Qualitative evaluation of the implementation and national roll-out of the NHS App in England by Claire Reidy, Chrysanthi Papoutsi, Sukriti KC, Bernard Gudgin, Anthony A. Laverty, Felix Greaves, John Powell

“…Participants included patients, carers, members of the public, clinical/non-clinical NHS staff from five GP practices (where we also conducted over 60 h of observations) across England, as well as other industry, policy and civil rights stakeholders. …”
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Development and validation of a prediction model for acute kidney injury following cardiac valve surgery by Xiaotong Jia, Jun Ma, Zeyou Qi, Dongni Zhang, Junwei Gao

“…Furthermore, the calibration curve revealed that the predicted outcome was in agreement with the actual observations. Finally, the DCA curves showed that the nomogram had a good clinical applicability value.ConclusionSeveral perioperative factors modulate AKI development following cardiac valve surgery, resulting in poor patient prognosis. …”
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Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration by Betül Ayça Yamak, İbrahim Ethem Güven, Mustafa Candemir

“…Significantly wider QRS interval (92 (86 to 96) vs. 83 (76.3 to 93), <i>p</i> < 0.001) and fQRS-T (23 (13 to 37) vs. 18 (6.3 to 27), <i>p</i> < 0.001) values were observed in the CD group. Among CD patients, those with longer disease duration (>38.5 months) exhibited significantly wider QRS intervals (94 (88 to 98) vs. 88 (84 to 94), <i>p</i> < 0.001) and frontal QRS-T angles (29 (14 to 47) vs. 16 (10 to 25), <i>p</i> < 0.001) compared to those with shorter disease duration. …”
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A supervised model to identify wolf behavior from tri-axial acceleration by Charlotte Lorand, Léa Bouet, Olivier Devineau, Marianna Chimienti, Alina L. Evans, Peggy Callahan, Mark Beckel, Timothy G. Laske, Ane Eriksen

“…Using simultaneous video observations, we trained Random Forest models to classify wolf acceleration data into specific behaviors. …”
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Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper by Alexandra Rucavado, Teresa Escalante, Catarina F. P. Teixeira, Cristina María Fernándes, Cecilia Díaz, José María Gutiérrez

“…Since no hemorrhage nor dermonecrosis were observed after injection of MT-III, despite a prominent increase in MMP expression, and since inflammatory exudate did not enhance hemorrhage induced by BaP1, it is suggested that endogenous MMPs released in the tissue are not responsible for the dermonecrosis and hemorrhage characteristic of B. asper envenomation. …”
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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds by Zhuo Deng, Jing Wang, Wentao Lyu, Xuwen Wieneke, Robert Matts, Xi Ma, Guolong Zhang

“…Eight compounds were subsequently observed to be comparable to sodium butyrate in inducing PBD3 mRNA expression in parental IPEC-J2 cells in the low micromolar range. …”
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Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III by Bernadette Corica, Giulio Francesco Romiti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip, on behalf of the GLORIA-AF Investigators

“…Similar results were observed for all-cause mortality. Conclusions In patients with AF, different treatment patterns can be identified. …”
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Immediate Results of Colonic Flat Epithelial Neoplasms Removal Using Diathermic Snare Endoscopic Mucosal Resection and Mucosectomy Combined with Dissection in the Submucosal Layer:... by A. A. Fedorenko, P. V. Pavlov, A. P. Kiryukhin, A. S. Tertychnyy

“…Both groups (96 adenomas) had a total of 10 (10.4 %) patients who experienced colonic perforations during the intervention, with 4 (4.1 %) cases observed in the EMR group and 6 (6.2 %) in the ESD group. …”
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Neuregulin1 ameliorates metabolic dysfunction-associated fatty liver disease via the ERK/SIRT1 signaling pathways by Chengan Xu, Shouhao Wang, Di Meng, Mingshan Wang, Rong Yan, Yining Dai

“…After the intervention of ERK inhibitor PD98059, the expression of NRG1 decreased significantly in vivo, but no significant change was observed in vitro. Moreover, NRG1 ameliorated hepatic steatosis, enhanced cell viability, reduced cell apoptosis, and attenuated liver injury both in vitro and in vivo. …”
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Comparative Analysis of Adverse Drug Reactions Associated with Fluoroquinolones and Other Antibiotics: A Retrospective Pharmacovigilance Study by Alshareef H, Alenzi KA, Albalawi BR, Alanazi RM, Albalawi NS, Alasoufi WS, Alqifari S, Ahmed R, Ali MAS

“…This study assessed the rate, severity, seriousness, outcomes, and types of FQs adverse drug reactions (ADRs) in reports submitted to a regional spontaneous ADR database.Methods: This was a retrospective cross-sectional observational study involving all patients with reported ADRs related to FQs or other antibiotics (ABs) that were submitted to the Regional Pharmacovigilance Center (PVC) database between January 2019 and December 2022. …”
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Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma by Huixian Li, Hui Hong, Jinling Zhang

“…The nomogram demonstrated good calibration in both cohorts, indicating strong agreement between predicted and observed outcomes. The threshold probabilities for DCA at 1-, 3-, and 5-years post-surgery in the training and validation cohorts were 0.08~k0.74, 0.25~0.80, and 0.08~0.89, and 0.13~0.60, 0.28~0.81, and 0.25~0.88, respectively.ConclusionsA nomogram incorporating a Lasso score effectively predicted prognosis in glioma patients. …”
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Contribution à l’analyse de la viabilité d’une petite population de gorilles, Gorilla beringei graueri (Hominidae, Primates), par modélisation et simulations de l’écosystème du Mon... by Jean‑Claude Kasolene Kyungu, Jean Mukulire Malekani, Lohandjola Nyamangombe

