Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects by Lei Wei, Sijie Ou, Youshi Meng, Lanfeng Sun, Lin Zhang, Yuling Lu, Yuan Wu

“…These patients experience progressive neuronal damage and poor outcomes. Therefore, there is an urgent need for disease-modifying therapy (DMT) that targets the pathogenesis of epilepsy. …”
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Evidence of pockmarks and seafloor gas venting in the northwestern Arabian Sea by Ahmed Abdelmaksoud, Aisha H. Al-Suwaidi, Moamen Ali, Azeem Shah, Sara S. Almehairbi, Lamia M. Al Ali, Mohammed Y. Ali

“…Thirty-five active gas bubble trains were observed, mostly not coincident with the mapped pockmarks. With progressive gas release, the gas seeps are anticipated to lead to development of pockmarks over time. …”
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Christology and the Catholic Encounter with World Religions by Francis V. Tiso

“…This essay takes note of recent trends in Christology, suggesting correction courses for both progressive and traditionalist approaches.…”
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The Political Economy of Tourism in Brazil (2003-2016): a “Positive” yet still Neoliberal Agenda? by Thiago Duarte Pimentel, Mariana Pereira Chaves Pimentel, Marcela Costa Bifano de Oliveira, Dominic Lapointe

“…According to our interpretative framework, we argue that this transformation stemmed from the positive alignment of macrosocial factors (such as the absence of crisis, coupled with international economic expansion driven by demand and a progressive national strategy) with the national agenda, creating favorable conditions for the expansion and diversification of the tourism sector in Brazil. …”
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Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes by Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Viviani

“…In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. …”
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A narrative review of proactive palliative care models for people with COPD by Amy Pascoe, Xinye Chen, Natasha Smallwood

“…Chronic obstructive pulmonary disease (COPD) refers to a group of lung diseases that are distinct in underlying aetiology but share a common disease course of persistent and progressive airflow restriction. People living with COPD, as well as the people who care for them, frequently have severe and unmet physical and psychosocial needs, including breathlessness, fatigue, cough, anxiety and depression. …”
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“Social Elevator”: Research of Affirmative Action Program by E. A. Tarasova

“…It was assumed that students of the program would show higher performance than their peers admitted on a general basis – this assumption follows from qualitative research that found that students of this program possess a progressive narrative of overcoming inequality. Regression with dummy variables based on administrative data on student performance and survey data on the socio-economic status of students are used for the analysis. …”
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Manipal model of telepsychiatry by Ravindra N. Munoli, P Rajeshkrishna Bhandary, Podila Sathya Venkata Narasimha Sharma

“…In the last eight years, four centers of Karnataka state have been covered under this model with progressive growth in a number of patients and this acted as a hands-on training model for the postgraduate trainees in starting telepsychiatry services independently. …”
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Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature by Mayuresh Naik, Anuj Mehta, Neha Mehrotra, Anil Solanki

“…A 2-year-old male child presented with a painless progressive mass in the inferolateral aspect of right orbit of three-month duration. …”
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Combination Immunosuppressive Therapy in Primary Autoimmune Inner Ear Disease in Pregnancy by Saikrishna Ananthapadmanabhan, Joe Jabbour, David Brown, Vanaja Sivapathasingam

“…Autoimmune inner ear disease (AIED) is a rare disorder characterized by rapidly progressive, sensorineural hearing loss that demonstrates good responsiveness to corticosteroid and immunosuppressive therapy. …”
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MITIGATING STRATEGIES OF THREATS TO QUANTITY SURVEYING PROFESSION IN THE NIGERIAN CONSTRUCTION INDUSTRY by Lekan Ojo, Bolarinwa Ibrahim, Ayodeji Oke, Akinsanmi Akindeinde

“…The factor analysis conducted grouped the mitigating strategies into four major groups, namely practice, knowledge, progressive learning and ethics. These groupings were discussed within the context of the study and in relation with previous researches. …”
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Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence by Lyudmila V. Savvateeva, Svetlana I. Erdes, Anton S. Antishin, Andrey A. Zamyatnin

“…As an autoimmune disease, CD is manifested in the small intestine in the form of a progressive and reversible inflammatory lesion due to immune response to self-antigens. …”
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Novel SMAD3 Mutation in a Patient with Hypoplastic Left Heart Syndrome with Significant Aortic Aneurysm by Kristi K. Fitzgerald, Abdul Majeed Bhat, Katrina Conard, James Hyland, Christian Pizarro

