Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock. by Zuo Wang, Shuang Wang, Yi Bi, Alessandra Boiti, Shengxiang Zhang, Daniela Vallone, Xianyong Lan, Nicholas S Foulkes, Haiyu Zhao

“…Circadian clocks in zebrafish peripheral tissues and even zebrafish-derived cell lines are entrainable by direct light exposure thus providing unique insight into the function and evolution of light regulatory pathways. …”
Get full text

Early Serum Heme Oxygenase-1, Soluble Vascular Endothelial Growth Factor Receptor-1, and B-Cell Lymphoma/Leukemia-2 Levels and Unfavorable Obstetric Outcomes by Havva Sutcu, G. Fusun Varol, Cihan Inan, Isil Uzun, N.Cenk Sayin

“…STUDY DESIGN: A total of randomly selected 140 pregnancies were included in this prospective study. Peripheral blood samples were obtained between 110/7 and 136/7 gestational weeks. …”
Get full text

Histological Consequences of Needle-Nerve Contact following Nerve Stimulation in a Pig Model by T. Steinfeldt, J. Graf, J. Schneider, W. Nimphius, E. Weihe, A. Borgeat, H. Wulf, T. Wiesmann

“…Nerve stimulation can facilitate correct needle placement in peripheral regional anesthesia. The aim of this study was to determine whether the high threshold current is associated with reduced nerve injury due to fewer needle-nerve contacts compared with low current. …”
Get full text

NETosis Secondary to the Use of Levamisole-Adulterated Cocaine: A Likely Underlying Mechanism of Vasculopathy by Manuela Osorio, Isabel Velásquez, Ruben Vargas, Adriana Vanegas-García, Mauricio Rojas, Gloria Vásquez, Carlos Muñoz-Vahos

“…Neutrophils were isolated from the peripheral blood of healthy controls by Ficoll-Hystopaque density gradient centrifugation followed by dextran sedimentation. …”
Get full text

Network Meta-Analysis of Once Weekly Selinexor-Bortezomib-Dexamethasone in Previously Treated Multiple Myeloma by Michael Dolph, Gabriel Tremblay, Adrienne M Gilligan, Hoyee Leong

“…**Conclusions:** The addition of XVd, which was designed with once weekly bortezomib dosing, to the treatment landscape for previously treated MM provides a regimen that may potentially be noninferior to the other top 5 regimens in both 2L and 3L+ settings and is associated with less peripheral neuropathy.…”
Get full text

Diagnosis and clinical significance of prostate calcification using computed tomography by Seong Cheol Kim, Tae Young Lee, Woocheol Kang, Hoyoung Bae, Ji Hyung Yoon, Sungchan Park, Kyung Hyun Moon, Sang Hyeon Cheon, Taekmin Kwon

“…Only a small number of calcifications were observed in the peripheral zone (0.9%). Multivariate analysis revealed that both age and prostate calcification were significant predictors of urinary symptoms. …”
Get full text

Female Consumers’ Involvement in Intentional Non-Sustainable and Unintentional Sustainable Apparel Decisions: An Emerging Market Perspective by Elizabeth Kempen, Rejoice Tobias-Mamina, Mariette Strydom, Lorna Christi, Mirriam Makopo

“…Applying the Elaboration Likelihood Model, it was possible to explain the lack of elaborated involvement in sustainable apparel practices resembling the peripheral route of the model. Unintentional sustainable practices have not been identified in the South African context, indicating the valuable contribution consumers in an emerging market context (EMC) can make if better awareness is created by the government and the retail sector specifically to address intentional non-sustainable purchasing behaviours in future.…”
Get full text

Neutrophils Are Dysregulated in Patients with Hereditary Angioedema Types I and II in a Symptom-Free Period by Tereza Grymova, Marcela Vlkova, Premysl Soucek, Roman Hakl, Jana Nechvatalova, Peter Slanina, Julie Stichova, Jiri Litzman, Tomas Freiberger

“…We assessed the relative mRNA expression of 10 genes related to neutrophil activation using RNA extracted from the peripheral blood neutrophils of 23 HAE patients in a symptom-free period and 39 healthy donors. …”
Get full text

Effect of Imatinib on Bone Marrow Morphology and Angiogenesis in Chronic Myeloid Leukemia by Neetu Pandey, Geeta Yadav, Rashmi Kushwaha, Shailendra Prasad Verma, Uma Shankar Singh, Ashutosh Kumar, Prabhaker Mishra

“…Hematological parameters and BCR-ABL transcript levels were assessed in the peripheral blood. Results. 86.21% of patients showed decrease in marrow cellularity with normalization of M:E ratio. 72.42% of patients had decrease in grade of fibrosis and 17.24% showed no change while 10.34% of patients showed progression of fibrosis grade. …”
Get full text

5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity by Thomas Stübig, Anita Badbaran, Tim Luetkens, York Hildebrandt, Djordje Atanackovic, Thomas M. C. Binder, Boris Fehse, Nicolaus Kröger

“…Functionality was assessed by a tumor lysis assay. Peripheral blood from patients treated with 5-Aza after alloSCT was monitored for changes in T-cell subpopulations. 5-Aza treatment resulted in a decrease in CD8+ T-cells, whereas CD4+ T-cells increased. …”
Get full text

The antimicrobial susceptibility patterns of diabetic foot ulcers in the South African public healthcare sector by M J Turner, S Leigh-de Rapper, T P Mokoena, S van Vuuren

“…Diabetic foot syndrome is defined as the presence of a diabetic foot ulcer (DFU) associated with neuropathy, peripheral artery disease and infection. While the use of antimicrobials in the treatment of DFU infection remains a mainstay, the choice of antimicrobial remains problematic owing to the presence of multidrug-resistant polymicrobial infections. …”
Get full text

