MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder by Yan Chen, Yun Liu, Ming Xiao, Chun Wang, Panpan Hu, Qiuchen Cao, Hu Feng, Jingfan Xu, Weixi Feng, Huaiqing Sun, Huachen Ding, Junying Gao

“…Additionally, a negative association between serum miR-451a and behavioural despair or anhedonia was observed in CRS mice. Notably, miR-451a expression was significantly downregulated in the mPFC of CRS-susceptible mice. …”
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INTERFAITH MARRIAGE CONTROVERSIES IN SEMARANG: AN ANALYSIS OF QUR'ANIC LEGAL EXEGESIS by Abdul Basid, Lilik Nur Kholidah, Muhammad Fahmi Hidayatullah, Eka Kurnia Firmansyah, Ahmad Iwan Zunaih, Reza Ahmad Zahid

“…Data collection is conducted through interviews, field observations, and document analysis, including Qur'anic exegesis, religious decrees, fatwas, and public commentary. …”
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Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…Methods This multicenter prospective observational study enrolled patients with EGFR‐mutated NSCLC who received first‐line osimertinib and another EGFR‐TKI as second‐ or third‐line treatment between September 2018 and August 2020. …”
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Gender inequalities in prescribing and initiation patterns of guideline-recommended drugs after acute myocardial infarction by Irene López-Ferreruela, Sara Malo, Blanca Obón-Azuara, María José Rabanaque, Adriana Gamba, Sara Castel-Feced, Isabel Aguilar-Palacio

“…Methods A population-based observational study of RWD was conducted in the CARhES (CArdiovascular Risk factors for hEalth Services research) cohort. …”
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Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis by Bin Yang, Leizhen Xia, Rufei Deng, Liping Wu, Zhiqin Zhang, Xingwu Wu, Tao Ding, Yan Zhao, Jialyu Huang, Jialyu Huang, Zhihui Huang

“…High DFI affected the blastocyst formation rate (56.44%, 55.32%, 53.72%, respectively; P=0.045) and the rate of transferable embryos (3.97 ± 2.71, 3.90 ± 2.7, 3.38 ± 2.4, respectively; P<0.001); however, no significant difference in pregnancy outcomes was observed among the three groups. Elevated DFI did not contribute to clinically relevant adverse maternal events during pregnancy, but it was associated with an increased risk of low birth weight (3.9%, 6.6%, 10.1%, respectively; P=0.006) in newborns.ConclusionsSperm DFI could influence embryonic development, with a higher risk of low birthweight infants in the high DFI group. …”
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Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group by Laura Massaro, Annamaria Iagnocco, Florenzo Iannone, Corrado Campochiaro, Maria De Santis, Ilaria Cavazzana, Piero Ruscitti, Roberto Giacomelli, Rosario Foti, Lorenzo Dagna, Giovanna Cuomo, Giacomo De Luca, Francesco Caso, Ilenia Di Cola, Clodoveo Ferri, Vincenzo Raimondo, Francesco Ursini, Veronica Brusi, Giuseppe Varcasia, Roberta Pellegrini, Domenico Olivo, Giuseppe Murdaca, Carlo Selmi, Olga Addimanda, Erika Pigatto, Francesca Francioso, Rossella De Angelis, Jacopo Ciaffi, Luana Mancarella, Marcella Visentini, Francesca Motta, Virginia Caira, Alberto Lo Gullo, Caterina Naclerio, Elena Marchetti, Sebastiano Lorusso, Jessica Luppino, Roberta Foti, Massimo Reta

“…Objectives To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study.Methods Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criteria: (a) onset of the rheumatic manifestations within 4 weeks from SARS-CoV-2 infection or (b) onset of the rheumatic manifestations within 4 weeks from the administration of one of the COVID-19 vaccines ws recruited.Results The final analysis cohort comprised 267 patients, of which 122 (45.2%) in the post-COVID-19 and 145 (54.8%) in the postvaccine cohort. …”
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A novel method for detecting intracranial pressure changes by monitoring cerebral perfusion via electrical impedance tomography by Ming-xu Zhu, Jun-yao Li, Zhan-xiu Cai, Yu Wang, Wei-ce Wang, Yi-tong Guo, Guo-bin Gao, Qing-dong Guo, Xue-tao Shi, Wei-chen Li

