Peripapillary atrophy area predicts the decrease of macular choroidal thickness in young adults during myopia progression by Xun Xu, Jianfeng Zhu, Ying Fan, Luyao Ye, Ya Shi, Menghan Li, Qiuying Chen, Guangyi Hu, Jiamin Xie, Jiangnan He

“…The areas under the receiver operating characteristic curves were analysed to ascertain the predictive capacity of the PPA area and axial elongation for the reduction in macular ChT.Results Initial measurements revealed that the average macular ChT was 240.35±56.15 µm in the non-HM group and 198.43±50.27 µm in the HM group (p<0.001). It was observed that the HM group experienced a significantly greater reduction in average macular ChT (−7.35±11.70 µm) than the non-HM group (−1.85±16.95 µm, p=0.004). …”
Get full text

Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in <i>Penicillium expansum</i> and <i>Penicillium chrysogenum</i> by Holly P. Bartholomew, Christopher Gottschalk, Bret Cooper, Michael R. Bukowski, Ronghui Yang, Verneta L. Gaskins, Dianiris Luciano-Rosario, Jorge M. Fonseca, Wayne M. Jurick

“…To shed light on this observation, we conducted a comparative genomic, transcriptomic, and metabolomic study of two <i>P. chrysogenum</i> (404 and 413) and two <i>P. expansum</i> (Pe21 and R19) isolates. …”
Get full text

The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Reg... by Márcio Junio Lima Siconelli, Danillo Lucas Alves Espósito, Nathália Cristina Moraes, Julia Maria Ribeiro, Lívia Perles, Maria Angélica Dias, Adolorata Aparecida Bianco Carvalho, Karin Werther, Natália Coelho Couto de Azevedo Fernandes, Silvia D'Andretta Iglezias, Karina Paes Bürger, Benedito Antonio Lopes da Fonseca

“…Among nine NHPs, gross hepatic involvement was observed in six animals, five of which were YFV-RT-qPCR-positive. …”
Get full text

Brief Warm and Aldo-Keto Reductase Family <i>AspiAKR1B1</i> Contribute to Cold Adaptation of <i>Aleurocanthus spiniferus</i> by Zhi-Fei Jia, Yan-Ge Cui, Meng-Yuan Liu, Jeremiah Joe Kabissa, Yong-Yu Xu, Zhi-Wei Kang, Zhen-Zhen Chen

“…Seasonal variation in levels of cold-resistant substances were also observed, with moisture decreasing during overwintering, while fat and glycerol levels increased. …”
Get full text

Mechanisms of blaIMP-4 dissemination across diverse carbapenem-resistant clinical isolates by Ying Fu, Faye C. Morris, Stephanie C. Pereira, Xenia Kostoulias, Yan Jiang, Callum Vidor, Galain Williams, Yogi Srikhanta, Nenad Macesic, Yunsong Yu, Dena Lyras, Anton Y. Peleg

“…Sequence homology was observed across all plasmids at the blaIMP-4 location, termed Region I, with IS26 on IncHI2A, and IS5075 and Tn3 resistance gene cassettes present on IncC plasmids. …”
Get full text

Cytoplasmic genetic diversity of potato varieties bred in Russia and FSU countries by Т. A. Gavrilenko, N. S. Klimenko, N. V. Alpatieva, L. I. Kostina, V. A. Lebedeva, Z. Z. Evdokimova, O. V. Apalikova, L. Y. Novikova, O. Yu. Antonova

“…A heteroplasmy state  was observed both in male-sterile and in male-fertile genotypes.…”
Get full text

Personalized screening strategies for TP53 R337H carriers: a retrospective cohort study of tumor spectrum in Li-Fraumeni syndrome adult carriersResearch in context by Pedro A.F. Galante, Gabriela D.A. Guardia, Janina Pisani, Renata L. Sandoval, Mateus C. Barros-Filho, Ana Carolina Leite Vieira Costa Gifoni, Diogo F.C. Patrão, Patricia Ashton-Prolla, Vitor Fiorin de Vasconcellos, Claire Freycon, Arnold Levine, Pierre Hainaut, Maria Isabel Achatz

