A blockchain-based secure path planning in UAVs communication network by Shubhani Aggarwal, Ishan Budhiraja, Sahil Garg, Georges Kaddoum, Bong Jun Choi, M. Shamim Hossain

“…It is gradually becoming an essential part of navigation as a consequence of high progress in military and civilian missions. Path planning of UAVs in military and civilian missions or in unknown and restricted environments is one of the biggest problems facing the operation of UAVs. …”
Get full text

Prognostic value of systemic immune-inflammation index in patients with small-cell lung cancer treated with immune checkpoint inhibitors by Yusuke Hamakawa, Ayumi Hirahara, Akiko Hayashi, Kota Ito, Hiroyuki Shinohara, Aya Shiba, Yuko Higashi, Masaharu Aga, Kazuhito Miyazaki, Yuri Taniguchi, Yuki Misumi, Yoko Agemi, Yukiko Nakamura, Tsuneo Shimokawa, Hiroaki Okamoto

“…Overall survival (OS) and progression-free survival (PFS) were compared between the groups using the Kaplan–Meier method and log-rank test. …”
Get full text

Identification of hub genes, non-coding RNAs and pathways in Renal cell carcinoma (RCC): A comprehensive in silico study by Ahmad Golestanifar, Hengameh Khedri, Parisa Noorabadi, Mohammadreza Saberiyan

“…Our approach combined differential expression analysis, functional enrichment through Gene Ontology (GO) and KEGG pathway mapping, and a Protein-Protein Interaction (PPI) network to identify crucial hub genes in KIRC progression. Results: Key findings include the identification of hub genes such as EGFR, FN1, IL6, and ITGAM, which were closely associated with immune responses, cell signaling, and metabolic dysregulation in KIRC. …”
Get full text

Mechanical Behavior of Ion-Exchanged Alkali Aluminosilicate Glass Ceramics by Bruno M. F. Nunes, André Dinis, Jorge C. Fernandes, Rui M. Almeida, Luís F. Santos

“…One of the areas of significant research and progress is that of high-mechanical-resistance glass. …”
Get full text

Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer by Anne Meunier, Javier Alejandro Hernández-Castro, Nicholas Chahley, Laudine Communal, Sara Kheireddine, Newsha Koushki, Nadia Davoudvandi, Sara Al Habyan, Benjamin Péant, Anthoula Lazaris, Andy Ng, Teodor Veres, Luke McCaffrey, Diane Provencher, Peter Metrakos, Anne-Marie Mes-Masson, David Juncker

“…Conclusions GµF uncovers the unexpected prevalence and frequency of cCTCs including sometimes very large ones in epithelial ovarian cancer patients, and motivates additional studies to uncover their properties and role in disease progression.…”
Get full text

Application of 2D polymerase chain reaction for single-tube detection of high-risk human papillomaviruses by Weifeng Wang, Min Jiang, Ying Liu, Xuan Wu, Yan Chen, Xiaoyun Zhang, Weiwei Liu

“…PurposeThe persistent infection of high-risk HPV (HR-HPV) is intricately linked to the onset and progression of cervical cancer. This research endeavored to develop a high-throughput 2D PCR method for closed-tube genotyping of 11 HR-HPVs.MethodsBase-quenched probes were specifically designed for FAM, VIC, and CY5 channels. …”
Get full text

Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome by Cristina Alonso, Alicia García-Culebras, Valentina Satta, Inés Hernández-Fisac, Álvaro Sierra, José A. Guimaré, Ignacio Lizasoain, Javier Fernández-Ruiz, Onintza Sagredo

“…Dravet Syndrome (DS) is a pediatric encephalopathy caused by mutations in Scn1a gene encoding the α1 subunit of the NaV1.1 voltage-gated sodium channel, which lead to early febrile seizures that progress to severe tonic-clonic seizures and several long-term behavioural comorbidities. …”
Get full text

Evaluating plasma biomarkers NfL, GFAP, GDF15, and FGF21 as indicators of disease severity in Charcot–Marie Tooth patients by Dace Pretkalnina, Dace Pretkalnina, Dace Pretkalnina, Elizabete Kenina, Elizabete Kenina, Linda Gailite, Dmitrijs Rots, Dmitrijs Rots, Kaj Blennow, Kaj Blennow, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Viktorija Kenina, Viktorija Kenina, Viktorija Kenina

“…Effective drugs for treatment are lacking, and we struggle to find sensitive markers to track the disease’s severity and progression. In this study, our objective was to investigate the levels of neurofilament light chain (NfL), glial fibrillary acid protein (GFAP), fibroblast growth factor 21 (FGF-21) and growth differentiation factor 15 (GDF-15) in individuals with CMT and to compare them to a control group. …”
Get full text

Characterization of G2/M checkpoint classifier for personalized treatment in uterine corpus endometrial carcinoma by Yiming Liu, Yusi Wang, Shu Tan, Xiaochen Shi, Jinglin Wen, Dejia Chen, Yue Zhao, Wenjing Pan, Zhaoyang Jia, Chunru Lu, Ge Lou

“…Compared with the subtype C2, the subtype C1 exhibited higher G2MC scores and was associated with faster disease progression, higher clinical staging, poorer pathological types, and lower therapy responsiveness of cisplatin, radiotherapy and immunotherapy. …”
Get full text

Cost-effectiveness analysis of durvalumab with chemotherapy and maintenance durvalumab with or without olaparib for advanced endometrial cancer by Jiahao Zhang, Jianying Lei, Caicong You, Wu Fu, Bin Zheng, Hongfu Cai, Maobai Liu, Na Li

