Optimising subsurface integrity and surface quality in mild steel turning: A multi-objective approach to tool wear and machining parameters by Muhammad Imran, Suo Shuangfu, Bai Yuzhu, Wang Yuming, Naveed Raheel

“…Finally, this study employs Grey Relational Analysis (GRA), Data Environment Analysis Ranking (DEAR), and Multi-objective Optimization based on Ratio Analysis Method (MOORA) optimization techniques with S/N ratios to refine 3D surface roughness (Sa, Sz, Sq) and material removal rates (MRR) in mild steel turning using a CVD-coated carbide tool.Key findings reveal that increasing Vc reduces surface roughness and improves morphology, while higher f and ap deteriorate both. Tool wear progresses through three stages, with the poorest surface quality occurring in the final stage. …”
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Artificial intelligence driven cyberattack detection system using integration of deep belief network with convolution neural network on industrial IoT by Mahmoud Ragab, Mohammed Basheri, Nasser N. Albogami, Alanoud Subahi, Omar A. Abdulkader, Hashem Alaidaros, Hassan Mousa, Abdullah AL-Malaise AL-Ghamdi

“…In power control systems, ICT technologies such as IIoT have improved automated monitoring, but legacy methods, originally autonomous, now connect with external networks. This progress has presented safety vulnerabilities from legacy ICT systems. …”
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Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance by Hussein Sabit, Borros Arneth, Timothy M. Pawlik, Shaimaa Abdel-Ghany, Aysha Ghazy, Rawan M. Abdelazeem, Amany Alqosaibi, Ibtesam S. Al-Dhuayan, Jawaher Almulhim, Noof A. Alrabiah, Ahmed Hashash

“…Recent developments in single-cell multi-omics technologies have provided the ability to identify diverse cell types and decipher key components of the tumor microenvironment (TME), leading to important advancements toward a much deeper understanding of how tumor microenvironment heterogeneity contributes to cancer progression and therapeutic resistance. These technologies are able to integrate data from molecular genomic, transcriptomic, proteomics, and metabolomics studies of cells at a single-cell resolution scale that give rise to the full cellular and molecular complexity in the TME. …”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…Despite the multilayered complexity of the mechanisms involved in the pathogenesis of DN, the conventional treatment is limited to just a few drug classes fraught with the risk of adverse events, including the progression of renal dysfunction. Phytoceuticals offer a promising alternative as they act on the many-sidedness of DN pathophysiology, multitargeting its intricacies. …”
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Multi-dimensional performance-based intelligent optimization of atrium building prototype with informed approach by Yiquan Zou, Yanyan Li, Han Chen, Benlin Xiao, Zhou Li

“…However, as the design process advanced, the potential to optimize building physical properties, space, and related performance gradually diminished, and the costs to achieve the same benefits were progressively increased. In this study, an enclosed atrium-style office space was chosen as a case study, and an intelligent optimization method for the atrium prototype space was proposed. …”
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Acute therapeutic effects and pathophysiology of eosinophilic granulomatosis with polyangiitis neuropathy by Fumitaka Shimizu, Mariko Oishi, Toshihiko Maeda, Yukio Takeshita, Hideaki Nishihara, Ryota Sato, Takashi Kanda, Masayuki Nakamori, Michiaki Koga, Miwako Fujisawa, Yuki Mizumoto, Nanami Yamanaka, Takashi Nawata, Tatsuya Okafuji, Susumu Fujikawa, Kinya Matsuo, Joe Nemoto, Masaya Honda

“…Intrafascicular oedema was found in 95% of all patients.Discussion Our results suggest three pathological pathways: (1) ischaemic peripheral nerve due to vasculitis mainly in ANCA-positive cases, (2) direct infiltration and degranulation of eosinophils in ANCA-negative cases and (3) progression of axonal ischaemia due to intrafascicular oedema in both cases. …”
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Multiangle Correlation Feature Extraction and Disease Prediction Model Construction for Patients With Post-Stroke Dysarthria by Ting Zhu, Shufei Duan, Huizhi Liang, Fujiang Li, Wei Zhang

“…The clinical diagnosis and treatment of motor dysarthria in post-stroke patients is often subjective and neglects the impact of psychological and emotional disorders on disease progression. This study aims to analyze the correlation among emotional expression, psychological state, facial expression, and dysarthria disease severity and is dedicated to the construction of a dysarthria prediction model. …”
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Impact of DLL3 Expression as Prognostic Factor in Extensive Stage of Small Cell Lung Cancer Treated With First‐Line Chemotherapy by Hohyung Nam, Soon‐Hee Jung, Jii Bum Lee, Jee Hyun Kong, Seungtaek Lim

“…In addition, tissue specimen should be available for immuno‐histochemical staining for DLL3, and their clinico‐pathologic data, including progression‐free survival (PFS) and overall survival (OS), were obtained. …”
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Keratoconus Diagnosis: Validation of a Novel Parameter Set Derived from IOP-Matched Scenario by Dan Lin, Lei Tian, Shu Zhang, Like Wang, Ying Jie, Yongjin Zhou