“…This study aimed to explore the use of electrical impedance tomography (EIT) to provide real-time early warning of elevated ICP by observing cerebral perfusion. Methods An intracranial hypertension model was prepared by injecting autologous un-anticoagulated blood into the brain parenchyma of twelve Landrace swine. …”
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Cytotoxic Function and Cytokine Production of Natural Killer Cells and Natural Killer T-Like Cells in Systemic Lupus Erythematosis Regulation with Interleukin-15 by Syh-Jae Lin, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Wen-I Lee, Ji-Yih Chen, Jing-Long Huang

“…We established that (1) perforin expression on SLE NK cells was decreased but unrelated to disease activity; (2) the MFI of granzyme B was increased in NK cells from SLE patients with active disease, associated with increased percentages of granzyme B+ CD56bright NK cells; (3) NK cells from active SLE patients, both CD56dim and CD56bright NK subsets, produced higher IFN-γ compared to controls; (4) CD56dim, but not CD56bright NK cells from active SLE patients, produced lower TNF-α, compared to inactive SLE patients and controls; (5) CD107a degranulation of SLE NK cells was comparable to controls; (6) IL-15 enhanced perforin/granzyme B expression, IFN-γ/TNF-α production, and CD107a degranulation of NK cells from SLE patients; and (7) similar observations were found for CD56+CD3+ NKT-like cells. …”
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Release velocity ImprovemenT with a new Metronome guIding chest COmpressions: The RITMICO simulation study by Maria Luce Caputo, Giuliana Monachino, Ruggero Cresta, Alessia Currao, Enrico Baldi, Simone Savastano, Andrea Cortegiani, Mariachiara Ippolito, Sara Accetta, Alessandra Gargano, Camilla Metelmann, Bibiana Metelmann, Carlos Ramon Hölzing, Julian Ganter, Michael Patrick Müller, Claudio Benvenuti, Stefania Tomola, Pierangelo Pinetti, Pier Luigi Ingrassia, Francesca Dalia Faraci, Angelo Auricchio

“…The double-click metronome led to significant improvements in CC depth and CCRV across all volunteer categories, with the greater effect observed in first responders and in non-specialized healthcare personnel. …”
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Efficacy of Fat Supplements with Different Unsaturated/Saturated FA Ratios Undergoing First Postpartum Ovulation in Lactating Anovulatory Goats by Caroline P. Silva, César C. L. Fernandes, Juliana P. M. Alves, Camila M. Cavalcanti, Felipe B. B. Oliveira, Alfredo J. H. Conde, Diana Celia S. N. Pinheiro, Darcio I. A. Teixeira, Anibal C. Rego, Davide Rondina

“…After estrus induction, no differences were observed in estrus response; however, the linseed group showed more and larger growing follicles (<i>p</i> = 0.016 and <i>p</i> < 0.01), a higher ovulation rate (<i>p</i> < 0.05), a larger CL area (<i>p</i> < 0.05), and higher progesterone levels (<i>p</i> < 0.001). …”
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Drought-induced shifts in gross primary production pathways in Moso bamboo forests: Insights from improved BIOME-BGC and structural equation modeling by Zhaodong Zheng, Fangjie Mao, Huaqiang Du, Xuejian Li, Fengfeng Ye, Xianfeng Teng, Ningxin Yang, Jiacong Yu, Meixuan Song, Yinyin Zhao

“…In this study, photosynthetic water stress module of BIOME-BGC was improved and optimized by long-term carbon flux observations from the Anji MBF site, then the temporal variations of Gross Primary Production (GPP) were simulated and analyzed from 2000 to 2019. …”
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E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age by E. Meldolesi, A. Nicolì, N. Dinapoli, G. Chiloiro, A. Romano, R. Menghi, R. Persiani, F. Pacelli, C. Coco, C. Ratto, S. Manfrida, L. Boldrini, B. Corvari, M.A. Gambacorta

“…Materials/methods: 788 rectal cancer patients were enrolled in this monocentric retrospective observational study (523 =>55 years and 265 < 55). All patients received neoadjuvant chemoradiation treatment. …”
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The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study by Pedro Javier Tárraga Marcos, Ángel Arturo López-González, Emilio Martínez-Almoyna Rifá, Hernán Paublini Oliveira, Cristina Martorell Sánchez, Pedro Juan Tárraga López, José Ignacio Ramírez-Manent