“…A Markov model based on DUO-E Phase III trial data simulated disease progression and outcomes. Total costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICER) were evaluated. …”
Get full text

SIRT1/PGC-1α-mediated mitophagy participates the improvement roles of BMAL1 in podocytes injury in diabetic nephropathy: evidences from in vitro experiments by Yanxia Rui, Yinfeng Guo, Linying He, Min-er Wang, Henglan Wu

“…Abstract Background Dysfunction in podocyte mitophagy has been identified as a contributing factor to the onset and progression of diabetic nephropathy (DN), and BMAL1 plays an important role in the regulation of mitophagy. …”
Get full text

Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function by Bo Li, Bo Li, Haoyu Wang, Haoyu Wang, Haoyu Wang, Mengmeng Wang, Mengmeng Wang, Hewei Liang, Hewei Liang, Hewei Liang, Tongyuan Hu, Tongyuan Hu, Tongyuan Hu, Jinlong Yang, Jinlong Yang, Jinlong Yang, Shangyong Li, Xinbi You, Xinbi You, Xinbi You, Binbin Xia, Binbin Xia, Binbin Xia, Yue Yuan, Yue Yuan, Yuanqiang Zou, Yuanqiang Zou, Yinglei Miao, Yinglei Miao, Yang Sun, Yang Sun, Yang Sun

“…Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the bacterial collection constructed in our previous studies, we founded that Bifidobacterium adolescentis AF91-08b2A has the potential beneficial function. …”
Get full text

Holocord syringomyelia in 18 dogs by Despoina Douralidou, Lorenzo Mari, Sophie Wyatt, Juan Jose Minguez, Patricia Alvarez Fernandez, Carlo Anselmi, Christoforos Posporis

“…The frequent occurrence of myelopathy and disease progression underscores the need for further research into the underlying etiopathogenesis, natural disease evolution, and response to therapeutic interventions.…”
Get full text

Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer by Feng Qi, Yihang Xu, Zicheng Xu, Qing Zou

“…All patients were divided into cytoreductive surgery group and no local therapy group according to the administration of cytoreductive surgery before progression to metastatic castration-resistant prostate cancer (mCRPC). …”
Get full text

Does therapy with immunosuppressive drugs improve gastrointestinal symptoms in patients with systemic sclerosis? by Oliver Distler, Cosimo Bruni, Suzana Jordan, Carina Mihai, Muriel Elhai, Rucsandra Dobrota, Alexandru Garaiman, Mike Oliver Becker, Lea Stamm, Sherif Ismail, Norina Zampatti, Aurora Maria Tatu

“…Objectives While important progress was made regarding the treatment of systemic sclerosis (SSc), there is still no evidence-based disease-modifying treatment available for SSc-related gastrointestinal (GI) manifestations. …”
Get full text

Ibuprofen-Induced Multiple Fixed Drug Eruption Confirmed by Re-Challenge: A Case Report and Literature Review by Yoshihito Mima, Masako Yamamoto, Hiyo Obikane, Yuta Norimatsu, Ken Iozumi

“…However, in multiple FDE, CD8-positive T cell activity may outweigh that of regulatory T cells, causing uncontrolled inflammation and leading to the spread of poorly-demarcated lesions that can progress to severe drug reactions such as Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). …”
Get full text

High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience by Veronica González‐Calle, Paula Rodriguez‐Otero, Maria J. Calasanz, Manuela Guijarro, Joaquin Martínez‐López, Laura Rosiñol, Miguel T. Hernández, Ana I. Teruel, Mercedes Gironella, Albert Oriol, Javier de laRubia, Ana P. González‐Rodríguez, Joan Bargay, Felipe deArriba, Luis Palomera, Marta‐Sonia González‐Pérez, Anna Sureda, Enrique Ocio, Juan J. Lahuerta, Joan Bladé, Jesus F. San Miguel, Maria V. Mateos, Norma C. Gutiérrez

“…The median follow‐up was 61 months, and the median progression‐free survival (PFS) and overall survival (OS) were 44 months and not reached, respectively. …”
Get full text

Chemokine family significance and prognostic value in colorectal cancer by Yi Ding, Yi Ding, Yi Ding, Yinnan Chen, Yinnan Chen, Yinnan Chen, Siyun Xie, Quanpeng Qiu, Quanpeng Qiu, Xiaolong Guo, Yun Feng, Yun Feng, Hongxia Li, Hongxia Li, Fang Zhu, Yaping Liu, Yaping Liu, Yaping Liu

“…The intricate tumor microenvironment plays a crucial role in CRC development and progression, where chemokines contribute significantly. …”
Get full text

Use of Attention Maps to Enrich Discriminability in Deep Learning Prediction Models Using Longitudinal Data from Electronic Health Records by Lucía A. Carrasco-Ribelles, Margarita Cabrera-Bean, Jose Llanes-Jurado, Concepción Violán

“…Methods: We developed four deep learning-based architectures with attention mechanisms that were progressively more complex to handle longitudinal data from EHRs. …”
Get full text

Role of YAP/TAZ in bone diseases: A transductor from mechanics to biology by Xin Chen, Xing Ji, Zhaobai Lao, Bin Pan, Yu Qian, Wanlei Yang

“…This systematic review summarizes current research progress, identifies unaddressed areas, and highlights potential future research directions. …”
Get full text