Immunolipid magnetic bead-based circulating tumor cell sorting: a novel approach for pathological staging of colorectal cancer by Qingyan Deng, Weidong Li, Yueming Huang, Haitao Wang, Xinhao Zhou, Zhifen Guan, Bohao Cheng, Yao Wang

“…The consistency of gene mutations was as follows: TP53 (91.31%), PIK3CA (76.00%), KRAS (85.36%), BRAF (51.00%), APC (65.67%), and EGFR (74.00%), with an overall gene mutation consistency of 85.06%.ConclusionOur CTC sorting system, which is based on Ep-IMBs and Vi-IMBs, effectively captures CTCs in the peripheral blood of CRC patients and enables clinical hotspot gene mutation testing via these enriched CTCs. …”
Get full text

Plantar Temperature Response to Walking in Diabetes with and without Acute Charcot: The Charcot Activity Response Test by Bijan Najafi, James S. Wrobel, Gurtej Grewal, Robert A. Menzies, Talal K. Talal, Mahmoud Zirie, David G. Armstrong

“…Fifteen individuals with Acute Charcot neuroarthropathy (CN) and 17 non-CN participants with type 2 diabetes and peripheral neuropathy were recruited. All participants walked for two predefined paths of 50 and 150 steps. …”
Get full text

Purtscher-Like Retinopathy by Rita Massa, Carolina Vale, Mafalda Macedo, Maria João Furtado, Miguel Gomes, Miguel Lume, Angelina Meireles

“…The ophthalmologic evaluation revealed the best corrected visual acuity (BCVA) of 20/32 in the right eye (RE) and of 20/40 in the left eye (LE); biomicroscopy of anterior segment showed scleral icterus and fundoscopy revealed peripapillary cotton-wool spots, optic disc edema, and RPE hypo- and hyperpigmentation in the middle peripheral retina in both eyes with an intraretinal hemorrhage in the LE. 15 months after the initial presentation, without ophthalmological treatment, there was an improvement of BCVA to 20/20 in both eyes and optical coherence tomography (OCT) revealed areas of reduction of retinal nerve fiber layer thickness corresponding to the previous cotton-wool spots. …”
Get full text

A 5.5–7.5‐GHz band‐configurable wake‐up receiver fully integrated in 45‐nm RF‐SOI CMOS by Rui Ma, Florian Protze, Frank Ellinger

“…In addition, the on‐chip digital bank‐end consists of a frequency divider, a phase corrector, a 31‐bit correlator and a serial peripheral interface. A proof‐of‐concept WuRX circuit occupying an area of 1200 μm by 900 μm has been fabricated in a GlobalFoundries 45‐nm RF‐SOI CMOS technology. …”
Get full text

Defining New Research Questions and Protocols in the Field of Traumatic Brain Injury through Public Engagement: Preliminary Results and Review of the Literature by Shumaila Hasan, Aswin Chari, Mario Ganau, Chris Uff

“…To gauge acceptance of this, and as per the guidelines set out by the National Research Ethics Service, we conducted a survey of TBI and non-TBI patients admitted to our Trauma ward and their families. 100 responses were collected between December 2017 and July 2018, incorporating two redesigns in response to patient feedback. 75.0% of respondents said that they would consent to a brain biopsy performed at the time of insertion of an intracranial pressure (ICP) bolt. 7.0% replied negatively and 18.0% did not know. 70.0% would consent to insertion of a jugular bulb catheter to obtain paired intracranial venous samples and peripheral samples for analysis of biomarkers. Over 94.0% would consent to neural tissue from ICP probes, external ventricular drains (EVD), and lumbar drains (LD) to be salvaged, and 95.0% would consent to intraoperative samples for further analysis.…”
Get full text

Expression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia by Fatemeh Manafzadeh, Behzad Baradaran, Seyed Gholamreza Noor Azar, Kamran Javidi Aghdam, Reza Dabbaghipour, Asghar Shayannia, Soudeh Ghafouri-Fard

“…In brief, our data demonstrated dysregulation of Wnt/β pathway related genes and lncRNAs in the peripheral blood of patients with schizophrenia and their potential as biomarkers for this disorder.…”
Get full text

How can urban expansion and ecological preservation be balanced? A simulation of the spatial dynamics of production-living-ecological spaces in the Huaihe River Eco-Economic Belt by Tonghui Yu, Shanshan Jia, Yu Zhang, Xufeng Cui

“…Future expansions of living space are expected to be prominent, following a radial expansion pattern from urban centers to peripheral areas. Overall, considering the vulnerability of production space to further encroachment, future strategies for the Huaihe River Eco-Economic Belt should prioritize protecting high-quality farmland and critical ecological zones, while regulating urban expansion and strengthening land-use planning to ensure PLES sustainability. …”
Get full text

Hyperemia-Related Changes in Arterial Stiffness: Comparison between Pulse Wave Velocity and Stiffness Index in the Vascular Reactivity Assessment by Juan Torrado, Daniel Bia, Yanina Zócalo, Ignacio Farro, Federico Farro, Ricardo L. Armentano

“…Stiffness index (SI) is obtained by analysis of the peripheral pulse wave and gives reproducible information about stiffness of large arteries. …”
Get full text

Genesis of feudalism in Western Europe and its influence to the globai process of history: The conceptions of L. Vasilyev and E. Gudavičius by Nerijus Babinskas

“…Otherwise, the social structure of peripheral societies would have been developing like in the Orient.   …”
Get full text