β-Glucan induced plasma B cells differentiation to enhance antitumor immune responses by Dectin-1 by Yu Bai, Jun Ding, Liuyang He, Zhichao Zhu, Jie Pan, Chunjian Qi

“…In mouse models of Lewis lung cancer (LLC) tumors, combining β-glucan with programmed death-1(PD-1) blocking antibodies led to increase recruitment of CD19+ B cells in the tumor microenvironment (TME), higher numbers of germinal centers B cells (GC B) in the spleen and draining lymph node (DLN), elevate Ig production, and delay tumor progression. Conclusions These findings reveal that β-glucan can serve as a potent adjuvant to modulate B cell immune responses in a Dectin-1 dependent manner and improve immune checkpoint blockade (ICB) therapy in antitumor. …”
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Using maternal sepsis patient journeys to map and prioritise barriers to quality maternal healthcare in Malawi: a multidisciplinary stakeholder consultation workshop by Yamikani Chimwaza, Dalisto Ndaferankhande, Leonard Mndala, Chifundo Ndamala, Emily Lifa, Mercy Machilika, Esther Mwagomba, Bernard Dossie, Meliya Kwelepeta, Bertha Maseko, David Lissauer, Maria Lisa Odland

“…Background Malawi has made progress in improving access to maternity care services, shifting the focus to quality of care as an essential determinant of maternal health outcomes. …”
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From the guest editors by Urszula Ledzewicz, Avner Friedman, Jacek Banasiak, Heinz Schättler, Edward M. Lungu

“…Therefore, a second focus area of the workshop was on improved and morerealistic models for the dynamic progression and treatment of various types ofcancer, a truly globally challenging problem. …”
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Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7 by Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu

“…However, the function of LMW-HA in PTC progression remains to be elucidated. In this study, we found that receptor of LMW-HA, TLR4, was aberrantly overexpressed in PTC tissues and cell line W3. …”
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VR-based body tracking to stimulate musculoskeletal training by Neidhardt M., Gerlach S., Schmidt F. N., Fiedler I. A. K., Grube S., Busse B., Schlaefer A.

“…We present an application for the HoloLens 2 to enable musculoskeletal training for elderly and impaired persons to allow for autonomous training and automatic progress evaluation. We designed a virtual downhill skiing scenario that is controlled by body movement to stimulate balance and body control. …”
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Research trends and hotspots in post-stroke speech rehabilitation: A bibliometric analysis by Nan Huang, Kang Zou, Fang Liu, Zhen Su, Long Chen, Yanbiao Zhong, Yun Luo, Maoyuan Wang, Li Xiao

“…However, comprehensive bibliometric analyses on post-stroke language rehabilitation are limited, restricting understanding of progress in this field. Objective: This study aimed to identify hotspots and trends in post-stroke speech rehabilitation research from 2003 to 2023 to guide future studies. …”
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A Strain Rate-Dependent Damage Evolution Model for Concrete Based on Experimental Results by Peng Wan, Xiaoyan Lei, Bin Xu, Hui Song

“…Cyclic uniaxial compression tests were conducted on concrete samples at three strain rates of 10−3s−1, 10−4s−1, and 10−5s−1, respectively, and ultrasonic wave measurements were made at specified strain values during the loading progress. A damage variable was defined using the secant and initial moduli, and concrete damage evolution was then studied using the experimental results of the cyclic uniaxial compression tests conducted at the different strain rates. …”
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Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease S... by V. T. Ivashkin, V. P. Chulanov, N. A. Mamonova, M. V. Maevskaya, M. S. Zharkova, I. N. Tikhonov, P. O. Bogomolov, E. V. Volchkova, A. S. Dmitriev, O. O. Znojko, E. A. Klimova, K. V. Kozlov, I. E. Kravchenko, E. Yu. Malinnikova, R. V. Maslennikov, M. I. Mikhailov, K. E. Novak, I. G. Nikitin, V. E. Syutkin, E. V. Esaulenko, A. A. Sheptulin, E. N. Shirokova, N. D. Yushchuk

“…Over the past 10 years, great progress has been made in the treatment of hepatitis C — direct acting antiviral drugs have appeared. …”
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Psychological Distress during Ovarian Cancer Treatment: Improving Quality by Examining Patient Problems and Advanced Practice Nursing Interventions by Cynthia Kline O'Sullivan, Kathryn H. Bowles, Sangchoon Jeon, Elizabeth Ercolano, Ruth McCorkle

“…High distress subjects who refused mental health intervention had more income and housing problems than the other subjects, received the fewest interventions at baseline, and progressively more throughout the study, exceeding the other sub-samples by study completion. …”
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Refactoring BZIP2 on the new‐generation sunway supercomputer by Xiaohui Liu, Zekun Yin, Haodong Tian, Wubing Wan, Mengyuan Hua, Wenlai Zhao, Zhenchun Huang, Ping Gao, Fangjin Zhu, Hua Wang, Xiaohui Duan

