Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach by Punchita Rujirachaivej, Teerapong Siriboonpiputtana, Kornkan Choomee, Kamonlapat Supimon, Thanich Sangsuwannukul, Pucharee Songprakhon, Krissada Natungnuy, Piriya Luangwattananun, Pornpimon Yuti, Mutita Junking, Pa-thai Yenchitsomanus

“…For KMS-12-PE cells, significant cytotoxic effects were observed even at an E:T ratio of 1:1, with 27.2 ± 3.7% (p = 0.0004), 44.4 ± 3.7% (p < 0.0001), and 68.6 ± 9.2% (p = 0.0004) cytotoxicity at E:T ratios of 1:1, 5:1, and 10:1, respectively. …”
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Prediction model for type 2 diabetes mellitus and its association with mortality using machine learning in three independent cohorts from South Korea, Japan, and the UK: a model de... by Hayeon Lee, Seung Ha Hwang, Seoyoung Park, Yunjeong Choi, Sooji Lee, Jaeyu Park, Yejun Son, Hyeon Jin Kim, Soeun Kim, Jiyeon Oh, Lee Smith, Damiano Pizzol, Sang Youl Rhee, Hyunji Sang, Jinseok Lee, Dong Keon Yon

“…Similar patterns and trends were observed in the validation cohorts (T1: 1.74 [1.49–2.03], T2: 1.97 [1.69–2.30], and T3: 3.31 [2.82–3.38] in validation cohort A; T1: 1.33 [1.03–1.71], T2: 1.54 [1.21–1.96], and T3: 1.73 [1.36–2.20] in validation cohort B). …”
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Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized... by Anthony C Keech, Vijaya Sundararajan, Bruce R King, Sara Vogrin, Richard J MacIsaac, Leon A Bach, Jane Speight, Alicia J Jenkins, Christel Hendrieckx, David O’Neal, Sybil A McAuley, Geoff R Ambler, Fergus J Cameron, Jan M Fairchild, Elizabeth A Davis, Timothy W Jones, Morton G Burt, Philip M Clarke, Neale D Cohen, Peter G Colman, Joey Kaye, Kavita Kumareswaran, Melissa H Lee, Roland W Mccallum, Barbora Paldus, Stephen N Stranks, Steven Trawley, Glenn M Ward, David N O’Neal, Sienna Russell-Green, Deborah Jane Holmes-Walker, Benjamin Lam, Jennifer A Halliday, Glenn Ward, Catriona M Sims, D Jane Holmes-Walker, Andrzej Januszewski, Hanafi Mohammed Husin, Martin I de Bock, Mary B Abraham

“…In particular, improvement in diabetes-specific positive well-being was observed 13 weeks after HCL initiation and maintained at 26 weeks. …”
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Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial by Verónica V. Olavarría, Paola R. Campodónico, Valeska Vollrath, Paula von Geldern, Carolina Velásquez, Patricia Pavez, Barbara Valente, Pamela Donoso, Alexandra Ginesta, Gabriel Cavada, Enrico Mazzon, Víctor Navia, Matías Guzmán, Pablo Brinck, Andrés Gallardo, Pablo Gonzalez, Pablo M. Lavados

“…Moreover, no significant differences in adverse events were observed between the groups. Conclusion Compared with a low-fat diet, the avocado-based MeDi did not significantly lower LDL-C in IS patients after three months. …”
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Reservoir water level decline accelerates ground subsidence: InSAR monitoring and machine learning prediction of surface deformation in the Three Gorges Reservoir area by Jiaer Yang, Jiaer Yang, Pinglang Kou, Pinglang Kou, Xu Dong, Xu Dong, Ying Xia, Qinchuan Gu, Yuxiang Tao, Jiangfan Feng, Qin Ji, Weizao Wang, Ram Avtar

“…A negative correlation was observed between reservoir water level decline and subsidence, highlighting the influence of seasonal hydrological adjustments. …”
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An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape by Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen

“…Our comprehensive analysis of SARS-CoV-2 spike-specific antibodies revealed the preferential use of specific Ig alleles among these antibodies. We observed an association between Ig alleles and antibody binding epitopes. …”
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Exploring the association between tissue sodium content, heart failure subtypes, and symptom burden: insights from magnetic resonance imaging by Djawid Hashemi, Djawid Hashemi, Djawid Hashemi, Djawid Hashemi, Karl Jakob Weiß, Karl Jakob Weiß, Karl Jakob Weiß, Patrick Doeblin, Patrick Doeblin, Patrick Doeblin, Moritz Blum, Radu Tanacli, Radu Tanacli, Radu Tanacli, Hana Camdzic, Hana Camdzic, Hans-Dirk Düngen, Hans-Dirk Düngen, Frank Edelmann, Frank Edelmann, Frank Edelmann, Titus Kuehne, Titus Kuehne, Titus Kuehne, Marcus Kelm, Marcus Kelm, Marcus Kelm, Sebastian Kelle, Sebastian Kelle, Sebastian Kelle

