An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…Results In this trial, molecular profiling of tumor and peripheral blood samples will be conducted which will enable in gaining biological insights for survival benefit. …”
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The Shanghai Cooperation Organization after Enlargement: New Challenges and Prospects by D. V. Efremenko

“…This enlargement of the SCO implies a considerable increase in its political and economic weight, as well as additional interstate contradictions, which have previously had a peripheral significance for the SCO.In that regard special attention is drawn to the new political dynamics within the SCO. …”
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NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation by Agata Habas, Srinivasa Reddy Natala, Jon K. Bowden-Verhoek, Emily M. Stocking, Diana L. Price, Wolfgang Wrasidlo, Douglas W. Bonhaus, Martin B. Gill

“…Together, these findings suggest that blockade of TLR2 and TLR9 may reduce inappropriate production of pro-inflammatory cytokines and chemokines from peripheral and central immune cells and thus potentially provide therapeutic benefit in neuroinflammatory/neurodegenerative disorders.…”
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Neurobiological Changes Associated with Excess Weight: A Narrative Review by B Sharmila, Sovan Bagchi, Mohd Imran, Tamalika Chakraborty, K Pushpalatha

“…Early reviews have often overlooked the intricate relationship between obesity and brain function, focusing more on peripheral effects, such as cardiovascular and metabolic complications, while neglecting the specific effects on brain structure and function. …”
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T-Cell Large Granular Lymphocytic Leukemia with Extremely Rare Immunophenotype (CD4/CD8 Double-Positive) Followed by Multiple Myeloma Diagnosis by Dina Soliman, Sherin Sallam, Susanna Akiki, Deena Mudawi, Feryal Ibrahim

“…We report a case of asymptomatic CD4/CD8 double-positive T-LGLL. Flow cytometry on peripheral blood revealed a subpopulation of CD4/CD8 double-positive T cells expressing CD57 and cTIA. …”
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E-Selectin/AAV Gene Therapy Promotes Myogenesis and Skeletal Muscle Recovery in a Mouse Hindlimb Ischemia Model by Antoine J. Ribieras, Yulexi Y. Ortiz, Yan Li, Nga T. Le, Carlos T. Huerta, Francesca A. Voza, Hongwei Shao, Roberto I. Vazquez-Padron, Zhao-Jun Liu, Omaida C. Velazquez

“…The response to ischemia in peripheral artery disease (PAD) depends on compensatory neovascularization and coordination of tissue regeneration. …”
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The Construction of Identities in Space Inversion (the Case of Blagoveshensk and Chei-Che) by I. Y. Okunev, D. V. Basova, M. I. Tislenko

“…Existing stable centre-peripheral relations in each country put some thought about the third state-building mechanism - internal “Other”. …”
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Immune-Mediated Cytotoxicity in Inflammatory Bowel Disease by Stephan R Targan, Richard L Deem, Fergus Shanahan

“…Elevated levels of cytotoxic T cells were found in peripheral blood lymphocytes of patients with IBD, particularly Crohn's disease. …”
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The relationship between histamine receptor type 4 gene polymorphism (rs11662595) and response to H1 antihistamine drugs in patients with chronic idiopathic urticaria by Ebrahim Mohammadi, Fakhredin Karimpour, Ramin Lotfi, Fatemeh Zamani, Abbas Aghaei, Rasoul Nasiri Kalmarzi

“…With the consent of the patients, 5 ml of peripheral blood was taken from each patient for DNA extraction (in a CBC tube) and IgE measurement (in a hemolysis tube without anticoagulant). …”
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Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients by Kamel Ait-Tahar, Amanda P. Anderson, Martin Barnardo, Graham P. Collins, Chris S. R. Hatton, Alison H. Banham, Karen Pulford

“…A significant γ-interferon CTL response was detected in peripheral blood mononuclear cells of 13/31 DLBCL patients following short-term cell stimulation with two novel HLA-A⁎0201 peptides and one previously reported HLA-A⁎0101-restricted nine-mer Sp17 peptide. …”
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Spectroscopic and Theoretical Studies of Hg(II) Complexation with Some Dicysteinyl Tetrapeptides by Elliot Springfield, Alana Willis, John Merle, Johanna Mazlo, Maria Ngu-Schwemlein

