Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…Additionally, favorable pharmacokinetic properties were observed in cynomolgus monkeys. Conclusions In summary, integrin αvβ8 is highly expressed in certain tumors and tumor-infiltrating macrophages. …”
Get full text

The Financial Implications of Pancreatic Surgery: The Hospital Is the Big Winner, Not the Surgeon! by Nitzan Zohar, MD, Avinoam Nevler, MD, Sean P. Maher, Matthew C. Rosenthal, Florence Williams, Wilbur B. Bowne, MD, FACS, Charles J. Yeo, MD, FACS, Harish Lavu, MD, FACS

“…In this retrospective observational study, patients who underwent pancreaticoduodenectomy (PD), total pancreatectomy, or distal pancreatectomy at one academic medical center during the fiscal year 2021 were evaluated. …”
Get full text

Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study by Gideon Kofi Helegbe, Paul Armah Aryee, Baba Sulemana Mohammed, Anthony Wemakor, David Kolbila, Abdul-Wahid Abubakari, Salam Askanda, Rashid Alhassan, Collins Barnie, Afua Aboagyewaa Donkoh, Ernest Ofosu

“…A comparatively high seroprevalence of malaria and its coinfection with HBV in pregnant women was observed in this study. Considering the effects that both malaria and HBV have on the liver, it would be expedient to conduct further studies to assess liver function among malaria/HBV-infected individuals, while interventions to prevent coinfections among pregnant women are intensified.…”
Get full text

Chemical Composition and Larvicidal Activity of Flower Extracts from Clitoria ternatea against Aedes (Diptera: Culicidae) by Darvin R. Ravindran, Madhuri Bharathithasan, Patmani Ramaiah, Mohd Sukhairi Mat Rasat, Dinesh Rajendran, Shakila Srikumar, Intan H. Ishak, Abd Rahman Said, Rajiv Ravi, Mohamad Faiz Mohd Amin

“…The highest larvicidal activity was observed against the early 4th instar larvae of Aedes aegypti with the LC50 and LC95 values of 1056 and 2491 mg/L, respectively. …”
Get full text

Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways by Yu Zhang, Hailong Lun, Naiqiang Zhu, Naiqiang Zhu, Ning Yang, Kaikai Ding, Bin Chen, Chengbing Chang, Haipeng Gu, Yanqi Liu

“…A parallel downregulation trend of miR-34a-5p was also observed in OS cells. Silencing C1QTNF1-AS1 led to a marked upregulation of LDHA and PDK3 in OS cells, which was partially attenuated by miR-34a-5p mimics. …”
Get full text

Sedentary Behavior and Its Association With Psychological Well-Being and Sleep Quality in Adolescents: Evidence from a Propensity Score Analysis by Zhang L, Zhao S, Zhao S, Zheng H, Ke Y, Yang W, Lei M

“…Propensity scores matching analysis was employed to investigate the associative relationship between sedentary lifestyles and the measured outcomes.Results: Prior to propensity scores matching, significant differences were observed in baseline characteristics between participants with and without sedentary lifestyles, including gender (P=0.01), dietary habits (P< 0.001), mobile device usage (P< 0.001), stress events (P=0.001), physical activity (P< 0.001), and chronic diseases (P=0.024). …”
Get full text

Spatial and temporal heterogeneity of soil respiration in a bare-soil Mediterranean olive grove by S. Aranda-Barranco, S. Aranda-Barranco, P. Serrano-Ortiz, P. Serrano-Ortiz, A. S. Kowalski, A. S. Kowalski, E. P. Sánchez-Cañete, E. P. Sánchez-Cañete

“…Higher <span class="inline-formula"><i>R</i>_s</span> was found on the southern face, and an exponential decay of <span class="inline-formula"><i>R</i>_s</span> was observed until the alley's center was reached. These spatial changes were used to weigh and project <span class="inline-formula"><i>R</i>_s</span> onto the ecosystem scale, whose annual balance was 1.6–2.3 times higher than the <span class="inline-formula"><i>R</i>_eco</span> estimated using EC-derived models. …”
Get full text

Effect of L-Citrulline on Creatine Kinase MM (CK-MM) Isoenzymes in Mice: An In Vivo Study Focusing on Immunohistochemistry Analysis by Dhoni Akbar Ghozali, Annisa Aghnia Rahma, Shafira Nur Hanifa, Muhana Fawwazy Ilyas

“…However, no significant differences were observed among the C1, T1, T2, and T3 groups. In conclusion, L-citrulline supplementation demonstrates promise in attenuating muscle damage following eccentric exercise, as evidenced by reduced CK-MM expression levels. …”
Get full text

Immune responses in children with secondary infection of mycoplasma pneumoniae after COVID-19: focus on eosinophils and IgE by Pingping Wang, Jin Yao, Yaqiong Li, Zhanjun Zhang, Ruiling Zhang, Shouting Lu, Meixia Sun, Xiaorong Huang

