Novel N-quaternary coumarin-3-yl-imidazo[1,2-a]pyridines as fluorescent hybrids: Their synthesis and biological evaluation in cancer cells by Karla Armendariz-Barrientos, Luis A. Pérez, Selene Lagunas-Rivera, Yolanda Alcaraz-Contreras, Marco A. García-Revilla, Heriberto Prado-Garcia, Rocío García-Becerra, Miguel A. Vazquez

“…A similar phenomenon is observed with the ethyl substituent in the 5a-c series, albeit with a less pronounced hydrophobic impact. …”
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Effects of combined inoculation of arbuscular mycorrhizal fungi and plant growth-promoting rhizosphere bacteria on seedling growth and rhizosphere microecology by Wanli Zeng, Dan Xiang, Xuemei Li, Qian Gao, Yudong Chen, Kunmiao Wang, Yingying Qian, Luoping Wang, Jing Li, Qili Mi, Haitao Huang, Li Xu, Mingfang Zhao, Yingzhen Zhang, Haiying Xiang

“…The highest values for these indices were observed in the combined treatment of F. mosseae and Pseudomonas sp. …”
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The short-, medium-, and long-term prevalence of physical health comorbidities in first-episode psychosis: a systematic review and meta-analysis protocol [version 2; peer review: 3... by Michael Norton, Brian O'Donoghue, Mary Clarke, Karen O'Connor, Jennifer Murphy, Anna Zierotin

“…By contrast, this review will focus on antipsychotic-naïve FEP cohorts and incorporate data from observational longitudinal studies and antipsychotic intervention studies to understand the progression of physical health comorbidities from the onset to later stages of psychosis. …”
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Prognostic implications of immune classification based on PD-L1 expression and tumor-infiltrating lymphocytes in endocervical adenocarcinoma by Li-Jun Wei, Zi-Yun Wu, Li-Yan Wu, Ying-Wen Wu, Hao-Yu Liang, Rong-Zhen Luo, Li-Li Liu

“…Results: PD-L1 positivity was observed in 319 out of 464 (68.8%) HPVA and 55 out of 76 (72.4%) NHPVA. …”
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Benefits and Risks of Clopidogrel vs. Aspirin Monotherapy after Recent Ischemic Stroke: A Systematic Review and Meta-Analysis by Maurizio Paciaroni, Birsen Ince, Bo Hu, Jiann-Shing Jeng, Kursad Kutluk, Liping Liu, Min Lou, Vladimir Parfenov, Ka Sing Lawrence Wong, Babak Zamani, Dara Paek, Jung Min Han, Michael del Aguila, Shalini Girotra

“…PubMed, Embase, and CENTRAL databases were searched from inception to May 2018 to identify clinical trials and observational studies comparing clopidogrel versus aspirin for secondary prevention in patients with recent ischemic stroke within 12 months. …”
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Effect of the Floor Level on the Probability of a Neurologically Favorable Discharge after Cardiac Arrest according to the Event Location by Han Joo Choi, Hyung Jun Moon, Won Jung Jeong, Gi Woon Kim, Jae Hyug Woo, Kyoung Mi Lee, Hyuk Joong Choi, Yong Jin Park, Choung Ah Lee

“…A longer call-to-patient time was observed for home events. The probability of a neurologically favorable discharge after a high-floor OHCA was significantly lower than that after a low-floor OHCA if the event occurred in a public place (adjusted odds ratio (aOR), 0.58; 95% confidence intervals (CI), 0.37–0.89) but was higher if the event occurred at home (aOR, 1.40; 95% CI, 0.96–2.03). …”
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Electrocardiogram-gated cardiac computed tomography-based patient- and segment-specific cardiac motion estimation method in stereotactic arrhythmia radioablation for ventricular ta... by Jingyang Xie, Alicia S. Bicu, Melanie Grehn, Mustafa Kuru, Adrian Zaman, Xinyu Lu, Christian Janorschke, Luuk H.G. van der Pol, Martin F. Fast, Jens Fleckenstein, Marcus Both, Stephan Hohmann, Egor Borzov, Peter Winkler, Roland R. Tilz, Dirk Rades, Frank A. Giordano, Daniel Buergy, Boris Rudic, David Duncker, Roland Merten, Tomer Charas, Mahmoud Suleiman, Thomas Brunner, Daniel Scherr, Evgeny Lian, Achim Schweikard, Oliver Blanck, Judit Boda-Heggemann, Lena Kaestner

