Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciproc... by Yanfang Liang, Qianqian Chen, Wenjing Du, Can Chen, Feifei Li, Jingying Yang, Jianyu Peng, Dongping Kang, Bihua Lin, Xingxing Chai, Keyuan Zhou, Jincheng Zeng

“…We found that elevated EBI3 may be associated with IL-12p35, gp130, and p-STAT3 to promote CRC progression. EBI3 blocking peptide promoted antitumor cytotoxic T lymphocyte (CTL) response by inducing Granzyme B, IFN-γ production, and p-STAT3 expression and inhibited CRC cell proliferation and tumor growth to associate with suppressing gp130 and p-STAT3 expression. …”
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Overall survival of patients with KIT-mutant metastatic GIST in the era of multiple kinase inhibitor availability by Valerie Haller, Carina Reiff, Rainer Hamacher, Karina Kostbade, Moritz Kaths, Juergen Treckmann, Stefanie Bertram, Yasmin Zaun, Sebastian Bauer, Johanna Falkenhorst

“…Patients and methods Overall survival (OS) and progression-free survival (PFS) were analyzed in patients with metastatic GIST, with diagnosis of metastases between 2008 and 2021, when at least three lines of treatment were available in Germany (n = 174). …”
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Feasibility of enzalutamide on patients with recurrent non-muscle-invasive bladder cancer with marker tumors: phase I study by Takashi Kawahara, Shuya Kandori, Takahiro Kojima, Bryan J. Mathis, Masanobu Shiga, Hiroyuki Nishiyama

“…As for efficacy, three patients showed no change while the remaining three showed disease progression. Immunohistochemical analysis did not showed the strong staining of AR in the latest tumors. …”
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Autophagy-related long non-coding RNA MIR210HG plays a therapeutic role in hepatocellular carcinoma by Chaoqun Zhang, Dianxing Sun, Huifang Zhou, Chao Liu, Jie Ruan, Jiwen Kang, Ying Xie

“…Conclusion The findings suggest that lncRNA MIR210HG contributes to hepatocellular carcinoma progression by regulating autophagy and could serve as a promising therapeutic target in hepatocellular carcinoma treatment strategies.…”
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Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristics by You Hu, Jun Xu, Jian Lv, Yan Qin, Yongda Lu, Fan Cen, Hongbao Yang, Kai Chen, Suhua Xia

“…Gastric cancer is characterized by high heterogeneity, with its complex microenvironment and intercellular communications playing critical roles in disease progression and treatment responses. In this study, we utilized single-cell sequencing to dissect the intricate landscape of gastric cancer, identifying diverse cell populations and their interactions. …”
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Early Driving Pressure Changes Predict Outcomes during Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome by Harry Magunia, Helene A. Haeberle, Philipp Henn, Martin Mehrländer, Peer O. Vlatten, Valbona Mirakaj, Peter Rosenberger, Michael Koeppen

“…Due to the extracorporeal gas exchange, the paO2/FiO2 ratio cannot be used as the primary marker for disease severity and progression. Therefore, we performed a propensity score-matched analysis to identify other potential predictors of outcomes in patients supported by ECMO therapy. …”
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Prognostic Value of GPNMB, EGFR, p-PI3K, and Ki-67 in Patients with Esophageal Squamous Cell Carcinoma by Bo Wang, Mengyan Li, Anna Su, Yongmei Gao, Yan Shi, Chao Li, Wenying Liu, Liping Su, Wan Li, Yuqing Ma

“…GPNMB is a newly discovered tumour-promoting factor that may promote tumour cell progression by activating the PI3K/AKT pathway by EGFR. …”
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Real life outcome analysis of breast cancer brain metastases treated with Trastuzumab Deruxtecan by Alessandra Fabi, Alessandro Rossi, Roberta Caputo, Simona Pisegna, Simone Scagnoli, Francesco Pantano, Giuliana D’Auria, Palma Fedele, Agnese Fabbri, Claudio Vernieri, Michela Palleschi, Luisa Carbognin, Gianluigi Ferretti, Elena Di Monte, Ida Paris, Francesco Pavese, Ornella Garrone, Antonio Franco, Michelino De Laurentiis, Gianluca Franceschini, Giovanni Scambia, Diana Giannarelli, Riccardo Masetti, Andrea Botticelli

“…Secondary endpoints were intra- and global progression free survival (iPFS - gPFS); other secondary objectives were the intracranial disease control rate (iDCR), duration of response (iDoR), clinical benefit rate at 6 and 12 months (iCBr), overall survival, and safety. iORR was 59%, iPFS was 15.6 months, gPFS was 11.8 months. iDCR was 94.9%, iDoR was 11.9 months, and iCBr at 6 and 12 months were 69.2% and 59%, respectively. …”
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Effect of Compression Loading on Human Nucleus Pulposus-Derived Mesenchymal Stem Cells by Hang Liang, Sheng Chen, Donghua Huang, Xiangyu Deng, Kaige Ma, Zengwu Shao