“…No significant differences in tissue sodium content were observed between the three HF entities. Sodium values did not differ significantly with clinical signs of congestion or diuretic use. …”
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Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study by Fiona Reid, Sophie Papa, John Maher, Jean-Pierre Jeannon, James Spicer, Victoria Gibson, Selvam Thavaraj, Michael Metoudi, Christopher Fisher, Nicholas Beckley-Hoelscher, Andrew Hope, Maria Elstad, Antonella Adami, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Abdel Douri, Marc Delord, Mike Lyne, Dharshene Shivapatham, Sakina Gooljar, Arindam Mitra, Linda Gomm, Cienne Morton, Rhonda Henley-Smith, Alice Santambrogio, Cynthia Andoniadou, Sarah Allen, Gary J R Cook, Ana C Parente-Pereira, David M Davies, Farzin Farzaneh, Anna Schurich, Teresa Guerrero-Urbano

“…Despite rapid progression at trial entry, stabilization of disease (Response Evaluation Criteria in Solid Tumors V.1.1) was observed in 9 of 15 subjects (60%) at 6 weeks post-CAR T-cell administration. …”
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Evaluation of treadmill cardiopulmonary exercise testing and field measurement results in women’s youth and adult national team water polo players by Mark Zamodics, Mate Babity, Attila Mihok, Csaba Bognar, Agnes Bucsko-Varga, Panka Kulcsar, Dora Boroncsok, Regina Benko, Alexandra Fabian, Balint Lakatos, Hajnalka Vago, Attila Kovacs, Bela Merkely, Orsolya Kiss

“…Comparing the youth (<18y) and the adult (≥18y) players, no differences in relative maximal aerobic capacity (44.4 ± 4.8vs.44.9 ± 5.5 ml/kg/min, p = 0.72) and in peak lactate values (8.2 ± 2.7vs.8.7 ± 1.9 mM, p = 0.48) were observed in CPET examinations, while maximal heart rates were higher in the youth group (200.7 ± 7.2vs.190.1 ± 9.6 BPM, p < 0.001).Similarly, maximal lactate levels showed no differences (9.1 ± 2.6vs.10.4 ± 2.7 mM, p = 0.13), while maximal heart rates were higher in the youth group during swimming examinations (197.7 ± 10.0vs.181.4 ± 8.9 BPM, p < 0.001).The combined use of both exercise tests enables the assessment of maximal physiological parameters (heart rate, lactate, aerobic capacity) during different types and intensities of physical exercise and identifies differences across age groups, facilitating the design of a more personalized and effective training program.…”
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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…Over the course of the disease, a decrease in angiogenic signatures was observed in two HIV-positive KS patients. Notably, HIV-negative KS samples showed alterations in NK cell-mediated immunity and cytotoxic response pathways, whereas HIV-positive samples exhibited changes in growth regulation and protein kinase activity pathways at the time of initial diagnosis. …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Exploratory assessments of patients receiving ICI+chemotherapy (n=4369) observed more favorable rwOS only in TMB≥20.Conclusions Across &gt;8000 patients treated with single-agent ICI, and within individual cancer types with sufficient power, elevated TMB based on the FDA-approved CDx was associated with more favorable rwOS compared with similar patients with lower TMB levels. …”
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Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong by Yin Zhang, Francisco T T Lai, Shirley Chiu Wai Chan, Chak Sing Lau, Xue Li, Eric Yuk Fai Wan, Lung Yi Mak, Celine S L Chui, Ivan F N Hung, Esther Wai Yin Chan, Vincent Ka Chun Yan, Deliang Yang, Carlos Wong, Ian Chi-Kei Wong

“…A greater magnitude of increased risk was observed especially among those hospitalised during a previous infection.Conclusion Among patients with COVID-19 infection requiring hospitalisation, COVID-19 re-infection was associated with increased post-acute mortality and morbidity compared with first-time infection. …”
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Productivity of water and heat resources and cotton yield response to cropping pattern and planting density in cotton fields in arid area by Zhenlin Dong, Sumei Wan, Yunzhen Ma, Jinbin Wang, Lu Feng, Yunlong Zhai, Tiantian Li, Zhengjun Cui, Jian Wang, Beifang Yang, Ze Yang, Zhan Zhao, Fei Yan, Shiwu Xiong, Yabing Li, Guodong Chen

