Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study by Liye Lai, Dave Laurence Juntilla, Monica Del, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

“…Results A total of 3,501 observations from 2,556 participants, with methylation measured at least once across two visits, were included in the analyses. …”
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Identification and Spatial Mapping of Locality of Streetscapes in Shanghai Hengfu Historic and Cultural Preservation Area by Yuhan SHAO, Sinan YIN, Dongbo MA, Yuting YIN

“…Streetscape in the northern and western parts of the Area is relatively open compared with other parts and the highest green visibility is observed in streets around Xujiahui Park located in the southwestern part of the Area. …”
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Compositional Design, Microstructure, and Thermal Processing of Aluminum-Based Complex Concentrated Alloys by Spyridon Chaskis, Constantinos Tiktopoulos, Evangelos Gavalas, Marianthi Bouzouni, Fotis Tsiolis, Spyros Papaefthymiou

“…However, alterations were observed in terms of the elemental composition of the phases in alloy A. …”
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THE RIGHT TO GOOD ADMINISTRATION AS A CONSTITUTIONAL RIGHT OF THE PERSON: EU EXPERIENCE by Tetyana Kaganovska, Vitalii Serohin

“…In general, we can say that the quality of administrative functioning is achieved by proper administrative practice (which includes the observance of fundamental rights) or, conversely, by the presence of improper management. …”
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Prospective Single-Arm Study of Remifentanil-Propofol Anesthesia with Manual Right Hypochondrial Compression for Painless Gastroscopy in Obese Patients by Wang M, Tang J, Pan Z, Jiang H, Hu D, Zhu B, Liang Z, Zhao X, Li Y

“…With the increase of class of obesity, a significant rise in the incidence of hypoxemia was observed, from class I by 11.8%, to 15.1% in class II, and 41.7% in class III. …”
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Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

“…Conclusion- Abuse and misuse of several drugs have been observed, efforts must be made to reduce the risk of self-medication by actively involving pharmacists in therapeutic patient education. …”
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Global phylogeography and genetic characterization of carbapenem and ceftazidime-avibactam resistant KPC-33-producing Pseudomonas aeruginosa by Longjie Zhou, Jiayao Yao, Ying Zhang, Xiaofan Zhang, Yueyue Hu, Haiyang Liu, Jintao He, Yunsong Yu, Minhua Chen, Yuexing Tu, Xi Li

“…Our previous study revealed that CZA-resistant KPC-33 had emerged in carbapenem-resistant P. aeruginosa (CRPA) and had resulted in death due to hypervirulence and extensive drug resistance; however, the evolutionary path of KPC-33-producing CRPA has not been investigated. Here, we observed the emergence of bla KPC-33 in CRPA under drug pressure, leading to resistance to CZA. …”
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Serum biomarkers in the metabolic dysfunction-associated steatotic liver fibrosis diagnosis in children by Yu.M. Stepanov, N.Yu. Zavhorodnia, I.A. Klenina, O.M. Tatarchuk, O.P. Petishko

“…In children with liver fibrosis, an increase in the ratio of HPf/HPp/b and the level of GAG in the blood serum was observed compared to patients with MASLD without fibrosis and with overweight and obese children. …”
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Grow-out of spiny lobster Panulirus sp. with high stocking density in controlled tanks by Rio Yusufi Subhan, Eddy Supriyono, Widanarni, Widanarni, Daniel Djokosetiyanto

“…This study used completely randomized design with three different stocking densities (KT10: 10 ind/m3; KT18: 18 ind/m3; and KT26: 26 ind/m3) and two replications. The parameters observed in this study included water quality (temperature, pH, salinity, dissolved oxygen, and total ammonia nitrogen), physiological responses (total haemocyte count, haemolymph glucose, and frequency of molt), and production performances, such as growth, specific growth rate, feed conversion ratio, and survival rate. …”
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Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment by Tangyi Wang, Yadian Lei, Jingwei Sun, Li Wang, Yuxin Lin, Zhijing Wu, Shoude Zhang, Chengzhu Cao, Chengzhu Cao, Chengzhu Cao, Haiyan Wang, Haiyan Wang, Haiyan Wang

“…The synergistic effect of Dig and PD-1 inhibition observed in animal models is promising and warrants further investigation into the role of immunotherapy in TNBC treatment. …”
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Effect of Tiaoxin Recipe on Memory Learning and Synaptic Plasticity in APP/PS1 Double Transgenic Alzheimer's Disease Mice based on αCaMKⅡ-CREB-BDNF Signal Pathway by Xiaowen WANG, Hong QIAN, Chunjuan SHEN, Yanjun LI, Haixin YUAN, Jian WANG

“…Objective:To observe the effects of Tiaoxin recipe on long-term potentiation (LTP) in hippocampal CA1 region, hippocampal alpha calcium/calmodulin-dependent kinaseⅡ (αCaMKⅡ), cyclic adenosine monophosphate response element binding protein (CREB), brain derived neurotrophic factor (BDNF), postsynaptic density 95 (PSD-95) mRNA and protein expression in hippocampal CA1 region of APP/PS1 double transgenic mice. …”
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Effect of Electroacupuncture at Shuigou Acupoint on L-type Voltage-gated Calcium Channels in hippocampal CA1 region of MCAO rats by Da LONG, Ling CHEN, Yu YAO, Mingan ZENG

