Wastewater-based analysis of antimicrobial resistance at UK airports: Evaluating the potential opportunities and challenges by Margaret E. Knight, Kata Farkas, Matthew Wade, Gordon Webster, Daniel A. Pass, William Perry, Peter Kille, Andrew Singer, Davey L. Jones

“…Our findings reveal that aircraft wastewater resistomes were compositionally distinct from those observed at airport terminals, despite their similar diversity. …”
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Dyssynchronous heart failure models in canines: New insights into electrocardiographic, echocardiographic and histological features by Han Jin, Shengwen Yang, Hao Huang, Sijing Cheng, Pengkang He, Sixian Weng, Min Gu, Hongxia Niu, Wei Hua, Yiran Hu, Hui Li

“…Three weeks of follow‐up were conducted to observe the changes in cardiac function and myocardial staining was performed at the end of the experiment. …”
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Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Inverse correlations were observed for 24 h urinary free cortisol and aldosterone with the ratio of left ventricular mass to end-diastolic volume (r = 0.470, P = 0.012 and r = −0.367, P = 0.046, respectively). …”
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Agronomic and Nutritional Evaluation of INIA 910—Kumymarca Ryegrass (<i>Lolium multiflorum</i> Lam.): An Alternative for Sustainable Forage Production in Department of Amazonas (NW... by Héctor V. Vásquez, Leandro Valqui, Leidy G. Bobadilla, Enrique Meseth, Milton J. Trigoso, Luis H. Zagaceta, Lamberto Valqui-Valqui, David Saravia-Navarro, Elgar Barboza, Jorge L. Maicelo

“…Significant correlations were observed between fresh and dry weight with plant height (<i>p</i> = 0.000; r = 0.84), fiber contents (<i>p</i> = 0.000; r = 1), and ash and protein content (<i>p</i> = 0.000; r = 0.85). …”
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Rab21-Targeted Nano Drug Delivery System-Based FFPG for Efficient Paclitaxel Delivery to Inhibit Lung Cancer Progression by Jing Wang, Xueying Yan, Wenfei Wang, Shu Wang, Hongxiang Jiang, Xinhua Zhu, Zhehui Li, Defu Cai, Yonggang Xia

“…The uptake of the NDDS was observed by confocal microscopy and flow cytometry. …”
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Assessment of the Heterotrophic Bacterial Contamination in Waterlines of Dental Units as a Potential Health Risk Factor in Occupational and Patient’s Exposures by Ali Shahryari, Amineh Zahed, Abdolhalim Rajabi, Maryam Shafipour, Niloufar Emrani, Hadi Rahimzadeh, Hamidreza Heidari

“…No significant differences were observed between departments (P>0.05). Furthermore, there were no significant differences in bacterial contamination between different days and hours of sampling (P>0.05), although bacterial levels were higher on Saturdays and mornings. …”
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MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB by Yihan Ma, Chongfu Zhao, Jingjing Feng, Junjie Gou, Enci Kang, Feng Guan, Qiong Wu, Xiang Li

“…Results Our findings demonstrate a robust positive correlation between the expression of GPNMB in BMMSCs and sEVs and the induction of cellular senescence. Notably, we observed that elevated levels of GPNMB, particularly those bearing bisecting N-acetylglucosamine (GlcNAc) modifications, significantly enhance the senescent phenotype of BMMSCs. …”
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Comparison between 18F-DCFPyL PET/MRI-guided ultrasound fusion targeted biopsy and systematic biopsy for tumor detection and grading in selected patients: A prospective randomized... by Shaoxi Niu, Yachao Liu, Liyan Ao, Xiaohui Ding, Xiao Chang, Jinhang Li, Jiajin Liu, Kan Liu, Nanxing Zou, Baixuan Xu, Yong Xu, Baojun Wang, Xu Zhang

