Panitumumab plus 5-fluorouracil and folinic acid or 5-fluorouracil and folinic acid alone as maintenance therapy in RAS wild-type metastatic colorectal cancer (PanaMa, AIO KRK 0212... by Arndt Stahler, Meinolf Karthaus, Stefan Fruehauf, Ullrich Graeven, Lothar Müller, Ludwig Fischer von Weikersthal, Karel Caca, Eray Goekkurt, Alexej Ballhausen, Greta Sommerhäuser, Annabel H.S. Alig, Swantje Held, Armin Jarosch, David Horst, Anke Reinacher-Schick, Stefan Kasper, Volker Heinemann, Sebastian Stintzing, Tanja Trarbach, Dominik P. Modest

“…Findings: In 248 patients of the Full Analysis Set recruited between May 2014 and February 2021, with a median observation of 64.0 (range 12.5–86.3) months and 59.7 (range 3.7–97.3) months in the treatment arms, 230 events for PFS (92.7%) and 196 events for OS (79.0%) were recorded. …”
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Principles, barriers and enablers to agroecological animal production systems: a qualitative approach based on five case studies by B. Dumont, C. Barlagne, P. Cassart, J.E. Duval, A. Fanchone, J-L. Gourdine, O. Huguenin-Elie, Y. Kazakova, J. Klötzli, A. Lüscher, E. Oteros-Rozas, D. Pomies, M.G. Rivera Ferre, W.A.H. Rossing, V. Stefanova, A. Swartebroeckx, C. Zagaria

“…Following a multilevel perspective, we propose a new eight-category framework to categorise barriers and enablers in these different socioecological contexts, and discuss the implications of these results for scaling out and scaling up agroecological niche innovations in animal production areas. Though we could observe activities related to each agroecological principle in each case study, the relative importance of each principle differed. …”
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FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage by Fan Wang, Yue Xu, Yajie Wang, Qian Liu, Yanan Li, Weiwei Zhang, Huiming Nong, Junhong Zhang, Hao Zhao, Huaqian Yang, Lingchuan Guo, Jianfeng Li, Jianfeng Li, Hong Li, Qianqian Yang

“…Inhibiting autophagy increased the expression of FAM134B, and aggravated Cis-induced SGN damage, while the opposite changes were observed when autophagy was activated. Additionally, co-treatment with the N-Acetyl-L-Cysteine (NAC), ROS scavenger, alleviated Cis-induced ER stress, ER-phagy, and apoptosis. …”
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Effect of practicing water-saving irrigation on greenhouse gas emissions and crop productivity: A global meta-analysis by Mingdong Tan, Ningbo Cui, Shouzheng Jiang, Liwen Xing, Shenglin Wen, Quanshan Liu, Weikang Li, Siwei Yan, Yaosheng Wang, Haochen Jin, Zhihui Wang

“…In this study, a global meta-analysis of 1230 observations from 62 publications were conducted to investigate the global patterns and underlying drivers of soil GHG emissions and crop productivity (crop yield and water use efficiency) induced by WSI, and the contributions of key factors to GHG emissions and crop productivity were further quantified. …”
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A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice by Xi Liu, Xi Zhang, Dongxu Wang, Ya Cao, Ling Zhang, Zhonghua Li, Qin Zhang, Yu Shen, Xian Lu, Keyu Fan, Mingxia Liu, Jingqiu Wei, Siping Hu, He Liu