“…Female R337H carriers were at a higher risk than males (65% vs 30%) and had a higher risk of developing a second primary cancer, underscoring a strong sex bias not observed in carriers of other variants. The most common cancers were breast cancer and soft tissue sarcoma in females, and soft tissue sarcoma and prostate cancer in males. …”
Get full text

Monitoring and evaluation in disaster management courses: a scoping review by George Teo Voicescu, Hamdi Lamine, Andra Elena Loșonți, Eugenia Maria Lupan-Mureșan, Sonia Luka, José García Ulerio, Luca Ragazzoni, Francesco Della Corte, Marta Caviglia

“…When corelating the learning objectives with the evaluation methodology, the authors observed a mismatch, as skills like the students’ ability to “Apply” and “Create” were evaluated using the second level of the New World Kirkpatrick model. …”
Get full text

Salt Stress Enhanced Bioactivity of Quinoa Leaf Extracts: An In Vitro and In Silico Study of Acetylcholinesterase and Tyrosinase Inhibition for Sustainable Drug Development by Narmine Slimani, Soumaya Arraouadi, Hafedh Hajlaoui, Antonio Cid-Samamed, Mohamed Ali Borgi, Mejdi Snoussi

“…The Q45 accession exhibited the highest accumulation of these compounds, particularly in the aqueous extracts at the 200 mM NaCl concentration. Increases were observed in flavonoids (144%), anthocyanins (125%), tannins (89%), and total polyphenols (65%) relative to controls. …”
Get full text

Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure by Jian Wu, Yurong Guo, Xuan Lu, Fen Huang, Feifei Lv, Daqiao Wei, Anquan Shang, Jinfeng Yang, Qiaoling Pan, Bin Jiang, Jiong Yu, Hongcui Cao, Lanjuan Li

“…Both IFN-γ and IL-10 showed gradual upward trend from the HC group to the AHE (both P<0.01), but IFN-γ showed a sharp downward trend from the AHE group to the HEV-ALF group (P<0.01) and IL-4 showed gradual upward trend from the AHE group to the HEV-ALF group (P<0.01).There was no significant difference in Th1 and Th2 cytokines between the HEV RNA(+) group and HEV RNA(-) group (all P>0.05). Th2 bias was observed from the AHE (ratio=58.65) to HEV-ALF (ratio=1.20) groups. …”
Get full text

High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression by Zhengyi Wu, Chao Li, Shouhua Zhang, Liang Sun, Junwen Hu, Bingbing Qiu, Shuiqiu Liu, Yiran Hong, Tianxiang Chen, Kai Wang, Xiangbao Yin, Jinlong Yan

“…In vitro experiments replicated the HIFP environment to observe changes in HCC cell behavior and protein expression, while in vivo studies involved mice portal hypertension to create an orthotopic liver cancer model, allowing for the evaluation of tumor progression. …”
Get full text

Clinical Outcomes and Patterns of Traumatic Injuries Associated with Subway Incidents at a Level 1 Trauma Center by Bharti Sharma, Aubrey May B. Agcon, George Agriantonis, Sittha Cheerasarn, Navin D. Bhatia, Zahra Shafaee, Jennifer Whittington, Kate Twelker

“…The mortality rates observed in the suicide and train-struck groups were higher than those in patients with severe falls.…”
Get full text

Enhanced membrane protein production in HEK293T cells via ATF4 gene knockout: A CRISPR-Cas9 mediated approach by Byung-Jo Choi, Ba Reum Kim, Ho Joong Choi, Ok-Hee Kim, Say-June Kim