“…No statistically significant difference was observed between the groups in terms of the positive surgical margin, complications, or 6-week postoperative prostate-specific antigen level. …”
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Incidence and risk of endocrine and metabolic abnormalities linked to PARP inhibitors in solid tumors: a meta-analysis by Shunlian Fu, Pingjin Zou, Zengyi Fang, Xinxiang Zhou, Junyang Chen, Cuicui Gong, Li Quan, Bing Lin, Qiu Chen, Jinyi Lang, Meihua Chen

“…No statistically significant disparities were observed for other outcomes associated with PARPi utilization. …”
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Development of an innovative intravaginal model of probiotic inoculation in dairy ovine flocks: positive effects on the vaginal microbiota, vaginitis and fertility by M. Toquet, J. Gomis, E. Jiménez-Trigos, E. Bataller, M. Barba, A. Sánchez, P. González-Torres, Á. Gómez-Martín

“…Specifically, increases in the percentages of pregnant sheep in flocks 1 and 4 (10.7 and 5.7% respectively; P > 0.05) and flock 3 (27.3%; P < 0.05) were observed in inoculated ewes. Overall, the administration of L2 on the day of intravaginal sponge insertion decreased the number of ewes with vaginitis by 11.13% at the time of sponge removal (T1). …”
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Changes in PD-1 expression on T lymphocyte subsets and related immune indicators before and after definitive chemoradiotherapy for esophageal squamous cell carcinoma by Xueling Shi, Hongyu Zhao, Jiaqi Yu, Peng Cai, Shixiang Zhou, Ning Yang, Duojie Li

“…Objective This study aimed to observe the dynamic changes in the expression of T lymphocytes, natural killer (NK) cells, and PD-1 in patients with first-diagnosed esophageal squamous cell carcinoma (ESCC) before and after chemoradiotherapy (CRT) and evaluate the impact of PD-1 expression in peripheral blood on the short-term outcome of patients with ESCC.Patients and Methods Seventy-three patients with ESCC who were treated with definitive CRT were enrolled. …”
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Provocative tests of anal sphincter function correlate with symptoms and subtypes of faecal incontinence by John McLaughlin, Dipesh H Vasant, Asbjørn Mohr Drewes, Abhiram Sharma, Matthew Davenport, Edward Kiff, Karen Telford, Alexander O'Connor, Donghua Liao, Niels Klarskov

“…This study uniquely explores all three methods in correlation with FI symptoms and subtypes.Methods This was a prospective observational study of patients with FI attending a tertiary pelvic floor unit between August 2022 and January 2024. …”
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Development and cross-validation of predictive equations for fat-free mass estimation by bioelectrical impedance analysis in Brazilian subjects with overweight and obesity by Kalina Veruska Da Silva Bezerra Masset, Analiza M. Silva, Analiza M. Silva, Gerson Ferrari, Gerson Ferrari, Breno Guilherme De Araújo Tinoco Cabral, Paulo Moreira Silva Dantas, Roberto Fernandes Da Costa

“…No FFM differences were observed between the new models and the reference method (p &gt; 0.05).ConclusionThe new proposed models provide valid options to estimate FFM in an adult population with overweight/obesity.…”
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Preoperative carcinoembryonic antigen to lymphocyte ratio serves as a prognostic predictor in elderly patients with colorectal cancer: a multicentre retrospective study by Lei Jiang, Ning Tan, Xiaonan Zhang, Jiayi Jiang, Xinyi Li, Gang Deng, Tao Liang, Haohan Ma, Weiping Deng, Lichang Guan, Kaijun Zhang, Xujie Cai, Lishu Xu

“…The carcinoembryonic antigen (CEA) to lymphocyte ratio (CLR) was derived from the derivation cohort and subsequently validated in two additional cohorts. The observed end point was all-cause death during the follow-up period postoperation.Results In the derivation cohort, CLR demonstrated an independent association with all-cause mortality. …”
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Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent by Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler

