A machine learning model to predict neurological deterioration after mild traumatic brain injury in older adults by Daisu Abe, Motoki Inaji, Takeshi Hase, Eiichi Suehiro, Naoto Shiomi, Hiroshi Yatsushige, Shin Hirota, Shu Hasegawa, Hiroshi Karibe, Akihiro Miyata, Kenya Kawakita, Kohei Haji, Hideo Aihara, Shoji Yokobori, Takeshi Maeda, Takahiro Onuki, Kotaro Oshio, Nobukazu Komoribayashi, Michiyasu Suzuki, Taketoshi Maehara

“…In this study, we developed a machine learning model to predict the occurrence of neurological deterioration after mild TBI using information obtained on admission.MethodsThis was a retrospective cohort study of data from the Think FAST registry, a multicenter prospective observational study of elderly TBI patients in Japan. …”
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Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients by Jiayi Wang, Lingyao Du, Dongmei Zhang, Chen Zhou, Yilan Zeng, Miao Liu, Xing Cheng, Xiaona Song, Han Chen, Ning Han, Enqiang Chen, Hong Tang

“…Methods: In this real-world prospective observational study, we recruited patients from the West China Hospital and Public Health Clinical Center of Chengdu in China. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…However, markedly downregulation of the mRNA level of pro-inflammatory cytokine il-1β (p < 0.05) was observed in 0.05 and 0.3T23 groups, compared with the control. 16S rRNA sequencing analysis data on gut microbiota indicated that supplementation of T23 at lower levels (0.05, 0.1 and 0.2) resulted in a remarkable elevation of the abundance of phylum Firmicutes and reduced the abundance of Proteobacteria, and the ratio of (Firmicutes +Bacteroidota +Fusobacteria) /Proteobacteria. …”
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Biologics as well as inhaled anti-asthmatic therapy achieve clinical remission: Evidence from the Severe Asthma Network in Italy (SANI) by Giorgio Walter Canonica, MD, Francesco Blasi, PhD, Pierluigi Paggiaro, MD, Enrico Heffler, PhD, Fulvio Braido, MD, Luisa Brussino, PhD, Giulia Scioscia, PhD, Cristina Cardini, MsC, Chiara Oriecuia, MsC, Isabella Sala, MsC, Vincenzo Bagnardi, PhD, Cecilia Calabrese, PhD, Gianna Camiciottoli, MD, Giovanna Elisiana Carpagnano, PhD, Stefano Centanni, PhD, Angelo Guido Corsico, PhD, Maria Teresa Costantino, MD, Claudia Crimi, PhD, Alice D'Adda, MD, Simona D’Alò, MD, Maria D'Amato, PhD, Corrado D'Andria, MD, Stefano Del Giacco, MD, Fabiano Di Marco, PhD, Nicola Cosimo Facciolongo, MD, Alessandro Farsi, MD, Manuela Latorre, PhD, Manlio Milanese, PhD, Eustachio Nettis, MD, Eleonora Nucera, MD, Giovanni Passalacqua, MD, Girolamo Pelaia, MD, Laura Pini, MD, Luisa Ricciardi, PhD, Fabio Luigi Massimo Ricciardolo, PhD, Luca Richeldi, PhD, Erminia Ridolo, PhD, Pierachille Santus, PhD, Nicola Scichilone, PhD, Gianenrico Senna, MD, Giuseppe Spadaro, MD, Antonio Spanevello, MD, Paolo Tarsia, MD

“…Differences in CR achievement according to type of biologic agent administered were observed. Interesting results were found when assessing the inhaled therapy (ICS/LABA/LAMA and no biologics) effectiveness: 34.5% patients reached complete CR, 34.5% partial CR, and 31.0% did not reach CR. …”
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Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…We show that in two KL mutant NSCLC xenograft models and a KL mutant PDX model, treatment with AHA-1031 monotherapy significantly inhibits tumor growth compared with vehicle-treated animals with no observable toxicity. Tumor tissues from treated mice exhibit significantly increased immune cell infiltrates and activated NK cell populations.Conclusions Activating NK cells through MICA/B stabilization and inducing ADCC offers an alternative and potent therapy option in KL tumors. …”
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Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes by Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata

“…In this retrospective observational study, we selected patients with drug-resistant pediatric epilepsies caused by variants in potassium channel encoding genes, followed at the Fondazione IRCCS Istituto Neurologico Carlo Besta of Milan, Italy. …”
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Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain by Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD

“…The aim of this study was to describe healthcare patterns of patients participating in a interdisciplinary pain program (IPP) for chronic low back pain. Methods: This observational cohort study describes the healthcare utilization of a group of adult patients (N=143) who participated in an IPP for chronic back pain compared to patients who did not complete the entire program (N=112), and those who were eligible for the program but chose not to participate (N=76). …”
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Perceived healthiness of sugary drinks and related social norms among adults in five countries: evidence from the International Food Policy Study by Virginie Drolet-Labelle, Christine M. White, Jean Adams, Sharon I. Kirkpatrick, Alejandra Jáuregui, Lilia S. Pedraza, Véronique Provencher, Gary Sacks, James F. Thrasher, Gabriela C. Armendariz, Simón Barquera, David Hammond, Lana Vanderlee

