Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief by Nicholas J. Wright, Yutaka Matsuoka, Hyeri Park, Wei He, Caroline G. Webster, Kenta Furutani, Justin G. Fedor, Aidan McGinnis, Yiquan Zhao, Ouyang Chen, Sangsu Bang, Ping Fan, Ivan Spasojevic, Jiyong Hong, Ru-Rong Ji, Seok-Yong Lee

“…Abstract The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. …”
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Risk factors for inflammatory bowel disease: an umbrella review by Tingping Wu, Honghui Cheng, Jiamei Zhuang, Xianhua Liu, Zichen Ouyang, Rui Qian

“…The findings in this paper help to develop better prevention and treatment measures to reduce the incidence of IBD, delay its progression, and reduce the burden of IBD-related disease worldwide.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023417175.…”
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Dose-Escalated Hypofractionated Intensity-Modulated Radiotherapy in High-Risk Carcinoma of the Prostate: Outcome and Late Toxicity by David Thomson, Sophie Merrick, Ric Swindell, Joanna Coote, Kay Kelly, Julie Stratford, James Wylie, Richard Cowan, Tony Elliott, John Logue, Ananya Choudhury, Jacqueline Livsey

“…Five-year overall survival (OS) was 83% and biochemical progression-free survival (bPFS) was 50% for 57 Gy. …”
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Field switching of microfabricated metamagnetic FeRh MRI contrast agents by Stephen Dodd, Natalia Gudino, Oleksii Zadorozhnii, Michal Staňo, Jan Hajduček, Jon Ander Arregi, H. Douglas Morris, Vojtěch Uhlíř, Mladen Barbic, Alan P. Koretsky

“…A thin-film (200 nm) FeRh sample was fabricated and patterned into an array of progressively smaller squares with sizes ranging from 500 μm down to 1 μm. …”
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Selenium’s Role in Plant Secondary Metabolism: Regulation and Mechanistic Insights by Yan Zhou, Kaiqin Nie, Lulu Geng, Yixin Wang, Linling Li, Hua Cheng

“…By integrating existing research progress, this paper will delve into the potential molecular regulatory mechanisms of Se on plant secondary metabolism, aiming to unravel the interplay between Se and plant secondary metabolism. …”
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Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children by Alina Paganini, Nora Fritschi, Cornelia Filippi, Nicole Ritz, Urs Simmen, Katrin Scheinemann, Andreas Filippi, Tamara Diesch-Furlanetto

“…Abstract Salivary cytokines have the potential to serve as biomarkers for evaluating cancer progression and treatment response in specific cancer types. …”
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The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis by Kun Meng, Yuying Li, Xiaoyi Yuan, Hui-Min Shen, Li-Ling Hu, Danya Liu, Fujin Shi, Dandan Zheng, Xinyu Shi, Nengqiao Wen, Yun Cao, Yun-Long Pan, Qing-Yu He, Chris Zhiyi Zhang

“…However, the importance and underlying mechanisms of these microproteins in alternative splicing-driven tumor progression have rarely been studied. Here, we show that the novel protein TPM3P9, encoded by the lncRNA tropomyosin 3 pseudogene 9, exhibits oncogenic activity in clear cell renal cell carcinoma (ccRCC) by enhancing oncogenic RNA splicing. …”
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Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase by Thomas Große-Steffen, Thomas Giese, Nathalia Giese, Thomas Longerich, Peter Schirmacher, G. Maria Hänsch, Matthias M. Gaida

“…Because in pancreatic cancers the transition to a mesenchymal phenotype coincides with the PMN infiltrate, a contribution of the inflammatory response to the induction of EMT and—by implication—to tumor progression is possible.…”
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Determination of the copy numbers of type A porcine endogenous retroviruses in domestic pigs and wild boars by R. B. Aitnazarov, N. S. Yudin, R. S. Kiril’chuk, N. N. Kochnev, S. P. Knyazev, M. I. Voevoda

“…To solve this problem, the use of animal organs and tissues for grafting to humans (xenografts) has been proposed. However, the progress in this direction is hampered by the risk of zoogenous infection of recipients. …”
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Quantum Fisher information of N-level atoms under the influence of the thermal field and the Stark effect by S. Jamal Anwar, M. Ibrahim, M. Khalid Khan, Haifa S. Alqannas, S. Abdel-Khalek