“…Cette tendance n’a pas changé en faisant une simulation d’une population en déclin ; 2) qu’en introduisant les paramètres de fécondité, de capacité de charge biologique en fonction de la mortalité (taux de fécondité moyen de 4.4 et de mortalité de 0.666 au début), la population de gorilles aura toujours tendance à diminuer ; 3) qu’avec de nouvelles femelles de repeuplement, la population de gorilles pourrait se stabiliser dans les 100 prochaines années ; 4) qu’avec l’analyse génétique pour la recherche de l’identité, les génotypes à partir des échantillons confirment la présence de gorilles mâles et femelles ; 5) qu’avec les pathologies, les résultats des observations et de simulation montrent que l’évolution des infections probables (shigelloses et salmonelloses) est resté constante et linéaire jusqu’à 78 ans. …”
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Predictive Laboratory Markers for Gastrointestinal Complications in Children with Henoch-Sch&ouml;nlein Purpura by Guo Q, Xia S, Ding Y, Liu F

“…Furthermore, a predictive model was developed by a Random Forest classifier to identify key markers and assess their ability to distinguish between patients with and without GIS complications.Results: Significant differences were observed in several laboratory parameters between HSP patients and the control group, and between patients with and without GIS complications. …”
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Feasibility of implementing family-integrated newborn care for hospitalised preterm and low birthweight infants in newborn care units of Ethiopia: a mixed-methods design by Hege Langli Ersdal, Araya Abrha Medhanyie, Damen Haile Mariam, Siren Rettedal, Znabu Hadush Kahsay

“…Despite the WHO’s call for family engagement in newborn care, evidence of the feasibility of implementation remains scarce.Design An observational feasibility study employing a mixed-methods design comprising a quantitative cross-sectional survey among 157 healthcare providers (HCPs) and a qualitative Participatory Rural Appraisal.Setting The study was conducted in 30 neonatal care units (NCUs) of hospitals in Tigray, Northern Ethiopia.Participants HCPs who were on duty in NCUs during the data collection period were included in the study.Analysis Descriptive statistics were obtained for the quantitative data using STATA V.16, while qualitative data were coded and analysed using a framework analysis approach with qualitative data analysis software (Atlas.ti V.9).Results In total, 157 HCPs were enrolled with a mean (SD) age of 32 (±6.8) years. …”
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Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells by Jan Trieschmann, Moritz Haustein, Annette Köster, Jürgen Hescheler, Konrad Brockmeier, Gerardus Bennink, Tobias Hannes

“…Both native myocardial tissue slices as well as hiPS-CBs showed action potential prolongation after Ik,r blockade, but early afterdepolarisations could be observed in native myocardial tissue slices only. The force-frequency relationship (FFR) varied at lower frequencies and was negative throughout at higher frequencies in hiPS-CBs. …”
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Mineral composition of repair raspberry (<i>Rubus idaeus</i> L.) fruits by S. M. Motyleva, S. N. Evdokimenko, M. A. Podgaetsky, T. A. Tumaeva, Y. V. Burmenko, N. Y. Svistunova, D. V. Panischeva, I. M. Kulikov

“…The minimum K content was observed in the ash of the Carolina cultivar (5.62 wt %), while in berries of this cultivar Mg (2.91), Ca (2.62) and Zn (0.14 wt %) accumulated above average. …”
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Study on Micro Displacement Mechanism of Hydraulic Fracturing by Oil Displacement Agent at High Pressure by Fengjiao Wang, Xu Wang, Yikun Liu, Qingjun Deng, Jianan Hu, Yingbo Lv

“…Moreover, the scanning electron microscopy (SEM) tests of cores were carried out to observe and analyze changes in pore-throat size and connectivity, mineral particle accumulation, and cementation before and after hydraulic fracturing by an oil displacement agent at high pressure. …”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…Reduced expression of maturation markers was observed on ASC-treated dendritic cells, while high levels of PD-L1 were maintained. …”
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Structured follow-up pathway to support people after transient ischaemic attack and minor stroke (SUPPORT TIA): protocol for a feasibility study and process evaluation by Grace M Turner, Melanie Calvert, Sue Jowett, Robbie Foy, Jonathan Mant, Sarah Tearne, Lou Atkins, Rachael Jones, Smitaa Patel, Phillip Collis

“…Assessment of feasibility and acceptability will include quantitative process variables (such as recruitment and questionnaire response rates), structured observations of study processes, and interviews with a subsample of participants and clinical staff.Ethics and dissemination Favourable ethical opinion was gained from the Wales Research Ethics Committee (REC) 1 (23 February 2021, REC reference: 21/WA/0036). …”
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Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise by Patrícia Martins Bock, Raíssa Borges Monteiro, Clara Krummenauer Maraschin, Ana Paula Alegretti, Mariela Granero Farias, Fabiane Spagnol, Patricia Luciana da Costa Lopez, Lucas Porto Santos, Lucas Helal, Ruy Silveira Moraes, Daniel Umpierre, Beatriz D. Schaan

“…Similarly, no difference in IL-6 levels was observed before and after exercise in healthy individuals (148.2, IQR 147.5-148.6 pg/mL and 148.2, IQR 147.7-148.6 pg/mL, respectively) and individuals with T1DM (147.2, IQR 145.9-147.7 pg/mL and 147.2, IQR 146.8-147.8 pg/mL, respectively). …”
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