Degradation of amyloid β-peptides catalyzed by nattokinase in vivo and in vitro by Aixin Ni, He Li, Ruya Wang, Rentong Sun, Yingjiu Zhang

“…Amyloid-β 1-42 (Aβ42) plays a pivotal role in Alzheimer disease (AD) pathogenesis. Peripheral clearance of Aβ42 largely affects its level in the brain and affects AD progression. …”
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Towards climate-resilient conservation: Integrating genetics and environmental factors in determining adaptive units of a xeric shrub by Yong-Zhi Yang, Pei-Wei Sun, Chong-Yi Ke, Min-Xin Luo, Jui-Tse Chang, Chien-Ti Chao, Run-Hong Gao, Pei-Chun Liao

“…Population structure analysis revealed both congruences and discrepancies between genetic and climatic clustering, particularly in peripheral regions, suggesting that adaptive genes may not follow isolation-by-distance rules like neutral genes. …”
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B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis by Xin Wei, Weifeng Yao, Huiping Li, Jingjing Qian, Yaosheng Xie, Zhuo Zhang, Hong Lu, Liang Shi, Xiangyang Lin

“…In this study, we evaluated the feedback function of changes in peripheral lymphocyte subsets on the condition of patients with pancreatitis. …”
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Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic Hepatitis B Virus Infected Patients by Juan Lv, Qinglong Jin, Haibo Sun, Xiumei Chi, Xiaoli Hu, Hongqing Yan, Yu Pan, Weihua Xiao, Zhigang Tian, Jinlin Hou, Damo Xu, Zhengkun Tu, Junqi Niu

“…Our results demonstrate that treatment with tenofovir leads to viral load reduction, and correlated with NK cell frequencies in peripheral blood of chronic hepatitis B virus infection. …”
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Specific types of male infertility are correlated with T cell exhaustion or senescence signatures by Giada Amodio, Giorgia Giacomini, Luca Boeri, Massimiliano Raffo, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Fausto Negri, Anna Maria Ferrara, Alessia d’Arma, Francesca Romana Santoni de Sio, Luca Pagliardini, Enrico Papaleo, Eugenio Ventimiglia, Massimo Alfano, Francesco Montorsi, Andrea Salonia, Silvia Gregori

“…We first observe that young infertile men have a pro-inflammatory milieu with increased frequency of myeloid cells and inflammatory mediators in the seminal fluid and the peripheral blood, which are immune alterations typically observed in healthy elderly men. …”
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Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults by Xixiang Wang, Jingjing Xu, Yiyao Gu, Jie Mu, Shaobo Zhou, Xiaojun Ma, Lu Liu, Yu Liu, Zhi Duan, Linhong Yuan, Ying Wang

“…Meanwhile, female subjects with peripheral obesity had a higher risk of abnormal UA levels. …”
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TLR2 Expression in Relation to IL-6 and IL-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math> and their Natural Regulators Production by PMN and...

“…For the purpose of comparison, the same activity of autologous peripheral blood mononuclear cells (PBMCs) was estimated. …”
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Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection by Thais F. C. Fraga-Silva, Luiza A. N. Mimura, Camila M. Marchetti, Fernanda Chiuso-Minicucci, Thais G. D. França, Sofia F. G. Zorzella-Pezavento, James Venturini, Maria S. P. Arruda, Alexandrina Sartori

“…EAE aggravation was associated with expansion of peripheral CD4+ T cells and production of high levels of TNF-α, IFN-γ IL-6, and IL-17 by spleen and CNS cells. …”
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Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis by Rongjiong Zheng, Songsong Xie, Qiong Zhang, Ling Cao, Shaniya Niyazi, Xiaobo Lu, Lihua Sun, Yan Zhou, Yuexin Zhang, Kai Wang

“…The frequencies of Th1, Th2, Th17, Treg, and PD-1 (programmed cell death protein 1) in peripheral blood were examined by flow cytometry, and the expressions of T lymphocyte cytokines in serum were detected by cytometric bead array. …”
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HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia by Grazia Locafaro, Giada Amodio, Daniela Tomasoni, Cristina Tresoldi, Fabio Ciceri, Silvia Gregori

“…DC-10 are present in the peripheral blood and are essential in promoting and maintaining tolerance via the induction of adaptive T regulatory (Treg) cells. …”
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Assessment of Patient’s Satisfaction and Associated Factors regarding Postoperative Pain Management at the University of Gondar Compressive Specialized Hospital, Northwest Ethiopia... by Yosef Belay Bizuneh, Girmay Fitiwi Lema, Demeke Yilkal Fentie, Yophtahe Woldegerima Berhe, Henos Enyew Ashagrie