“…Conclusions Shifts over time in social norms and perceived healthiness observed in Mexico and associations with intake of sugary drinks in most countries suggest that targeted interventions to change norms and perceptions could help reduce sugary drink consumption.…”
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Genomic selection strategies to overcome genotype by environment interactions in biosecurity-based aquaculture breeding programs by Ziyi Kang, Jie Kong, Qi Li, Juan Sui, Ping Dai, Kun Luo, Xianhong Meng, Baolong Chen, Jiawang Cao, Jian Tan, Qiang Fu, Qun Xing, Sheng Luan

“…With a genetic correlation of 0.8, genotyping 20 SG individuals in each candidate family achieved 93.2% of the genetic gain observed for NBS. However, when the genetic correlation fell below 0.5, the number of genotyped SG individuals per family had to be increased to 50 or more. …”
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Atherosclerotic Risk Factors in Children with Celiac Disease by Anna Rybak, Aldona Wierzbicka, Piotr Socha, Anna Stolarczyk, Bożena Cukrowska, Łukasz Obrycki, Zbigniew Wawer, Roman Janas, Beata Oralewska, Anna Szaflarska-Popławska, Barbara Iwańczak, Elżbieta Cyrta-Jarocka, Urszula Grzybowska-Chlebowczyk, Wojciech Cichy, Grażyna Czaja-Bulsa, Jerzy Socha

“…Material and Methods. 277 patients with CD from 7 Polish clinics were enrolled in the study (210 children treated for at least 5 years and 67 children included in the study on the day of CD diagnosis and observed for 1 year on a GFD). We obtained selected clinical data, and we assessed lipid profile, apolipoproteins (A1, B, and E), lipoprotein (a), homocysteine, as well as antioxidants (folic and uric acid), and high-sensitivity CRP (hsCRP) for all patients. …”
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Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan by Jeffrey M. Hord, Sarah Burns, Tobias Willer, Matthew M. Goddeeris, David Venzke, Kevin P. Campbell

“…Results Our data showed that in Pomt1skm mice O-mannosylated DG is required for sarcolemma resilience, remodeling of muscle fibers and muscle tissue, and neuromuscular function. Notably, we observed similar body size limitations, sarcolemma weakness, and neuromuscular weakness in Large1skm mice that only lacked matriglycan. …”
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System-Technology Co-Optimization for Dense Edge Architectures Using 3-D Integration and Nonvolatile Memory by Leandro M. Giacomini Rocha, Mohamed Naeim, Guilherme Paim, Moritz Brunion, Priya Venugopal, Dragomir Milojevic, James Myers, Mustafa Badaroglu, Marian Verhelst, Julien Ryckaert, Dwaipayan Biswas

“…The framework builds on a systolic array accelerator to provide the design-technology characterization points using advanced imec A10 nanosheet CMOS node along with emerging, high-density voltage-gated spin-orbit torque (VGSOT) magnetic memories (MRAM), combined with memory-on-logic fine-pitch 3-D wafer-to-wafer hybrid bonding. We observe that the 3-D system integration of static random-access memory (SRAM)-based design leads to 9% power savings with 53% footprint reduction at iso-frequency with respect to 2-D implementation for the same memory capacity. …”
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Spatial variations in the microbiota: comparative analysis of microbial composition and predicted functions across different intestinal segments and feces in donkeys by Yanwei Wang, Yanwei Wang, Yanwei Wang, Tong Hu, Tong Hu, Kaixuan Liang, Kaixuan Liang, Shinuo Li, Shinuo Li, Qiyue Zhang, Qiyue Zhang, Qiyue Zhang, Wenqiang Li, Honglei Qu, Honglei Qu, Boying Dong, Haihua Zhang, Qiugang Ma, Qiugang Ma, Ru Jia, Shimeng Huang, Shimeng Huang

“…No significant differences in the indices of alpha diversity were observed among the donkey’s duodenum, jejunum, ileum, cecum, colon, and feces. …”
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Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral... by Shuai Yang, En Deng, Linxin Chen, Yanbin Pi, Anhong Wang, Linghui Dai, Hongjie Huang, Xiaoning Duan, Xin Fu, Jiying Zhang, Qinwei Guo, Weili Shi

“…Results: At 2, 4, and 6 months postoperatively, the gross view evaluation using the International Cartilage Repair Society (ICRS) scoring system and the imaging assessment with the magnetic resonance observation of cartilage repair tissue (MOCART) scoring system showed similar results in the AOCT and AOPT groups, both superior to those of the control group. …”
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Assessing the role of genotype by environment interaction of winter wheat cultivars using envirotyping techniques in North China by Haiwang Yue, Yanbing Wang, Zhaoyang Chen, Jiashuai Zhu, Partha Pratim Behera, Pengcheng Liu, Haoxiang Yang, Jianwei Wei, Junzhou Bu, Xuwen Jiang, Xuwen Jiang, Wujun Ma