“…We identified a novel SMAD3 mutation in a patient with hypoplastic left heart syndrome (HLHS) who developed progressive aortic aneurysm requiring surgical replacement of the neoaortic root, ascending aorta, and proximal aortic arch. …”
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Classification of LEED World Standard Indicators in Sustainable Architecture of Contemporary Iranian Cities Based on Regional Ecological Characteristics: A Case Study of Qom City by Hassan Haji Amiri, Arash Seghfi Asl, mehdi ashjaee

“…Using the Sustainable Architecture approach based on the principles of world standard is one of the most effective steps in this field. Progressive research, combined with the LEED World Standard Code of Conduct as a basis for evaluation, has revised the classification of the indicators of this Code based on biological and indigenous characteristics in the Qom city. …”
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Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis by Catarina Araújo, Cristina Resende, Francisco Pardal, Celeste Brito

“…She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. …”
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Hyperparathyroidism Jaw Tumor Syndrome Presenting as Recurrent Femur Fractures in a Young Woman; a Rare Presentation of a Rare Disease by Piyumi S. A. Wijewickrama, Noel P. Somasundaram

“…Hyperparathyroidism jaw tumor syndrome is an important diagnosis to consider in a young patient presenting with classic clinical features due to the risk of malignancy, familial involvement, and need to monitor for progressive systemic manifestations. As this is a rare disease, it can often be missed due to low degree of suspicion and the ability of the jaw tumor to mimic a metastatic deposit.…”
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The Biphasic Effect of Vitamin D on the Musculoskeletal and Cardiovascular System by Armin Zittermann

“…Cohort studies report a progressive increase in cardiovascular disease (CVD) events at 25OHD levels < 50 nmol/L. …”
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PSFCS: Robust Emergency Communications Supporting High Mobility Based on WiMAX MMR Networks by Wen-Kang Jia, Chia-Yao Chen, Yaw-Chung Chen

“…Since it is difficult to fully eliminate the Doppler effect under high speed moving environment, we propose an enhanced CRC-based error correction scheme that carries as much extra segmented frame Check Sequence (FCS) information as subblocks of emergency multicast/broadcast service (MBS) frame, called progressive and selective frame check sequence (PSFCS). …”
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Spatiotemporally Combined Dimensionality Reduction Algorithm for Optimizing Long-term Operation of Multi-reservoir Systems by CHEN Jia, ZHANG Hanjun, XU Nan

“…To alleviate the “curse of dimensionality” and improve the solution efficiency while ensuring the quality of solutions in optimizing the operation of multi-reservoir systems,this paper proposes a spatiotemporally combined dimensionality reduction algorithm which integrates and improves the dynamic programming with successive approximation (DPSA) and the progressive optimality algorithm (POA).First,a chain-based successive approximation strategy is proposed to expand the DPSA's optimization mode from “single reservoir alternation” to “cascade reservoir chain alternation”,which makes up for the DPSA's shortcomings in dealing with the hydraulic coupling relationships among cascade reservoirs.Then,a dynamic variable decoupling strategy and perturbation mechanism are proposed to deal with the POA's blind search problem and dimensionality problem.Finally,the two improved algorithms are combined,in which the improved POA is applied to solving the optimization problems of cascade reservoir chains under the framework of the improved DPSA.The power generation operation problem of the cascade reservoirs in the Yuan River Basin of Hunan Province and the classical ten-reservoir problem are utilized to test the performance of the proposed algorithm.The proposed algorithm outperforms seven existing alternatives in terms of solution quality and efficiency.The results indicate that the proposed algorithm can effectively alleviate the “curse of dimensionality” in optimizing the operation of multi-reservoir systems,improve the efficiency while ensuring the quality of solutions and has potential to be applied to optimizing the operation of complex large-scale multi-reservoir systems.…”
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The Doomsday Project, Deep Events, and the Shrinking of American Democracy by Peter Dale Scott

“…The second, closely related, is the progressive shrinking of public politics and the rule of law as they are subordinated, even domestically, to the requirements of covert U.S. operations abroad.The third, also closely related, is the important and increasingly deleterious impact on American history and the global extension of American power, of what I have called deep events. …”
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