gahee Park, Sanghoon Song, Seunghwan Shin, Yoojoo Lim, Wonkyung Jung, Heon Song, Hyojin Kim, Taebum Lee, Sukjun Kim, Chang Ho Ahn, Seokhwi Kim, Ben W Dulken, Stephanie Bogdan, Maggie Huang, Chiyoon Oum, Siraj M. Ali

“…We evaluated the correlation between the IIP and ICI treatment outcomes in terms of objective response rates (ORR), progression-free survival (PFS), and overall survival (OS) in a cohort of 1,806 ICI-treated patients representing over 27 solid tumor types retrospectively collected from multiple institutions.Results We observed an overall IIP prevalence of 35.2% and significantly more favorable ORRs (26.3% vs 15.8%), PFS (median 5.3 vs 3.1 months, HR 0.68, 95% CI 0.61 to 0.76), and OS (median 25.3 vs 13.6 months, HR 0.66, 95% CI 0.57 to 0.75) after ICI therapy in IIP compared with non-IIP patients, respectively (p<0.001 for all comparisons). …”
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A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma by Jie Zha, Qinwei Chen, Wei Zhang, Hongmei Jing, Jingjing Ye, Huanhuan Liu, Haifeng Yu, Shuhua Yi, Caixia Li, Zhong Zheng, Wei Xu, Zhifeng Li, Zhijuan Lin, Lingyan Ping, Xiaohua He, Liling Zhang, Ying Xie, Feili Chen, Xiuhua Sun, Liping Su, Huilai Zhang, Haiyan Yang, Weili Zhao, Lugui Qiu, Zhiming Li, Yuqin Song, Bing Xu

“…Abstract Background Disease progression within 24 months (POD24) significantly impacts overall survival (OS) in patients with follicular lymphoma (FL). …”
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