“…Abstract High‐performance computing is progressively assuming a fundamental role in advancing scientific research and engineering domains. …”
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The impact of policy-oriented agricultural insurance on China’s grain production resilience by Tao Zheng, Tao Zheng, Tao Zheng, Guiqian Zhao

“…At the same time, the mechanism analysis shows that policy-oriented agricultural insurance can have a positive impact on grain production resilience by improving agricultural technology progress, land transfer, and grain cultivation specialization.DiscussionThis paper reveals that policy-oriented agricultural insurance has a positive impact on grain production resilience and provides relevant policy suggestions for the government. …”
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Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway by Chunxue Li, Rongrong Zhang, Yating Zhan, Jianjian Zheng

“…Enhanced Hippo pathway activation has also been reported to inhibit tumor progression and liver fibrosis. In the present study, the role of the Hippo pathway in mediating the effects of Res on hepatic stellate cells (HSCs) was examined. …”
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Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review by Harinisubasri M, Priyadharsini Nataraj, Dineshkumar Thayalan, Divya Bose, Rameshkumar Annasamy, Rajkumar K

“…Only few studies were noted explaining the pathogenesis involved in its cancer progression. Aim: The aim of the study is to bring in a spotlight for masquerading the role of TGF-β by determining its expression using immunohistochemistry in the malignant transformation of oral lichen planus. …”
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The Impact of Modifiable Risk Factors on the Endothelial Cell Methylome and Cardiovascular Disease Development by Hashum Sum, Alison C. Brewer

“…Although the molecular mechanisms underlying the aetiology of atherosclerosis remain unknown, it is clear that both its development and progression are associated with significant changes in the pattern of DNA methylation within the vascular cell wall. …”
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WALLABY Pilot Survey and ASymba: Comparing H i Detection Asymmetries to the SIMBA Simulation by Mathieu Perron-Cormier, Nathan Deg, Kristine Spekkens, Mark L. A. Richardson, Marcin Glowacki, Kyle A. Oman, Marc A. W. Verheijen, Nadine A. N. Hank, Sarah Blyth, Helga Dénes, Jonghwan Rhee, Ahmed Elagali, Austin Xiaofan Shen, Wasim Raja, Karen Lee-Waddell, Luca Cortese, Barbara Catinella, Tobias Westmeier

“…The statistical power of quantitative comparisons of asymmetries such as the one presented here will improve as the WALLABY survey progresses and as simulation volumes and resolutions increase.…”
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Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature by Sandra Maria Barbalho, Beatriz Leme Boaro, Jéssica da Silva Camarinha Oliveira, Jiří Patočka, Caroline Barbalho Lamas, Masaru Tanaka, Lucas Fornari Laurindo

“…Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by the dysregulation of molecular pathways and activation of the brain’s immune system, resulting in the release of pro-inflammatory and oxidative molecules. …”
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Key insights into recent advances and challenges in COVID-19 management by Prakash Monika, Anushka A. Poola, Prithvi S. Prabhu, K. Samrat, C. Likhitha

“…A collaborative and integrative approach between academic, scientific, social, and economic factors, along with close supervision and reinforcement of the current public safety protocols, can help to ensure a better management strategy to control the progression of COVID-19. Graphical Abstract…”
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Numerical and Analytical Calculations for Modeling and Designing Drilling Wicks or Rotary Cutters Based of Functionally Graded Materials by Luc Leroy Mambou Ngueyep, Joseph Ndop, Elise Rose Atangana Nkene, Jean-Marie Bienvenu Ndjaka

“…The radial stresses and tangential and vertical stresses progressively increase with the axial force Fz. The force Fz affects more tangential stresses that the radial stresses. …”
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The spatiotemporal and paradoxical roles of NRF2 in renal toxicity and kidney diseases by Yiying Bian, Jize Dong, Zhengsheng Zhou, Hua Zhou, Yuanyuan Xu, Qiang Zhang, Chengjie Chen, Jingbo Pi

“…Herein, NRF2 exhibits diverse expression patterns and downstream gene profiles across distinct kidney regions and cell types, and during specific phases of nephropathic progression. These changes are directly or indirectly connected to altered antioxidant defense, damage repair, inflammatory response, regulated cell death and fibrogenesis, culminating ultimately in either protective or deleterious outcomes. …”
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Reassessing the schedule of the sugar season in maple under climate warming by Gian de Lima Santos, Roberto Silvestro, Sara Yumi Sassamoto Kurokawa, Guillaume de Lafontaine, Sergio Rossi

“…With climate change, producers will be forced to progressively readjust the schedule of their field activities and tapping to match the shifting sugar season.…”
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