“…Methods This study is a retrospective observational study, and a total of pediatric patients who were treated in our hospital from January 2023 to December 2023 were included. …”
Get full text

Experimental use of mycobacterial antigens in tuberculin skin test on water buffalo by Alessandra Martucciello, Federica Signorelli, Piera Mazzone, Francesco Grandoni, Giovanna Cappelli, Lucia Boccia, Giuseppe Parente, Monica Cagiola, Maria Beatrice Boniotti, Esterina De Carlo, Francesco Napolitano, Giorgio Galiero

“…A peak response was observed at 48 hours to PPDA and to 20 μg of the ESAT6-CFP10 protein cocktail, followed by a decrease. …”
Get full text

4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…These symptoms included a notable increase in both the number of calcified tissues and osteophytes (p < 0.001), an enlargement of the calcified meniscus and synovial tissue volume (p < 0.001), and thickening of the synovial lining layer attributable to M1 macrophage accumulation (p = 0.035). Additionally, we observed elevated histological scores for synovitis (p < 0.001). …”
Get full text

Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia by Jana Lücht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong

“…Cooling conveyed neuroprotection in OGD/R-injury as observable in increased cell viability as well as induced gene expressions of cold shock proteins. …”
Get full text

Effect of Rifaximin and a Multi-Strain Probiotic on the Intestinal Microbiome and Cardiovascular Risk Indicators in Patients with Coronary Heart Disease by E. A. Kashukh, E. A. Poluektova, A. V. Kudryavtseva, G. S. Krasnov, V. I. Kazey, P. D. Sobolev, P. V. Gremyakova, V. T. Ivashkin

“…After rifaximin therapy, a decrease in the proportion of bacteria of the Clostridiaceae (p &lt;0.05) and Peptostreptococcaceae (p &lt;0.05) families, a decrease in Enterobacteriaceae (p &gt; 0.05) family and a decrease in the Clostridium and Escherichia/Shigella (p &gt; 0.05) genera was observed. The use of the probiotic after a course of treatment with rifaximin did not have a significant effect on the composition of the microflora. …”
Get full text

Patterns and wavelet coherence analysis of tidal dynamics and chlorophyll a concentration by M.N. Hidayat, R. Wafdan, M. Ramli, Z.A. Muchlisin, S. Rizal

“…Similar trends were observed for tidal current and current magnitude. The continuous wavelet transform analysis provides data on chlorophyll a and the rate of change of chlorophyll a within 6, 12, and 24 hour, sea level changes within 8–16 hours, and consistent tidal effects on tidal current and current magnitude in the range of 5–7 hour. …”
Get full text

Traditional herbal medicine legislative and regulatory framework: a cross-sectional quantitative study and archival review perspectives by Sileshi Dubale, Rashed Edris Usure, Yesuneh Tefera Mekasha, Gemmechu Hasen, Firdos Hafiz, Dereje Kebebe, Sultan Suleman

“…Among regulatory experts, weak performance was identified in the practical implementation of THM regulatory activities, with 70.2% of weak performance observed at the federal level and 41.7% at the regional level. …”
Get full text

Massive permafrost rock slide under a warming polythermal glacier deciphered through mechanical modeling (Bliggspitze, Austria) by F. Pfluger, S. Weber, S. Weber, J. Steinhauser, C. Zangerl, C. Fey, J. Fürst, M. Krautblatter

“…In this paper, we hypothesize that the transition from cold- to warm-based glaciers, a scarcely observed but widespread phenomenon, caused the massive rock slide. …”
Get full text

Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache by Linda D’Antona, Sanjay Cheema, Dwij Mehta, Fion Bremner, Laurence Dale Watkins, Ahmed Kassem Toma, Manjit Singh Matharu

“…Methods This single-centre, retrospective observational study was conducted at a tertiary referral centre specialising in SIH and CSF dynamics disorders. …”
Get full text

Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration by Ping-Wu Zhang, Zi-He Wan, Weifeng Li, Abhishek Vats, Kunal Mehta, Laura Fan, Lingli Zhou, Sean Li, Gloria Li, Casey J. Keuthan, Cynthia Berlinicke, Cheng Qian, Noriko Esumi, Elia J Duh, Donald J. Zack

“…Microglia activation and MLKL protein upregulation were observed primarily in photoreceptors 12 h after LD, as assessed by immunohistochemistry. …”
Get full text

Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…Lower acceptance rates were observed for ages 15– 25 years (aOR = 0.84; 95% CI = 0.70– 0.99) and 46– 65 years (aOR = 0.83; 95% CI = 0.70– 0.99) compared to ages 26– 35 years. …”
Get full text

Differences in Optical Two-dimensional Morphological Characteristics of Downward Lightning Channels with Different Polarities by Mei Ji, Lü Weitao, Qi Qi, Xu Weiqun, Wu Bin, Ma Ying, Liu Hengyi, Chen Lüwen, Zhang Yang

“…In contrast, 76% (19/25) of positive CG lightning cases only observed the return stroke channel, without any additional bifurcations. …”
Get full text