Photobiomodulation on Bax and Bcl-2 Proteins and SIRT1/PGC-1α Axis mRNA Expression Levels of Aging Rat Skeletal Muscle by Fang-Hui Li, Yan-Ying Liu, Fei Qin, Qing Luo, Hai-Ping Yang, Quan-Guang Zhang, Timon Cheng-Yi Liu

“…This indicates that LLLI has potential to decrease progression of myocyte apoptosis in sarcopenic muscles.…”
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In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in ELANE Gene Causing Autosom... by Khyber Shinwari, Mikhail A. Bolkov, Muhammad Yasir Akbar, Liu Guojun, Svetlana S. Deryabina, Irina A. Tuzankina, Valery. A. Chereshnev

“…This research sheds light on how ELANE failure upon mutation results in disease progression, including congenital neutropenia, and validation of these novel predicted nsSNPs is required through the wet lab.…”
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Subnational mapping of anaemia and aetiologic factors in the West and Central African region by Kaleab Baye, Bayuh Asmamaw Hailu, Simeon Nanama, John Ntambi, Arnaud Laillou

“…Without renewed efforts to integrate activities and align various sectors in the prevention of anaemia, progress is likely to remain elusive. …”
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Difference of clinical characteristics in patients with reinfection and primary infection variants of SARS-CoV-2: a retrospective study in China by Chao-Chao Qiu, Xiao-Qing Lin, Qiang Zhang, Ya-Long Chen, Xiao-Qiao Su, Ming-Ying Zhang, Le-Fei Zhu, Zhi-Ruo Lin, Fang Cheng, Shang-Ren Xie, Ji-Chan Shi, Xian-Gao Jiang

“…Abstract Background The number of patients experiencing re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is progressively increasing. In this study, we aimed to explore the differences in clinical characteristics between patients with primary infection and those with re-infection of SARS-CoV-2. …”
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Exploring the expression of DLL3 in gastroenteropancreatic neuroendocrine neoplasms and its potential diagnostic value by L. Yin, R. Wang, X. Ma, K. Jiang, Y. Hu, X. Zhao, L. Zhang, Z. Wang, T. Long, M. Lu, J. Li, Y. Sun

“…It was not correlated with progression-free survival (PFS) or overall survival(OS), regardless of cutoff value (1%, 50%, 75%). …”
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D-ribose-5-phosphate inactivates YAP and functions as a metabolic checkpoint by Cheng-E Tu, Yong-Feng Liu, Hong-Wei Liu, Chun-Mei Jiao, Quentin Liu, Mien-Chie Hung, Peng Li, Xiang-Bo Wan, Xin-Juan Fan, Yun-Long Wang

“…Importantly, D5P synergistically enhances the tumor-suppressive effect of GLUT inhibitors and inhibits cancer progression in mice. Conclusions Our study identifies D5P as a metabolic checkpoint linking glucose limitation stress and YAP activation, indicating that D5P may be a potential anti-cancer metabolite by enhancing glucose limitation sensitivity.…”
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Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and fatty acid metabolism-associated gene by Hong Li, Yongyun Xu, Aiting Wang, Chuanxin Zhao, Man Zheng, Chunyan Xiang

“…These findings not only contribute to our understanding of AS but also present potential biomarkers for the disease, opening avenues for more effective monitoring and progression tracking of AS.…”
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Effective sources of powdery mildew resistance among spring bread wheat for the northwest of the Russian Federation by T. V. Lebedeva, A. N. Brykova, E. V. Zuev

“…Development of cultivars resistant to powdery mildew is the most important trend in spring bread wheat breeding. Its progress is determined by new sources of effective resistance genes and their incorporation into promising spring bread wheat cultivars. …”
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circICMT upregulates and suppresses the malignant behavior of bladder cancer by Xin Luo, FangMei Xie, Guoqiang Qin, Ge Zou, Xu Lu, Chaofeng Zhang, Zeping Han, Ying Zhao, Xiaoyu Song, WenFeng Luo, Yongsheng Li, JinHua He, Jian Shen

“…Bioinformatics predictions have found that circICMT can bind to a variety of miRNAs and RBPs and may form a complex regulatory network to regulate the progression of bladder cancer. Conclusion: circICMT is significantly highly expressed in bladder cancer, and intervening circICMT expression affects the malignant phenotype of bladder cancer cells in vivo and in vitro, which may provide potential biomarkers and therapeutic targets for the management of bladder cancer.…”
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New insights into the ferroptosis and immune infiltration in endometriosis: a bioinformatics-based analysis by Lusha Liu, Feifei Han, Naiyi Du, Yakun Liu, Aihong Duan, Shan Kang, Bin Li

“…Specifically, the ferroptosis subcluster with stage III-IV of endometriosis is more inclined to the immunosuppressive microenvironment.ConclusionsOur study showed that ferroptosis may jointly promote endometriosis progression by remodeling the immune microenvironment, offering new insights into pathogenesis and therapeutics.…”
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Understanding Autoimmune Mechanisms in Multiple Sclerosis Using Gene Expression Microarrays: Treatment Effect and Cytokine-related Pathways by A. Achiron, M. Gurevich, D. Magalashvili, I. Kishner, M. Dolev, M. Mandel

