Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients by Francesco Giudici, Tiziana Cavalli, Cristina Luceri, Edda Russo, Daniela Zambonin, Stefano Scaringi, Ferdinando Ficari, Marilena Fazi, Amedeo Amedei, Francesco Tonelli, Cecilia Malentacchi

“…Finally, for the first time, we have observed a lower rate of responsiveness to azathioprine in patients carrying an hz881 and a 3020insC.…”
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The expression profile of genes associated with behavior, stress, and adult neurogenesis along the hippocampal dorsoventral axis in tame and aggressive foxes by Yu. V. Alexandrovich, E. V. Antonov, S. G. Shikhevich, A. V. Kharlamova, L. V. Meister, Y. V. Makovka, D. V. Shepeleva, R. G. Gulevich, Yu. E. Herbeck

“…A decrease in many indices of the hypothalamic–pituitary–adrenal activity was observed in tame animals. Also, adult hippocampal neurogenesis was more intense in tame foxes, and this fact may relate to reduced stress levels in this experimental population of foxes. …”
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Impact of the COVID-19 pandemic on utilisation of facility-based essential maternal and child health services from March to August 2020 compared with pre-pandemic March–August 2019... by Grace J Chan, Delayehu Bekele, Bezawit Mesfin Hunegnaw, Kimiko Van Wickle, Chalachew Bekele, Fanos Ashenafi Gebremeskel, Michelle Korte, Christine Tedijanto, Lisanu Taddesse

“…Enablers of service utilisation included communities’ decreased fear of COVID-19 and awareness-raising activities.Conclusion We observed a decline in essential MNCH services particularly in sick children and new family planning visits. …”
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Automatic GPR detection of grouting defects behind the tunnel shield segments based on wavelet coherence analysis combined with modified Res-RCNN by Dengyi Wang, Ming Peng, Liu Liu, Xiongyao Xie, Zhenming Shi, Yaoying Liang, Jian Shen, Qiyu Wu

“…The wavelet coherence analysis enables the observation of grouting defects behind tunnel shield segments with interferences of steel rebars. …”
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Titin fragment is a sensitive biomarker in Duchenne muscular dystrophy model mice carrying full-length human dystrophin gene on human artificial chromosome by Yosuke Hiramuki, Miwa Hosokawa, Kayo Osawa, Taku Shirakawa, Yasuhiro Watanabe, Ritsuko Hanajima, Hiroyuki Kugoh, Hiroyuki Awano, Masafumi Matsuo, Yasuhiro Kazuki

“…The human dystrophin derived from DYS-HAC1 improved pathological phenotypes observed in DMD-null mice, which lack the entire 2.4 Mb of the dystrophin gene. …”
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Prevalence of diabetes-related sarcopenia and its defining components within primary care: A cross-sectional study by Rubén Silva-Tinoco, Lilia Castillo-Martínez, Berenice Cabrera-Victoria, Eileen Guzmán-Olvera, Christian Hinojosa-Segura, Alejandro Avalos-Bracho, Cira Santillán-Díaz

“…An altered MF assessment was observed in 159 participants, with 14.1 % exhibiting sarcopenia, 5.4 % isolated low muscle strength, and 41.4 % isolated low muscle mass. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…N’Dama breed showed the earliest regulation of immune response, associated with a strong activation of cellular energy production, also observed in Lagune, and to a lesser extent in Baoulé. …”
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Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Furthermore, LCG CAR-T cells modulated pro-inflammatory cytokine release, thereby reducing in vivo inflammatory responses and surpassing the effects observed with unmodified CAR-T cells.ConclusionsCollectively, our results demonstrate the high safety and efficacy of non-viral, low CpG Passer transposon CAR-T cells, offering new avenues for improving CAR-T cell efficacy while minimizing in vivo inflammation.…”
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Effect of total intravenous-based immediate extubation on patient outcomes in adult liver transplantation: A retrospective cohort study by Yan-Jun Chu, Hui Zhang, Bing-Xin Jin, Yu-Fan Liu, Yong-Xing Yao

“…No significant differences in continuous renal replacement therapy use (2.86 % vs 13.08 %; odds ratio, 0.195; P = 0.088), early mortality rate, percentage reduction of bilirubin, the incidence of exploratory laparotomy, pneumonia, or thrombosis were observed between groups. Conclusion: TIIE is safe, effective, and associated with a lower incidence of postoperative bacterial infection.…”
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Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China by Xiaowen Wang, Junhui Wu, Yao Wu, Mengying Wang, Zijing Wang, Tao Wu, Dafang Chen, Xun Tang, Xueying Qin, Yiqun Wu, Yonghua Hu

“…KCNQ1 had pleiotropic effects on lipids and T2DM, and the unexpected genetic effect on association of HDL-C with T2DM was observed, indicating the different pathways to lipids and T2DM. …”
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Nursing of a patient with radiotherapy- and chemotherapy-induced adverse reactions treated with aruricualr acupoint pressing combined with meridian acupoint Tuina (耳穴贴压联合经穴推拿治疗放化疗后... by JIN Yi (金艺), MIN Tingyan (闵婷燕)

