Androgen receptor dynamics in prostate cancer: from disease progression to treatment resistance by Caihong Li, Dongkai Cheng, Peng Li

“…Mutations and amplifications of the AR are closely associated with disease progression and treatment resistance. While traditional therapies such as androgen deprivation therapy (ADT) and AR antagonists like enzalutamide have been effective, resistance persists due to reactivation of AR signaling through mechanisms like ligand-independent activation. …”
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Research progress of powder metallurgical nano-particulate reinforced titanium matrix composites by LI Shaopeng, SUI Xiaodong, WANG Meiqi, XIAO Shan, HAN Yuanfei, WANG Xiangming

“…This paper reviews the research progress of the process features，fabrication methods，microstructure characteristics and mechanical properties，analyses and identifies a series of fundamental issues such as dispersion and heat stability of nano-reinforced material that constrain its development，and proposes the directions for future research. …”
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Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer by Biying Wang, Lunmin Bao, Xiaoduo Li, Guang Sun, Wu Yang, Nanzi Xie, Ling Lei, Wei Chen, Hailong Zhang, Man Chen, Xing Zhao, Xiufang Wan, Rui Yuan, Hongmei Jiang

“…Abstract Background Human kinesin family member 11 (KIF11) plays a vital role in regulating the cell cycle and is implicated in the tumorigenesis and progression of various cancers, but its role in endometrial cancer (EC) is still unclear. …”
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Mechanistic insights toward progress in alogliptin beyond glycemic control: translational perspective by Faraha Ahmed, Syed Sufian Ahmad, M. Mumtaz Alam, M. Shaqiquzzaman, Abul Kalam Najmi, Mohammad Ahmed Khan

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The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection by Rongrong Yang, Qianhui Chen, Fangzhou Jiao, Xingxia Yu, Yong Xiong

“…Risk factors related with the progression of liver diseases were included in both univariable and multivariable logistic regression. …”
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Recent Progress of Graphene-Based Photoelectrode Materials for Dye-Sensitized Solar Cells by Kaustubh Patil, Soheil Rashidi, Hui Wang, Wei Wei

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Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression by Yicheng Zhu, Jiaoshun Chen, Chen Chen, Rong Tang, Jin Xu, Si Shi, Xianjun Yu

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Identification of core biomarkers for tuberculosis progression through bioinformatics analysis and in vitro research by Zhanpeng Chen, Qiong Wang, Quan Ma, Jinyun Chen, Xingxing Kong, Yuqin Zeng, Lanlan Liu, Shuihua Lu, Xiaomin Wang

“…These four genes may serve as core biomarkers for TB progression and can be utilized in the development of more effective anti-tuberculosis drugs and host therapy.…”
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Research progress on modeling of heavy metal adsorption by biochar based on machine learning by FENG Ding, LIU Jingjing, MA Wendan, LIU Yuxue, YANG Chen, ZHANG Mengmeng

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MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry Study by Valentina Fioravanti, Francesca Benuzzi, Luca Codeluppi, Sara Contardi, Francesco Cavallieri, Paolo Nichelli, Franco Valzania

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Recent advances in the role of high-salt diet in anti- and pro-cancer progression by Shiwei Tang, Juan Xu, Ping Wan, Ping Wan, Ping Wan, Shumen Jin, Ying Zhang, Ying Zhang, Linting Xun, Linting Xun, Jinli Wang, Jinli Wang, Mei Luo, Mei Luo, Wenjie Chen, Wenjie Chen, Zan Zuo, Zan Zuo, Zan Zuo, Hui Tang, Hui Tang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi

“…Dietary behaviors significantly influence tumor progression, with increasing focus on high-salt diets (HSD) in recent years. …”
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Research Progress of Hydrological Big Data Based on CiteSpace Knowledge Graph by MENG Lu, YANG Haibo

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Progress Analysis and Development Prospects of Soil Ecological and Environmental Effects of Interlayer Construction by JIA Zhenjiang, WU Yangyang, LI Wangcheng, MA Dongxiang, CHEN Jihong, GAO Susu, NIU Xiaoxiao, XU Tianyuan

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Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers by Gautam Kundu, Selvakumar Elangovan

“…<b>Methods</b>: In this study, we conducted a further examination of the transcriptomic expression profile of SPP1 (Osteopontin) during the progression of cancer in four human tissues, breast, prostate, renal and skin, in order to understand the circumstances conducive to its activation and dysregulation, the biological pathways and other mechanisms involved as well as differences in its splicing patterns influencing its expression and functionality. …”
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Correction: Predictive modeling of ALS progression: an XGBoost approach using clinical features by Richa Gupta, Mansi Bhandari, Anhad Grover, Taher Al-shehari, Mohammed Kadrie, Taha Alfakih, Hussain Alsalman

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Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy by Na Liu, Liuqing Xu, Yingfeng Shi, Shougang Zhuang

“…Recent studies suggest that activation of autophagy in podocytes may be a potential therapy to prevent the progression of DN. Here, we review the mechanisms of autophagy in podocytes and discuss the current studies about alleviating proteinuria via activating podocyte autophagy.…”
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Survival and Disease Progression in Older Adult Patients With Cirrhosis: A Retrospective Study by Khaled Al-Smadi, Ammar Qureshi, Michelle Buitrago, Besher Ashouri, Zeid Kayali

“…A prospective study is needed to further investigate the effect of age and obesity on survival and disease progression in older adult patients with cirrhosis.…”
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Global asymptotic properties of staged models with multiple progression pathways for infectious diseases by Andrey V. Melnik, Andrei Korobeinikov

“…We consider global asymptotic properties of compartment staged-progression models for infectious diseases with long infectious period, where there are multiple alternative disease progression pathways and branching. …”
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The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids by Hui Tang, Jing Lu, Yazhuo Duan, Dejun Li

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Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment by Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke

“…HIF-1α-mediated tumor hypoxia drives angiogenesis, immune suppression, and extracellular matrix remodeling, creating an environment that promotes tumor progression and resistance to immunotherapies. HIF-1α regulates critical pathways, including the expression of vascular endothelial growth factor and immune checkpoint upregulation, leading to tumor-infiltrating lymphocyte dysfunction and recruitment of immunosuppressive cells like regulatory T cells and myeloid-derived suppressor cells. …”
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