“…These structural insights on peripheral mercury-peptide interactions provide additional understanding of the chemistry of mercury(II) with side-chain donor groups in peptides.…”
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Pattern of morphological and neurophysiologic changes in women with the syndrome of the descending perineum by Yu. A. Shelygin, A. Yu. Titov, A. B. Shekhter, A. A. Mudrov, O. M. Birukov, Yu. A. Dzhanayev, M. A. Voynov

“…Along with distinct changes of connective tissue structures of perineum, DPS it is characterized by neurophysiologic disorders of pelvic floor registered not only in peripheral innervation zone, but also along the whole reflex arch.…”
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Effects of Neoadjuvant Denosumab on Radiological and Histological Responses in Patients Undergoing En Bloc Resection for Giant Cell Tumor of Bone: A Systematic Review by Hendra Aditama, Yo Tendy Pratama, Dhanan Prastanika S, Dita Anggara K, Rhyan Dharma S

“…Six studies showed increased significant bone reconstitution as a radiological response in the GCTB locale, replaced the extending tumor into soft tissue by abundant bone production with peripheral shell, and increased ease of en bloc resection. …”
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The Angiotensin-Melatonin Axis by Luciana A. Campos, Jose Cipolla-Neto, Fernanda G. Amaral, Lisete C. Michelini, Michael Bader, Ovidiu C. Baltatu

“…Contemporary research is evidencing the existence of specific clock genes forming central and peripheral clocks governing circadian rhythms. Further research on the interaction between these two neurohormones and the clock genes governing circadian clocks may progress our understanding on the pathophysiology of disease with possible impact on chronotherapeutic strategies.…”
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Reconstructing skeletal homeostasis through allogeneic hematopoietic stem cell transplantation in myelofibrosis by Mathias Schäfersküpper, Alexander Simon, Timur A. Yorgan, Felix N. von Brackel, Maximilian M. Delsmann, Anke Baranowsky, Nico Gagelmann, Francis Ayuk, Thorsten Schinke, Michael Amling, Nicolaus Kröger, Tim Rolvien

“…Despite unimpaired bone microarchitecture at peripheral skeletal sites, we observe a marked increase in bone mineral density at the lumbar spine and proximal femur, which is histologically related to severe bone marrow fibrosis and osteosclerosis, fully normalizing after allo-HSCT. …”
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Thyroid Storm with Multiorgan Failure Treated with Plasmapheresis by Ann Miller, Kristi D. Silver

“…First line treatment of thyroid storm is directed towards decreasing thyroid hormone production and peripheral conversion of T4 to T3, and treating adrenergic symptoms. …”
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A randomised trial comparing the clinical effectiveness of different emergency department healthcare professionals in soft tissue injury management by Jonathan Richard Benger, Jane Powell, Fiona Cramp, Carey Middleton McClellan

“…Participants were adults (older than 16 years) presenting to the ED with a peripheral soft tissue injury eligible for management by any of the three professional groups. …”
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Triple antiviral therapy in patient with liver cirrhosis: complications and options of pharmacological treatment by M. V. Mayevskaya, I. N. Tikhonov, V. T. Ivashkin

“…Assessment of indications to thrombocytopoiesis stimulation, correction of dozes of drug and regular monitoring of peripheral blood parameters are important points.Conclusion. …”
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Seroprevalence of Canine Ehrlichiosis and Microscopic Screening for Canine Babesiosis in Dogs in Harare, Zimbabwe, 2016-2017 by Solomon Dhliwayo, Brighton Chihambakwe, Knowledge Taonezvi, Silvester M. Chikerema, Musavengana T. Tivapasi, Davies M. Pfukenyi

“…Sera from randomly selected dogs were tested for antibodies to Ehrlichia spp. using an enzyme-linked immunosorbent assay while microscopy of peripheral blood smears was used to confirm babesiosis. …”
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Pure Neuritic Leprosy In Children With Grade 2 Disability On Hands And Feet: A Rare Case And Literature Review by Gunawan H, Ruchiatan K, Puspitosari D, Hindritiani R, Usman HA, Widjaja S

“…This variant of leprosy only involves peripheral nerves without skin involvement or acid-fast bacilli (AFB) found on slit-skin smear examination. …”
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