Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer by Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang

“…Moreover, IFN-γ and IL-2 secretion were found to be enriched in the tumor TME.ConclusionOur study indicated that combination of PO and anti-PD-1 could synergistically suppress CRC progression and altered the tumor microenvironment in favor of antitumor immune responses.…”
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Augmenter of Liver Regeneration Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic SteatosisSummary by Xiao-lin Wang, Jia-hao He, Ping Xie, Yuan Wu, Ling-yue Dong, Wei An

“…Augmenter of liver regeneration (ALR) is an important liver regulatory protein, and the insufficiency of ALR expression is reported to accelerate liver steatosis progression to liver fibrosis or even hepatic carcinoma (HCC). …”
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Development and Validation of LAMP Assays for Distinguishing MPXV Clades with Fluorescent and Colorimetric Readouts by Nazente Atceken, Sara Asghari Dilmani, Ahmed Choukri Abdullah, Mutlu Sarıkaya, Defne Yigci, Gozde Korkmaz, Savas Tasoglu

“…Clade-I has been associated with more severe disease progression and higher mortality compared to Clade-II, and thus the differentiation between clades can play an important role in predicting disease prognosis. …”
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Advancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids by Suya Shen, Bing Liu, Wenyan Guan, Ziyao Liu, Yuqing Han, Yingzhe Hu, Yiqiang Chen, Siyuan Liu, Jian He, Zhiwen Li, Weifeng Tang, Pengju Zhang, Wei Ren, Yudong Qiu, Hongping Zheng, Jingjing Li

“…The paclitaxel plus cisplatin (TP)-sensitive group demonstrated significantly longer progression-free survival (PFS) compared to the resistant groups, Hazard ratio (HR), 5.12; 95% confidence intervals (CI 0.58–44.71; p < 0.05), thus illustrating the potential of this approach for guiding personalized treatment strategies. …”
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Systemic Therapy of Neuroendocrine Neoplasia: Single Center Experience from a Cohort of 110 Consecutive Cases by Karin Mayer, Selina Kiry, Anna Yordanova, Hojjat Ahmadzadehfar, Florian C. Gaertner, Ralph A. Bundschuh, Markus Essler, Maria A. Gonzalez-Carmona, Christian P. Strassburg, Hanno Matthaei, Philipp Lingohr, Savita Bisht, Peter Brossart, Georg Feldmann

“…Combination chemotherapy with etoposide plus cisplatin or carboplatin showed disease control rates (DCRs) of overall 74%, with a short median progression-free survival (PFS) of 7 or 5 months, respectively. …”
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Technologically-Treated Polyclonal Affinity-Purified Antibodies to the Tumor Necrosis Factor-α, Brain Specific S-100 Protein and Histamine in Treatment of Functional Dyspepsia: Res... by Yu. O. Shulpekova, I. V. Maev, V. B. Grinevich, I. B. Khlynov, Yu. G. Shvarts, V. T. Ivashkin

“…None of the patients in Kolofort® group had progression of FD symptoms or required additional therapy. …”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…Despite advancements in anticancer drugs and optimised chemotherapy regimens that have improved cure rates for malignant tumours, the presence of tumour heterogeneity has resulted in substantial variations among patients in terms of disease progression, clinical response, sensitivity to therapy, and prognosis, posing significant challenges in attaining optimal therapeutic outcomes for each patient. …”
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Model Test on the Behaviors of Deep Excavation with Lateral Confined Water by Mingyuan Wang, Minyun Hu, Chaohua Li, Xiaobing Xu, Zefeng Ye, Qi Hu

“…During stage 2 (the excavation and supporting process, K1–Z4), as excavation and strut installation progressed, the lateral pressure on the diaphragm wall decreased, while both bending moment and horizontal displacement increased, with the most pronounced changes occurring when excavation reached the depth of the lateral confined aquifer. …”
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CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance by Xuemeng Xu, Qiu Peng, Zongyao Ren, Yaqian Han, Xianjie Jiang, Zhu Wu, Shiming Tan, Wenjuan Yang, Linda Oyang, Xia Luo, Jinguan Lin, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Hao Tian, Yujuan Zhou, Qianjin Liao

“…The m6A modification of ITGB1 mRNA is modulated by the phase separation of IGF2BP1, thereby promoting the malignant progression of oral cancer cells. This evidence positions circRNF13 as a crucial regulatory molecule in the pathogenesis of oral cancer and suggests its potential as a therapeutic target. …”
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Blinded by the Mind: Exploring the Hidden Psychiatric Burden in Glaucoma Patients by Jeniffer Jesus, João Ambrósio, Dália Meira, Ignácio Rodriguez-Uña, João Melo Beirão

