An Assay System for Plate-based Detection of Endogenous Peptide:N-glycanase/NGLY1 Activity Using A Fluorescence-based Probe by Hiroto Hirayama, Tadashi Suzuki

“…This system enables the accurate measurement of endogenous NGLY1 activity in various samples, including cell lines, tissues, peripheral blood mononuclear cells, and NGLY1-deficient patient-derived cells, without the interference of proteolytic degradation. …”
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Multiple Acrometastases in a Patient with Renal Pelvic Urothelial Cancer by Ryoko Sawada, Yusuke Shinoda, Aya Niimi, Tohru Nakagawa, Masachika Ikegami, Hiroshi Kobayashi, Sakae Tanaka, Yukio Homma, Nobuhiko Haga

“…Metastasis may occur in any bone but more commonly occurs in the spine, pelvis, or other axial bones. Metastasis in peripheral bones located distal to the elbow or knee, so-called acrometastasis, is rare. …”
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Lessons Learned from Experimental Human Model of Zinc Deficiency by Ananda S. Prasad

“…Development of sensitive immunological biomarkers may be more sensitive than an assay of zinc in plasma and peripheral blood cells for diagnosis of marginal zinc deficiency in human.…”
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Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes by June Seok Heo, Youjeong Choi, Hyun Ok Kim

“…In this study, adipose-derived MSCs (AdMSCs) and human peripheral blood monocytes (PBMCs) were isolated and cultured to examine the effects of MSC-induced macrophages (iMΦ) on inflammation and immune modulation. …”
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Lack of Disease Specificity Limits the Usefulness of In Vitro Costimulation in HIV- and HCV-Infected Patients by Stefanie Kuerten, Tobias R. Schlingmann, Tarvo Rajasalu, Doychin N. Angelov, Paul V. Lehmann, Magdalena Tary-Lehmann

“…Measurements of antigen-specific T cell responses in chronic diseases are limited by low frequencies of antigen-specific cells in the peripheral blood. Therefore, attempts have been made to add costimulatory molecules such as anti-CD28 or IL-7/IL-15 to ELISPOT assays to increase sensitivity. …”
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Transcatheter Proximal Coil Blocking with n-Butyl-2-Cyanoacrylate Injection via the Pulmonary Artery Alone for Rasmussen’s Aneurysm by Atsushi Ugajin, Hiroyuki Fujii, Hiroyasu Nakamura, Akifumi Fujita, Takahiro Sasaki, Naoko Mato, Hideharu Sugimoto

“…Rasmussen’s aneurysm is a peripheral pulmonary artery pseudoaneurysm (PAP) within a tuberculosis cavity. …”
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Stromal-Cell-Derived Factor-1 (SDF-1)/CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg Ischaemia by Teik K. Ho, X. Shiwen, D. Abraham, J. Tsui, D. Baker

“…In the Western world, peripheral vascular disease (PVD) has a high prevalence with high morbidity and mortality. …”
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VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia by Ioana Cristina Rotar, Diana Elena Dumitras, Radu Anghel Popp, Felicia Maria Petrisor, Paul Cotutiu, Florin Stamatian, Daniel Muresan

“…From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. …”
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Understanding the Immune System and Biospecimen-Based Response in Glioblastoma: A Practical Guide to Utilizing Signal Redundancy for Biomarker and Immune Signature Discovery by Luke R. Jackson, Anna Erickson, Kevin Camphausen, Andra V. Krauze

“…However, there are gaps in the understanding of the intricate interactions between GBM and the peripheral immune system and how these interactions change with standard and immune-modulating treatments. …”
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The role of KNDy neurons in human reproductive health by Aki Oride, Haruhiko Kanasaki

“…Kiss1 neurons in humans are concentrated in the infundibular nucleus (equivalent to the ARC), with few Kiss1 neurons localized to the preoptic area (equivalent to the AVPV), and the mechanisms underlying GnRH surge secretion in humans are poorly understood. However, peripheral administration of kisspeptin to humans promotes gonadotropin secretion, and administration of kisspeptin to patients with hypothalamic amenorrhea or congenital hypogonadotropic hypogonadism restores the pulsatile secretion of GnRH/luteinizing hormone. …”
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HDL Subclass Distribution Shifts with Increasing Central Adiposity by Nicholas J. Woudberg, Sandrine Lecour, Julia H. Goedecke

