Cellular and immune landscape of chronic liver diseases: insights from immunophenotyping by Shaghayegh Soleimani, Shaghayegh Soleimani, Ozgur Albayrak, Kayra Somay, Hong Yang, Buket Yigit, Burge Ulukan, Dila Atak, Murat Akyildiz, Metehan Gursoy, Elif Demirtas, Adil Mardinoglu, Adil Mardinoglu, Atay Vural, Atay Vural, Murat Dayangac, Mujdat Zeybel

“…Immune cell populations were characterized by flow cytometry from isolated hepatic and peripheral mononuclear cells.ResultsSignificant differences in immune cell characteristics were observed among patients with three clinical conditions. …”
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HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degraders by Qin Wang, Xinyi Zhu, Jing Li, Sanjia Xu, Ali Wang, Xinwen Zhang, Xingxing Wang, Xiaopeng Cai, Haimei Xing, Ye Liu, Xuesong Liu, Zhiwei Wang, Lai Wang, Lai Wang, Xi Yuan

“…Similarly, HPK1 kinase inhibitor (Compound 1) and cereblon-based (CRBN-based) HPK1 degrader (Compound 2) elicited similar degrees of maximum TCR-induced activation in primary human peripheral blood T cells. In summary, the results of this study suggested that HPK1 kinase inhibitor may be sufficient for HPK1 targeting in T cell mediated cancer immunotherapy.…”
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NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway by Alexander J. Gill, Matthew D. Smith, Danny Galleguillos, Thomas Garton, Jackson W. Mace, Sachin P. Gadani, Swati Kumar, Aayush Pokharel, Krista Solem, Saahith Potluri, Omar Hussein, Giuliana Sardi Rogines, Arihant Singh, Annatje Clark, Peter A. Calabresi, Marjan Gharagozloo

“…To minimize the effects of Nlrx1 −/− on peripheral lymphocyte priming during EAE, we performed adoptive transfer experiments, in which activated myelin-specific T cells were transferred into lymphocyte-deficient Rag −/− or Nlrx1 −/− Rag −/− mice. …”
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Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome by Hamad Al Shahi, Kazunori Shimada, Katsumi Miyauchi, Takuma Yoshihara, Eiryu Sai, Tomoyuki Shiozawa, Ryo Naito, Tatsuro Aikawa, Shohei Ouchi, Tomoyasu Kadoguchi, Tetsuro Miyazaki, Hiroyuki Daida

“…We evaluated inflammatory cytokines and chemokine in peripheral blood mononuclear cells (PBMCs) in patients with either acute coronary syndrome (ACS) or stable coronary artery disease (CAD). …”
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Regulatory T Cell Phenotype Related to Cytokine Expression Patterns in Post‐COVID‐19 Pulmonary Fibrosis and Idiopathic Pulmonary Fibrosis by Sara Gangi, Laura Bergantini, Irene Paggi, Marco Spalletti, Paolo Cameli, Elena Bargagli, Miriana d'Alessandro

“…The aim of the present study was to analyze and compare the different subsets of CD4‐ and CD8‐T cells, along with specific cytokine expression patterns, in peripheral blood (PB) from patients affected by PCLF and IPF and healthy controls (HCs). …”
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Cardio-renal effect of dapagliflozin and dapagliflozin- saxagliptin combination on CD34 + ve hematopoietic stem cells (HSCs) and podocyte specific markers in type 2 diabetes (T2DM)... by Seshagiri Rao Nandula, Arad Jain, Sabyasachi Sen

“…Abstract Introduction Effects of Dapagliflozin (Dapa) and Dapagliflozin-Saxagliptin combination (Combo) was examined on peripheral blood derived CD34 + Hematopoetic Stem Cells (HSCs) as a cellular CVD biomarker. …”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Anti-TIGIT mode-of-action-related pharmacodynamic effects were observed in peripheral blood and in tumor tissue. RDEs were 1600 mg every 2 weeks or 2400 mg every 3 weeks for M6223 monotherapy and 1600+1200 mg every 2 weeks for M6223+BA.Conclusions M6223±BA had a manageable safety profile, with RDEs defined for both monotherapy and combination therapy. …”
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Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

“…N -Acetylneuraminic acid (Neu5Ac) is a negatively charged nine-carbon amino sugar that is often the peripheral sugar in human cell-surface glycoconjugates. …”
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques by Taisuke Okano, Kengo Sato, Remina Shirai, Tomomi Seki, Koichiro Shibata, Tomoyuki Yamashita, Ayaka Koide, Hitomi Tezuka, Yusaku Mori, Tsutomu Hirano, Takuya Watanabe

“…β-Endorphin, an endogenous opioid peptide, and its μ-opioid receptor are expressed in brain, liver, and peripheral tissues. β-Endorphin induces endothelial dysfunction and is related to insulin resistance. …”
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T cell immune senescence is associated with frailty and sarcopenia in lung transplant candidates by Joanna M. Schaenman, MD, PhD, Harry Pickering, PhD, Elaine F. Reed, PhD, Maura Rossetti, PhD, Benjamin Seligman, MD, S. Samuel Weigt, MD, Michael Shino, MD, David Sayah, MD, PhD, John Belperio, MD, Ashley Hu, MD, Ashley Prosper, MD, Kathleen Ruchalski, MD, Abbas Ardehali, MD, Reshma Biniwale, MD