“…Mechanical loading plays a vital role in the progression of intervertebral disc (IVD) degeneration, but little is known about the effect of compression loading on human nucleus pulposus-derived mesenchymal stem cells (NP-MSCs). …”
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Similarities between Tumour Immune Response and Chronic Wound Microenvironment: Influence of Mesenchymal Stromal/Stem Cells by Kimberly Thando Peta, Melvin Anyasi Ambele, Michael Sean Pepper

“…Compelling evidence to suggest that MSCs are an effective treatment option against tumour progression is lacking.…”
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Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia by Vilen Molotov-Luchanskiy, Altynbek Nukhuly, Larissa Muravlyova, Ryszhan Bakirova, Aruna Kossybayeva, Dmitry Klyuyev, Ludmila Demidchik, Irina Beinikova

“…We study the indices of oxidative stress and oxidized-modified proteins of neutrophils in CAP patients, depending on the degree of severity, and also compare the detection frequency of neutrophil extracellular traps in the progression of pneumonia. Materials and Methods. 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. …”
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Bacterial Diversity Associated with Terrestrial and Aquatic Snails by Konstantinos Apostolou, Canella Radea, Alexandra Meziti, Konstantinos Ar. Kormas

“…The steadfast technological progress in nucleic acid-based approaches would cause one to expect that scientific works on the microbial symbionts of animals would be balanced at least for the farmed animals of human interest. …”
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Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve by Min Zheng, Yanping Ruan, Lin Sun, Xiaowei Liu, Jiancheng Han, Yihua He

“…Fetuses with BAV should be followed up prenatally for the aortic valve and ascending aorta as they progressively deteriorate with gestational age.…”
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Digital twins as global learning health and disease models for preventive and personalized medicine by Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

“…This issue stems from the complex nature of diseases, which involve altered interactions among thousands of genes across multiple cell types and organs. Disease progression can vary between patients and over time, influenced by genetic and environmental factors. …”
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Preventive interventions for diabetic foot ulcer adopted in different healthcare settings: A scoping review protocol. by Açucena Leal de Araújo, Francisca Diana da Silva Negreiros, Raquel Sampaio Florêncio, Thiago Dos Santos Garces, Virna Ribeiro Feitosa Cestari, Samuel Miranda Mattos, Samara Jesus Sena Marques, Francisca Eridan Fonteles Albuquerque, Wánderson Cássio Oliveira Araújo, Vanessa de Brito Poveda, Thereza Maria Magalhães Moreira

“…The literature can provide valuable insights for developing tailored interventions and strategies to effectively address these gaps, potentially accelerating progress toward improved outcomes in diabetic foot ulcer prevention.…”
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The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis by Katarzyna Kasperkiewicz, Anna S. Świerzko, Marta Przybyła, Janusz Szemraj, Jarosław Barski, Mikael Skurnik, Andrzej Kałużyński, Maciej Cedzyński

“…The aim of this work was to investigate whether Yersinia LPS (coinjected with collagen) is associated with arthritis progression or other pathological effects and to elucidate the mechanism of this association. …”
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Case report: Novel multi-exon homozygous deletion of ZBTB24 causes immunodeficiency, centromeric instability, and facial anomalies syndrome 2 by Yan Long, Chenghan Wang, Jie Xiao, Yunhua Huang, Xiaoting Ling, Chaoyu Huang, Ying Chen, Jiaqi Luo, Rongheng Tang, Faquan Lin, Yifang Huang

“…During the follow-up, the patient’s pneumonia continued to progress despite receiving intravenous immunoglobulin (IVIG) replacement and anti-infective therapy. …”
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Transcriptomics and Physiological Analyses of Soybean Stay-Green Syndrome by Dagang Wang, Yanan Wang, Ruidong Sun, Yong Yang, Wei Zhao, Guoyi Yu, Yueying Wang, Feng Wang, Lin Zhou, Zhiping Huang

“…Stay-green syndrome (SGS) is an important factor that causes soybean (<i>Glycine max</i>) yield reduction. Despite progress being made, the regulatory mechanism remains largely unclear. …”
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CanKiwi: A Mechanistic Competition Model of Kiwifruit Bacterial Canker Disease Dynamics by Oussama Hadj Abdelkader, Hadjer Bouzebiba, Miguel G. Santos, Danilo Pena, António Pedro Aguiar, Susana M. P. Carvalho

“…They also show that the environmental effects on the vine’s growth and the infection progress are taken into account and align with the previous studies. …”
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Modified Center-Edge Angle in Children with Developmental Dysplasia of the Hip by Katharina S. Gather, Fabian Sporer, Christos Tsagkaris, Marco Götze, Simone Gantz, Sebastien Hagmann, Thomas Dreher

“…This study showed that the MCE angle can be used adequately in children under four years and could be used as a progression parameter to diagnose DDH.…”
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