Measurement and influencing factors of urban waterfront street vitality from the perspectives of behavior and perception by Xiang Ji, Yao Fu, Jiaxuan Shi, Haixiao Liu

“…Serving as the direct interface for interaction between the waterfront and urban dwellers, the street space environment significantly influences people’s living experiences and social interactions. Despite progress in the renovation and development of waterfront streets, these areas remain underutilized and lack the vitality expected of such locations. …”
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Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes by Yunus E. Dogan, Yunus E. Dogan, Yunus E. Dogan, Niharika Bala, Niharika Bala, Erika S. Galban, Erika S. Galban, Russell L. Lewis, Nancy D. Denslow, Sihong Song, Abdel A. Alli, Abdel A. Alli

“…IntroductionRecombinant alpha-1 antitrypsin (AAT) therapy has been shown to have beneficial effects to mitigate the progression of various diseases. Here, we hypothesized that administration of pharmaceutical-grade human AAT (hAAT) is effective in mitigating hypertension induced by salt-loading in juvenile mice by reducing the concentration of diacylglycerols (DAGs) and activity of protein kinase C (PKC) in the kidney.MethodsFour-week old 129Sv mice were salt-loaded to induce hypertension and then administered hAAT or vehicle.ResultsAdministration of hAAT was found to significantly reduce high blood pressure in both the active and inactive cycles of the 129Sv hypertensive mice. …”
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Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis by Jiasheng Xu, Kaili Liao, Weimin Zhou

“…It is well known that these cells communicate with each other and thereby regulate the progression of the tumor. Recent studies have provided evidence that exosomes mediate the interactions between different types of cells in the tumor microenvironment, providing further insight into how these cells interact through exosome signaling. …”
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The impact of environmental fees to taxes on total factor productivity of manufacturing enterprises: empirical evidence from China by Jing Huang, Zhaoyang Zhao, Xinjing Yang, Yuhang Tian

“…Additionally, while effective management practices have a positive moderating effect, financing constraints hinder this progress. (3) the impact of the TEPFT on TFP is particularly pronounced in state-owned enterprises and in provinces where tax rates are elevated.…”
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The Impact of Spatial Dynamic Error on the Assimilation of Soil Moisture Retrieval Products by Xuesong Bai, Zhengkun Qin, Juan Li, Shupeng Zhang, Lili Wang

“…The results clearly demonstrate that for soil variable assimilation studies with strong spatial heterogeneity, progressively refined dynamic error estimation is a crucial direction for improving land surface assimilation performance.…”
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Management of Diabetes Mellitus in Patients with Chronic Liver Diseases by Yingying Zhao, Huichun Xing, Xiaomei Wang, Weini Ou, Hong Zhao, Ben Li, Yue Li, Ying Duan, Liwei Zhuang, Wei Li, Danying Cheng, Min Quan, Yu Zhang, Shibo Ji

“…Therefore, effective measures to curb the occurrence and development of diabetes assist in improving patients’ quality of life, delay the progression of DM in the population, and ease a social burden. …”
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Internal Astigmatism and Its Role in the Growth of Axial Length in School-Age Children by Liangcheng Wu, Chenghai Weng, Fei Xia, Xiaoying Wang, Xingtao Zhou

“…IA was observed to be associated with AL and might be a risk factor of the onset and progress of myopia in school-age children.…”
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TLR2 Derangements Likely Play a Significant Role in the Inflammatory Response and Thrombosis in Patients with Ph(−) Classical Myeloproliferative Neoplasm by Jen Chin Wang, Guanfang Shi, Chi Chen, Ching Wong, Vladimir Gotlieb, Gardith Joseph, Kiron V Nair, Lakshmi Boyapati, Enayati Ladan, James T. Symanowski, Lishi Sun

“…These data suggests that MPNs initially involve TLR2, with minor contributions from TLR4, and with S100A9, leading to ROS formation, JAK2 mutation, and progression to MF or leukemia. Furthermore, patients with JAK2 mutations or leukocytosis exhibited higher TLR2 expression. …”
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Impact of frequent ARID1A mutations on protein stability provides insights into cancer pathogenesis by Rajen K. Goutam, Gangtong Huang, Exequiel Medina, Feng Ding, William J. Edenfield, Hugo Sanabria

“…Despite the frequency of mutations, the impact on ARID1A’s stability and contribution to cancer progression remains unclear. We analyzed five frequent missense mutations R1020S, M1022K, K1047Q, G1063V, and A1089T identified in The Cancer Genome Atlas (TCGA) to assess their effects on the stability of the ARID domain using a hybrid experimental and computational approach. …”
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Transcriptome analysis of liver injury of fatty liver disease induced by ALDH2 deficiency by Ziying Xu, Yagang Gao, Zihui Yu, Rui Zhang, Ruikun Wang, Shang Li, Shuowen Wang, Bing Du, Ziyan Tian, Lijuan Huang, Zanbo Ding, Jing Yuan

