CBGS-YOLO: A Lightweight Network for Detecting Small Targets in Remote Sensing Images Based on a Double Attention Mechanism by Zhenyuan Wu, Di Wu, Ning Li, Wanru Chen, Jie Yuan, Xiangyue Yu, Yongqiang Guo

“…With the continuous progress of remote sensing technology, the demand for means of detecting small targets in remote sensing images is escalating. …”
Get full text

Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms by Mohammad Mehdi Banoei, Abdulrazagh Hashemi Shahraki, Kayo Santos, Gregory Holt, Mehdi Mirsaeidi

“…This study aimed to leverage metabolomics for the early diagnosis of sarcoidosis and to identify metabolic phenotypes associated with disease progression. <b>Methods:</b> Serum samples from patients with sarcoidosis (<i>n</i> = 40, including stage 1 to stage 4), were analyzed for metabolite levels by semi-untargeted liquid chromatography–mass spectrometry (LC-MS). …”
Get full text

Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…This result provides a new direction for uncovering how ERS regulates EMT and a foundation for preventing the progression of EMT in HCC.…”
Get full text

SACWOM: Synergistic Adaptive Congestion Window Optimization Mechanism for Self-Clocked Algorithm by Haider Dhia Zubaydi, Ahmed Samir Jagmagji, Sandor Molnar

“…While CC algorithms like Self-Clocked Rate Adaptation for Multimedia (SCReAM) and Bottleneck Bandwidth and Round-trip propagation time (BBR) have shown progress, each faces limitations: BBR encounters difficulty in balancing responsiveness and fairness when rapid fluctuations in network conditions arise, which can lead to inefficient performance in shared environments. …”
Get full text

The socioeconomic impact of kidney disease on African families: a scoping review by Ikponmwosa Jude Ogieuhi, Nicholas Aderinto, Gbolahan Olatunji, Emmanuel Kokori, Victor Oluwatomiwa Ajekiigbe, Komolafe Babajide Ayodeji, Adetola Emmanuel Babalola, Ifeanyichukwu Muogbo, Alabi Badrudeen Olalekan, Aarushi Venkatraman, Oluwaseun Oyewo

“…Unfortunately, most people are unaware that they have this condition until it has progressed. Research aimed at systematically summarizing findings on the socioeconomic effects of kidney disease on families in Africa was reviewed. …”
Get full text

EGFR-TKIs or EGFR-TKIs combination treatments for untreated advanced EGFR-mutated NSCLC: a network meta-analysis by Ao Liu, Xiaoming Wang, Lian Wang, Han Zhuang, Liubo Xiong, Xiao Gan, Qian Wang, Guanyu Tao

“…Osimertinib plus chemotherapy and lazertinib plus amivantamab showed the highest efficacy in improving progression-free survival. New third-generation EGFR-TKIs demonstrated comparable efficacy to osimertinib alone but did not surpass it. …”
Get full text

A Novel Attention-Guided Enhanced U-Net With Hybrid Edge-Preserving Structural Loss for Low-Dose CT Image Denoising by Muhammad Zubair, Helmi Md Rais, Talal Alazemi

“…The proposed model undergoes iterative training, using a custom loss function to refine its parameters and improve CT image denoising progressively. Its performance is rigorously evaluated both qualitatively and quantitatively on the &#x2018;2016 Low-dose CT AAPM Grand Challenge dataset&#x2019;. …”
Get full text

Adolescent girls’ explanations of high rates of low mood and anxiety in their population: a co-produced qualitative study by Ola Demkowicz, Rebecca Jefferson, Pratyasha Nanda, Lucy Foulkes, Jo Lam, Steven Pryjmachuk, Rhiannon Evans, Bernadka Dubicka, Liz Neill, Laura Anne Winter, Georgina Nnamani

“…There is a paucity of mental health research that meaningfully progresses understanding of these gender disparities, including that engages adolescent girls’ own perspectives, limiting our ability to direct further research and enhance intervention approaches. …”
Get full text

Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…This manuscript describes the conception, establishment, and progress of Young TPI from its start to present, detailing its strategy for communication, activities, and funding mechanisms, and ongoing endeavors to enlist new members and forge strategic alliances in pursuit of its mission.…”
Get full text

Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice by Henry Tan, Devon J. Griggs, Devon J. Griggs, Lucas Chen, Kahte Adele Culevski, Kathryn Floerchinger, Alissa Phutirat, Gabe Koh, Nels Schimek, Pierre D. Mourad, Pierre D. Mourad

“…Given the near ubiquity of diagnostic ultrasound systems, further progress along this line of research could one day lead to the widespread use of diagnostic ultrasound to intentionally modulate human brain function during exogenous stimulation.…”
Get full text

Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats by Diego Salagre, Miguel Navarro-Alarcón, Luis Gerardo González, Mohamed A. Elrayess, Marina Villalón-Mir, Rocío Haro-López, Ahmad Agil

