Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

“…Functional experiments demonstrate the requirement of PLAC8 in SARS-CoV-2 pancreatic productive infection by pseudovirus and full SARS-CoV-2 infectious virus inoculum from Wuhan-1 and BA.1 strains. Finally, we observe an overlap between PLAC8 and SARS-CoV-2 immunoreactivities in the pancreas of deceased patients. …”
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Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis by Jian Zhang, Xiaomei Li, Ying Hu, Bin Dong, Yongning Jia, Ziyu Li, Xiaojing Cheng, Jinyao Shi, Jiafu Ji, Zhongwu Li, Hong Du, Ting Guo, Shuqin Jia, Xiaofang Xing, Yunsheng Dou

“…Then we performed multiplex fluorescence staining of a panel of immune markers (CD3, CD4, CD8, FOXP3 and PDL1) and T cell receptor β-chain sequencing to phenotype and enumerate T cell subpopulations and clonal expansion in paired GC samples (prechemotherapy and postchemotherapy) from another cohort of 30 cases of stage II/III GC patients.Results Infiltration of CD68+ macrophages in residual tumors after NAC was significantly decreased compared with treatment-naïve GC patients, while no significant difference observed with respect to other immune markers. In residual tumors, post-NAC CD8 +T cells and CD68+ macrophages levels were significantly associated with chemotherapy response. …”
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Exploring the physiological and biochemical mechanisms underlying growth rate variability in Hong Kong oyster (Crassostrea hongkongensis) by Na Hu, Wenhong Li, Pingping He, Pinyuan Wei, Ke Bai, Junliang Guan, Li Zhang, Yongxian Chen, Wei Li, Yusi Zheng, Qingsong He, Longcheng Liu, Xingzhi Zhang, Jinxia Peng

“…Significantly elevated activities of α-amylase and lipase (341.71 μg/min/mg prot and 363.83 nmol/min/mg prot) were observed in the SL group compared to the CL and CS groups (p < 0.05). …”
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Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…Similar results were observed for progression-free survival (PFS). Based on the results retrieved from organ-specific irAEs, ‘aggregated’ burden scores were developed to distinguish ‘protective’ (endocrine and musculoskeletal) and ‘harmful’ (gastrointestinal, pneumonitis, neurological, hepatic) irAEs showing prognostic effects on OS and PFS.Conclusions Our results demonstrate that not all irAEs could exert a protective effect on oncologic outcome. …”
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Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV by Giovanni Guaraldi, Jovana Milic, Elena Bacchi, Federica Carli, Marianna Menozzi, Iacopo Franconi, Alessandro Raimondi, Giacomo Ciusa, Valentina Masi, Michela Belli, Stefano Guaraldi, Emanuele Aprile, Maria Mancini, Cristina Mussini, Jordan E. Lake, Kristine M. Erlandson

“…We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up. Methods: In an observational cohort study from 2007 to 2019 at Modena HIV Metabolic Clinic, Italy, ART-experienced but INSTI-naive PLWH were grouped as INSTI-switchers vs non-INSTI. …”
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Early sST2 Liberation after Implantation of a Left Ventricular Assist Device in Patients with Advanced Heart Failure by Philipp Opfermann, Elisabeth Simader, Alessia Felli, Michele Bevilacqua, Caroline Holaubek, Martin Dworschak, Mohamed Mouhieddine, Daniel Zimpfer, Jan Hendrik Ankersmit, Barbara Steinlechner

“…While 1-year survivors had persistently lower sST2 values compared to nonsurvivors during the first 3 weeks after LVAD implantation (p=0.012), no differences were observed in the temporal pattern of IL-6 or IL-33. …”
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Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, resp... by Fei Wang, Yongjiu Wang, Bin Xiong, Zhenlin Yang, Jingfen Wang, Yumin Yao, Lixiang Yu, Qinye Fu, Liang Li, Qiang Zhang, Chao Zheng, Shuya Huang, Liyuan Liu, Chun Liu, Huaibo Sun, Beibei Mao, Dong-Xu Liu, Zhigang Yu