“…The study underscores the impact of Aldh2 deficiency and HiAlc Kpn on NAFLD progression, revealing potential therapeutic strategies. …”
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Analysis of long noncoding gene expression and its interactions with protein-coding genes in vascular endothelial cells in keloids by Yunxiang Luo, Zi Ye, Yi Li, Chau Wei Wong, Shuqia Xu, Yu Deng, Zhicheng Su, Xueqing Li, Yingxiong Huang, Bing Han

“…Conclusions Through the in-depth mining of keloid microarray data using bioinformatic methods, we speculated that VECs can affect the development and progression of keloids by epigenomic regulation via lncRNA‒mRNA interactions.…”
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IVS1 −397T>C Estrogen Receptor α Polymorphism Is Associated with Low-Grade Systemic Inflammatory Response in Type 1 Diabetic Girls by Monika Ryba-Stanisławowska, Karolina Rybarczyk-Kapturska, Agnieszka Brandt, Małgorzata Myśliwiec, Jolanta Myśliwska

“…This finding may help the physicians to predict the onset and progression of diabetic microvascular complications.…”
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The Relationship between a New Biomarker of Vagal Neuroimmunomodulation and Survival in Two Fatal Cancers by Y. Gidron, M. De Couck, D. Schallier, J. De Greve, J. L. Van Laethem, R. Maréchal

“…The vagus nerve may slow tumor progression because it inhibits inflammation. This study examined the relationship between a new vagal neuroimmunomodulation (NIM) index and survival in fatal cancers. …”
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Omega-3 Polyunsaturated Fatty Acids Enhance Neuronal Differentiation in Cultured Rat Neural Stem Cells by Masanori Katakura, Michio Hashimoto, Toshiyuki Okui, Hossain Md Shahdat, Kentaro Matsuzaki, Osamu Shido

“…Furthermore, AA did not affect the number of Tuj-1-positive cells or cell cycle progression. These results indicated that EPA could be involved in neuronal differentiation by mechanisms alternative to those of DHA, whereas AA did not affect neuronal differentiation in NSCs.…”
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Self-sovereign management scheme of personal health record with personal data store and decentralized identifier by Tong Min Kim, Taehoon Ko, Byoung Woo Hwang, Hyung Goo Paek, Wan Yeon Lee

“…Conventional personal health record (PHR) management systems are centralized, making them vulnerable to privacy breaches and single points of failure. Despite progress in standardizing healthcare data with the FHIR format, hospitals often lack efficient platforms for transferring PHRs, leading to redundant tests and delayed treatments. …”
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Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis by Ningyang Gao, Li Ding, Jian Pang, Yuxin Zheng, Yuelong Cao, Hongsheng Zhan, Yinyu Shi

“…Metabolites like ethanol and tyrosine might participate differentially in OA and RA progression via the gap junction pathway and phagosome pathway, respectively. …”
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The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) by Øyvind Helgeland, Jens K. Hertel, Anders Molven, Helge Ræder, Carl G. P. Platou, Kristian Midthjell, Kristian Hveem, Ottar Nygård, Pål R. Njølstad, Stefan Johansson

“…Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD). The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between the adjacent regions is not fully addressed. …”
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Chronic non-communicable diseases in patients and families with retinitis pigmentosa by Raisa Hernández Baguer, Raisa Ivis Beltràn Saìnz, Asunciòn Fortunata Rodrìguez Morris, Dagmara Magdalena Cordero Ruiz, Loida Mevis Savòn George, Bàrbara Cid Vàzquez

“…<p><strong>Background:</strong> retinitis pigmentosa, an ocular disease of genetic origin and low prevalence, slowly progresses over years towards severe visual impairment and affects social performance. …”
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Demise of Kreutz Sungrazing Comet C/2024 S1 (ATLAS) by David Jewitt, Jane Luu, Jing Li

“…We find that the coma scattering cross section peaked near 0.075 au and faded progressively, by a factor  ∼20, toward the last observation at 0.02 au. …”
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Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon by Ying Zheng, Benjamin Moorlach, Desiree Jakobs-Schönwandt, Anant Patel, Chiara Pastacaldi, Stefan Jacob, Ana R. Sede, Manfred Heinlein, Minna M. Poranen, Karl-Heinz Kogel, Maria Ladera Carmona

“…Leaf application of dsRNA to the cereal model species Brachypodium distachyon suppressed the progression of leaf blast disease. Notably, the sequence-unspecific effect of dsRNA depends on higher doses, while pure sequence-specific effects were observed at low concentrations of dsRNA ( < 0.03 ng/µL). …”
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