A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease by Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng

“…However, current treatments only manage symptoms and lack the ability to slow or prevent disease progression. We utilized a systems genetics approach to identify potential risk genes and repurposable drugs for PD. …”
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Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study by Rongrong Xu, Yanping Zhang, Tingting Wu, Hao Liu, Jianhao Peng, Zhanshan Wang, Te Ba, Baorong Zhang, Zhigang Li, Yongjie Wei

“…Recently, lung microbiome is proposed to be characterized with development and progression of respiratory diseases. However, the underlying effects of TRAP exposure on lung microbiome are rarely explored. …”
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A national survey of physicians regarding active surveillance for low-risk thyroid cancer in Korea by Min Joo Kim, Jae Hoon Moon, Eun Kyung Lee, Young Shin Song, Kyong Yeun Jung, Ji Ye Lee, Ji-hoon Kim, Woojin Lim, Kyungsik Kim, Sue K. Park, Young Joo Park

“…Although the respondents recognized the benefits of AS, such as avoiding surgery and reducing surgical complications, they expressed concerns about potential risks, including the possibility of patient lawsuits due to disease progression and patient worry and anxiety about the disease. …”
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An Effect of Ursodeoxycholic Acid on Inflammation, Steatosis and Liver Fibrosis and Atherogenesis Factors in Patients with Non-Alcoholic Fatty Liver Disease: Results of the USPEH S... by M. V. Mayevskaya, M. Yu. Nadinskaia, V. D. Lunkov, I. Yu. Pirogova, E. V. Chesnokov, Kh. B. Kodzoeva, V. T. Ivashkin

“…Against the background of UDCA administration, there was no progression of liver fibrosis. None of the participants in the observational programme reached a normal body mass by the end of the program; therefore, the attained positive changes should be attributed directly to the effects of UDCA.…”
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Learning Automata Based Incremental Learning Method for Deep Neural Networks by Haonan Guo, Shilin Wang, Jianxun Fan, Shenghong Li

“…Deep learning methods have got fantastic performance on lots of large-scale datasets for machine learning tasks, such as visual recognition and neural language processing. Most of the progress on deep learning in recent years lied on supervised learning, for which the whole dataset with respect to a specific task should be well-prepared before training. …”
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Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease by Wei Li, Wenkang Gao, Shengqi Yan, Ling Yang, Qingjing Zhu, Huikuan Chu

“…Recent research highlights the gut microbiota’s significant role in the progression of alcohol-related liver disease. In patients with alcohol-related liver disease, the relative abundance of pathogenic bacteria, including <i>Enterococcus faecalis</i>, increases and is positively correlated with the level of severity exhibited by alcohol-related liver disease. …”
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Salivary Metabolomics of Well and Poorly Controlled Type 1 and Type 2 Diabetes by Sompop Bencharit, James Carlson, Warren C. Byrd, Escher L. Howard-Williams, Jackson T. Seagroves, Susan McRitchie, John B. Buse, Susan Sumner

“…The concentrations of endogenous metabolites in saliva can be altered based on the systemic condition of the hosts and may, in theory, serve as a reflection of systemic disease progression. Hemoglobin A1C is used clinically to measure long-term average glycemic control. …”
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p38δ MAPK: Emerging Roles of a Neglected Isoform by Carol O’Callaghan, Liam J. Fanning, Orla P. Barry

“…In summary, while our knowledge of p38δ MAPK has progressed somewhat since its identification in 1997, our understanding of this particular isoform in many cellular processes still strikingly lags behind that of its counterparts.…”
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Phytochemical Profiles and Anticancer Effects of Calophyllum inophyllum L. Extract Relating to Reactive Oxygen Species Modulation on Patient-Derived Cells from Breast and Lung Canc... by Jetsada Ruangsuriya, Jirapast Sichaem, Apichat Tantraworasin, Somcharoen Saeteng, Phanchaporn Wongmaneerung, Angkhana Inta, Neal M. Davies, Kewalin Inthanon

“…Overall, our findings highlight the anticancer potential of C. inophyllum extract, emphasize its ability to modulate cellular ROS levels and target key molecular pathways involved in cancer progression. This study sheds light on the promising therapeutic implications of C. inophyllum extract as a novel agent for cancer treatment, which is safe for normal cells.…”
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Grid-Integrated Dual Wind Turbine System Using SEPIC Converter with Whale Optimized PI Controller by Kishore R.D., Sravani K., Sai Kumar N.D., Preetham C.G., Bentu B.2

“…Main objectives of the study are to progress a dual independent doubly fed induction generator (DFIG)-based wind energy conversion system (WECS) for stable and efficient power delivery to an AC microgrid while ensuring grid stability and compliance with power quality standards. …”
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Coinfection of Herpes Simplex virus 2 and Mycobacterium chelonae in acute hydrops associated with keratoconus: A case report by Pedro Marques-Couto, Ana Gama-Castro, Teresa Carvalho, Rodrigo Vilares-Morgado, João Pinheiro-Costa, Dolores Pinheiro, Ana Maria Cunha

