Oscillatory mechanoluminescence of Mn2+-doped SrZnOS in dynamic response to rapid compression by Hao Wang, Tingting Zhao, Mei Li, Junlong Li, Ke Liu, Shang Peng, Xuqiang Liu, Bohao Zhao, Yanlong Chen, Jiao An, Xiaohui Chen, Sheng Jiang, Chuanlong Lin, Wenge Yang

“…Abstract Photon emission may be continuously produced from mechanical work through self-recoverable mechanoluminescence (ML). Significant progress has been made in high-performance ML materials in the past decades, but the rate-dependent ML kinetics remains poorly understood. …”
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Role of the androgen receptor in melanoma aggressiveness by Marzia Di Donato, Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna, Lucia Carmela Passacatini, Margaret Ottaviano, Paolo Antonio Ascierto, Ferdinando Auricchio, Ennio Carbone, Antimo Migliaccio, Gabriella Castoria

“…Nevertheless, the disease often progresses and becomes resistant to the therapies. As such, the discovery of new targets and drugs for advanced melanoma still remains a difficult task. …”
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Development of a prognostic gene signature and exploration of P4HA1 in the modulation of cuproptosis in colorectal cancer by RenJie Jiang, LinLin Ruan, Taohui Ding, Hongtao Wan, Yanglin Chen, XiaoJian Zhu, Zhijiang Huang, Dengke Yao, Ming Li, Bo Yi, Dan Liu

“…P4HA1 was identified as a key gene of interest, where downregulation was found to inhibit tumor progression in single-cell sequencing analyses and in vitro experiments. …”
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Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-... by Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen

“…Macrophages and fibroblast-like synoviocytes (FLSs) play crucial roles in the progression of RA. Hence, synergistic combination of ROS scavenging, macrophage polarization from pro-inflammatory M1 phenotype towards M2 anti-inflammatory phenotype, and restoring homeostasis of FLSs will provide a promising therapeutic strategy for RA. …”
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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Our findings show that AgNPs effectively do not affect cell viability in Calu-3 cells, inhibit viral infection in Vero-E6 cells and progression of infection in vitro. Additionally, AgNPs impair caspase-1 activation, lactate dehydrogenase release and IL-1β production by human monocytes. …”
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Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis by Xueqin Huang, Yingqi Yang, Hanlin Zhou, Liping Hu, Annan Yang, Hua Jin, Biying Zheng, Jiang Pi, Jun Xu, Pinghua Sun, Huai-Hong Cai, Xujing Liang, Bin Pan, Junxia Zheng, Haibo Zhou

“…Meanwhile, the MNase-mediated strategy characterized by high specificity and sensitivity successfully discriminated between patients with sepsis (n = 7) and healthy participants (n = 3), as well as monitored the prognostic progression of the disease (n = 2). Overall, benefiting from highly active and dense “hot spot” substrate, MNase-mediated cascade response strategy, and colorimetric/SERS dual-signal output, this methodology will offer a promising avenue for the early diagnosis of S. aureus infection.…”
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Simplified MS2 phage-like particle production including a novel maturation protein internal fusion affinity tag by Enos C. Kline, Rose Duong, Qin Wang, Barry R. Lutz

“…Key developments in PLP controls have enhanced the packing efficiency of RNAs into particles, reduced the complexity of their plasmid expression systems, and shifted purification from ultracentrifugation to affinity chromatography, producing progressively greater yields with higher purity. Expanding on prior improvements, this study establishes a revised set of plasmid vectors for Emesvirus zinderi (MS2) derived PLPs that streamline vector manipulations for rapid prototyping of new particles, provide validation of an alternative affinity tag for purification, and contributes a high-throughput low-volume spin column purification strategy. …”
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The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease by Xudong Sha, Jiayuan Lin, Kexin Wu, Jia Lu, Zhihua Yu

“…Abstract Microglia are progressively activated by inflammation and exhibit phagocytic dysfunction in the pathogenesis of neurodegenerative diseases. …”
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BMP6, a potential biomarker of inflammatory fibrosis and promising protective factor for dilated cardiomyopathy by Feng Jiang, Jiayang Tang, Xiaoqi Wei, Hai Pan, Xinyi Fan, Peng Zhang, Shuzhen Guo

“…Inflammation plays a pivotal role throughout the progression of DCM to heart failure, while age acts as a natural predisposing factor for all cardiovascular diseases. …”
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Leveraging Global Fund’s investments to expand innovative public-private provider engagement in TB by M.A. Yassin, L. Kimbo, E. Wandwalo, A. Rashid, A. Dzokoto, U. Weber, G. Stallworthy

“…The COVID-19 pandemic disrupted progress in the global TB response. Most patients with TB initially seek care from private providers, whereas only a small proportion are engaged by national programmes. …”
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Gut microbiota in the association between obesity and kidney function decline: a metagenomics-based study in a rat model by Akehu Alemasi, Lijiang Gu, Yilun Zhou