“…Endoplasmic reticulum (ER) stress is a crucial factor in the progression of obesity-related type 2 diabetes (diabesity), contributing to skeletal muscle (SKM) dysfunction, calcium imbalance, metabolic inflexibility, and muscle atrophy. …”
Get full text

Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer by Xiaohong Liu, Xing Wang, Jie Ren, Yuan Fang, Minzhi Gu, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Jialu Bai, Decheng Jiang, Yuemeng Tang, Bo Ren, Lei You, Yupei Zhao

“…Amino acids play a prominent role in the occurrence and progression of pancreatic cancer as essential building blocks for protein synthesis and key regulators of cellular metabolism. …”
Get full text

Integrating Information Gain and Chi-Square for Enhanced Malware Detection Performance by Fauzi Adi Rafrastara, Wildanil Ghozi, Ramadhan Rakhmat Sani, Lekso Budi Handoko, Abdussalam Abdussalam, Elkaf Rahmawan Pramudya, Faizal M. Abdollah

“…Detecting malware is essential to safeguard devices and systems from risks such as data corruption, data theft, account compromises, and unauthorized access that could result in total system takeover. As malware has progressed from its simpler, monomorphic variants to more sophisticated forms like oligomorphic, polymorphic, and metamorphic, a machine learning-based detection system is now required, surpassing the limitations of traditional signature-based methods. …”
Get full text

Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Despite new immunotherapeutic strategies entering standard clinical care for various tumors, progress in AML remains poor. Multi-omics analyses, such as single-cell transcriptomics, have revealed many potential new targets to improve AML prognosis from an immunological perspective.MethodsDNA from 307 AML patients and 316 healthy individuals were extracted. …”
Get full text

Open-source code for analysis of the lifetime total physical activity questionnaire (LTPAQ) by Coral Sánchez-Martín, Javier Leal-Martín, Timo Rantalainen, Irene Rodríguez-Gómez, Luis M. Alegre, Ignacio Ara

“…Advancing research to understand the impact of lifetime physical activity patterns on health is essential. While some progress on the topic has been made, further research is nevertheless warranted. …”
Get full text

Factors associated with successful treatment outcomes among tuberculosis patients in a district municipality of Vhembe, Limpopo by Busisiwe Mkhavele, Slindile Zondi, Lindiwe Cele, Mabina Mogale, Margeret Mbelle

“…Background: Treatment success rate is a critical indicator for monitoring the progress of tuberculosis (TB) treatment programmes at both the patient and population levels. …”
Get full text

Impaired Growth during Childhood in Patients with Primary Ciliary Dyskinesia by Tamara Svobodová, Jana Djakow, Daniela Zemková, Adam Cipra, Petr Pohunek, Jan Lebl

“…In children with PCD, body length/height progressively decreased from +0.40±0.24 SDS (the 1st birthday), +0.16±0.23 SDS (3 years old), and -0.13±0.21 SDS (5 years old) to -0.54±0.19 SDS (7 years old; P=0.01 versus 0), -0.67±0.21 SDS (9 years old; P=0.005 versus 0), -0.52±0.24 SDS (11 years old; P=0.04 versus 0), and -0.53±0.23 SDS (13 years old; P=0.03 versus 0). …”
Get full text

Weakly Supervised Nuclei Segmentation with Point-Guided Attention and Self-Supervised Pseudo-Labeling by Yapeng Mo, Lijiang Chen, Lingfeng Zhang, Qi Zhao

“…Due to the labor-intensive manual annotations for nuclei segmentation, point-supervised segmentation based on nuclei coordinate supervision has gained recognition in recent years. Despite great progress, two challenges hinder the performance of weakly supervised nuclei segmentation methods: (1) The stable and effective segmentation of adjacent cell nuclei remains an unresolved challenge. (2) Existing approaches rely solely on initial pseudo-labels generated from point annotations for training, and inaccurate labels may lead the model to assimilate a considerable amount of noise information, thereby diminishing performance. …”
Get full text

Using Real‐Time Power BI Formative Feedback to Improve Nurse Anesthesia Students' Clinical Competence: An Educational Intervention by Ali Khalafi, Sajjad Choopani, Nooshin Sarvi‐Sarmeydani, Elham Maraghi

“…The intervention group showed a notable progression in clinical competency scores from baseline to endpoint (mean scores: 35.06 ± 1.62 to 79.58 ± 1.02), significantly outperforming the control group (mean scores: 29.93 ± 1.38 to 62.09 ± 1.47, p‐value < 0.0001). …”
Get full text

Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Abstract Repeat expansions in the C9ORF72 gene are a frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Considerable progress has been made in identifying C9ORF72-mediated disease and resolving its underlying etiopathogenesis. …”
Get full text