The potential of Curcuma longa L. bioactive compounds as RSK inhibitors for the treatment of prostate cancer: in silico study by Olusola Olalekan Elekofehinti, Foluso Adeola Taiwo, Moses Orimoloye Akinjiyan, Ifeoluwa Rachael Adetoyi, Folasade Oluwatobiloba Ayodeji, Adedotun Olayemi Oluwatuyi, Oluwapelumi Nifesimi Akintoye, Idayat Oyinkansola Kehinde, Bolanle Esther Adedapo, Opeyemi Iwaloye

“…The p90 ribosomal s6 kinase (RSK) has attracted increased attention due to its overexpression in cancer cells, especially prostate cancer cells. Significant progress has been made recently to develop RSK inhibitors to treat prostate cancer, but these efforts have shown limited success. …”
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Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level by Monika Pazgan-Simon, Anna Szymanek-Pasternal, Joanna Górka-Dynysiewicz, Anna Nowicka, Krzysztof Simon, Ewa Grzebyk, Michał Kukla

“…Conclusions Chemerin increases with the number of neoplastic lesions and decreases with the progression of liver failure as assessed using the CTP score.…”
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Cross-Supervised LiDAR-Camera Fusion for 3D Object Detection by Chao Jie Zuo, Cao Yu Gu, Yi Kun Guo, Xiao Dong Miao

“…Recently, significant progress has been made in 3D object detection methods based on lift-splat-shot (LSS-based) approaches. …”
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Prevalence of Elevated Alanine Aminotransferase by Diagnostic Criterion, Age, and Gender among Adolescents by Jing Zhang, Zheng-Ying Wang, Jing-Ping Zhang, Hua Zhou, Zan Ding

“…For age, the overall trends were increasing progressively, regardless of the use of diagnostic criteria for an elevated ALT activity. …”
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Understanding the Relationship Between Cerebrovascular Disease and the Gut Microbiome by William Roth, Elaine Lo, Orlando De Leon, Sajid Suriya, Farima Fakhri, James R. Brorson, Sean Polster, Tareq Kass‐Hout, Shyam Prabhakaran, James E. Siegler

“…Each of these components of the gut microbiome correlate with the development or progression of many conditions including atherosclerosis. …”
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Involvement of RBP-J interacting and tubulin-associated protein in the distribution of protein regulator of cytokinesis 1 in mitotic spindles by Julia Caspers, Andreas Ritter, Badi Bahrami, Samira Catharina Hoock, Susanne Roth, Alexandra Friemel, Franz Oswald, Frank Louwen, Nina-Naomi Kreis, Juping Yuan

“…As both RITA and PRC1 are closely associated with malignant progression, further work is required to elucidate the detailed molecular mechanisms by which RITA acts as a modulator in central spindle formation and cytokinesis.…”
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Integrating artificial Intelligence-Based metaheuristic optimization with Machine learning to enhance Nanomaterial-Containing latent heat thermal energy storage systems by Ali Basem, Hanaa Kadhim Abdulaali, As’ad Alizadeh, Pradeep Kumar Singh, Komal Parashar, Ali E. Anqi, Husam Rajab, Pancham Cajla, H. Maleki

“…Progress in artificial intelligence and machine learning has significantly improved the capability to accurately predict the properties of nano-enhanced phase change materials (NePCMs). …”
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Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Elevated sPLA2 activity has been linked to the progression of DHF. Purpose: This study aimed to evaluate the sPLA2 inhibitory activity of T. hispida plant extracts with bee venom and dengue patient serum sPLA2. …”
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Management of Recurrent Ventriculoperitoneal Shunt Infections in Adult Patients by Neval Elgormus, Yusuf Elgormus, Bagnu Dundar, Fatma Bozkurt, Huseyin Dogu, Hafize Uzun

“…Certain treatment options, such as 3GCs plus glycopeptide, should be revised based on clinical progress and microbiological culture results.…”
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Synthesis of a Cationic Polyacrylamide under UV Initiation and Its Flocculation in Estrone Removal by Jiaoxia Sun, Xiqin Ma, Xiang Li, Jianxin Fan, Qingkong Chen, Xuelian Liu, Jin Pan

“…Results indicated that the charge neutralization, adsorption, and birding effects were dominant in the E1 removal progress.…”
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Combining a Standardized Growth Class Assessment, UAV Sensor Data, GIS Processing, and Machine Learning Classification to Derive a Correlation with the Vigour and Canopy Volume of... by Ronald P. Dillner, Maria A. Wimmer, Matthias Porten, Thomas Udelhoven, Rebecca Retzlaff