“…Functional analysis indicated that the gut microbiota in the HFD group primarily correlated with infectious diseases, signal transduction, and signaling molecules and interactions.Conclusions This study provides evidence that the consumption of a HFD induces modifications in the composition and functionality of the gut microbiome in rats, which may serve as a potential mechanism underlying the relationship between obesity and the progression of kidney function decline.…”
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Exploring the role of volume energy density in altering microstructure and corrosion behavior of nitinol alloys produced by laser powder bed fusion by Gopinath Perumal, Karthikeyan Tamil Selvam, Mark Swayne, Eanna McCarthy, Abhishek Babu, Dmitry Dzhurinskiy, Dermot Brabazon

“…Abstract In the realm of materials science and engineering, the pursuit of advanced materials with tailored properties has been a driving goal behind technological progress. Scientific interest in laser powder bed fusion (L-PBF) fabricated NiTi alloy has in recent times seen an upsurge of activity. …”
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Predicting Traffic Accident Risk in Seoul Metropolitan City: A Dataset Construction Approach by Ji-Woong Yang, Hyeon-Jin Jung, Tae-Wook Kim, Han-Jin Lee, Ellen J. Hong

“…In contemporary society, the rapid progression of urbanization and technological advancements has led to a substantial increase in the number of vehicles, consequently elevating the rate of traffic accidents. …”
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Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI by Siqi Zhang, Wen Zhao, Longwei Sun, Guohua Liang, Xiaodong Wang, Hongwu Zeng

“…Conclusion The risk of cardiac iron deposition increases as age progresses, and the mid-inferolateral segment is more susceptible to iron accumulation. …”
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Public Administration Digitalization and Government Effectiveness in EU Countries by Armenia Androniceanu, Irina Georgescu

“…It aims to identify and analyse the progress made by EU administrations in terms of digitization and effective governance in the period 2019–2021. …”
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KLF9-GRK5-HDAC6 axis aggravates osteoarthritis pathogenesis by promoting chondrocyte extracellular matrix degradation and apoptosis by Xiaonan Zhou, Peng Jiang, Huangqi Tan, Yanfang Wang, Lunhao Bai

“…These results demonstrate that the KLF9-GRK5-HDAC6 axis plays a crucial role in promoting the progression of OA.…”
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DIGITAL INFORMATION’S INFLUENCE ON FORMING TOURISM EVENT IMPRESSIONS: THE INTERPLAY OF GENDER AND TOURISM TYPES by Amany E. SALEM, Thowayeb H. HASSAN, Mahmoud I. SALEH, Mostafa A. HASSANIN, Hassan Marzok Elsayed MAHMOUD, Ashraf Mohamed ANAS, Hadeel Sa'ad AL-HYARI, Hisham Mohammad AL-SMADI, Yasmine E. HAMZA

“…These insights suggest that destination marketers should employ nuanced, personalized strategies catered to specific tourism types, considering the varying levels of digital information reliance and the changing needs of tourists as their engagement progresses. For leisure and adventure tourism, this may involve front-loading comprehensive digital information, while cultural tourism may benefit from a more consistent information flow throughout the experience. …”
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The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer by Si Chen, Caihong Yao, Na Tian, Chunying Zhang, Yuemei Chen, Xuting Wang, Yue Jiang, Tonghao Zhang, Tingting Zeng, Yali Song

“…Aims This study aimed to explore how chronic pathogenic infections influence the immune microenvironment, impacting tumorigenesis, cancer progression, and treatment strategies. Additionally, it seeks to investigate the effects of these infections on specific immune checkpoints and identify potential targets for immunotherapy. …”
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<i>Pseudomonas syringae</i> Pathovar <i>syringae</i> Infection Reveals Different Defense Mechanisms in Two Sweet Cherry Cultivars by Claudia Carreras, Alan Zamorano, Luis Villalobos-González, Paula Pimentel, Lorena Pizarro, María Francisca Beltrán, Weier Cui, Manuel Pinto, Franco Figueroa, Carlos Rubilar-Hernández, Analia Llanes, Assunta Bertaccini, Nicola Fiore

“…Through this study, it has been possible to progress the knowledge of relevant factors related to the susceptibility of the two studied cherry cultivars to <i>P. syringae</i> pv. …”
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Early Diagnosis and Severity Assessment of Weligama Coconut Leaf Wilt Disease and Coconut Caterpillar Infestation Using Deep Learning-Based Image Processing Techniques by Samitha Vidhanaarachchi, Janaka L. Wijekoon, W. A. Shanaka P. Abeysiriwardhana, Malitha Wijesundara

“…This paper presents a study conducted in Sri Lanka, demonstrating the effectiveness of employing transfer learning-based Convolutional Neural Network (CNN) and Mask Region-based-CNN (Mask R-CNN) to identify WCWLD and CCI at their early stages and to assess disease progression. Further, this paper presents the use of the You Only Look Once (YOLO) object detection model to count the number of caterpillars distributed on leaves with CCI. …”
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