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Development and validation of a clinical prediction model of acute kidney injury in intensive care unit patients at a rural tertiary teaching hospital in South Africa: a study prot...
Published 2022-07-01“…With the only therapeutic option being supportive therapy, prevention and early diagnosis will facilitate timely interventions to prevent progression to chronic kidney disease. While many factors have been identified as predictive of AKI, none have shown adequate sensitivity or specificity on their own. …”
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15122
Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia
Published 2024-05-01“…Research has demonstrated that inflammatory reactions occurring in microglia can impact the progression of the disease. It has also been established that genetically determined changes in IL-1 can contribute to schizophrenia, thereby confirming the role of the IL-1 gene cluster in disease susceptibility. …”
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The Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) Performance in Elite Team Handball Players Playing with Shoulder Pain, Previous Pain, or No Pain
Published 2024-02-01“…# Background Physical therapists use tests that could determine strength and weaknesses of the shoulder for overhead throwing athletes to enhance performance, prevent injury, and safely progress rehabilitation. The Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) has been proposed to assess muscular capacity and dynamic shoulder stability in overhead athletes, which could provide information to determine a risk of injury…”
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15125
Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study.
Published 2025-01-01“…However, to confirm the effectiveness of these genes as therapeutic targets, more in-depth mechanistic studies are needed in the future, particularly to explore the feasibility and specific mechanisms of combating disease progression by regulating the expression of these genes.…”
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15126
Comparison of the Efficacy and Safety of PD‐1/PD‐L1 Inhibitors in the Treatment of Small Cell Lung Cancer
Published 2025-01-01“…Treatment effectiveness was measured by overall response rate (ORR), disease control rate (DCR), overall survival (OS), and progression‐free survival (PFS), utilizing chi‐square and T‐tests, along with Kaplan–Meier and log‐rank analyses. …”
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Activating Transcription Factor 5 Promotes Tumorigenic Capability in Cervical Cancer Through the Wnt/β-Catenin Signaling Pathway
Published 2025-01-01“…Activating transcription factor 5 (ATF5) plays a crucial role in cell proliferation, survival, and apoptosis, and has been implicated in the progression of various types of cancer. However, the biological function and precise mechanism of ATF5 in cervical cancer remain unclear. …”
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Mapping evidence on the regulations affecting accessibility, availability and management of snake antivenom globally: a scoping review protocol
Published 2024-12-01“…The initial screening for titles and abstracts is currently in progress, and thereafter the second round of screening will be done for full texts. …”
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The value of fixed segment mobility in posterior dynamic stabilization: a single-center retrospective study
Published 2025-02-01“…Conclusion Compared to the first-generation, less mobile Isobar TTL, the second-generation, more mobile Isobar EVO offers superior preservation of the surgical segment and slows the progression of degeneration in the upper adjacent segments. …”
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Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration
Published 2025-01-01“…Chemical screening identified Glucosyringic acid (GA) as a direct inhibitor of POSTN, which delayed IDD progression. Conclusion The study elucidates the pivotal role of POSTN in mediating NP cell pyroptosis through the NLRP3 inflammasome and highlights GA as a promising therapeutic candidate for IDD. …”
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Sky High or Grounded: Nest Site Selection of Herons and Egrets in a Mixed‐Species Colony
Published 2025-01-01“…Both vertical and horizontal stratification were observed, with nests progressively moving higher and further from the tree trunk as the breeding season advanced. …”
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Extracting Fruit Disease Knowledge from Research Papers Based on Large Language Models and Prompt Engineering
Published 2025-01-01“…Research papers are the primary sources of professional knowledge that represent the cutting-edge progress in fruit disease research. Traditional knowledge engineering methods for knowledge acquisition require extensive and cumbersome preparatory work, and they demand a high level of professional background and information technology skills from the handlers. …”
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Ultrasound-Guided Thoracic Paravertebral Injection of Platelet-Rich Plasma for the Treatment of Thoracic Herpes Zoster-Related Pain: A Study Protocol
Published 2024-12-01“…Abstract Background Herpes zoster (HZ), triggered by the reactivation of the varicella-zoster virus, manifests as a painful rash known as zoster-associated pain (ZAP), which can progress to postherpetic neuralgia (PHN). This study evaluates the efficacy and safety of ultrasound-guided thoracic paravertebral injections of platelet-rich plasma (PRP) in managing acute ZAP and preventing PHN. …”
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Shared genetic factors and the interactions with fresh fruit intake contributes to four types squamous cell carcinomas.
Published 2024-01-01“…We identified six novel index SNPs in the progression of SCCs, which were also strongly interacted with fresh fruit intake. …”
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