Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with nested case–co... by Luis Alberto García Rodríguez, Pareen Vora, Luke Roberts, Gunnar Brobert, Samuel Fatoba, María Eugenia Sáez, Antonio González-Pérez

“…These findings may reflect residual confounding and biases that were difficult to control, as also seen in other observational studies. They should, therefore, be interpreted with caution, and prescribers should adhere to the dosing instructions in the respective Summary of Product Characteristics. …”
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Effects of yeast culture on growth performance, antioxidant capacity, immune function, and intestinal microbiota structure in Simmental beef cattle by Xueqiang Li, Xueqiang Li, Nan An, Nan An, Hui Chen, Hui Chen, Dacheng Liu, Dacheng Liu

“…Furthermore, YC feeding significantly enhanced the immunoglobulin G (IgG), IgA, IgM levels, lysozyme content, alkaline phosphatase activity, as well as the contents of interleukin-1β (IL-1β), IL-6, and interferon-γ in the cattle serum. The Shannon and Observed species indexes of fecal samples in YC group were remarkably higher than those in the control group, with the former group exhibiting a significant increase in the relative abundance of Paraprevotellace_CF231 and Peptostreptococcaceae_Clostridium at the genus level, while the relative abundance of Spirochaetaceae_Treponema decreased significantly. …”
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Genetic differentiation and historical dynamics of the endemic species Rheum pumilum on the Qinghai-Tibetan Plateau inferred from phylogeography implications by Shuliang Liu, Jianxin Gao, Bo Xiao, Wenjie Guo, Qiushi Yu, Ailan Wang, Weiwei Li

“…Haplotype divergence of Rh. pumilum approximately 11 million years ago, with notable divergence peaks observed during the late Miocene, as well as the Pliocene, Pleistocene and Holocene. …”
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Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain by Jordi Antón, Estefania Moreno Ruzafa, Mireia Lopez Corbeto, Rosa Bou, Judith Sánchez Manubens, Sonia Carriquí Arenas, Joan Calzada Hernández, Violetta Bittermann, Carolina Estepa Guillén, Juan Mosquera Angarita, Lucía Rodríguez Díez, Estíbaliz Iglesias, Miguel Marti Masanet, Berta Lopez Montesinos, Maria I. González Fernández, Alfonso de Lossada, Carmen Peral, Mónica Valderrama, Noelia Llevat, María Montoro Álvarez, Immaculada Calvo Penadés

“…**Methods:** Children were enrolled in this 24-month observational, multicentric, cross-sectional, retrospective study (N = 107) if they had been treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs), had participated in a previous study (ITACA), and continued to be followed up at pediatric rheumatology units at 3 tertiary Spanish hospitals. …”
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Prognostic and diagnostic accuracy of intracoronary electrocardiogram recorded during percutaneous coronary intervention: a meta-analysis by Jun Fan, Weijie Li, Yizhi Pan, Jialin He, Jiankai Huang, Pingan Chen

“…This up-to-date meta-analysis of published studies was conducted to evaluate the prognostic and diagnostic accuracy of IC-ECG recorded during PCI.Methods Relevant studies were identified by searches of MEDLINE until 19 June 2021. Observational and diagnostic studies which reported the prognostic or diagnostic accuracy of IC-ECG were included. …”
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The intersection of intimate partner violence with sexual reproductive health in the Pacific: findings from a Kiribati population study by Anneliese Spiteri-Staines, Luz Viviana Sastre Gomez, Jess Letch, Anna Bornemisza, Kristin Diemer

“…Results Of the n = 3,106 women who had been intimately partnered or sexually active in the last year, 20% had unmet need for either spacing or limiting, the greatest unmet need being observed in women aged 15–24 years (28.8%). Half (51%) of ever-partnered Kiribati women experienced physical IPV from an ex/partner in their lifetime, one quarter experienced sexual IPV (24%) and 46% psychological IPV. …”
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LC-MS Analysis, 15-Lipoxygenase Inhibition, Cytotoxicity, and Genotoxicity of Dissotis multiflora (Sm) Triana (Melastomataceae) and Paullinia pinnata Linn (Sapindaceae) by Alian Désiré Afagnigni, Maximilienne Ascension Nyegue, Steve Valdi Djova, François-Xavier Etoa

“…No genotoxic effect was observed against both strains tested. These extracts are sources of compounds which can be used to control infectious diseases and associated inflammation. …”
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Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006–2017) by Gábor Tóth, Nóra Szentmáry, Gábor László Sándor, Béla Csákány, Erika Maka, Jeannette Tóth, Zsuzsanna Antus, Milán Tamás Pluzsik, Achim Langenbucher, Zoltán Zsolt Nagy, Olga Lukáts

“…However, changes were not observed for surgical diseases, infectious and inflammatory causes, or for miscellaneous and unclassified diseases. …”
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Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) Related to Age, Sex, and Stress Perception in a Prospective Cohort of Healthy Schoolchildren by Anna Krahel, Elzbieta Paszynska, Justyna Otulakowska-Skrzynska, Szymon Rzatowski, Amadeusz Hernik, Agnieszka Slopien, Tomasz Hanć, Paula Szczesniewska, Ewa Bryl, Yves Boucher, Marta Tyszkiewicz-Nwafor, Maria Gawriolek, Monika Dmitrzak-Weglarz