“…No new adverse events were observed with the addition of pyrotinib. Patients with co-mutations of TP53 and PIK3CA exhibited lower rates of early partial response compared to those without or with a single gene mutation (36.0% vs. 60.0%, P = 0.08). …”
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Features of the functioning of the hypothalamic-pituitary-thyroid axis in mice with Lewis carcinoma on the background of induced hyperthyroidism by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, I. V. Neskubina, E. I. Surikova, A. I. Shikhlyarova, L. K. Trepitaki, M. A. Gusareva, I. A. Udalenkova, E. O. Vasilieva, N. D. Cheryarina, V. V. Pozdnyakova

“…In males, in 73 % of the observations, the T3 level was increased against the background of high T4 and FT4 values and unchanged TSH levels. …”
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Prediction of digestible energy requirement in growing finishing stage of pigs using machine learning models by Nibas Chandra Deb, Jayanta Kumar Basak, Sijan Karki, Elanchezhian Arulmozhi, Dae Yeong Kang, Niraj Tamrakar, Eun Wan Seo, Junghoo Kook, Myeong Yong Kang, Hyeon Tae Kim

“…While evaluating the model's performance under different datasets, it was observed that the RFR model exhibited the best performance with DS4, explaining over 97 % and 95 % of actual and predicted data during the training and testing phases, respectively, while MLR model demonstrated the worst accuracy (R2 < 0.93 and RMSE >6.1 MJ/pig day) compared to the other models. …”
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Associations between hypovitaminosis D, adiposity indices and insulin resistance in adolescents: mediation analyses from NHANES 2011–2018 by Yaping Deng, Yingting Luo, Yilei Shen, Yong Zhao, Wei Cao, Jie Cao, Lijuan Xu, Lin Kong

“…Notably, subgroup analysis indicated a pronounced hypovitaminosis D -adiposity association in female adolescents, which was not observed in males. The XGBoost algorithm pinpointed obesity and blood lipid indicators significantly affecting IR, with total fat mass, triglyceride, cholesterol, BMI, and FMI ranked by descending importance. …”
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Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients by Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Piotr Ceranowicz, Jakub Kucharz, Anna Ząbek-Adamska, Barbara Maziarz, Ryszard Drożdż, Marek Kuźniewski

“…Decline in eGFR was observed in 17 patients and increase in uACR in 10 patients. …”
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Effects of a novel non-pharmacological intervention based on respiratory biofeedback, neurofeedback and median nerve stimulation to treat children with ADHD by Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Anayali Estudillo-Guerra, Lna Ali, Diana Martinez, Roberto Hornero, Roberto Hornero, Leon Morales-Quezada

“…Correlations between EEG changes and clinical outcomes were observed, suggesting a potential relationship between neurophysiological markers and ADHD symptoms measured by standardized scales.DiscussionThe study findings suggest that the proposed R-BFB/NFB intervention may be an effective non-pharmacological therapy for ADHD, with the additional application of MNS potentially enhancing its effects.…”
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Genotypic and ecological variability of zinc content in the grain of spring bread wheat varieties in the international nursery KASIB by V. P. Shamanin, P. Flis, T. V. Savin, S. S. Shepelev, O. G. Kuzmin, A. S. Chursin, I. V. Pototskaya, I. E. Likhenko, I. Yu. Kushnirenko, A. A. Kazak, V. A. Chudinov, T. V. Shelaeva, A. I. Morgounov

“…The most favorable environmental conditions for accumulation of zinc in wheat grain were observed in the Omsk region. In Omsk, the average zinc content in all studied varieties was 50.4 mg/kg, with 63.7 mg/kg in the best variety ‘OmGAU 100’. …”
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Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway by Zhaowei Zou, Bin Liu, Lisi Zeng, Xianzi Yang, Renli Huang, Cheng Wu, Huijuan Zhu, Yi Gao, Dongdong Yuan, Jinlong Yu