“…The maximum motion per patient was observed in basal and mid-cavity LV segments in 3D. …”
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Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma by Inés Zugasti, Marta Tormo-Ratera, Aina Oliver-Caldés, Juan Carlos Soler-Perromat, Verónica González-Calle, David F. Moreno, Valentín Cabañas, Nieves López-Muñoz, Álvaro Bartolomé-Solanas, Marta Español-Rego, Juan Luis Reguera-Ortega, Laura Rosiñol, Lucía López-Corral, Natalia Tovar, Luis Gerardo Rodríguez-Lobato, Rosa Maria Alvarez Perez, Sara Varea, Eulàlia Olesti, Adolfo Gomez-Grande, Laura Frutos, Pilar Tamayo, Manel Juan, José M. Moraleda, Álvaro Urbano-Ispizua, E. Azucena González-Navarro, Joaquín Martínez-López, Maria-Victoria Mateos, Xavier Tomás, Xavier Setoain, Carlos Fernández de Larrea

“…No differences were observed in progression-free survival (PFS) or overall survival (OS) between patients with or without plasmacytomas. …”
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Autoantibodies in type 1 diabetes: Prevalence and clinical profiles by Raja Hazime, Saad Lamjadli, Morad Guennouni, Mounir Belkrachni, Fatima-Ezzohra Eddehbi, Ider Oujamaa, Lahcen Elmoumou, Aicha Bourrahouate, Imane Ait Sab, Hicham Baizri, Nawal El Ansari, Brahim Admou

“…Additionally, 45,67 % of patients had one a-Abs, 28.36 % had a two, 21.15 % had three, and 4.8 % had all four a-Abs.A statistically significant difference was observed between the seropositive and seronegative groups regarding the presence of associated autoimmune diseases (p = 0.005). …”
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Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations by Hannah Schmieg, Hermann Ferling, Karina Annika Bucher, Stefanie Jacob, Julia Regnery, Hannah Schrader, Julia Schwaiger, Anton Friesen

“…In a first experiment, individually kept trout (body weight ca. 200 g) were exposed to a single dose of brodifacoum and observed for 15 days. In a second experiment, fish (body weight ca. 330 g) were kept in groups and fed every 7 or 8 days with brodifacoum-spiked feed for up to 60 days. …”
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CO2 levels and SARS-CoV-2 transmission in public schools: A retrospective cohort study in Montreal (Canada) by Olivier Séguin, Dorra Ghorbal, Gabrielle Denault, Karine Trudeau, Patrick Poulin, Catherine Dea, Stéphane Perron

“…No positive association was observed between the incidence rates of school-acquired cases and higher mid-class CO2 concentrations in both unadjusted and adjusted models.…”
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Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials by Flávio Taira Kashiwagi, Regina El Dib, Huda Gomaa, Nermeen Gawish, Erica Aranha Suzumura, Taís Regina da Silva, Fernanda Cristina Winckler, Juli Thomaz de Souza, Adriana Bastos Conforto, Gustavo José Luvizutto, Rodrigo Bazan

“…Twelve RCTs (273 participants) and 4 non-RCTs (94 participants) proved eligible. We observed a benefit in overall USN measured by the line bisection test with NIBS in comparison to sham (SMD −2.35, 95% CI −3.72, −0.98; p=0.0001); the rTMS yielded results that were consistent with the overall meta-analysis (SMD −2.82, 95% CI −3.66, −1.98; p=0.09). …”
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Are Suggested Hiking Times Accurate? A Validation of Hiking Time Estimations for Preventive Measures in Mountains by Marco Vecchiato, Nicola Borasio, Emiliano Scettri, Vanessa Franzoi, Federica Duregon, Sandro Savino, Andrea Ermolao, Daniel Neunhaeuserer

“…<i>Results</i>: Significant discrepancies were observed between actual hiking times and estimates from Komoot (ΔWK: −48.92 ± 57.16 min), Outdooractive (ΔWO: −69.13 ± 58.23 min), and mountain signage (ΔWS: −29.59 ± 59.90 min; all <i>p</i> < 0.001). …”
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Toward measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime by Debjit Roy, Xavier Michalet, Evan W. Miller, Kiran Bharadwaj, Shimon Weiss

“…By artificially modulating potassium concentration gradients across the membrane using an ionophore, we have obtained a Bacillus subtilis-specific MP versus VF lifetime calibration and estimated the MP for unperturbed B. subtilis cells to be −65 mV (in minimal salts glycerol glutamate [MSgg]), −127 mV (in M9), and that for chemically depolarized cells as −14 mV (in MSgg). We observed a population-level MP heterogeneity of ∼6-10 mV indicating a considerable degree of diversity of physiological and metabolic states among individual cells. …”
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Reinvestigation into the role of lipopolysaccharide Glycosyltransferases in Helicobacter pylori protein glycosylation by Hong Li, Xiaoqiong Tang, Tiandi Yang, Tingting Liao, Aleksandra W. Debowski, Tiankuo Yang, Yalin Shen, Hans-Olof Nilsson, Stuart M. Haslam, Barbara Mulloy, Anne Dell, Keith A. Stubbs, Wolfgang Fischer, Rainer Haas, Hong Tang, Barry J. Marshall, Mohammed Benghezal