“…Conversely, negative correlations were observed with relative humidity at 2 meters (RH2M), total precipitation (PRECTOT), potential evapotranspiration (PETP), and dew point temperature at 2 meters (T2MDEW). …”
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Effect of Tonifying deficiency and Zhengqi porridge on immune function reconstruction in HIV/AIDS patients with Qi deficiency (补虚正气粥对艾滋病气虚型患者免疫功能重建的影响研究)... by WEI Yan (魏艳), LI shu (李树), YUAN Hongxia (袁洪霞), ZHANG Ying (张英), LIU Xiaoli (刘小丽), LIU Lingling (刘玲玲)

“…Objective To observe the effect of Tonifying deficiency and Zhengqi porridge on immune function reconstruction of HIV/AIDS patients with Qi deficiency. …”
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Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies by Xiangjun Wang, Xiaowen Xia, Xianliang Song, Yi Zhou, Mingyu Ma, Yashuang Ren, Xitai Chen, Zenghui Xia, Yinghui Guo, Chunhong Song

“…HE staining and Golgi staining were performed to observe the neuronal damage in rat hippocampus. UHPLC-MS/MS targeted metabolomics was performed to detect the changes of neurotransmitter content in rat hippocampus. …”
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The azimuthal correlation between the leading jet and the scattered lepton in deep inelastic scattering at HERA by ZEUS Collaboration, I. Abt, R. Aggarwal, V. Aushev, O. Behnke, A. Bertolin, I. Bloch, I. Brock, N. H. Brook, R. Brugnera, A. Bruni, P. J. Bussey, A. Caldwell, C. D. Catterall, J. Chwastowski, J. Ciborowski, R. Ciesielski, A. M. Cooper-Sarkar, M. Corradi, R. K. Dementiev, S. Dusini, J. Ferrando, B. Foster, E. Gallo, D. Gangadharan, A. Garfagnini, A. Geiser, G. Grzelak, C. Gwenlan, D. Hochman, N. Z. Jomhari, I. Kadenko, U. Karshon, P. Kaur, R. Klanner, U. Klein, I. A. Korzhavina, N. Kovalchuk, M. Kuze, B. B. Levchenko, A. Levy, B. Löhr, E. Lohrmann, A. Longhin, F. Lorkowski, E. Lunghi, I. Makarenko, J. Malka, S. Masciocchi, K. Nagano, J. D. Nam, Yu. Onishchuk, E. Paul, I. Pidhurskyi, A. Polini, M. Przybycień, A. Quintero, M. Ruspa, U. Schneekloth, T. Schörner-Sadenius, I. Selyuzhenkov, M. Shchedrolosiev, L. M. Shcheglova, N. Sherrill, I. O. Skillicorn, W. Słomiński, A. Solano, L. Stanco, N. Stefaniuk, B. Surrow, K. Tokushuku, O. Turkot, T. Tymieniecka, A. Verbytskyi, W. A. T. Wan Abdullah, K. Wichmann, M. Wing, S. Yamada, Y. Yamazaki, A. F. Żarnecki, O. Zenaiev

“…Perturbative calculations at $$\mathcal {O}(\alpha _{s}^2)$$ O ( α s 2 ) accuracy successfully describe the data within the fiducial region, although a lower level of agreement is observed near $$\Delta \phi \rightarrow \pi $$ Δ ϕ → π for events with high jet multiplicity, due to limitations of the perturbative approach in describing soft phenomena in QCD. …”
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Deltopectoral approach without subscapularis detachment for reverse shoulder arthroplasty. Technique and results of a safe and reproducible subscapularis-sparing approach by Adrien Jacquot, MD, MSc, Thomas Cuinet, MD, Lisa Peduzzi, MD, Patrice Wong, MD, Marc-Olivier Gauci, MD, PhD, Julien Uhring, MD

“…Results: There was no intraoperative complication, and the mean operative time was 62 minutes. We observed a significant improvement in Constant score (from 36 to 70, P <.001), simple shoulder value (from 33 to 81, P <.001), pain (from 6.3 to 0.7, P <.001), strength (from 0.5 to 3.5, P <.001), and most of the active mobilities. …”
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Are bacterial communities and aggregation in fragile soils influenced by the management system? by Tiago Paula da Silva, Caio Simões dos Santos Nicolau, Carlos Wagner Ribeiro Junqueira, Gustavo Souza Lima Sant’Anna, Everaldo Zonta, Nivaldo Schultz, Irene da Silva Coelho, Marcos Gervasio Pereira

“…A higher proportion of biogenic aggregates (53–64%) was observed compared to physicogenic aggregates (36–47%). …”
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