“…Quantitative analysis via PAGE revealed a 77.2 ± 30.6% increase in purified membrane protein yields, consistent with the observed enhancements. Flow cytometry using Membrane-GFP further demonstrated a 22.9 ± 9.7% increase in productivity. …”
Get full text

Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review by Laura García-Bravo, Ángela Villegas, Bárbara López Uceda, Anaís Mariscal, Cristina Vadillo, M Asunción Nieto Barbero, Juan Luis Rodríguez-Hermosa, Beatriz Mediero Valeros, José Carlos Plaza-Hernández, Miguel Fernández-Arquero, María Guzmán-Fulgencio, Gloria Candelas-Rodríguez, Silvia Sánchez-Ramón, Juliana Ochoa-Grullón

“…Further research is essential to elucidate the causal relationships and molecular mechanisms behind these observations.…”
Get full text

Comparison between sevoflurane and propofol induction in I-gel insertion in pediatric patients undergoing inguinal herniotomy by Harshita Singh, Harpreet Kaur, Shirin Parveen, Narendra Singh Bafila, Kirtika Yadav, Anam Rizwan, Dhruvraj Singh

“…Materials and Methods: The prospective observational study included 66 children aged 6 months–8 years with American society of anesthesiologists physical status I and II, scheduled for elective herniotomy. …”
Get full text

Tracking Immunity: An Increased Number of COVID-19 Boosters Increases the Longevity of Anti-RBD and Anti-RBD-Neutralizing Antibodies by Ching-Wen Hou, Stacy Williams, Veronica Boyle, Alexa Roeder, Bradley Bobbett, Izamar Garcia, Giavanna Caruth, Mitch Magee, Yunro Chung, Douglas F. Lake, Joshua LaBaer, Vel Murugan

“…Conclusions: The high levels of anti-RBD antibodies observed reflect substantial vaccine uptake within this population. …”
Get full text

Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor by M. Satue, L. Jarauta, J. Obis, M. Cipres, M. J. Rodrigo, C. Almarcegui, I. Dolz, J. R. Ara, J. Martin, L. E. Pablo, E. Garcia-Martin

“…Significant correlations were observed between structural retinal measurements and functional parameters, especially between the inner macular areas and measurements corresponding to contrast sensitivity and perimetry indexes. …”
Get full text

Exosomes Derived from Schistosoma japonicum Cystatin-Treated Macrophages Attenuated CLP-Induced Sepsis in Mice by Feifei Huang, Yayun Qian, Huihui Li, Liang Chu, Chen Wan, Qili Shen, Qianqian Li, Xiuxiu Li, Xinyue Wu, Bin Zhan, Rui Zhou, Xiaodi Yang

“…The treatment effect of exosomes on sepsis was assessed by examining the survival rate of mice up to 72 hr and measuring serum levels of inflammatory cytokines, liver/kidney damage biomarkers, and observing pathological changes in tissue sections. …”
Get full text

Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry by Shani A D Mathara Diddhenipothage, Katharina J Beck, Gayana Amiyangoda, Jillian Bryce, Luminita Cima, Katya De Groote, Yana Deyanova, Evgenia Globa, Gloria Herrmann, Anders Juul, Anna Sophie L Kjaer, Anette Tønnes Pedersen, Sukran Poyrazoglu, Ursina Probst-Scheidegger, Theo C J Sas, Simona Fica, Sumudu Nimali Seneviratne, Justyna Karolina Witczak, Elizabeth Orchard, Jeremy W Tomlinson, S Faisal Ahmed, Helen E Turner

“…Methods: Retrospective multicentre observational study of patients aged ≥18 years included in the I-TS (International-TS) registry (2020–2022), using registry and participating centre-collected data. …”
Get full text

A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease by Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang

“…The astrocyte-related gene CHI3L1 was found to be highly expressed in the Astro-C0 subpopulation. Furthermore, we observed increased levels of CHI3L1 mRNA and protein in LPS-induced astrocytes. …”
Get full text