“…Following the injection of retrograde transport fluorescent‐labeled virus into NAc, glutamatergic neurons projecting from the PVT to NAc were observed, confirming the projection relationship between PVT and NAc. …”
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Association of glycemic control with Long COVID in patients with type 2 diabetes: findings from the National COVID Cohort Collaborative (N3C) by Jane E B Reusch, Rachel Wong, Nasia Safdar, Harold Lehmann, Brijesh Patel, Til Stürmer, Hongfang Liu, Peter Robinson, Elaine Hill, Richard Moffitt, Justin Guinney, Joel Gagnier, Cavin Ward-Caviness, Noha Sharafeldin, Justin Starren, Amit Saha, Lesley Cottrell, Melissa A Haendel, Margaret A Hall, Vignesh Subbian, Kristin Kostka, Farrukh M Koraishy, Andrew E Williams, Robert Hurley, Steve Johnson, Usman Sheikh, Rishi Kamaleswaran, Christopher Dillon, Michele Morris, Randeep Jawa, Hemalkumar Mehta, Benjamin Bates, Tellen D Bennett, Nabeel Qureshi, Katie Rebecca Bradwell, Federico Mariona, Adam B Wilcox, Adam M Lee, Alexis Graves, Amin Manna, Amy Olex, Andrea Zhou, Andrew Southerland, Andrew T Girvin, Anita Walden, Anjali A Sharathkumar, Benjamin Amor, Brian Hendricks, Caleb Alexander, Carolyn Bramante, Charisse Madlock-Brown, Christine Suver, Christopher Chute, Chunlei Wu, Clare Schmitt, Cliff Takemoto, Dan Housman, Davera Gabriel, David A Eichmann, Diego Mazzotti, Eilis Boudreau Don Brown, Elizabeth Zampino, Emily Carlson Marti, Emily R Pfaff, Evan French, Fred Prior, George Sokos, Greg Martin, Heidi Spratt, Hythem Sidky, JW Awori Hayanga, Jami Pincavitch, Jaylyn Clark, Jeremy Richard Harper, Jessica Islam, Jin Ge, Joel H Saltz, Joel Saltz, Johanna Loomba, John Buse, Jomol Mathew, Joni L Rutter, Julie A McMurry, Karen Crowley, Kellie M Walters, Ken Wilkins, Kenneth R Gersing, Kenrick Dwain Cato, Kimberly Murray, Lavance Northington, Lee Allan Pyles, Leonie Misquitta, Lili Portilla, Mariam Deacy, Mark M Bissell, Marshall Clark, Mary Emmett, Mary Morrison Saltz, Matvey B Palchuk, Meredith Adams, Meredith Temple-O'Connor, Michael G Kurilla, Nicole Garbarini, Ofer Sadan, Patricia A Francis, Penny Wung Burgoon, Rafael Fuentes, Rebecca Erwin-Cohen, Richard A Moffitt, Richard L Zhu, Robert T Miller, Saiju Pyarajan, Sam G Michael, Samuel Bozzette, Sandeep Mallipattu, Satyanarayana Vedula, Scott Chapman, T Shawn, Soko Setoguchi O'Neil, Stephanie S Hong, Tiffany Callahan, Umit Topaloglu, Valery Gordon, Warren A Kibbe, Wenndy Hernandez, Will Beasley, Will Cooper, William Hillegass, Xiaohan Tanner Zhang, Samuel Soff, Yun Jae Yoo, Jared Davis Huling, Daniel Brannock, Zachary Butzin-Dozier, Alfred Jerrod Anzalone, Philip RO. Payne, Rena Patel

“…However, this association was not observed in patients with T2D without a history of COVID-19. …”
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Dynamic monitoring and drivers of ecological environmental quality in the Three-North region, China: Insights based on remote sensing ecological index by Leyi Zhang, Xia Li, Xiuhua Liu, Zhiyang Lian, Guozhuang Zhang, Zuyu Liu, Shuangxian An, Yuexiao Ren, Yile Li, Shangdong Liu

“…In contrast, grassland degradation and urbanization adversely affected it. These observations are important for accurately assessing the quality of ecological environments, effectively implementing ecological projects, and ensuring a sustainable regional development. …”
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Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China by Keyi Wu, Weidong Fan, Jing Wei, Jianyun Lu, Xiaowei Ma, Zelin Yuan, Zhiwei Huang, Qi Zhong, Yining Huang, Fei Zou, Xianbo Wu

“…Furthermore, stronger associations were observed during the cold season than during the warm season. …”
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The Effect of Coronary Artery Disease on the Prognosis of Hypertrophic Cardiomyopathy: A Multi-Center Cohort Study by Guoqing Hou, Qian Liao, Huihui Ma, Yan Shu, Shengzhi Zeng, Yongmei Zhou, Liangjun Luo, Gang Zhao, Tao He, Mingjiang Liu, Jianhong Tao, Wei Hua, Xiaoping Li