“…The etiology of MS, as well as the mechanisms associated with its unexpected onset, the unpredictable clinical course spanning decades, and the different rates of progression leading to disability over time, remains an enigma. …”
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Delineating urban flooding when incorporating community stormwater knowledge by Madeline Scolio, Peleg Kremer, Virginia Smith, Achira Amur, Bridget Wadzuk, Kate Homet, Eric Devlin, Md Abdullah Al Mehedi, Laura Moore

“…Overall, Philadelphia, PA is a city with a large proportion of vulnerable populations and is plagued by flooding, with expectations that flood risk will increase as climate change progresses. An array of data, including remotely sensed satellite imagery after major flooding events, Federal Emergency Management Agency’s Special Flood Hazard Areas, First Street Foundation’s Flood Factor, road closures, National Flood Insurance Program claims, and community surveys, were compared for the study areas. …”
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Assessment of retinal pigment epithelium tears in eyes with submacular hemorrhage secondary to age-related macular degeneration by Tomoko Ueda-Consolvo, Syogo Takahashi, Toshihiko Oiwake, Tomoko Nakamura, Masaaki Ishida, Shuichiro Yanagisawa, Atsushi Hayashi

“…Out of the 8 eyes, 5 eyes progressed fibrotic scars within 3 months despite successful SMH removal and showed decrease in their visual acuity (VA). …”
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Mapping neonatal vulnerability using the Small Vulnerable Newborn (SVN) framework—secondary analysis of PRISMA Pakistan studyResearch in context by Hajra Malik, Nida Yazdani, Sameeta Kumari, Sheikh Asad Jamal, Muhammad Kashif, Azqa Mazhar, Zahra Hoodbhoy

“…Summary: Background: Despite progress in global neonatal mortality, South Asia continues to lag behind in reducing neonatal deaths. …”
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Dietary quality and adherence to dietary recommendations in Chinese patients with chronic kidney disease by Wenwei Ouyang, Wenwei Ouyang, Bingjie Xiao, Huifen Chen, Lizhe Fu, Fang Tang, Gaetano Marrone, Xusheng Liu, Yifan Wu, Yifan Wu, Juan Jesús Carrero

“…The diet was considered of moderate quality (CHEI score 59.5 ± 11.0), and patients with CKD stages 4–5 scored progressively worse (P trend = 0.008). Total grains and tubers supplied 50 and 30% of the total energy and protein intake, respectively. …”
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Large Pretrained Foundation Model for Key Performance Indicator Multivariate Time Series Anomaly Detection by Xu Wang, Qisheng Xu, Kele Xu, Ting Yu, Bo Ding, Dawei Feng, Yong Dou

“…Yet, the development of effective deep learning models is hindered by several challenges: scarce and complex labeled data, noise interference from data handling, the necessity to capture temporal dependencies in time series KPI data, and the complexity of multivariate data analysis. Despite recent progress in large models that show potential for handling complex, multidimensional tasks, the lack of extensive, high-quality datasets presents a significant barrier for directly training these models in KPI anomaly detection. …”
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Drawing-Aware Parkinson’s Disease Detection Through Hierarchical Deep Learning Models by Ioannis Kansizoglou, Konstantinos A. Tsintotas, Daniel Bratanov, Antonios Gasteratos

“…Parkinson’s disease (PD) is a chronic neurological disorder that progresses slowly and shares symptoms with other diseases. …”
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Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells by Huilong Li, Huilong Li, Haotian Lin, Haotian Lin, Tinghui Fan, Linfei Huang, Li Zhou, Xiaoyu Tian, Ruzhou Zhao, Yanhong Zhang, Xiaopan Yang, Luming Wan, Hui Zhong, Nan Jiang, Congwen Wei, Wei Chen, Wei Chen, Lihua Hou, Lihua Hou

“…IntroductionCoronavirus disease 2019 (COVID-19) is characterized by fever, fatigue, dry cough, dyspnea, mild pneumonia and acute lung injury (ALI), which can lead to acute respiratory distress syndrome (ARDS), and SARS-CoV-2 can accelerate tumor progression. However, the molecular mechanism for the increased mortality in cancer patients infected with COVID-19 is unclear.MethodsColony formation and wound healing assays were performed on Huh-7 cells cocultured with syncytia. …”
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Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism by Rocio Diaz Escarcega, Vijay Kumar M. J., Vasilia E. Kyriakopoulos, Guadalupe J. Ortiz, Aaron M. Gusdon, Huihui Fan, Pedram Peesh, Maria P. Blasco Conesa, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Stella H. Kim, Miriam Hinojosa, Christine M. Farrell, Sean P. Marrelli, Akihiko Urayama, Bhanu P. Ganesh, Paul E. Schulz, Louise D. McCullough, Andrey S. Tsvetkov

“…Metabolic pathways have been implicated in AD progression, but studies to date examined targeted pathways, leaving many metabolites unmeasured. …”
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NOL-7 serves as a potential prognostic-related biomarker for hepatocellular carcinoma by Qiucheng Lei, Yingchun Huang, Feiwen Deng, Huazhen Zheng, Xitao Hong, Peng Wang, Jin Lv, Huanwei Chen, Zhenling Ji

“…Elevated NOL7 expression correlated with decreased overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) (all P < 0.05). Multivariate analysis revealed that NOL7 was an independent prognostic factor that was significantly related to OS and DSS. …”
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