Histological Ex Vivo Evaluation of Peri-Incisional Thermal Effect Created by a New-Generation CO2 Superpulsed Laser by G. Palaia, A. Del Vecchio, A. Impellizzeri, G. Tenore, P. Visca, F. Libotte, C. Russo, U. Romeo

“…CO2 laser demonstrated a good surgical effectiveness provoking little peripheral damage onto the cut edges and allowing a safe histological diagnosis.…”
Get full text

Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages by G. Chinetti-Gbaguidi, C. Copin, B. Derudas, N. Marx, J. Eechkoute, B. Staels

“…Here we report that PPARγ activation increases the expression of TFPI-1 in human macrophages in vitro as well as in vivo in circulating peripheral blood mononuclear cells. The induction of TFPI-1 expression by PPARγ ligands, an effect shared by the activation of PPARα and PPARβ/δ, occurs also in proinflammatory M1 and in anti-inflammatory M2 polarized macrophages. …”
Get full text

Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route by Anne-Claire Groo, Thomas Curel, Aurélie Malzert-Fréon, Line Séguy, Ophélie Bento, Sophie Corvaisier, Thomas Culerier, Romain Legrand, Noëlle Callizot, Alexandre Henriques, Georgia Culley, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagne

“…Further, bambuterol, in the form of a liposomal gel, showed a good bioavailability in CNS after intranasal administration, which should reduce any side effects linked to peripheral terbutaline release. Indeed, even if the latter is more selective than other β2-mimetics towards bronchial β2-AR, cardiovascular effects (tachycardia, arrhythmias…) could occur upon cardiac β1-AR activation. …”
Get full text

Glial fibrillary acidic protein and S100b protein immunoreactivity in the hippocampus of weaning rats from dams treated with acrylamide during pregnancy by Karol Rycerz, Aleksandra E. Krawczyk, Jadwiga Jaworska-Adamu, Ewa Tomaszewska, Siemowit Muszyński, Piotr Dobrowolski, Marcin Arciszewski

“…It was demonstrated that acrylamide has a neurotoxic effect in newborn animals in both the central and peripheral nervous system after prenatal exposure to this substance. …”
Get full text

Clinical and genetic analysis of a Chinese family with GM1 gangliosidosis caused by a novel mutation in GLB1 gene by Biao Zhang, Xiao-li Huang, Xin-xin Lu, Heng-bin Huang, Yan-an Wu

“…Two siblings and their parents underwent WES of the peripheral blood. A reported missense mutation c.446C>T and a novel mutation c.1058_1059delinsAA in GLB1 gene inherited from the mother and father respectively were identified. …”
Get full text

Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…We confirmed that Elo strongly promoted NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) against SLAMF7-positive MM cells in a CD16-dependent NK cell line, and also activated expanded NK cells derived from peripheral blood mononuclear cells of healthy donors and patients with MM in the present study. …”
Get full text

Functional analysis of a novel homozygous missense IVD gene variant: a case report with dual genetic diagnoses by Yuying Zhu, Ke Wu, Hanying Wen

“…Herein, we are the first to report a 5-year-old boy with the blended phenotypes of infantile hypotonia, severe neurodevelopmental disorder, patent ductus arteriosus, cryptorchidism, obesity, distinctive facial features, and elevated isovaleryl carnitine.MethodsTrio-based whole-exome sequencing was performed on genomic DNA from peripheral blood samples from the boy and his parents. …”
Get full text

Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris by Lei Ma, HaiBo Xue, Tianqin Gao, MeiLan Gao, YuJie Zhang

“…Notch1, Hes-1, RORγt, Foxp3, IL-17, and IL-10 mRNA expression, as well as Th17 and Treg cell percentages in peripheral CD4+ T cells, were detected by real-time quantitative RT-PCR and flow cytometry, and serum concentrations of IL-17 and IL-10 were detected by ELISA in 36 PV patients and 32 healthy controls. …”
Get full text

Donkey whey proteins ameliorate dextran sulfate sodium-induced ulcerative colitis in mice by downregulating the S100A8-TRAF6-NF-κB axis-mediated inflammatory response by Mohan Li, Qilong Li, Rayhnigul Abdlla, Jiali Chen, Xiqing Yue, Siew Young Quek

“…In addition, DWPs significantly decreased NF-κB and CD86 levels more than BWPs or the negative control in both LPS-stimulated human peripheral blood mononuclear cells or cell lines. These findings indicate that DWPs comprise a promising anti-colitis functional food, and this work has established a foundation for future research on these compounds.…”
Get full text

GENDER AND AGE SPECIFIED PREVALENCE OF OSTEOPOROSIS ANDOSTEOPENIA IN AN APPARENTLY HEALTHY PAKISTANI POPULATION by Zuneera Akram, Fatima Zahra, Rehana Perveen, Muzammil Hussain, Aisha Noreen, Maryam Inayat, Sobia Akhter, Usman Ghani Farooqi

