Sympathetic innervation induced by nerve growth factor promotes malignant transformation in gastric cancer by Takefumi Itami, Yukinori Kurokawa, Takaomi Hagi, Shinnosuke Nagano, Rennosuke Nakamoto, Yu Kamakura, Tsuyoshi Takahashi, Takuro Saito, Kazuyoshi Yamamoto, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki

“…Abstract Sympathetic nerves regulate nearly all human organs. Their peripheral nerves are present in tumor tissue. Activation of the sympathetic nervous system promotes malignant transformation in several cancers. …”
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Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…The modulation of the gut microbiota is also addressed as a peripheral strategy that could influence neuroinflammatory and degenerative processes in the brain. …”
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CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite by Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fábio Magalhães-Gama, Jacqueline Almeida Gonçalves Sachett, Iran Mendonça Silva, Kerolaine Fonseca Coelho, Eliane Campos Alves, Andréa Monteiro Tarragô, Luiz Carlos de Lima Ferreira, Adriana Malheiro, Wuelton Marcelo Monteiro, Allyson Guimarães Costa

“…These were categorized into two groups according to the development of AKI (AKI(-)/AKI(+)), using healthy donors as the control (HD). Peripheral blood samples were collected at three-time points: before antivenom administration (T0) and at 24 and 48 hours after antivenom (T1 and T2, respectively). …”
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High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice by Lu Luo, Meixi Liu, Hongyu Xie, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Junfa Wu, Congyu Jiang, Yi Wu

“…Furthermore, HIIT was superior to MOD in terms of reducing lipid accumulation, levels of IL-1β and IL-6 in paretic gastrocnemius, and improving peripheral blood CD4+/CD8+ T cell ratio, level of IL-10. …”
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A real-world Pharmacovigilance study of brodalumab based on the FDA adverse event reporting system by Ke He, Kaidi Zhao, Tingyi Yin, Meng Liu, Jiashu Liu, Wenqian Du, Xinyi Liu, Baochen Cheng, Dewu Zhang, Yan Zheng

“…Additionally, we found potential adverse reactions not noted on the drug’s label that exhibited positive signals, including depression, increased blood pressure, peripheral swelling, gait disturbance, inability to walk, stress, myocardial infarction, sepsis, uveitis, nephrolithiasis, and interstitial lung disease. …”
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The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment by Helene Sauer, Isabelle Mack, Silke Kohler, Stefanie Siegle, Nicole Rieber, Stephan Zipfel, Bärbel Otto, Yvonne Ritze, Stephan C. Bischoff, Paul Enck

“…Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. …”
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How to convert a 3D printer to a personal automated liquid handler for life science workflows by Dulguunnaran Naranbat, Benjamin Phelps, John Murphy, Anubhav Tripathi

“…The PALH system was evaluated through common life science assays, including preparing real-time PCR samples, end-point PCR with novel pipet-based downstream purification, and genomic DNA extraction from peripheral whole blood. In real-time PCR experiments targeting the YWHAZ gene, the PALH system demonstrated comparable performance to manual preparation across DNA quantities (1 pg to 100 ng). …”
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Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis... by Iwao Seki, Miwa Takai-Imamura, Tomomi Kohara-Tanaka, Satoshi Shirae, Minoru Sasano, Hiroaki Matsuno, Hiroyuki Aono

“…The combined treatment exhibited synergistic effects of the two drugs in reducing the serum matrix metalloproteinase-3 level and the number of peripheral CD11bhigh osteoclast precursor cells. Moreover, tacrolimus inhibited the cytokine-induced osteoclast differentiation in synergy with etanercept in an in vitro assay. …”
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The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients... by L. V. Topchieva, V. A. Korneva, I. V. Kurbatova

“…The level of transcripts in peripheral blood leukocytes (PBL) was assessed by real-time PCR. …”
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A review of parameter settings for galvanic vestibular stimulation in clinical applications by Yishai Valter, Yishai Valter, Linda Vataksi, Aaron R. Allred, Jeffrey R. Hebert, Tad T. Brunyé, Tad T. Brunyé, Torin K. Clark, Jorge Serrador, Abhishek Datta, Abhishek Datta

