Genetic Parameters of Semen Traits and Their Correlations with Conformation Traits in Chinese Holstein Bulls by Xiao Wang, Jian Yang, Jie Xue, Miao Zhang, Fan Zhang, Kun Wang, Yanqin Li, Yuanpei Zhang, Xiaoping Wu, Feng Wang, Xiuxin Zhao, Junqing Ni, Yabin Ma, Rongling Li, Lingling Wang, Guosheng Su, Yundong Gao, Jianbin Li

“…The elite bull plays an extremely important role in the genetic progression of the dairy cow population. The previous results indicated the potential positive relationship of large scrotal circumference (SC) with improved semen volume, concentration, and motility. …”
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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

“…Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between necroptosis-associated lncRNAs and BRCA. …”
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MSTD: A Multi-Scale Transformer-Based Method to Diagnose Benign and Malignant Lung Nodules by Xiaoyu Zhao, Jiao Li, Man Qi, Xuxin Chen, Wei Chen, Yongqun Li, Qi Liu, Jiajia Tang, Zhihai Han, Chunyang Zhang

“…The identification of benign and malignant lung nodules is crucial for timely treatment to reduce the risk of the progression and metastasis of diseases. However, the varied sizes, diverse morphologies, non-fixed positions, and dynamic growth of lung nodules in computed tomography (CT) images make their accurate identification challenging. …”
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Quantifying the sources and health risks of groundwater nitrate via dual NO isotopes and Monte Carlo simulations in a developed planting-breeding area by Jianwei Liu, Shuo Qiao, Shilong Zhao, Hui Chen, Yong Wu, Donghao Li, Ping Liu, Ling Li

“…However, the contribution of N fertilizer may be underestimated because it has undergone a long-term applied history and have progressively accumulated in the soil, and then promoted the entry of groundwater under frequent rainfall and irrigation practices. …”
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Influence of Adipose Tissue-Derived Stem Cells on the Burn Wound Healing Process by Claudio Luciano Franck, Alexandra Cristina Senegaglia, Lidiane Maria Boldrini Leite, Sérgio Adriane Bezerra de Moura, Nathália Forti Francisco, Jurandir Marcondes Ribas Filho

“…The first was on the same day of the burn, when 3.2×106 ADSCs were transplanted shortly after the burned region cooled, while the second stage occurred four days later with the same number of ADSCs. The progress was evaluated by immunohistochemical methods and H&E, Masson’s trichrome, Picrosirius red, and Lyve-1 immunofluorescence staining. …”
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Bioinformatics combining machine learning and single-cell sequencing analysis to identify common mechanisms and biomarkers of rheumatoid arthritis and ischemic heart failure by Ziyi Sun, Jianguo Lin, Xiaoning Sun, Zhangjun Yun, Xiaoxiao Zhang, Siyu Xu, Jinlong Duan, Kuiwu Yao

“…The findings underscore the critical roles of sarcomere organization, prolactin signaling, protein methyltransferase activity, and immune responses in the progression of IHF in RA patients. These insights not only identify valuable biomarkers and therapeutic targets but also offer promising directions for early diagnosis, personalized treatments, and preventive strategies for IHF in the context of RA. …”
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Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome by Kun-Chen Lin, Christopher Glenn Wallace, Tsung-Cheng Yin, Pei-Hsun Sung, Kuan-Hung Chen, Hung-I Lu, Han-Tan Chai, Chih-Hung Chen, Yi-Ling Chen, Yi-Chen Li, Pei-Lin Shao, Mel S. Lee, Jiunn-Jye Sheu, Hon-Kan Yip

“…Flow cytometry demonstrated that albumin levels and numbers of inflammatory cells (Ly6G+/CD14+/CD68+/CD11b/c+) in bronchoalveolar lavage fluid were the highest in untreated ARDS, were progressively reduced across SW, Mito, and SW + Mito (all p<0.0001), and were the lowest in sham controls. …”
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Self-Reported Disability in Adults with Severe Obesity by I. Kyrou, G. Osei-Assibey, N. Williams, R. Thomas, L. Halder, S. Taheri, P. Saravanan, S. Kumar

“…Self-reported disability in performing daily life activities was assessed in adults with severe obesity (BMI ≥ 35 kg/m2) using the Health Assessment Questionnaire (HAQ). 262 participants were recruited into three BMI groups: Group I: 35–39.99 kg/m2; Group II: 40–44.99 kg/m2; Group III: ≥45.0 kg/m2. Progressively increasing HAQ scores were documented with higher BMI; Group I HAQ score: 0.125 (median) (range: 0–1.75); Group II HAQ score: 0.375 (0–2.5); Group III HAQ score: 0.75 (0–2.65) (Group III versus II P<0.001; Group III versus I P<0.001; Group II versus I P=0.004). …”
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The individualization of the educational and training process in fencing in the context of improving efficiency and health of young athletes of different ages by Mykhailo Bocharov, Georgiy Korobeynikov, Iryna Kryventsova, Victoriia Klymenchenko, Igor Vypasniak

“…The training program lasted for 12 months, including specialized exercises and tests to evaluate progress in physical and technical-tactical readiness. …”
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A novel validation approach shows new, solid reasons why vertical jump height should not be used to predict leg power by Luis Fernando Aragón-Vargas, María Isabel González-Lutz