“…These psychiatric issues are often exacerbated by the gradual, irreversible, and typically silent progression of the disease, contributing to increased mental health challenges for affected individuals. …”
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The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial by Elena Giudice, Tzu-Ting Huang, Jayakumar R. Nair, Grant Zurcher, Ann McCoy, Darryl Nousome, Marc R. Radke, Elizabeth M. Swisher, Stanley Lipkowitz, Kristen Ibanez, Duncan Donohue, Tyler Malys, Min-Jung Lee, Bernadette Redd, Elliot Levy, Shraddha Rastogi, Nahoko Sato, Jane B. Trepel, Jung-Min Lee

“…Secondary outcomes were safety and progression-free survival (PFS). 49 heavily pretreated patients were enrolled (24 in cohort 5, 25 in cohort 6). …”
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Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonists for the treatment of obesity and diabetes mellitus by Alexander C. Martins, Beatriz G. de la Torre, Fernando Albericio

“…Pharmaceutical companies have made significant progress in developing drugs that address both diabetes and obesity. …”
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Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a viciou... by Yin Jin, Apostolia Topaloudi, Sudhanshu Shekhar, Guangxin Chen, Alicia Nicole Scott, Bryce David Colon, Petros Drineas, Chris Rochet, Peristera Paschou

“…We bring together 14 different genomic and neuropathology datasets (6960 individuals) and we integrate our GWAS findings with transcriptomic and phenotypic data aiming to also identify biomarkers for AD progression. We uncover novel genetic associations to AD neuropathology, including BIN1 and OPCML. …”
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The Role of IL-6 and TNF-Alpha Biomarkers in Predicting Disability Outcomes in Acute Ischemic Stroke Patients by Ciprian-Ionuț Băcilă, Maria-Gabriela Vlădoiu, Mădălina Văleanu, Doru-Florian-Cornel Moga, Pia-Manuela Pumnea

“…Introduction: Inflammatory biomarkers, including Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-alpha), play a significant role in influencing stroke outcomes, particularly in the progression of post-stroke disability. While numerous studies have suggested a correlation between elevated levels of these cytokines and poor functional recovery, further investigation is needed to understand their prognostic value in acute ischemic stroke. …”
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Evaluating Sampling Designs to Survey Fish Diversity in Lakes From Northern Temperate Zones by Erik García‐Machado, Eric Normandeau, Guillaume Côté, Isabeau Caza‐Allard, Charles Babin, Louis Bernatchez

“…In recent years, environmental DNA has progressively become a tool of choice in survey programs. …”
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Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy by Seyma Isik, Mukaddes Ozcesmeci, Ayfer Kalkan Burat, Esin Hamuryudan, Ozge Can, Muge Serhatli

“…The ability of ZnPc1 to simultaneously target tumor cells and disrupt angiogenesis establishes it as a potent candidate for integrated cancer therapies that combine both antitumor and antiangiogenic strategies, offering a more effective approach to combat cancer progression.…”
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Consistency Regularization for Semi-Supervised Semantic Segmentation of Flood Regions From SAR Images by G. Savitha, S. Girisha, Pundarika Sughosh, Dasharathraj K. Shetty, Jayaraj Mymbilly Balakrishnan, Rahul Paul, Nithesh Naik

“…Nonetheless, the lack of consistent large datasets presents a barrier that prevents these algorithms from progressing and being used in real-world scenarios. …”
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High expression of nucleotide-binding oligomerization domain protein 1 correlates with poor prognosis and immune cell infiltration in Glioblastoma Multiforme patients by Hongyang Zhao, Beiwu Lan, Zenghui Zhao, Peining Zhu, Chong Wang, Yufei Gao

“…GSEA and enrichment analysis revealed that NOD1 might play a vital role in immune response and GBM progression. TIMER analysis showed a positive correlation between NOD1 expression and 17 types of tumor-infiltrating immune cells. …”
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Clinical Recommendations of the Northwest Society for Enteral and Parenteral Nutrition, Interregional Association for Emergency Surgery, Russian Gastroenterological Association, Un... by Yu. V. Averyanova, E. M. Batyrshin, A. E. Demko, G. E. Ivanova, V. T. Ivashkin, L. N. Kostyuchenko, A. V. Lapitsky, I. N. Leiderman, V. M. Luft, I. V. Maev, I. G. Nikitin, M. S. Novruzbekov, Е. A. Poluektova, A. L. Potapov, A. V. Sytov, A. S. Trukhmanov

“…The main referral indications for small bowel transplantation (SBT) are: fast-progressing cholestatic liver disease-complicated irreversible intestinal failure; thrombosis of two or more central venous conduits used for parenteral nutrition; recurrent catheter-associated bloodstream infection.Conclusion. …”
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Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness by Liang Shen, Yanfei Tong, Shichao Li, Yuda Chen, Ruhan A, Zhen Li, Wenling Wang, Lijuan Yin, Jiuming Zou, Ziyong Sun, Changcheng Wu, Wenjie Tan, Haijuan Wang

“…This study explored a rare instance of intraocular infection and bilateral deafness caused by S. suis and emphasized the importance of timely diagnosis and treatment to prevent disease progression. Methods:. The diagnosis was made on the basis of clinical symptoms, imaging, molecular detection, and isolated culture methods. …”
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