“…Firstly, different methods, such as Cx43 inhibitors (18-α-GA and oleamide) or siRNA targeting Cx43 and N-acetyl cysteine (NAC) (a kind of ROS scavenger), were used to observe the effects of Cx43 channels mediating ROS transfer on intestinal injury. …”
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Leveraging Autofluorescence for Tumor Detection, Diagnosis, and Accurate Excision with Surgical Margin Assessment in Tumor Excision by Antonis Perdiou, Ramona Dumitrescu, Daniela Jumanca, Octavia Balean, Ruxandra Sava-Rosianu, Serban Talpos, Dacian Virgil Lalescu, Atena Galuscan

“…<b>Results:</b> Statistically significant differences were observed in tumor-free margins between the control (73.17%) and experimental (97%) groups (<i>p</i> = 0.003). …”
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Considerations for determining warm-water coral reef tipping points by P. Pearce-Kelly, A. H. Altieri, J. F. Bruno, C. E. Cornwall, M. McField, A. I. Muñiz-Castillo, J. Rocha, R. O. Setter, C. Sheppard, R. M. Roman-Cuesta, C. Yesson

“…., 2023a) and a literature search to identify and summarise the diverse range of interacting stressors that need to be considered for determining tipping point thresholds for warm-water coral reef ecosystems. Considering observed and projected stressor impacts, we endorse the global tipping point revision's conclusion of a global mean surface temperature (relative to pre-industrial) tipping point threshold of 1.2 <span class="inline-formula">°C</span> (range 1–1.5 <span class="inline-formula">°C</span>) and the long-term impacts of atmospheric <span class="inline-formula">CO₂</span> concentrations above 350 ppm, while acknowledging that comprehensive assessment of stressors, including ocean warming response dynamics, overshoot, and cascading impacts, have yet to be sufficiently realised. …”
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Effectiveness of multicomponent interventions in primary healthcare settings to promote continuous smoking cessation in adults: a systematic review by Carlos Martín Cantera, Elisa Puigdomènech, Jose Luis Ballvé, Olga Lucía Arias, Lourdes Clemente, Ramon Casas, Lydia Roig, Santiago Pérez-Tortosa, Laura Díaz-Gete, Sílvia Granollers

“…Both nicotine replacement and bupropion therapy were safe and effective, with no observed differences.Conclusions Multicomponent/complex interventions in PC are effective and safe, appearing to achieve greater long-term continuous smoking cessation than usual care and counselling alone. …”
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Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the pro... by Zeyu Li, Guoying Wang, Joseph M. Braun, Xiumei Hong, Giehae Choi, Shawn P. O’Leary, Chang Ho Yu, Colleen Pearson, William G. Adams, Zhihua (Tina) Fan, Jessie P. Buckley, Xiaobin Wang

“…Conclusions: Early life exposure to individual PFAS and their mixture were associated with a higher risk of childhood OWO, with stronger associations observed in older child age groups and in children of non-OWO mothers. …”
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The Relationship between Simple Snoring and Metabolic Syndrome: A Cross-Sectional Study by Juanjuan Zou, Fan Song, Huajun Xu, Yiqun Fu, Yunyan Xia, Yingjun Qian, Jianyin Zou, Suru Liu, Fang Fang, Lili Meng, Hongliang Yi, Jian Guan, Huaming Zhu, Bin Chen, Shankai Yin

“…A significant linear trend was observed between snoring intensity and metabolic score. …”
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The Role of 3D Virtual Anatomy and Scanning Environmental Electron Microscopy in Understanding Morphology and Pathology of Ancient Bodies by Sara Salucci, Mirko Traversari, Laura Valentini, Ilaria Versari, Luca Ventura, Emanuela Giampalma, Elena Righi, Enrico Petrella, Pietro Gobbi, Gianandrea Pasquinelli, Irene Faenza

“…Environmental scanning electron microscope, with the advantage of observing mummified samples without prior specimen preparation, details on the state of tissue fragments. …”
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