“…Jump height continues to bewidely used to predict power in humans. Individual progress is often monitored on the basis of estimated power, butprediction equations are based on group data. …”
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Genetically engineered pig heart transplantation in non-human primates by Avneesh K. Singh, Corbin E. Goerlich, Tianshu Zhang, Billeta Lewis, Alena Hershfeld, Gheorghe Braileanu, Kasinath Kurvi, Kathryn Rice, Faith Sentz, Sarah Mudd, Patrick Odonkor, Erik Strauss, Brittney Williams, Allen Burke, Anuj Gupta, Cinthia B. Drachenberg, David Ayares, Bartley P. Griffith, Muhammad M. Mohiuddin

“…Abstract Background Improvement in gene modifications of donor pigs has led to the prevention of early cardiac xenograft rejection and significantly prolonged cardiac xenograft survival in both heterotopic and orthotopic preclinical non-human primate (NHP) models. This progress formed the basis for FDA approval for compassionate use transplants in two patients. …”
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Vaginal microbiome distinction in women with HPV+, cervical intraepithelial neoplasia, and cervical cancer, a retrospective study by Yuanyue Li, Yuanyue Li, Xiaomei Wu, Xiaomei Wu

“…Additionally, an elevated proportion of Gardnerella was identified as a high-risk bacterium associated with HPV infection, potentially contributing to the progression of cervical lesions. High-risk HPV genotypes, particularly HPV16, 52, and 33, were found to be more prevalent among women with HPV+, CIN, and cervical cancer. …”
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Development and validation of a LAMP-based method for rapid and reliable detection of Xanthomonas albilineans, the causal agent of sugarcane leaf scald by Moutoshi Chakraborty, Moutoshi Chakraborty, Shamsul Arafin Bhuiyan, Shamsul Arafin Bhuiyan, Simon Strachan, Simon Strachan, Muhammad J. A. Shiddiky, Nam-Trung Nguyen, Rebecca Ford, Rebecca Ford

“…This assay also effectively determined optimal sampling times and plant parts by monitoring the progression of the disease over time.DiscussionThis diagnostic assay holds significant potential as a commercial opportunity for a kit-based DNA extraction/purification-free molecular detection alternative. …”
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Comparative analysis of EGFR mutations in circulating tumor DNA and primary tumor tissues from lung cancer patients using BEAMing PCR by Duhita Mirikar, Nandini Banerjee, Kumar Prabhash, Rajiv Kumar Kaushal, Vanita Naronha, C. S. Pramesh, George Karimundackal, Amit Joshi, Swapnil Rane, Ranjan Basak

“…This could be useful for disease monitoring and progression.…”
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Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

“…In particular, we emphasize that there is complex lipid metabolism connections between TAMs and distinct tumors, which influences TAM to bias from M1 to M2 phenotype in tumor progression, and ultimately promotes tumor occurrence and development. …”
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INTRAPERITONEAL AEROSOL CHEMOTHERAPY UNDER PRESSURE (IACUP) – AN INNOVATIVE METHOD OF TREATMENT OF PATIENTS WITH PERITONEAL CARCINOMATOSIS by A. D. Kaprin, V. M. Khomyakov, A. B. Ryabov, L. V. Bolotina, A. V. Ivanov, A. B. Utkina, V. V. Cheremisov, I. V. Kolobaev, A. V. Chaika, D. D. Sobolev, L. A. Koroleva

“…The treatment Protocol consisted of a laparotomy or laparoscopy for the staging of the tumor process, 3–4 courses of systemic chemotherapy scheme XELOX followed by conducting at least 3 sessions of intraperitoneal aerosol chemotherapy under pressure (IACUP) with an interval of 6 weeks on the background of chemotherapy. In the case of progression the patient was excluded from the study. …”
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Role of T cell metabolism in brain tumor development: a genetic and metabolic approach by Bo Yang, Zhenyu Li, Peiliang Li, Bo Liang, Yuhan Liu, Enshan Feng

“…Recent studies emphasized the crucial involvement of the immune system, especially T cells, in driving tumor progression and influencing patient outcomes. The emerging field of immunometabolism has shown that metabolic pathways play a pivotal role in regulating immune responses within the tumor microenvironment. …”
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Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population by Monika Chorąży, Natalia Wawrusiewicz-Kurylonek, Edyta Adamska-Patruno, Olga Zajkowska, Katarzyna Kapica-Topczewska, Renata Posmyk, Adam Jacek Krętowski, Jan Kochanowicz, Alina Kułakowska

“…Multiple sclerosis (MS) is an autoimmune disease, and genetic factors play an important role in its pathogenesis and progression. The aim of our study was to evaluate the frequencies of alleles and genetic variants of the T-cell homeostasis-related genes, in subjects with MS, as well as to investigate the association with MS clinical manifestations and disability. …”
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Knowledge, attitude, and practice toward vitiligo among vitiligo patients: a mediation analysis by Hua Feng, Xiulian Xu, Shuzhen Qi, Kun Chen, Mei Ju, Xiaofang Li, Shuxian Shang

“…Abstract Knowing provoking factors of vitiligo progression and how to avoid them is essential to the successful self-management of vitiligo. …”
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Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer by Zhao Sicheng, Zhao Sicheng, Zhang Jingcheng, Zhang Jingcheng, Zhang Shuo, Zhang Shuo, Lou Jiaheng, Lou Jiaheng, Cai Yan, Cai Yan, Bai Xing, Bai Xing, Jiang Tao, Jiang Tao, Jiang Tao, Zhang Guangji, Zhang Guangji, Zhang Guangji

“…Through single-cell sequencing data analysis, fibroblast subpopulations associated with the key gene set are identified in GC, showing significant correlations with cancer progression and inflammation regulation pathways. Transcription factor analysis and developmental trajectory analysis reveal the potential role of fibroblasts in GC development. …”
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