“…Determining a parameter set after eliminating the influence from IOP is useful in revealing the essential differences between keratoconus and normal corneas and possibly facilitating further progress in keratoconus diagnosis.…”
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Therapeutic applications of artemisinin in ophthalmic diseases by Hao Sun, Ping Zhao, Lianghui Zhao, Zhizhong Zhao, Haoyu Chen, Cong Ren, Bin Guo

“…To better explore and perfect the mechanism of action of artemisinin in ophthalmic diseases, and to better promote the clinical application of artemisinin, this study reviews the latest progress of artemisinin treatment for uveitis, uveal melanoma, age-related macular degeneration, diabetic retinopathy, ocular neovascularization, and dry eye, and it will provide theoretical support for the large-scale application of artemisinin in ophthalmic diseases in the future.…”
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Development and validation of risk models to predict chronic kidney disease among people living with HIV: protocol for a systematic review by A P Kengne, Adesola Z Musa, Babatunde L Salako, Nasheeta Peer, Oluwatosin Olaseni Odubela, Nkiruka Odunukwe

“…A predictive model showing an individual’s risk of prevalent and/or progression to kidney failure is useful for initiating timely interventions that prevent further worsening of kidney function. …”
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Autophagy activation alleviates annulus fibrosus degeneration via the miR-2355-5p/mTOR pathway by Zilin Yu, Chunyang Fan, Yubo Mao, Xiexing Wu, Haiqing Mao

“…These findings suggest a potential therapeutic target for mitigating IVDD progression.…”
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The up-regulation of SPTAN1 expression in Pancreatic adenocarcinoma is associated with tumor immune invasion and poor clinical prognosis by Wei Guo, LingYu Hu, ZhaoFeng Gao, XiaoRong Liu, XiaoDan Yang, XiaoGuang Wang

“…More and more studies have shown that SPTAN1 may be involved in the development and progression of a variety of tumors, including rectal cancer, Pancreatic adenocarcinoma, etc., and may affect their prognosis. …”
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Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

“…Abstract Cholangiocarcinoma (CCA) is a lethal cancer with rapid progression and poor survival. Novel and more effective therapies than those currently available are, therefore, urgently needed. …”
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Evaluating different drought products for assessing drought and implications on agriculture in Nepal by Shishir Chaulagain, Manoj Lamichhane, Urusha Chaulagain, Sushant Gyawali, Sadina Shrestha, Vishnu Prasad Pandey

“…By utilizing Soil Water Deficit Index (SWDI) alongside Standardized Precipitation Evapotranspiration Index (SPEI) and Standardized Flow Index (SFI), this research highlights the complex progression from meteorological to agricultural and hydrological droughts. …”
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Anthocyanins as functional food components by R. S. Yudina, E. I. Gordeeva, O. Yu. Shoeva, M. A. Tikhonova, E. K. Khlestkina

“…Starting with the first studies on the physicochemical properties of anthocyanins carried out in the 17th century by British naturalist Robert Boyle, the science about these unique compounds has progressed substantially. To date, the structure and functions of anthocyanins in plant cells have been well studied, and the pathway of their biosynthesis is one of the most fully characterized pathways of secondary metabolite biosynthesis at both the biochemical and genetic levels. …”
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Associations between intake of different types of vegetables and metabolic dysfunction-associated fatty liver disease: a population-based study by Chong Liu, Yubo Liu, Jie Liu, Jia Liu, Ting Lu, Jingjia Yu, Guogang Zhang, Kai Xu

“…The consumption of healthy diets rich in an abundant assortment of vegetables has been scientifically validated to mitigate the progression of MAFLD. However, it remains uncertain whether all categories of vegetables confer benefits for MAFLD. …”
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G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells by Chiao-Chun Liao, Yuqing Long, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Chia-Hwa Lee

“…Abstract Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, limiting their applicability in preclinical drug investigations. …”
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Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD by Lijuan Zhou, Jingyi Zhao, Kaile Ma, Rui Hao, Chensi Yao, Xiaowen Gou, Chuanxi Tian, Li Wan, Min Li, Xiaolin Tong

“…BackgroundNon-alcoholic fatty liver disease (NAFLD) constitutes the most prevalent chronic liver disease worldwide. Progression to non-alcoholic steatohepatitis (NASH), the immune cell reservoir within the liver undergoes remodeling, exacerbating liver inflammation and potentially leading to liver fibrosis. …”
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MicroRNA-451 as an Early Predictor of Chronic Kidney Disease in Diabetic Nephropathy by Mostafa Abdelsalam, A. M. Wahab, Maysaa El Sayed Zaki, Mohamad Motawea

“…MicroRNAs are not only new and promising markers for early diagnosis but also, but they may also play a role in the prevention of disease progression. Methods. This study included ninety patients with type 2 DM in addition to 30 control subjects. …”
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