“…According to the category of age - groups (20–29, 30–39, 40–49, 50–59, 60–69, and =70 years) in males osteoporosis rate were 30, 20, 20, 10, 10, and 10 percent respectively, while prevalence in females were 8.33, 16.66, 8.33, 25, 25, and 16.66 percent respectively, at peripheral (radius) bone. Body mass index, and lifestyle including (smoking, physical activity, and diet) were correlated with BMD. …”
Get full text

Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing by Sabrina Valente, Carmen Ciavarella, Emanuela Pasanisi, Francesca Ricci, Andrea Stella, Gianandrea Pasquinelli

“…Vascular ulcers are a serious complication of peripheral vascular disease, especially in diabetics. …”
Get full text

Application of Anterior Segment Optical Coherence Tomography in Pediatric Ophthalmology by Ricardo Salles Cauduro, Caroline do Amaral Ferraz, Maira Saad Ávila Morales, Patricia Novita Garcia, Yara Cristina Lopes, Paulo Henrique Souza, Norma Allemann

“…The most common OCT findings were corneal hyperreflectivity and thickening (n=15), shallow anterior chamber with iris-lens diaphragm anterior displacement (n=4), atypical corneal curvature (n=4), corneal thinning (n=4), peripheral synechiae with angle closure (n=3), increased anterior chamber depth (n=2), and proximal portion of glaucoma drainage tube (n=2). …”
Get full text

A rare case of extrapelvic endometriosis in the right sciatic notch by Gregory Liller, DO, Sahejmeet Guraya, MD, Nathan Katragadda, BA, Vijaya Kosaraju, MD, Richard Barger, MD, Peter Young, MD, Patrick Getty, MD, Navid Faraji, MD

“…Rarely, endometriosis can manifest outside of the pelvis and can uncommonly involve the musculoskeletal and peripheral nervous systems. Extrapelvic endometriosis is a difficult radiologic diagnosis due to its rarity and varied magnetic resonance imaging (MRI) appearance. …”
Get full text

Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease by Min Joo Kim, Sun Wook Cho, Sumin Choi, Dal Lae Ju, Do Joon Park, Young Joo Park

“…REE positively correlated with thyroid hormone levels, peripheral deiodinase activity, and thyroid’s secretory capacity. …”
Get full text

Evaluation of B cell related markers and autoantibodies in rheumatoid arthritis patients treated with abatacept by Ting Wang, Natalia V. Giltiay, Christian Lood, Ning Wang, Bobby Kwanghoon Han

“…Serum levels of soluble biomarkers were measured with ProcartaPlex by Luminex or ELISA. Peripheral blood mononuclear cells were isolated and analysed for T cell and B cell subsets by flow cytometry. …”
Get full text

Acquired hypothyroidism, iodine status and hearing impairment in adults: A pilot study. by Tereza Grimmichova, Ludmila Verespejova, Zuzana Urbaniova, Martin Chovanec, Martin Hill, Radovan Bilek

“…<h4>Methods</h4>30 patients with untreated and newly diagnosed peripheral hypothyroidism (H) and a control group of 30 healthy probands (C) were enrolled in the study. …”
Get full text

Tissue-resident immune cells: from defining characteristics to roles in diseases by Jia Li, Chu Xiao, Chunxiang Li, Jie He

“…Abstract Tissue-resident immune cells (TRICs) are a highly heterogeneous and plastic subpopulation of immune cells that reside in lymphoid or peripheral tissues without recirculation. These cells are endowed with notably distinct capabilities, setting them apart from their circulating leukocyte counterparts. …”
Get full text

The Role of IL-17 Promotes Spinal Cord Neuroinflammation via Activation of the Transcription Factor STAT3 after Spinal Cord Injury in the Rat by Shaohui Zong, Gaofeng Zeng, Ye Fang, Jinzhen Peng, Yong Tao, Keke Li, Jingmin Zhao

“…ELISA was used to determine the peripheral blood serum levels of IL-6, IL-21, and IL-23. …”
Get full text

Application of ursodeoxycholic acid at non-alcoholic and alcohol-induced steatohepatitis by Ye. A. Fedos’ina, M. V. Mayevskaya

“…Disorders of carbohydrate metabolism (including insulin resistance) serve as the indication for prescription of drugs, that sensitize peripheral tissues to insulin. At alcohol-induced steatohepatitis abstinence is categorical. …”
Get full text

Molecular cloning of EZH2 oncogene in chronic myeloid leukemia and therapeutic prospects by Juliana Costa Gaspar, Lucas Santos de Santana, Camila Menezes Freire de Souza, Marcos Montani Caseiro, Rosane Rezende de Souza Giuliani, Cleide Barbieri de Souza

“…For this reason, the EZH2 gene was isolated from peripheral blood genomic DNA from CML patients and cloned in prokaryotic systems. …”
Get full text