“…As LPS is a unique component of virtually all Gram-negative bacteria, our data suggest that when observing protein electrophoretic mobility shifts between wild-type and LPS mutant strains or between subcellular fractionation samples, the influence of LPS on protein electrophoretic migration should be considered first, rather than interpreting it as potential protein glycosylation that is dependent upon LPS biosynthetic pathway.…”
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Quantitative Validation of Hematocrit Percentage Drop Cutoff Points in Postpartum Hemorrhage: An Automated Gravimetric Approach by Venance Basil Kway, José Enrique Calacuayo Rojas, Josué Sidonio Rodríguez Cuevas, Ursula Medina Moreno, José Sergio Camacho Juárez, Jorge Francisco Ayala González, Karla Krebs Larraga, Ilse Veronica Castro Martinez, Roberto Arturo Castillo Reyther, Antonio Gordillo Moscoso, Yang Pan

“…A positive correlation was observed between the volume of blood loss and the percentage drop in hematocrit, with a Pearson correlation index of 0.70 and P < 0.0001. …”
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Monitoring of Circulating Tumor DNA and Indication of De-Escalation Adjuvant Targeted Therapy for EGFR-Mutated NSCLC After Complete Resection by Song Dong, PhD, Bingfa Yan, PhD, Si-Yang Liu, PhD, Xuan Gao, PhD, Hui-Zhao Hong, MD, Hong-Ji Li, MD, Wei Gao, PhD, Hong-Hong Yan, PhD, Si-Yang Maggie Liu, PhD, Hai-Yan Tu, PhD, Yi Pan, PhD, Qing Zhou, PhD, Xue-Ning Yang, PhD, Xue-Feng Xia, PhD, Xin Yi, PhD, Wen-Zhao Zhong, PhD, Yi-Long Wu, MD, Jia-Tao Zhang, PhD

“…Methods: From January 2019 to December 2022, 71 patients with stages I to III NSCLC and EGFR (exon 19 deletion or L858R) mutations were enrolled in this observational study. A total of 375 blood samples were analyzed using the MRD_Navigator assay. …”
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International study of the perceived stress and psychological impact of the 7 October attacks on Holocaust survivors by Bruno Halioua, Patrick Bantman, Rachel Rimmer, Eric Ghozlan, Muriel Vaislic, Dan Halioua, Fabienne Amson, Charles Taieb, Richard Prasquier, Jean-François Gutthman, Robert Ejnes, Stéphanie Dassa, Alexis Astruc, Marc Cohen, Samuel Sarfati, Marc Fohlen-Weill, Odile Namia-Cohen, Aline Deutscher, Jonathan Taieb

“…Approximately two-thirds felt that the events had rekindled memories of their Holocaust experiences, and nearly one-third observed a decline in their health since the attacks. …”
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Evaluation of the Efficacy of Lusutrombopag for Chronic Liver Disease Based on Pre‐Treatment Platelet Counts: A Retrospective Multicenter Study by Takayoshi Suga, Satoru Kakizaki, Atsushi Naganuma, Takeshi Hatanaka, Satoshi Takakusagi, Daichi Takizawa, Hirotaka Arai, Takashi Ueno, Keisuke Iizuka, Toru Fukuchi, Shuichi Saito, Hiroki Tojima, Yuichi Yamazaki, Toshio Uraoka

“…The main adverse event observed was thrombosis (2.9%). Discussion Lusutrombopag increases platelet count regardless of pretreatment levels, but efficacy, defined as achieving a platelet count of ≥ 50 000/μL, may be insufficient in patients with a pretreatment platelet count < 40 000/μL. …”
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End of Pandemic Parental Hesitancy Towards Pediatric COVID-19 Vaccination: A Cross-sectional Survey at Two Lebanese Tertiary Hospitals by Sabine Shehab, Lina Anouti, Celina F. Boutros, Christelle Radi, Silma El Baasiri, Arabia Badih, Rawan Korman, Marwa El Masri, Joudie Alwan, Maha Monzer, Yara Bitar, Mona Kassem, Mayse Naser, Yara Salameh, Sarah Khafaja, Murielle Bou Ghosn, Dany Al Hamod, Sarah Ghadban, Soha Ghanem, Ghassan S. Dbaibo

“…Abstract Background This observational prospective cross-sectional study was conducted during the last 4 months of the COVID-19 pandemic to determine whether parental hesitancy to vaccinate their children against COVID-19 had improved compared to earlier studies in other countries showing high levels of hesitancy. …”
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