Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease by María José Pérez, Rodrigo A. Quintanilla

“…In the AD brain is common to observe the accumulation of senile plaques formed by amyloid-beta (Aβ) peptide and the neurofibrillary tangles composed of modified tau protein, which both lead to cellular damage and progressive neurodegeneration. Currently, there is no effective therapy for AD; however several studies have shown that the treatments with the peroxisome proliferators activated receptor-gamma (PPARγ) agonists known as thiazolidinedione drugs (TZDs), like rosiglitazone and pioglitazone, attenuate neurodegeneration and improve cognition in mouse models and patients with mild-to-moderate AD. …”
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What is “Hyper” in the ALS Hypermetabolism? by Alberto Ferri, Roberto Coccurello

“…The progressive and fatal loss of upper (brain) and lower (spinal cord) motor neurons and muscle denervation concisely condenses the clinical picture of amyotrophic lateral sclerosis (ALS). …”
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Mechanical Behavior of Triaxial Geogrid Used for Reinforced Soil Structures by Jun Zhang, Wen-Zhao Cao, Yan-Jun Zhou

“…The interface friction between the soil and the geogrid develops in a progressive mode, and an elasto-plastic-softening characteristic is detected experimentally due to the extensibility of geogrid.…”
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Transitory Spontaneous Remission of Myelodysplasia in an Elderly Man while Receiving Intravesical Bacillus Calmette-Guérin for Bladder Cancer: A Case Report and Review of the Liter... by Nigel P. Murray, Cynthia Fuentealba, Isidora Salazar, Aníbal Salazar, Marco Antonio Lopez, Simona Minzer

“…Myelodysplasia is a clonal disorder characterized by progressive cytopenias. Intravescial BCG is standard immunotherapy for superficial bladder cancer. …”
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The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease by Kemal Ugur Tufekci, Sermin Genc, Kursad Genc

“…Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. …”
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Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin by Yinka K. Davies, Cynthia J. Tsay, Dario V. Caccamo, Kathleen M. Cox, Ricardo O. Castillo, Kenneth L. Cox

“…Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. …”
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Updates in Biliary Atresia: Aetiology, Diagnosis and Surgery by Mark Davenport

“…Affected infants present with a triad of conjugated jaundice, pale stools, and dark urine and may have hepatosplenomegaly upon examination, with later ascites coincident with the onset of progressive liver disease. Rapid, efficient, and expeditious diagnosis is essential with the initial treatment being surgical, typically with an attempt to restore the bile flow (Kasai portoenterostomy (KPE)) or primary liver transplantation (<5%) if considered futile. …”
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Modeling environmental transmission of MAP infection in dairy cows by Kokum R. De Silva, Shigetoshi Eda, Suzanne Lenhart

“…This model includes the progression of the disease and the age structure of the cows. …”
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Pediatric hypertrophic cardiomyopathy caused by a novel TNNI3 variant by Natsuko Inagaki, Tomoya Okano, Masatake Kobayashi, Masatsune Fujii, Yoshinao Yazaki, Yasuyoshi Takei, Hisanori Kosuge, Shinji Suzuki, Takeharu Hayashi, Masahiko Kuroda, Kazuhiro Satomi

“…The patient exhibited progressive myocardial fibrosis, left ventricular remodeling, and life-threatening arrhythmias. …”
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A 75-Year-Old Female with Hemoptysis and Recurrent Respiratory Infections by Mary S. Baker, Khalil Diab

“…Review of her chest CT upon presentation to the hospital showed a large necrotic lingular infiltrate, which had been progressively increasing in size over at least one year. …”
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A Case of Growth Hormone Use in Dyggve–Melchior–Clausen Syndrome by Ravi Upadhyay, Claire Ruane, Rachel Umans, Beth A. Pletcher, Aditi Khokhar, Kristin Wong

“…Skeletal dysplasia in Dyggve–Melchior–Clausen (DMC) syndrome tends to be progressive, typically with hip involvement, and ultimately leads to bilateral dislocation of the hip joints. …”
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An Unusual Transudative Pleural Effusion Succeeded by Pulmonary and Brain Edema and Death by Sayyed Gholam Reza Mortazavimoghaddam, H. R. Riasi

“…Despite the medical treatment, progressive dyspnea, headache, and high intracranial pressure followed by death nine months after pleurodesis. …”
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Huge Primary Parasitic Leiomyoma in a Postmenopausal Lady: A Rare Presentation by Nkencho Osegi, E. Yilaiba Oku, C. Stanley Uwaezuoke, K. Timothy Alawode, S. Adeniyi Afolabi

“…The case presented is a 58-year-old grand-multiparous, menopausal lady with progressive abdominal swelling of three-year duration. …”
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Du livre à l’information : un tournant historiographique by Jérôme Lamy, Johann Petitjean

“…The third and last debate concerns the finest scriptural materials, examined from the most discrete markers of thought as well as the process, modern, of progressive diversification of the supports during the period. …”
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Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae by J. Gonzales Zamora, A. R. Murali

“…Rhinoscleroma is a chronic, slowly progressive granulomatous bacterial infection that is endemic to the tropical world, namely, Central America and Africa. …”
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Respiratory pathology in the mdx/utrn -/- mouse: A murine model for Duchenne Muscular Dystrophy (DMD). by Marán Y Hernández Rodríguez, Debolina D Biswas, Aoife D Slyne, Jane Lee, Evelyn Scarrow, Sarra M Abdelbarr, Heather Daniels, Ken D O'Halloran, Leonardo F Ferreira, Charles A Gersbach, Mai K ElMallah

“…Duchenne muscular dystrophy (DMD) is an X-linked devastating disease caused by a lack of dystrophin which results in progressive muscle weakness. As muscle weakness progresses, respiratory insufficiency and hypoventilation result in significant morbidity and mortality. …”
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Bilateral Vocal Cord Paralysis and Cervicolumbar Radiculopathy as the Presenting Paraneoplastic Manifestations of Small Cell Lung Cancer: A Case Report and Literature Review by Jeffrey C. Yeung, C. Elizabeth Pringle, Harmanjatinder S. Sekhon, Shaun J. Kilty, Kristian Macdonald

“…A 58-year-old female presented to an Otolaryngology clinic with a history of progressive hoarseness and dysphagia. Flexible nasolaryngoscopy demonstrated BVCP. …”
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A Rare Complication of Tracheal Intubation: Tongue Perforation by Loreto Lollo, Tanya K. Meyer, Andreas Grabinsky

“…A 65-year-old female with intraparenchymal brain hemorrhage with rapidly progressive neurologic deterioration had the airway secured prior to arrival at the referral institution. …”
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Evaluation and Interpretation of Transcriptome Data Underlying Heterogeneous Chronic Obstructive Pulmonary Disease by Seokjin Ham, Yeon-Mok Oh, Tae-Young Roh

“…Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease, featured by airflow obstruction. …”
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‘In physical things a man may invent; in moral things he must obey’: Addressing the Child(like) in George MacDonald’s Fairy Stories by Audrey Doussot

“…MacDonald actually wrote for children as much as for adults, insofar as he wanted to address a reader in particular that he conceptualized as the ‘childlike’, that is, an ideal ageless individual characterized by remarkable innocence and open-mindedness who would be able to grasp his progressive message. The author thus used fantasy to explore the human condition, question commonly-accepted values and certainties and launch his protagonists and readers on a metaphysical quest for meaning and personal improvement. …”
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