“…Conclusions: In this study, it was observed that there was no statistically significant disparity in mortality rates between patients diagnosed with HCM who concurrently had CAD and those who did not exhibit CAD. …”
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Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, m... by Prithwish Banerjee, Guy A MacGowan, Frans H Rutten, Iacopo Olivotto, Petar M Seferović, Jonathan Mant, Djordje G Jakovljevic, Oscar Fernandez, Josep Darbà, Nduka C Okwose, Jose Zamorano, Duncan Edwards, David Sinclair, Lazar Velicki, Amy Groenewegen, Lars S Maier, Dimitris Fotiadis, Sarah Jane Charman, Annamaria Del Franco, Maria Tafelmeier, Andrej Preveden, Cristina Garcia Sebastian, Amy S Fuller, Anne Pauline Nelissen, Petros Malitas, Aikaterini Zisaki, Zoran Bosnic, Petar Vracar, Fausto Barlocco, Marta Jiménez-Blanco Bravo, Nenad Filipovic, Bano Fatima, Williams Kate, Fornaro Alessandra, Milovancev Aleksandra, Ascanio Meritxell, Aguera Ainoa, Pičulin Matej, Flis Borut, Boucharas Dimitrios, Manousos Dimitris, Tsiknakis Manolis, Kassiotis Thomas, Sustersic Tijana, Milicevic Bogdan, Hobbs FD Richard, Kaagman Onno

“…The secondary outcomes are the demographic and clinical predictors of risk, diagnosis and progression of HF.Methods and analysis STRATIFYHF is a prospective, multicentre, longitudinal study that will recruit up to 1600 individuals (n=800 suspected/at risk of HF and n=800 diagnosed with HF) aged ≥45 years old, with up to 24 months of follow-up observations. Individuals suspected of HF will be divided into two categories based on current definitions and predefined inclusion criteria. …”
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Utilization of donor CLL-1 CAR-T cells for the treatment of relapsed of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation by Meng Zhang, Meng Zhang, Xiaomei Zhang, Xiaomei Zhang, Jiaxi Wang, Wenyi Lu, Xia Xiao, Hairong Lyu, Xiaoyuan He, Yedi Pu, Juanxia Meng, Cuicui Lyu, Xinping Cao, Mingfeng Zhao, Mingfeng Zhao

“…Cytokine Release Syndrome (CRS) was observed in all patients, with 5 patients experiencing grade ≥3. 3 patients developed cytokine release syndrome-associated encephalopathy (CRES), and 1 patient had a grade 4 severity level. …”
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Effect of acupoint application combined with moxibustion in the treatment of postoperative constipation in patients with thoracolumbar compression fracture (艾灸联合穴位贴敷治疗胸腰椎压缩性骨折患者术后便... by WANG Tingting (王亭亭), LIU Fei (柳菲), NIE Shanshan (聂珊珊), YANG Qiujing (杨秋景), YANG Yang (杨杨)

“…Objective To observe the therapeutic effect of acupoint application therapy combined with moxibustion on postoperative constipation in patients with thoracolumbar compression fracture. …”
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Characteristics, controlling factors of development and exploration areas of deep coal-rock reservoirs in rift basins: a case study of the second member of Cretaceous Nantun Format... by Geng GAO, Yingyi XIE, Beibei HOU, Wenjuan MA, Hui XU, Yujie WANG, Yingdong HUO, Jingyuan ZHANG, Shichao LIU, Wei ZHAO, Yuan LIANG

“…Based on drilling and seismic data from the Huhehu Sag, the characteristics and main controlling factors of the high-quality coal rock reservoirs in N2 are studied through core and thin section observations and experimental analysis. The coal-rock reservoirs in N2 of the Huhehu Sag have the characteristics of low ash content, ultra-low moisture content, and medium to high volatile matter. …”
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Reflecting on the impact of the COVID pandemic on patient management and its subsequent influence on long-term outcomes: a case–control study in the field of esophago-gastric cance... by Mohamed Alasmar, Nadia Matias, Norah Ali M. Alhamed, Omneya Alwani, Brogan Rudge, Terngu David Moti, Muhammad Ossama Yassin Abdelwahab, Jennifer Stockton, Charef Raslan, Jess Cairney-Hill, Mohammad Altarawni, Bilal Alkhaffaf, on behalf Greater Manchester Oesophago-Gastric Service