“…No difference related to age or sex between groups was observed for cortisol and OPI. However, OPI levels were higher and correlated to prior stress exposure in children (0.31±0.4 vs. 0.26±0.5 ng/mL, p=0.031). sAA was negatively correlated to low mood self-declaration in children in the last two weeks (r=−0.10, p=0.045). …”
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Expression and correlation of endoglin, sEndoglin, and MMP-14 on preeclampsia placenta by Febriana Catur Iswanti, Ninik Mudjihartini, Reni Paramita, Yuditiya Purwosunu, Ani Retno Prijanti

“…Purpose: This study aimed to investigate the roles of endoglin, soluble endoglin (sEndoglin), and matrix metalloproteinase-14 (MMP-14) in the angiogenic imbalance observed in preeclampsia placentas compared to normal-term placentas. …”
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The role of Ashwagandha in modulating gut parameters in dogs—a randomized double-blind placebo-controlled trial by Kala Kumar Bharani, Ashok Kumar Devarasetti, Rajendar Bobbili, Amit Khurana, Donga Durga Veera Hanuman, Roupesh Gudepu, Swapna Guda

“…Moreover, a significant decrease in important serum liver biomarkers (alanine transaminase [ALT], aspartate transaminase [AST]; p < 0.01 and p < 0.001 at day 60) was observed in the ARE-treated dogs compared to that in the placebo control group. …”
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Decoding mpox: a systematic review and meta-analysis of the transmission and severity parameters of the 2022–2023 global outbreak by Adriana Buitrago-Lopez, Zulma M Cucunubá, Candida Diaz Brochero, Laura Cristina Nocua-Báez, Jorge Alberto Cortes, Kelly Charniga

“…We aim to synthesise the key epidemiological parameters related to the dynamics, transmission, and severity of mpox (incubation period, serial interval, generation time, infectious period, basic (R0) and effective (R(t)) reproductive number, and case fatality rate (CFR)).Methods Systematic review of observational studies in MEDLINE, EMBASE and other sources up to September 2023 (PROSPERO: CRD42023404503). …”
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Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity by Yue Fang, Lingjie Meng, Jun Xia, Yasuhiro Gotoh, Tetsuya Hayashi, Keizo Nagasaki, Hisashi Endo, Yusuke Okazaki, Hiroyuki Ogata

“…Previously reported long-term observations revealed that these viruses display seasonal fluctuations in abundance. …”
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Factors Associated with Midterm Visual Field Variability in Patients with Stable Glaucoma by Maria Emília V. Guimarães, Carolina P. B. Gracitelli, Syril Dorairaj, Fábio N. Kanadani, Tiago S. Prata

“…This retrospective observational study included 59 eyes of 39 stable glaucoma patients. …”
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A Wearable System for Experimental Knee Pain During Real-World Locomotion: Habituation and Motor Adaptation by Jesse M. Charlton, Liam H. Foulger, Calvin Kuo, Jean-Sebastien Blouin

“…Over three 10-minute walking bouts, we observed significant pain habituation (p<0.001) to the tonic electrical stimuli after 60-210 seconds. …”
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Effects of Hook Maneuver on Oxygen Saturation Recovery After −40 m Apnea Dive—A Randomized Crossover Trial by Francisco DeAsís-Fernández, Álvaro Reina-Varona, Evangelos Papotsidakis, Juan Lafuente, José Fierro-Marrero

“…Significant differences in SpO₂ were observed between the HB and UB groups at 30–45 s post-apnea, with higher SpO₂ values in the HB group; between 1.64 and 5.08% of SpO₂ in favor of the HB intervention. …”
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Pumpkin and watermelon production constraints and management practices in Uganda by Fred B. Masika, Titus Alicai, Hussein Shimelis, Gabriel Ddamulira, Shahasi Y. Athman, Perpetua Ipulet, Morgan Andama, Arthur K. Tugume

“…Mixing of several agrochemicals was observed in watermelon fields coupled with gross lack of knowledge of proper usage or purpose of these chemicals may result in pesticide resistance, health and environmental hazards. …”
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Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis by Hamdy A. Makhlouf, Amr K. Hassan, Nereen A. Almosilhy, Ahmed S.A. Osman, Shrouk Ramadan, Moaz Elsayed Abouelmagd

“…Mendelian Randomization (MR) studies revealed that expression of HMGCR was associated with an increased risk of migraine with odds ratio (OR) ranging from 1.38 to 1.55 (P < 0.001). Three observational studies investigating the relationship between statins and migraine risk demonstrated a protective effect, with odds ratios ranging from 0.73 to 0.94 (P < 0.001). …”
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Prevalence of the Helicobacter pylori babA2 Gene in Children Mainly Depends on the PCR Primer Set Used by Anja Šterbenc, Maja M. Lunar, Matjaž Homan, Boštjan Luzar, Nina Zidar, Mario Poljak

“…Our results reaffirm previous observations that the use of certain babA2 PCR primer sets can significantly impact estimation of the prevalence and clinical relevance of the H. pylori babA2 gene in children, suggesting babA2 detection methods should be carefully selected.…”
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Implementing curriculum at Sekolah Rimba Indonesia by Imaanuddin Muhtar, Haliza Hanif, Winny Azwita Putri, Lisa Amelia

“…The curriculum discussion at Sekolah Rimba was carried out because Sekolah Rimba has a combined curriculum between nature-based and religious education aligned with the current curriculum. Through observation and analysis, this article explores how the Sekolah Rimba curriculum is designed to create a holistic and contextual learning environment. …”
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