“…Moreover, we suggested that all patients who underwent major surgery should receive peripheral nerve block as part of multimodal analgesia to decrease the incidence and severity of post op pain.…”
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Mercury Vapour Long-Lasting Exposure: Lymphocyte Muscarinic Receptors as Neurochemical Markers of Accidental Intoxication by E. Roda, A. Giampreti, S. Vecchio, P. Apostoli, T. Coccini

“…Conclusion. l-MRs modulatory effect supports their use as peripheral neurochemical marker in Hg poisoning diagnosis and chelation therapy monitoring.…”
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The Expression of T Cell FOXP3 and T-Bet Is Upregulated in Severe but Not Euthyroid Hashimoto’s Thyroiditis by Stana Tokić, Mario Štefanić, Ljubica Glavaš-Obrovac, Sonja Jaman, Eva Novosadová, Jana Petrkova, Zdenka Navratilova, Mirjana Suver Stević, Martin Petrek

“…In summary, severe but not euthyroid HT was associated with robust upregulation of T-bet and FOXP3 mRNA in peripheral T cells, independent of the thyroid hormone status but proportional to disease activity.…”
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Changes in Corneal Volume at Different Areas and Its Correlation with Corneal Biomechanics after SMILE and FS-LASIK Surgery by Pinghui Wei, George PM Cheng, Jiamei Zhang, Alex LK Ng, Tommy CY Chan, Vishal Jhanji, Yan Wang

“…The central region significantly increased after SMILE, while both central and peripheral regions increased following FS-LASIK in the early postoperative period. …”
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IMRAS-Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS. by Martha Sedegah, Michael R Hollingdale, Harini Ganeshan, Maria Belmonte, Jun Huang, Arnel Belmonte, Sandra Inoue, Rachel Velasco, Bradley Hickey, Nimfa Teneza-Mora, Joanne Lumsden, Sharina Reyes, Jo Glenna Banania, Anatalio Reyes, Ivelese Guzman, Thomas L Richie, Judith E Epstein, Eileen Villasante

“…IFN-γ and IL2 responses to TRAP, CelTOS and CSP occurred only in protected subjects. Peripheral IFN-γ, IL2, and IFN-γ+IL2 responses were short-lived and low by 27 weeks post-CHMI but were restored by boosting.…”
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The role of TRECs/KRECs as immune indicators that reflect immunophenotypes and predict the risk of infection in systemic autoimmune diseases by Takuji Itakura, Hirokazu Sasaki, Tadashi Hosoya, Natsuka Umezawa, Tetsuya Saito, Hideyuki Iwai, Hisanori Hasegawa, Hiroyuki Sato, Akihiro Hirakawa, Kohsuke Imai, Tomohiro Morio, Naoki Kimura, Shinsuke Yasuda

“…In conclusion, TREC and KREC levels reflect peripheral blood immunophenotypes, specifically recent-emigrated T and B cells, in patients under treatment-naïve and immunosuppressive conditions. …”
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Navigating the Collective: Nanoparticle-Assisted Identification of Leader Cancer Cells During Migration by Anastasia Alexandrova, Elizaveta Kontareva, Margarita Pustovalova, Sergey Leonov, Yulia Merkher

“…We observed a significant difference in encapsulation efficiency between leader and peripheral cells for both high-MP (<i>p</i> < 0.013) and low-MP (<i>p</i> < 0.02) cells. …”
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Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury by Akira Ikumi, Yuki Hara, Eriko Okano, Sho Kohyama, Norihito Arai, Yu Taniguchi, Hisashi Sugaya, Tomokazu Yoshioka, Akihiro Kanamori, Masashi Yamazaki

“…Platelet-rich plasma (PRP), an autologous product with proven therapeutic effects for musculoskeletal disorders, is a new treatment option for peripheral nerve injury. We hypothesized that PRP could stimulate healing of digital nerve injuries. …”
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Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain by Wen S. Sheng, Priyanka Chauhan, Shuxian Hu, Sujata Prasad, James R. Lokensgard

“…Links between cannabinoid receptor 2 (CB2R) and peripheral neuropathy have been established in animal models using nerve transection, chemotherapy-induced pain, and various other stimuli. …”
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MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…Abstract Diabetes is an incurable, chronic disease that can lead to many complications, including angiopathy, peripheral neuropathy, and erectile dysfunction (ED). …”
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