“…Objective:To observe the effect of electroacupuncture at Shuigou acupoint on the recovery of neurological function to explore the mechanism of the L-type voltage-gated calcium channels in hippocampal CA1 region of middle cerebral artery occlusion(MCAO)model mice, and to investigate the brain protection mechanism of electroacupuncture at Shuigou acupoint on cerebral ischemia.Methods:A total of thirty health male adult Wistar mice were choosed. …”
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POPULATION STRUCTURE OF LEAF PATHOGENS OF COMMON SPRING WHEAT IN THE WEST ASIAN REGIONS OF RUSSIA AND NORTH KAZAKHSTAN IN 2017 by E. I. Gultyaeva, N. M. Kovalenko, V. P. Shamanin, V. A. Tyunin, E. R. Shreyder, E. L. Shaydayuk, А. I. Morgunov

“…The phenotypes TLTTR (avirulent to TcLr16, TcLr19, TcLr24, TcLr26), TCTTR (avirulent to TcLr9, TcLr16, TcLr19, TcLr24), and TBTTR (avirulent to TcLr9, TcLr16, TcLr19, TcLr24, TcLr26) were observed in all the populations. The phenotypes TQTTR (avirulent to TcLr19, TcLr24, TcLr26) and TGTTR (avirulent to TcLr9, TcLr19, TcLr24, TcLr26, TcLr9, TcLr19, TcLr24, TcLr26) were common in the Omsk and the North Kazakhstani population, while THPTR (avirulent to avTcLr9, TcLr11, TcLr19, TcLr24) and TCTTQ (avirulent to TcLr9, TcLr16, TcLr19, TcLr20, TcLr24) were common in the Omsk and the Chelyabinsk population. …”
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Mechanism of Electroacupuncture at Baihui and Shenting Alleviating Cerebral Ischemia-reperfusion Injury via Regulating BNIP3L-Mediated Mitophagy by ZHONG Xiaoyong, LI Cheng, WANG Fang, CHEN Bin, LIANG Hui, RUAN Su

“…After 7 days of intervention, the left cerebral cortex tissue of each group was obtained, hematoxylin-eosin (HE) staining was used to observe the pathological changes of the brain tissue, the expression level of LC3-Ⅱ/LC3-Ⅰ protein was detected by Western blot, and the tissue immunofluorescence technology was applied to detect the expression and colocalization of mitophagy-related protein BNIP3L and SQSTM1 labeled. …”
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Wild grasses as the reservoirs of infection of rust species for winter soft wheat in the Northern CaucasusWild grasses as the reservoirs of infection of rust species for winter sof... by E. I. Gultyaeva, L. A. Bespalova, I. B. Ablova, E. L. Shaydayuk, Zh. N. Khudokormova, D. R. Yakovleva, Yu. A. Titova

“…Stem rust in the region is mainly absent or observed at the end of the wheat growing season to a weak degree. …”
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Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

“…Conclusion- Abuse and misuse of several drugs have been observed, efforts must be made to reduce the risk of self-medication by actively involving pharmacists in therapeutic patient education. …”
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IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization... by Xinyu Feng, Cheng Yang, Ting Wang, Jinxin Zhang, Han Zhou, Bin Ma, Ming Xu, Ganzhen Deng

“…In this study, a notable decline of bta-miR-30b-5p expression via the increase of SOCS1 was observed in uterine tissues of pregnant cows. We then confirmed that the 3′UTR of SOCS1 was to be directly targeted by bta-miR-30b-5p. …”
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Association between major depressive disorder or depressive symptoms and the risk of vascular complications among patients with type 2 diabetes, and the mediating role of metabolic... by Guochen Li, Yongfu Yu, Chunqing Lin, Shichen Zheng, Hong Tu, Wanghong Xu

“…A series of circulating metabolites involving lipid profile, renal function, and inflammation were observed to mediate the associations of MDD with vascular complications. …”
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Recurrent adenoid cystic carcinoma of the left upper palate accompanied by massive maxillary hemorrhage: a case report and literature review by ZHANG Wangru, CHEN Yuanyuan, LI Zhiping, MENG Jian

“…The patient was monitored for four years post-surgery, during which no signs of tumor recurrence were observed. However, at the fifth year of follow-up, the patient developed recurrence with lung metastasis, classified as T4N0M1. …”
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Lower incidence of hepatocellular carcinoma with tenofovir alafenamide in chronic hepatitis B: Evidence from a large-scale cohort by Hye-Jin Yoo, Jae-Young Kim, Jeong-Ju Yoo, Hye Won Lee, Sang Gyune Kim, Young Seok Kim

“…From a practical perspective, these findings can guide physicians in prescribing more effective treatments, assist researchers in designing further studies to explore the mechanisms behind the effectiveness of TAF, and inform policymakers to craft healthcare policies that optimize patient outcomes while considering potential limitations, such as the observational nature of the study and residual confounding factors.…”
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