“…These data suggest that in certain experimental designs and in several tissue types, human COR signatures correlate with disease progression as measured by the bacterial burden in the preclinical TB model pipeline. We observed the best performance when the model most closely reflected human infection or disease conditions. …”
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Local Recurrence of Rectal Cancer After Transanal Total Mesorectal Excision and Risk Factors: A Nationwide Multicenter Cohort Study in Japan by Takeru Matsuda, MD, PhD, Ichiro Takemasa, MD, PhD, Hideki Endo, MD, MPH, Shinichiro Mori, MD, PhD, Suguru Hasegawa, MD, PhD, Koya Hida, MD, PhD, Takuya Tokunaga, MD, PhD, Keitaro Tanaka, MD, PhD, Toshiki Mukai, MD, PhD, Jun Watanabe, MD, PhD, Junichiro Kawamura, MD, PhD, Kei Kimura, MD, PhD, Yoshihiro Kakeji, MD, PhD, Masahiko Watanabe, MD, PhD, Seiichiro Yamamoto, MD, PhD, Takeshi Naitoh, MD, PhD, Ta-Ta-Mi study group collaboratives in Japan Society of Laparoscopic Colorectal Surgery

“…A multifocal pattern was observed in 14 (25%) of 56 patients with LR. Tumor height from the anal verge, pathological T4 disease, pathological stage III/IV, positive perineural invasion, and R1 resection were significant risk factors for LR in multivariable analysis. …”
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Balancing selection at a wing pattern locus is associated with major shifts in genome-wide patterns of diversity and gene flow by Rodríguez de Cara, María Ángeles, Jay, Paul, Rougemont, Quentin, Chouteau, Mathieu, Whibley, Annabel, Huber, Barbara, Piron-Prunier, Florence, Ramos, Renato Rogner, Freitas, André V. L., Salazar, Camilo, Silva-Brandão, Karina Lucas, Torres, Tatiana Teixeira, Joron, Mathieu

“…Testing this hypothesis with forward simulations supported the observation of increased diversity in populations with the supergene. …”
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Protocol for a nested case-control study: identifying neuroimaging biomarkers for the progression of subclinical depression and qi-stagnation constitution to major depressive disor... by Jing Wang, Chengfeng Zhang, Yueqi Zhang, Yuanyuan Liu, Jingli Zhang, Xingwei Fang, Wangyang Xia, Yanzhao Xie, Zhongli Lan, Jinhui Wang, Jinhui Wang, Jinhui Wang, Jinhui Wang, Min Lu, Jun Chen, Jun Chen

“…Finally, differences in these neuroimaging measures between the two groups at baseline will be analyzed to identify biomarkers that can predict the progression from adolescents with SD and QSC to those with MDD.Study registrationThis study protocol does not involve clinical interventions and is classified as an observational study, so it was not subject to prior registration.…”
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Associations between exposure to volatile organic compounds with obesity in adults by Runmiao Wu, Lei Jia, Xu Zhu, Gongchang Guan, Junkui Wang, Rutai Hui, Meijuan Ma, Zhao Zhao, Hui Pang, Ling Zhu

“…With the exception of BMA and DHBMA, similar results were observed regarding the association between urine VOC metabolites and the prevalence of abdominal obesity. …”
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Influenza Immunization in Very-Low-Birth-Weight Infants: Epidemiology and Long-Term Outcomes by Marie-Theres Dammann, Hannah Kraft, Guido Stichtenoth, Kathrin Hanke, Michael Zemlin, Janina Soler Wenglein, Isabell Ricklefs, Alexander Herz, Alexander Humberg, Dorothee Viemann, Geraldine Engels, Matthias Volkmar Kopp, Folke Brinkmann, Carsten Fortmann-Grote, Wolfgang Göpel, Egbert Herting, Christoph Härtel, Ingmar Fortmann, on behalf of the German Neonatal Network

“…This study aimed to provide epidemiological data on influenza immunization for German VLBWIs and hypothesized that immunization would protect VLBWIs from infection-mediated neurodevelopmental impairment and preserves lung function at early school age. Methods: In this observational population-based German Neonatal Network (GNN) study, infants born between 2009 and 2015 were invited to partake in a 6-year follow-up investigation including lung function and developmental testing. …”
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