“…A percentage decrease in large HDL subclasses was associated with a percentage increase in central fat mass (visceral adipose tissue (VAT) area, p<0.05) and a percentage decrease in peripheral fat mass (leg fat mass). These preliminary findings suggest that a relative redistribution of body fat from the periphery to the abdominal region were associated with a decrease HDL subclass size in black South African women and provide a novel link between body fat distribution and lipidology in this population.…”
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Comparison of Chest-to-Back Skin-to-Skin Contact and Chest-to-Chest Skin-to-Skin Contact on the Risk of Oxygen Desaturation and Change in Heart Rate in Low Birth Weight and/or Prem... by Sisay Gere, Yemane Berhane, Alemayehu Worku

“…We used a parallel-group randomized controlled clinical trial. Peripheral arterial blood oxygen saturation (SpO2) and heart rate (HR) were measured using an OxiMaxN-600X Pulse Oximeter. …”
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The Role of Clopidogrel in 2020: A Reappraisal by Giuseppe Patti, Giuseppe Micieli, Claudio Cimminiello, Leonardo Bolognese

“…Antiplatelet therapy is the mainstay of treatment and secondary prevention of cardiovascular disease (CVD), including acute coronary syndrome (ACS), transient ischemic attack (TIA) or minor stroke, and peripheral artery disease (PAD). The P2Y12 inhibitors, of which clopidogrel was the first, play an integral role in antiplatelet therapy and therefore in the treatment and secondary prevention of CVD. …”
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Some Movement Mechanisms and Characteristics in Pebble Bed Reactor by Xingtuan Yang, Yu Li, Nan Gui, Xinlong Jia, Jiyuan Tu, Shengyao Jiang

“…However, this application is held back by the existence of mixing zone between central and peripheral regions, which results from pebbles’ dispersion motions. …”
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Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation by Dylan J. Sebo, Irshad Ali, Audrey R. Fetsko, Aubrey A. Trimbach, Michael R. Taylor

“…Additionally, we discovered a significant increase in the proliferation of microglia and infiltration of peripheral neutrophils indicative of a stereotypical neuroinflammatory response. …”
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The Effects of Nebulized Inhaled Triptolide on Airway Inflammation in a Mouse Model of Asthma by Yafang Miao, Li Wei, Hao Chen, Zeming Zhang, Li Han

“…Then bronchoalveolar lavage fluid (BALF), peripheral blood, and lung tissue were collected. Relevant cytokines, transcriptional factors, and CD4+Th17+ T cell proportions were assessed and compared. …”
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Corneal Transplant Infection due to Alternaria alternata: A Case Report by Vasileios Konidaris, Andreana Mersinoglou, Timoleon-Achilleas Vyzantiadis, Domniki Papadopoulou, Kostas G. Boboridis, Panagiotis Ekonomidis

“…Three weeks after keratoplasty, epithelial edema and a stromal opacity with an infiltrate and development of peripheral corneal opacities appeared. The diagnosis of Alternaria alternata keratitis was made. …”
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Variations of the ulnar nerve within the ulnar tunnel and palm in a select South African population by Lutho Daza, Julia Fernandes, Geney Gunston, Jeshika Luckrajh-Williams

“…Background: Ulnar tunnel syndrome (UTS) is a rare peripheral neuropathy associated with the entrapment of the distal portion of the ulnar nerve (UN) in its course through the fibro-osseous ulnar tunnel (eponymously known as Guyon's canal) at the wrist. …”
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Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension by Carmine Savoia, Lidia Sada, Luigi Zezza, Lorenzo Pucci, Francesco Maria Lauri, Alberto Befani, Alessandro Alonzo, Massimo Volpe

“…Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. …”
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Differences in phenotypes of normal and malignant cells concerning chromosomal fragility and ganglioside expression by Iskra Sainova, Vera Kolyovska, Desislava Drenska, Dimitar Maslarov, Dimitrina Dimitrova-Dikanarova, Tzvetanka Markova

“…The spontaneous chromosomal fragility was tested by light microscopy observation of metaphases from peripheral blood lymphocytes of 8 patients with malignancies and of 8 healthy controls. …”
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