“…<b>Conclusions</b>: The risk of developing MetS and HTW among healthcare personnel is influenced by lifestyle habits, sex, and age, with the highest ORs observed in nursing assistants and orderlies. Future research that delves deeper into the causal relationship between lifestyle factors and the severity of MetS and HTW in healthcare personnel will improve understanding and facilitate the development of preventive activities to reduce their incidence.…”
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Are changes in pain intensity related to changes in balance control in individuals with chronic non-specific low back pain? A systematic review and meta-analysis by Daniel K.Y. Zheng, Jae Q.J. Liu, Jeremy R. Chang, Jeffrey C.Y. Ng, Zhixing Zhou, Jinlong Wu, Chelsia K.C. Cheung, Frank F. Huang, Sabina M. Pinto, Dino Samartzis, Manuela L. Ferreira, Kanchana Ekanayake, Stephen Lord, Xueqiang Wang, Arnold Y.L. Wong

“…However, no significant association was observed between pain reduction and CoP area or velocity in anteroposterior/mediolateral directions. …”
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Delirium Management Quality Improvement Project to Improve Awareness and Screening in a Medical ICU by Hirsh Makhija, Kyle Digrande, Omar Awan, Russell G. Buhr, Rajan Saggar, Victoria Ramirez, Rainbow Tarumoto, Janelle M. Fine, Atul Malhotra, Dale M. Needham, Jennifer L. Martin, Biren B. Kamdar

“…<b>Results:</b> Using a dataset that spanned 9 pre- and 37 post-project months and included 3612 patients, 4470 admissions, and 33,913 patient days, we observed that delirium education was followed by a dramatic rise in CAM-ICU documentation, from <1% for daytime and nighttime shifts to peaks of 73% and 71%, respectively (<i>p</i> < 0.0001 for trend), and a fall in the proportion of mechanically ventilated patients ever receiving benzodiazepine infusions (69% to 41%; <i>p</i> < 0.0001). …”
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Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study by Shihan Zhen, Na Li, Yan Li, Qian Li, Lu Zheng, Zhouxin Yin, Yan Dou, Shuqi Wu, Yilin Liu, Xiaoyan Zhang, Xinyue Yang, Ye Wang, Wenxiu Ge, Xiaoyu Gao, Jing Yang, Fengchao Liang, Jiajin Hu, Ying Zhao

“…For each 10 μg/m³ increase in PM2.5, the odds ratios of birth defects were 1.68 (95% CI: 1.65, 1.70) and 2.41 (95% CI: 2.36, 2.45) during the preconception period and pregnancy, respectively. We observed a J-shaped association between maternal PM2.5 exposure during both the preconception period and pregnancy and the risk of total birth defects. …”
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Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients by Minjie Li, Yu Gao, Lin Han, Ping Wang, Jie Li, Junhua Song, Shasha Du, Yunfei Zhang, Yumin Lyu

“…However, no significant relationship was observed between the dic frequency and acute marrow toxicity after RT (P ​> ​0.05). …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…Additionally, key indicators such as TLR4, NF-κB, TNF-α were investigated to validate the mechanistic aspects of putative AOPs associated with pulmonary fibrosis. We observed significant changes in body weight and neutrophil count, recognized indicators of inflammation, along with inflammatory cell infiltrates, in the group exposed to the mixture of the two biocides. …”
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Determining the mechanism of Shuxuening injection against liver cirrhosis through network pharmacology and animal experiments by Qiyao Liu, Tingyu Zhang, Yongan Ye, Xin Sun, Huan Xia, Xu Cao, Xiaoke Li, Wenying Qi, Yue Chen, Xiaobin Zao

“…Conclusion: This study highlighted the therapeutic effects of SXN in alleviating LC using both bioinformatics and experimental methods. The observed effect was associated with modulation of hub gene expression, particularly MAPK8, and CASP3.…”
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Study on exhaled volatile organic compounds identifying cognitive fatigue induced by N-back task in healthy young adults by Xiaoyu Zhang, Xiaoyan Dong, Qiang Huang, Zhe Liu, Qin Wang

“…It was found that the scale scores of the task group (n = 50) significantly increased after the induction, whereas no such findings were observed in the control group (n = 10), indicating that the cognitive fatigue state of the task group was effectively induced through the performance of the N-back task. …”
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