“…A further significant observation was the emergence of more aggressive tumour characteristics, particularly in the P2 group, albeit without a statistically significant difference in two-year overall survival rates among the groups (p-value 0.31). …”
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Bidirectional effect modifications of temperature and PM2.5 on myocardial infarction morbidity and mortality in Beijing, China from 2007 to 2021 by Piaopiao Hu, Qinghui Zeng, Jie Chang, Moning Guo, Feng Lu, Yue Qi, Zhao Yang, Pingping Jia, Qiuju Deng, Jing Liu

“…The temperature effect on MI morbidity was also modified by PM2.5, with a gradual upward risk trend observed with increasing PM2.5 concentration. Specifically, the heat wave effect was greater at high PM2.5 concentration strata (1.097, 95 % CI: 1.042, 1.155) than at low strata (0.954, 95 % CI: 0.890, 1.023) (PZ test=0.002). …”
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Early Outcomes from Proton Craniospinal Irradiation for Leptomeningeal Metastasis From Solid Tumors by Keng Lam, MD, Lewis F. Nasr, MD, Clark R. Andersen, MS, Kathryn E. Marqueen, MD, Jing Li, MD, PhD, Chenyang Wang, MD, Thomas H. Beckham, MD, PhD, Nazanin K. Majd, MD, PhD, Ashley E. Aaroe, MD, Monica Loghin, MD, Barbara J. O'Brien, MD, Susan L. McGovern, MD, PhD

“…Following pCSI, 4% received intrathecal chemotherapy, 67% systemic therapy, and 9% hospice care; 18% were observed and 2% lost to follow-up. Median overall survival was 13.7 months (95% confidence interval [CI], 11.2 to not reached), and median progression-free survival was 6.5 months (95% CI, 4.9-12.8). …”
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Association of blood group types and clinico-pathological features of gynecological cancers (GCs) by Syed Sameer Aga, Muhammad Anwar Khan, Mubarak Al Mansour, Rana Mohammed Hasosah, Lulu Abdullah Alsubaie, Dala Ahmad Alfaify, Malak Badr Alansari, Shahad Obaidallah Almutairi, Saniya Nissar

“…In case of the patient dependent GCs, a significant association between ovarian cancers and recurrence, fallopian tube cancers and adverse events and survival status, vaginal/vulval cancers and TNM stage and mixed GCs and tumor type (carcinoma) was observed (P < 0.05). Furthermore, multinomial analysis between various confounding factors and GCs revealed that the risk of Cervical, Endometrial and Ovarian cancers to be significant for Type B BG (P < 0.05). …”
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Altered regional brain activity and functional connectivity in relation to blood lead levels by Yi Shi, Linfeng Yan, Yang Yang, Fenfen He, Wenhao Li, Jianbin Zhang, Fang Zhao, Diya Wang, Wen Wang, Zaihua Zhao, Xuefeng Shen

“…Furthermore, negative correlations were observed between lead levels and FC of the left insula with the left fusiform gyrus (r = − 0.586), left superior frontal gyrus (r = − 0.556), and left middle frontal gyrus (r = − 0.626), as well as between FC of the right insula and the right middle frontal gyrus (r = − 0.587). …”
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Persistent organochlorine pesticides and cardiometabolic outcomes among middle-aged Latina women in a California agricultural community: The CHAMACOS Maternal Cognition Study by Marcella Warner, Stephen Rauch, Brenda Eskenazi, Lucia Calderon, Robert B. Gunier, Katherine Kogut, Nina Holland, Weihong Guo, Julianna Deardorff, Jacqueline M. Torres

“…Although credible intervals crossed the null, consistent positive associations were observed for DDT and β-HCH with blood pressure and for DDT with insulin resistance. …”
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Sexual health and healthy relationships for Further Education (SaFE) in Wales and England: results from a pilot cluster randomised controlled trial by Fiona V Lugg-Widger, Chris Bonell, James White, Honor Young, Ruth Lewis, Rachel Brown, Jason Madan, Julia Townson, Lauren Copeland, Philip Pallmann, G J Melendez-Torres, Rhys Williams-Thomas, Muhammad Riaz, Gemma S Morgan

“…Over 80% of onsite sexual health services were attended by a nurse; onsite publicity about sexual health services was observed at all intervention settings and 137 staff were trained. …”
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