“…The extracted canopy features were progressively grouped into seven input feature groups for model training. …”
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Navigating complex choices through legitimation: Narrative strategies in risk-reduction mastectomy decision-making among unaffected women with genetic risk for breast cancer in Swi... by Maria Caiata-Zufferey, Reka Schweighoffer, Monica Aceti, Carla Pedrazzani, Maria C. Katapodi, Souria Aissaoui, Mekdes Alemu, Murat Aykut, Fulvia Brugnoletti, Rachel Bunger, Nicole Bürki, Pierre O. Chappuis, Muriel Fluri, Rossella Graffeo, Karl Heinimann, Ashley Machen, Christian Monnerat, Olivia Pagani, Manuela Rabaglio, Eveline Schönau, Simon Wieser, Ursina Zürrer-Härdi

“…To navigate this uncertainty, women progressively built their decision through a triple process of making sense: framing RRM as an obligated, empowering and mundane choice. …”
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LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis by Akbar Bagheri, Tohid Jafari-Koshki, Leila Alizadeh, Mortaza Raeisi, Yaghoub Moaddab, Abbas Karimi

“…DNA hypomethylation, particularly of Long Interspersed Nuclear Element-1 (LINE-1) repetitive sequences, has been implicated in CRC development and progression. The purpose of this meta-analysis and systematic review was to evaluate the prognostic value of LINE-1 methylation level in patients with CRC. …”
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Transcriptomic dynamics and cell-to-cell communication during the transition of prospermatogonia to spermatogonia revealed at single-cell resolution by Zhen He, Rong-Ge Yan, Qin-Bang Shang, Qi-En Yang

“…The overexpression of Id2 in prospermatogonia caused severe defects in the progression of prospermatogonia to spermatogonia. Conclusion Together, these findings provide a crucial dataset for dissecting key genes that direct the establishment of the foundational spermatogonial pool and the fate transitions of different somatic cell lineages in the testis during fetal and neonatal periods of development.…”
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Mushroom Intoxication in Türkiye: A Nationwide Cohort Study Based on Demographic Trends, Seasonal Variations, and the Impact of Climate Change on Incidence by Dilara Turan Gökçe, Derya Arı, Naim Ata, Hale Gökcan, Ramazan İdilman, Mustafa Mahir Ülgü, Murat Harputluoglu, Mesut Akarsu, Zeki Karasu, Mustafa Okan Ayvalı, Şuayip Birinci, Meral Akdoğan Kayhan

“…Hospitalization occurred in 8.9% of cases, with a 6.6% mortality rate within 90 days and 1.3% progressing to liver transplantation. Notably, mushroom intoxication cases increased by 130% in the first half of 2023, particularly in May and June, correlating with increased rainfall. …”
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DAMPs prognostic signature predicts tumor immunotherapy, and identifies immunosuppressive mechanism of pannexin 1 channels in pancreatic ductal adenocarcinoma by Qianxue Wu, Qian Xiao, Qian Xiao, Xin Tang, Liuying Li, Daqiang Song, Yang Zhou, Benhua Li, Benhua Li, Guosheng Ren, Guosheng Ren, Fang Luo

“…Mechanically, through Bulk-RNA sequencing and experiments, we found that PANX1 promoted tumor progression and immune regulation via the ATP release to active NOD1/NFκB signaling pathway in PDAC.ConclusionOur in silico analyses established a classification system based on ICD-related DAMPs genes in PDAC, and constructed a DAMPs-related prognostic model to predict the efficacy of immunotherapy. …”
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Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis by Jie Yang, Lin Yang, Yanjiao Wang, Lu Huai, Bohan Shi, Di Zhang, Wei Xu, Di Cui

“…This article summarized the inflammatory mechanisms of IL-6 cross-talked with other mediators of some chronic diseases in vitro, animal models, and human experiments, leading to the activation of pathways and accelerating the progression of sepsis. The clinicians should be highlight to this kind of diseases and more clinical trials are needed to provide more reliable theoretical basis for health policy formulation.…”
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Corrosion behavior of NiTi alloys fabricated by laser powder bed fusion in relation to the formed passive films in Hank's solution by Yi-Fan Zhang, Liang-Yu Chen, Yong Liu, Hong-Yu Yang, Jin-Hua Peng, Chuanbo Zheng, Lina Zhang, Lai-Chang Zhang

“…The sample with the dominant B2 phase has a slower passive film formation rate and a higher corrosion rate than those with mixed B2/B19′ phases at the early film formation stage. As corrosion progresses, the passive films rapidly form within 24 h, followed by gradual degradation, represented by their varied charge transfer resistance. …”
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Factors Predicting Renal Function Outcome after Augmentation Cystoplasty by Shahbaz Mehmood, Raouf Seyam, Sadia Firdous, Waleed Mohammad Altaweel

“…We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency.…”
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A randomized double-blind clinical trial investigating the effects of ellagic acid on glycemic status, liver enzymes, and oxidative stress in patients with non-alcoholic fatty live... by Sara Mighani, Rasoul Samimi, Mohamadreza Rashidi Nooshabadi, Seyed Amir Farzam, Hossein Khadem Haghighian, Maryam Javadi

“…Abstract Background It seems that oxidative stress is involved in the occurrence and progression of non-alcoholic fatty liver disease (NAFLD). …”
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