“…The QE of a higher dimensional atomic system such as the 5-level atom increases with the evolution of time at larger values of the SS parameter, and it also sustains as time progresses. The effect of the SS is more prominent on the 5-level atomic system. …”
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Expression of Annexin-A1 and Galectin-1 Anti-Inflammatory Proteins and mRNA in Chronic Gastritis and Gastric Cancer by Yvana Cristina Jorge, Mayra Mioto Mataruco, Leandro Pires Araújo, Ana Flávia Teixeira Rossi, Juliana Garcia de Oliveira, Marina Curado Valsechi, Alaor Caetano, Kenji Miyazaki, Célia Sebastiana de Jesus Fazzio, Jorge Alberto Thomé, Paula Rahal, Sonia Maria Oliani, Ana Elizabete Silva

“…The anti-inflammatory proteins annexin-A1 and galectin-1 have been associated with tumor progression. This scenario prompted us to investigate the relationship between the gene and protein expression of annexin-A1 (ANXA1/AnxA1) and galectin-1 (LGALS1/Gal-1) in an inflammatory gastric lesion as chronic gastritis (CG) and gastric adenocarcinoma (GA) and its association with H. pylori infection. …”
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Chemotherapeutic hormesis induced by the tumor microenvironment in refractory ovarian cancer by Xuboya Chang, Satoshi Tamauchi, Atsushi Nakagawa, Wang Xinyuan, Kosuke Yoshida, Akira Yokoi, Nobuhisa Yoshikawa, Hiroaki Kajiyama

“…Mechanistically, low-dose CDDP upregulates pathways involved in cell cycle progression, specifically the G2/M checkpoint and mitotic spindle formation, accelerating rather than arresting the cell cycle. …”
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Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection by Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Jinkang Li, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Yu He, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng

“…Since 2017, the morbidity and mortality rates associated with ARV infection in poultry have been on the rise, progressively emerging as a significant viral disease impacting the duck farming industry in China. …”
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Reinspecting the Climate-Crop Yields Relationship at a Finer Scale and the Climate Damage Evaluation: Evidence from China by Yongbin Zhu, Yajuan Shi, Changxin Liu, Bing Lyu, Zhenbo Wang

“…Compared to previous studies, our model introduced monthly climate variables in the production function of crops, which enables separating the yield changes induced by climate change and those caused by inputs variation and technique progress, as well as examining different climate effects during each growing stage of crops. …”
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High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance by Masanori Nakata, Boyang Zhang, Yifei Yang, Takashi Okada, Norihito Shintani, Hitoshi Hashimoto, Toshihiko Yada

“…Antagonism of VPAC1-R may prevent progression of HFD-induced insulin resistance in the liver, providing a novel antidiabetic strategy.…”
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Do Increased Doses to Stem-Cell Niches during Radiation Therapy Improve Glioblastoma Survival? by Sebastian Adeberg, Semi Ben Harrabi, Nina Bougatf, Denise Bernhardt, Angela Mohr, Juliane Rieber, Christian Koelsche, Stefan Rieken, Juergen Debus

“…We aimed to analyze the effect of higher radiation doses to the stem-cell niches on progression-free survival (PFS) and overall survival (OS) in glioblastoma patients. …”
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Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats by Evon S. Ereifej, Seth M. Meade, Cara S. Smith, Keying Chen, Nanette Kleinman, Jeffrey R. Capadona

“…Nine-week-old, 225–250 gram male rats were reported to experience tremor progressing to seizures within minutes after given injections of resveratrol (30 mg/kg) dissolved in a 40 : 60 propylene glycol/corn oil vehicle solution by direct intraperitoneal (IP) slow bolus injection or via a preplaced intraperitoneal catheter. …”
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Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study of Safety, Efficacy, and Cost-Effectiven... by Linu A. Jacob, S. Aparna, K. C. Lakshmaiah, D. Lokanatha, Govind Babu, Suresh Babu, Sandhya Appachu

“…The incidence of Acute Myeloid Leukemia (AML) increases progressively with age and its treatment is challenging. …”
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Hybrid Onboard Smartphone Sensors Measurements to Improve Heading Estimation for Indoors Positioning Solutions by Haval Darwesh Abdalkarim, Halgurd Sarhang Maghdid

“…In the last decade, there is a significant progression and huge demand in using technology; specifically, those technologies are embedded in smartphones (SP). …”
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Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer by Wang Caixia, Peng Changsheng, Xie Chuan

“…In all cases or in cases treated with platin, high expression of MFAP4 and EFEMP1 was linked to shortened overall survival and progression-free survival. MFAP4 and EFEMP1 were positively correlated with epithelial–mesenchymal transition, TGF-β signaling, KRAS signaling, and so on. …”
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