“…Lint and seed cotton yields showed positive correlations with soil heat production efficiency (PEsoil) and negative correlations with water production efficiency (WPc), with optimal patterns observed in the four-row, low-density and six-row, medium-density treatments. …”
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Effects of nitrogen fertilizer basal-to-top-dressing ratios on maize straw decomposition, soil carbon and nitrogen, and bacterial community structure in different soil textures on... by Jingyu Li, Jingyu Li, Xiaonan Yang, Rui Hou, Yujie Ma, Yanqun Wang, Yang Ma, Wenchao Zhen, Yuanyuan Huang, Xin Fu, Zhengping Peng, Zhengping Peng, Mingxin Men

“…N application significantly influenced bacterial diversity, with higher diversity observed with the N4:6 ratio in loam and the N5:5 ratio in clay loam. …”
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Comprehensive analysis of Pan-Immune Inflammation and all-cause mortality in rheumatoid arthritis: a database-driven approach, 1999-2018 by Muradil· Mardan, Huoliang Zheng, Qingyin Xu, Shaokuan Song, Zeyu Lu, Hui Deng, Hao Cai, Qizhu Chen, Bingyi Yang, Kudelaiti· Abuduwufuer, Pengbo Chen, Bo Li, Shengdan Jiang, Leisheng Jiang, Xin-feng Zheng

“…Subgroup analyses confirmed consistent findings, with a notable interaction observed in diabetic patients (P for interaction = 0.002).ConclusionsPIV is a significant and independent predictor of all-cause mortality in RA patients, characterized by a nonlinear association and a distinct threshold effect. …”
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Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults by Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, Chang-Yuil Kang, Sang Hwan Seo, Jae-Ouk Kim, Deok Ryun Kim, Nathaniel S. Hwang, Jae Seung Yang, Jerome H. Kim, Byoung-Shik Shim, Manki Song

“…Notably, while no significant difference was observed between the groups in the induction of most S1-specific antibody features, the high-dose group exhibited higher levels of antibodies and a stronger Fc receptor binding response specific to the S2 antigen. …”
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Identifying the predictors of ultra early neurological improvement and its role in functional outcome after endovascular thrombectomy in acute ischemic stroke by Yuzheng Lai, Mohammad Mofatteh, José Fidel Baizabal-Carvallo, José Fidel Baizabal-Carvallo, Jianfeng He, Wenhao Wu, Daohong Wang, Wenshan Yan, Jicai Ma, Sijie Zhou, Yu Sun, Yu Sun, Yi He, Shumei Li, Hao Sun

“…The presence of UENI was independently associated with a better outcome OR: 7.999 (95% C.I. 4.415–14.495).ConclusionUENI was observed in about a quarter of patients with AIS undergoing EVT. …”
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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…Finally, analysis of RET expression in ER+ breast cancer patients treated with endocrine therapy showed that high RET expression correlated with poor clinical outcomes. We further observed a shorter median survival to combined CDK4/6i and endocrine therapy in patients with RET-positive compared to RET-negative tumors, but this difference did not reach statistical significance.ConclusionsOur findings show that RET is overexpressed in ER+ metastatic breast cancer resistant to combined CDK4/6i and endocrine therapy, rendering RET inhibition a promising therapeutic approach for patients who experience disease progression on combined CDK4/6i and endocrine therapy.…”
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Artificial intelligence-based, non-invasive assessment of the central aortic pressure in adults after operative or interventional treatment of aortic coarctation by Renate Oberhoffer, Peter Ewert, Harald Kaemmerer, Nicole Nagdyman, Oliver Dewald, Frank Klawonn, Michael Huntgeburth, Andreas Eicken, Christian Meierhofer, Sebastian Freilinger, Martin Middeke, Pinar Bambul Heck, Annika Freiberger, Frank Harig, Manuel Lösch, Fritz Mellert, Fabian von Scheidt, Elsa Ury, Nicole Wolfrum, Ann-Sophie Kaemmerer-Suleiman, Mathieu N. Suleiman

“…An increased augmentation index as an indicator of arterial stiffness was observed in nine patients (19.1%). Comparing PBP and CABP in the entire collective, significant differences were found for CABP in relation to the procedure performed, with higher values in patients after prosthesis interposition as their last treatment (p&lt;0.05).Conclusion AI-PWA provides valuable insights into cardiovascular stress in CoA patients, beyond PBP measurements. …”
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Outcomes and risk factors of transported patients with extracorporeal membrane oxygenation: An ECMO center experience by Lingjuan Liu, Dingji Hu, Tong Hao, Shanshan Chen, Lei Chen, Yike Zhu, Chenhui Jin, Jing Wu, Haoya Fu, Haibo Qiu, Yi Yang, Songqiao Liu

“…A non-significant difference in 28-day survival was observed between the two groups after propensity score matching (P=0.56). …”
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