“…The method has been tested for decades for both medical and non-medical applications and has demonstrated promise in treating a variety of disorders including peripheral vestibular conditions, central vestibular pathology due to neurodegenerative diseases, and post-stroke motor rehabilitation. …”
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Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production by Lucas Faustino, Daniel Mucida, Alexandre Castro Keller, Jocelyne Demengeot, Karina Bortoluci, Luiz Roberto Sardinha, Maisa Carla Takenaka, Alexandre Salgado Basso, Ana Maria Caetano Faria, Momtchilo Russo

“…Foxp3+CD25+CD4+ regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. …”
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Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Traditional anti-inflammatory and immunomodulatory drugs are effective in peripheral inflammatory illnesses. Still, they face substantial hurdles when applied to the central nervous system (CNS), such as the blood–brain barrier (BBB) and unwanted systemic effects. …”
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Chronic Atrophic Gastritis Presenting as Hemolytic Anemia due to Severe Vitamin B12 Deficiency by Amanda M. Woodford, Rabhea Chaudhry, Gabriella A. Conte, Varsha Gupta, Madhurima Anne

“…The presentation will usually mirror that of a thrombotic microangiopathy (TMA), including hemolytic anemia with schistocytes on peripheral blood smear and thrombocytopenia, as it did in this patient. …”
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Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells by Nuwanka K. Abeysinghe, Ira Thabrew, Sameera R. Samarakoon, Meran K. Ediriweera, Kamani H. Tennekoon, Varuni P. C. Pathiranage, Anuka S. Mendis

“…Antiproliferative effects of vernolactone in NTERA-2 cells and human peripheral blood mononuclear cells (control cells) were evaluated using the Sulforhodamine B (SRB) assay and WST-1 antiproliferative assays, respectively. …”
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Blocks identical by descent in the genomes of the indigenous population of Siberia demonstrate genetic links between populations by N. A. Kolesnikov, V. N. Kharkov, K. V. Vagaitseva, A. A. Zarubin, V. A. Stepanov

“…High ethnic diversity is a feature of Siberia, as one of the regions of the peripheral settlement of modern human. The vast expanses of this region and the small number of aboriginal populations contributed to the formation of significant territorial and genetic subdivision. …”
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Analysis of Fine Needle Non Aspiration Cytology for the Diagnosis of Cervical Lymph Node Tuberculosis: A Cross-sectional Study by S Rajesh Kumar Jain, Samta, RK Divya, V Abhirami

“…Comparatively, Fine Needle Non Aspiration Cytology (FNNAC) is a simple, reliable, inexpensive, painless, less invasive, outpatient procedure for the diagnosis of peripheral LNTB and is recommended as the first diagnostic technique for this condition. …”
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Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation by Inmaculada Gayoso, Sara Cantisán, Carolina Cerrato, Joaquín Sánchez-García, Carmen Martin, Rafael Solana, Antonio Torres-Gomez, Julian Torre-Cisneros

“…In addition, a detectable IFN-γ production in response to HCMV peptides (cutoff 0.2 IU/mL IFN-γ; “reactive” QuantiFERON-HCMV test) was statistically associated with HCMV replication after transplantation (OR=11; P=0.026), recipients ≥40 versus <40 years old (OR=11; P=0.026), and the use of peripheral blood versus bone marrow as stem cell source (OR=17.5; P=0.024). …”
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tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats by Alireza Majdi, Liyi Chen, Lars E. Larsen, Robrecht Raedt, Myles Mc Laughlin

“…However, recent evidence suggests that some tDCS effects may be mediated through co-stimulation of peripheral or cranial nerves, particularly the trigeminal nerve (TN). …”
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NKG2C+CD57+ Natural Killer Cell Expansion Parallels Cytomegalovirus-Specific CD8+ T Cell Evolution towards Senescence by John Heath, Nicholas Newhook, Emilie Comeau, Maureen Gallant, Neva Fudge, Michael Grant

“…Expansion of NKG2C+CD57+ NK was measured in peripheral blood mononuclear cells (PBMC) from groups distinguished by HCMV and human immunodeficiency virus (HIV) infection status. …”
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Identification of candidate genes involved in Zika virus-induced reversible paralysis of mice by John D. Morrey, Venkatraman Siddharthan, Hong Wang, Alexandre L. R. Oliveira, Keiichiro Susuki, Rakesh Kaundal, Sara M. Freeman, Aaron J. Thomas, Naveen Duhan, Nathan G. Corry

“…Abstract Zika virus (ZIKV) causes a variety of peripheral and central nervous system complications leading to neurological symptoms such as limb weakness. …”
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