“…Posteriorly, she developed dendritic epithelial lesions suggestive of Herpes Simplex virus infection. These lesions progressed, leading to a central corneal infiltrate and descemetocele. …”
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Establishment of performance parameters for the Qubit™ 1X dsDNA HS Assay for use in forensic genetics casework by Adele Lauren Kaleigh Naidoo, Donna-Lee Pamela Martin, Laura Jane Heathfield

“…This study has advanced our progression towards implementing a molecular autopsy sequencing workflow in South Africa and provides the first performance parameters for the Qubit™ 1X dsDNA HS Assay Kit which may be useful for other laboratories.…”
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Self-induced optical non-reciprocity by Zhu-Bo Wang, Yan-Lei Zhang, Xin-Xin Hu, Guang-Jie Chen, Ming Li, Peng-Fei Yang, Xu-Bo Zou, Peng-Fei Zhang, Chun-Hua Dong, Gang Li, Tian-Cai Zhang, Guang-Can Guo, Chang-Ling Zou

“…Exciting experimental progress has been achieved by either introducing spatial-temporal modulation of the optical medium or combining Kerr-type optical nonlinearity with spatial asymmetry in photonic structures. …”
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Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy by Kaichiro Sawada, Masao Toyoda, Noriko Kaneyama, Sawako Shiraiwa, Hitomi Moriya, Han Miyatake, Eitaro Tanaka, Naoyuki Yamamoto, Masaaki Miyauchi, Moritsugu Kimura, Takehiko Wada, Masafumi Fukagawa

“…Podocyte injury plays an important role in the onset and progression of diabetic nephropathy (DN). Downregulation of α3β1-integrin expression in podocytes is thought to be associated with podocyte detachment from the glomerular basement membrane, although the mechanisms remain obscure. …”
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VaSe-MRP: Velocity-aware and stability-estimation–based multi-path routing protocol in flying ad hoc network by Zhongyu Ma, Qun Guo, Ji Ma, Zhe Zhang, Hongfeng Ma, Linru Peng, Ying Li

“…In routing maintenance progress, a path similarity and path remaining survival duration–based multi-path selection mechanism is proposed. …”
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Relationship between neutropenia caused by nanoliposomal irinotecan/fluorouracil/leucovorin and treatment outcomes in the NAPOLEON-2 study (NN-2301) by Tomonori Araki, Yuki Sonoda, Mototsugu Shimokawa, Taiga Otsuka, Kohei Hayashi, Takuya Honda, Kazuhiko Nakao, Taro Shibuki, Junichi Nakazawa, Shiho Arima, Keisuke Miwa, Yoshinobu Okabe, Futa Koga, Yujiro Ueda, Yoshihito Kubotsu, Hozumi Shimokawa, Shigeyuki Takeshita, Azusa Komori, Kazuo Nishikawa, Satoshi Otsu, Ayumu Hosokawa, Hisanobu Oda, Tatsunori Sakai, Shuji Arita, Machiko Kawahira, Hiroki Taguchi, Kengo Tsuneyoshi, Yasunori Kawaguchi, Toshihiro Fujita, Takahiro Sakae, Tsuyoshi Shirakawa, Toshihiko Mizuta, Kenji Mitsugi

“…The primary endpoint was overall survival (OS), and the secondary endpoints were overall response rate, progression-free survival (PFS), and relative dose intensity. …”
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Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis by Yuh-Shyan Tsai, Hong-Lin Cheng, Tzong-Shin Tzai, Nan-Haw Chow

“…The overall risks of disease progression for patients with EGFR or ErbB2 overexpression were 4.5 (95% CI: 2.5–8.4) and 1.1 (95% CI: 0.6–1.9), and the risks of mortality were 3.0 (95% CI: 1.6–5.9) and 1.1 (95% CI: 1.0–1.2), respectively. …”
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Management of adult patients with alcoholic liver disease: clinical guidelines of the Russian Scientific Liver Society by V. T. Ivashkin, M. V. Mayevskaya, Ch. S. Pavlov, Yu. P. Sivolap, V. D. Lunkov, M. S. Zharkova, R. V. Maslennikov

“…The alcoholic liver disease (ALD) is a clinical and morphological entity that encompasses several forms of the liver parenchyma lesions resulting from alcohol abuse, that range from steatosis to alcoholic hepatitis (steatohepatitis) followed by progression to fibrosis, liver cirrhosis and hepatocellular carcinoma. …”
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TransDeep: Transformer-Integrated DeepLabV3+ for Image Semantic Segmentation by Tengfei Chai, Zhiguo Xiao, Xiangfeng Shen, Qian Liu, NianFeng Li, Tong Guan, Jia Tian

“…In recent years, image semantic segmentation algorithms have made significant progress driven by deep learning technology, and are widely used in fields such as medical image analysis, assistive technology for the visually impaired people, and autonomous driving. …”
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ACD-ML: Advanced CKD detection using machine learning: A tri-phase ensemble and multi-layered stacking and blending approach by Mir Faiyaz Hossain, Shajreen Tabassum Diya, Riasat Khan

“…It is extremely important to slow down the progression of kidney deterioration to prevent kidney dialysis or transplant. …”
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