“…Immune phenotyping was performed using multichannel flow cytometry of peripheral blood mononuclear cells (PBMC) in a total of 26 lung transplant candidates. …”
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Cord Direct Antiglobulin Test for Predicting the Need for Phototherapy in Neonates with ABO Incompatibility: A Prospective Cohort Study by Ranjith Balan, Sakthipriya Balaji, Arun Kumar, Subash Sundar, Shrinidhi Krishnan, Ashok Chandrasekaran

“…Serum bilirubin levels, complete blood counts with peripheral smear analysis and reticulocyte counts were performed on day 3 or earlier, as clinically indicated. …”
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Risk Factors and Outcome of Sepsis in Traumatic Patients and Pathogen Detection Using Metagenomic Next-Generation Sequencing by Yiqing Tong, Jianming Zhang, Yimu Fu, Xingxing He, Qiming Feng

“…A total of 89 blood samples from 89 septic patients underwent standard microbiological blood cultures and 89 samples of peripheral blood (n = 21), wound secretion (n = 41), bronchoalveolar lavage fluid (BALF) (19), ascites (n = 5), and sputum (n = 3) underwent mNGS. …”
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The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development by Jana Vcelakova, Radek Blatny, Zbynek Halbhuber, Michal Kolar, Ales Neuwirth, Lenka Petruzelkova, Tereza Ulmannova, Stanislava Kolouskova, Zdenek Sumnik, Pavlina Pithova, Maria Krivjanska, Dominik Filipp, Katerina Stechova

“…In this study, using gene expression microarrays, we analysed the effect of diabetes-associated autoantigens on peripheral blood mononuclear cells (PBMCs) with the purpose of identifying (pre)diabetes-associated cell processes. …”
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Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated wit... by E. V. Grigor’eva, A. A. Malakhova, E. S. Yarkova, J. M. Minina, Y. V. Vyatkin, J. A. Nadtochy, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, S. M. Zakian

“…By reprogramming the patient’s peripheral blood mononuclear cells, we obtained induced pluripotent stem cells (iPSCs). …”
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Avatares de la energía nuclear en Argentina by Milagros Rodríguez

“…While the Ministry of Economy attempted to face the dismantling of the Entrepreneur State and peripheral privatization of most industries at its charge, the Executive approved an ambitious plan for the construction of Nuclear Power Plants inspired in centralization, planning and self-sufficiency. …”
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The Correlation between Time in Range and Diabetic Microvascular Complications Utilizing Information Management Platform by Xia Sheng, Guo-Hui Xiong, Peng-Fei Yu, Jian-Ping Liu

“…TIR less than 40% was a risk factor for DN (OR = 1.249, 95% CI: 0.915–1.375). (3) There were 1,296 patients diagnosed with diabetic peripheral neuropathy (DPN). The difference of TIR value between DPN and non-DPN was significant (T = 3.844, P<0.01). …”
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Small intestinal bacterial overgrowth syndrome and systemic inflammation in pathogenesis of hemodynamic changes at liver cirrhosis by R. V. Maslennikov, A. A. Driga, K. V. Ivashkin, M. S. Zharkova, M. V. Mayevskaya, Ch. S. Pavlov, M. G. Arslanyan, N. B. Musina, Ye. N. Berezina, V. T. Ivashkin

“…Lactulose hydrogen breath test, serum level of C-reactive protein and cardiac ultrasound with simultaneous blood pressure (BP) and heart rate measurement, estimation of basic hemodynamic scores: mean blood pressure (MBP), cardiac output (CO), total peripheral vascular resistance (TPVR) were investigated in all patients. …”
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Characterization of adult T-cell leukemia/lymphoma patients with specific skin lesions in a tertiary dermatological service in Brazil by Mariana Valente, José Antonio Sanches, Youko Nukui, Jade Cury-Martins, Bruno Castro Souza, Juliana Pereira, Denis Miyashiro

“…Thirty-four patients (79.1%) had increased lactate dehydrogenase; 20 (45.5%) lymphocytosis; six (13.6%) flower cells in peripheral blood; six (14.6%) hypercalcemia; five (12.2%) hypoalbuminemia. …”
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Effect of primary tumor volume on survival of concurrent chemoradiotherapy in stage IV non‐small cell lung cancer by Xiaxia Chen, Wei Zhang, Lan Luo, Shimei Fu, Dongdong Cao, Shengfa Su, Qingsong Li, Wengang Yang, Yichao Geng, Bing Lu, Weiwei Ouyang

“…Multivariate Cox regression analyses suggested that peripheral lung cancer, radiation dose ≥63 Gy, GTV <150 cm3, 4–6 cycles of chemotherapy, and CR + PR are good prognostic factors for patients with stage IV non‐small cell lung cancer. …”
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Elevated Kappa Index in the Absence of Cerebrospinal Fluid IgG Oligoclonal Bands: Contribution of Intrathecal IgM and IgA Synthesis by Krzysztof Smolik, Roberta Bedin, Patrizia Natali, Martina Cardi, Diego Franciotta, Anna Maria Simone, Paolo Immovilli, Mario Santangelo, Matteo Gastaldi, Giulia De Napoli, Francesca Vitetta, Diana Ferraro

“…Diagnoses were classified as multiple sclerosis (MS), or other inflammatory (INFL), infectious (INFECT), or non-inflammatory (Other) central/peripheral nervous system disorders. Sixty-nine Kappa+OCB- patients and 50 controls (24 Kappa-OCB- and 26 Kappa+OCB+ patients) were included in this study. …”
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