“…After intervention, the patient was observed with less pain, relief of nausea and vomiting, improved sleep quality, relief of anxiety, and improved bone marrow function and nutritional status scores. …”
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The MyFlex-ζ Foot: A Variable Stiffness ESR Ankle-Foot Prosthesis by Johnnidel Tabucol, Vera G. M. Kooiman, Marco Leopaldi, Ruud Leijendekkers, Giacomo Selleri, Marcello Mellini, Nico Verdonschot, Magnus Oddsson, Raffaella Carloni, Andrea Zucchelli, Tommaso M. Brugo

“…Greater sagittal-plane rotation and higher energy absorption were observed in most tasks with more compliant settings, although one participant’s results were limited due to selecting close stiffness settings. …”
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Antioxidant Properties of Tonsil-Derived Mesenchymal Stem Cells on Human Vocal Fold Fibroblast Exposed to Oxidative Stress by Sung-Chan Shin, Hyung-Sik Kim, Yoojin Seo, Cho Hee Kim, Ji Min Kim, Hyun-Keun Kwon, Jin-Choon Lee, Eui-Suk Sung, Byung-Joo Lee

“…We have, therefore, shown that the changes in hVFF proliferative capacity and ECM gene expression induced by oxidative stress are consistent with in vivo phenotypes observed in aging vocal folds and vocal fold scarring and that TMSCs may function to reduce oxidative stress in aging vocal folds.…”
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Transcriptomic Insights into Dual Temperature–Salinity Stress Response in “Shuike No. 1”, a Pioneering Rainbow Trout Strain Bred in China by Xiaojun Liu, Gaochao Wang, Tianqing Huang, Enhui Liu, Wei Gu, Peng Fan, Kaibo Ge, Datian Li, Yunchao Sun, Gefeng Xu

“…Differential gene expression analysis identified a substantial number of DEGs, with the liver showing the most pronounced response and a clear synergistic effect observed under combined high-temperature and salinity stress. …”
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Comparative analysis of the intestinal flora of Siniperca chuatsi at different growth stages under three feeding practices by Yunyun Yan, Fubao Wang, Xiao Chen, Junjian Dong, Fengying Gao, Hetong Zhang, Xing Ye, Chengbin Wu, Chengfei Sun

“…A relatively high number of marker genera were observed in the compound feed group, of which Stenotrophomonas and Cetobacterium are potentially valuable in the application of feed additives for S. chuatsi. …”
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Effect of botanical powders and the assassin bug, Alloeocranum biannulipes Mont. and Sign. (Hemiptera: Reduviidae) against Dinoderus porcellus Lesne (Coleoptera: Bostrichidae) infe... by Kitherian SAHAYARAJ, Antonio SINZOGAN, Manuele TAMO, Joelle TOFFA, Yêyinou Laura Estelle LOKO, Armand VODOUNNON, Innocent DJEGBE

“…No significant difference in terms of the survival of A. biannulipes exposed to botanical powders was observed compared to the positive control. Under farm conditions, B. ferruginea leaf powder showed a sub-lethal effect on the predator A. biannulipes and no impact on the abundance of D. porcellus. …”
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Low-dose radiation ameliorates PM2.5-induced lung injury through non-canonical TLR1/TLR2-like receptor pathways modulated by Akkermansia muciniphila by Li Wang, Zhipeng Li, Huan He, Lijing Qin, Weiqiang Xu, Hongyuan Tian, Rongrong Liu, Xinru Lian, Wen Li, Yali Qi, Zhicheng Wang

“…Here, we aim to investigate the impact of LDR on PM2.5-induced lung injury in vivo and in vitro, and elucidated the potential mechanisms of anti-inflammation activated by gut microbiota. We observed that LDR ameliorated the lung damage induced by PM2.5 in mice. …”
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Identification of glutamine as a potential therapeutic target in dry eye disease by Xiaoniao Chen, Chuyue Zhang, Fei Peng, Lingling Wu, Deyi Zhuo, Liqiang Wang, Min Zhang, Zhaohui Li, Lei Tian, Ying Jie, Yifei Huang, Xinji Yang, Xiaoqi Li, Fengyang Lei, Yu Cheng

“…Inhibition of glutamine reversed the anti-inflammatory, anti-apoptotic, and homeostasis-preserving effects observed with combined therapy, highlighting the critical role of glutamine in dry eye therapy. …”
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Extracellular Lipase from Pseudomonas aeruginosa SB-37: Production by Solid State Fermentation, Immobilization, and Characterization by Titin Haryati, Norman Yoshi Haryono, Dian Nugraheni, Fenti Fatmawati, Alfina Kusuma Dewi, Muhammad Zahran Edlian Syach

“…While the highest transesterification activity was observed with acetonitrile solvent and substrates of pNP_8 and isopropanol with the activity value at 0.6 U/g gel. …”
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Screening of <em>FecLL</em> prolific allele of the <em>B4GALNT2</em> gene in Algerian sheep populations by Assia Hadjazi, Fatima Zahra Belharfi, Fatima Zohra Mahammi, Stéphane Fabre, Semir Bechir Suheil Gaouar, Nacera Tabet-Aoul

“…The frequency of the FecLL allele in the Algerian D’man population (0.11) is close to what is observed in Lacaune sheep and remains relatively low compared to Moroccan (0.58) and Tunisian (0.65) D’man sheep. …”
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